| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Yagame, K Jinde, D Suzuki, N Saotome, H Takano, R Tanabe, H Sato, K Kurokawa, H Sakai, M Matsumae, H Mase, T Haran. A diabetic case with hemoglobin J-Meerut and low HbA1C levels. Internal medicine (Tokyo, Japan). vol 36. issue 5. 1997-09-09. PMID:9213173. |
high performance liquid chromatography and isoelectric focusing indicated that her abnormal hemoglobin was hb j-meerut [alpha 120(h3)ala-->glu] and it accounted for 28.3% of the total hemoglobin. |
1997-09-09 |
2023-08-12 |
Not clear |
| F Shen, X Zheng, J Wang, M Ratna. Identification of amino acid residues that determine the differential ligand specificities of folate receptors alpha and beta. Biochemistry. vol 36. issue 20. 1997-06-23. PMID:9166787. |
the homologous murine fr types alpha and beta, which are functionally analogous to the human receptor isoforms, also contain a similar ala vs leu substitution. |
1997-06-23 |
2023-08-12 |
human |
| R Yamaguchi, M Kurasaki, Y Kojim. A mutant metallothionein which has inverse fragment composition exhibits high cadmium-binding ability. Biochemistry and molecular biology international. vol 41. issue 1. 1997-06-13. PMID:9043634. |
in order to investigate the role of the alpha-fragment of metallothionein (mt) in metal-binding, two mutant mts, beta ala alpha cys- and alpha cys beta cys-mutant mts, expressed in escherichia coli were analyzed for their metal-binding ability. |
1997-06-13 |
2023-08-12 |
Not clear |
| R Yamaguchi, M Kurasaki, Y Kojim. A mutant metallothionein which has inverse fragment composition exhibits high cadmium-binding ability. Biochemistry and molecular biology international. vol 41. issue 1. 1997-06-13. PMID:9043634. |
a mutant mt where all of the cysteine residues in the beta-fragment of mt were substituted by alanine residues and another mutant mt that had the inverse fragment composition (alpha-beta, i.e., beta-alpha in wild-type mt) were designated as the beta ala alpha cys and the alpha cys beta cys-mutant mt's, respectively. |
1997-06-13 |
2023-08-12 |
Not clear |
| S Szmelcman, N Sassoon, M Hofnun. Residues in the alpha helix 7 of the bacterial maltose binding protein which are important in interactions with the Mal FGK2 complex. Protein science : a publication of the Protein Society. vol 6. issue 3. 1997-05-27. PMID:9070445. |
these three identified residues, tyr 210, ala 213, and glu 214, which are constituents of alpha helix 7, therefore seem to play some important role in maltose transport, most probably in a productive interaction between the male protein and the membrane bound malfgk2 complex. |
1997-05-27 |
2023-08-12 |
Not clear |
| W Lu, I Apostol, M A Qasim, N Warne, R Wynn, W L Zhang, S Anderson, Y W Chiang, E Ogin, I Rothberg, K Ryan, M Laskowsk. Binding of amino acid side-chains to S1 cavities of serine proteinases. Journal of molecular biology. vol 266. issue 2. 1997-04-04. PMID:9047374. |
bovine chymotrypsin a alpha (tyr, pro, trp), porcine pancreatic elastase (leu/ala, arg, ala), subtilisin carlsberg (cys, pro, glu), streptomyces griseus proteinase a (cys, pro, leu) and b (cys, pro, lys) and human leukocyte elastase (ile, asp, ile). |
1997-04-04 |
2023-08-12 |
human |
| K Ogasahara, K Yutan. Equilibrium and kinetic analyses of unfolding and refolding for the conserved proline mutants of tryptophan synthase alpha subunit. Biochemistry. vol 36. issue 4. 1997-03-13. PMID:9020793. |
to elucidate the role of conserved proline residues of the tryptophan synthase alpha subunit from escherichia coli in stability and folding, equilibrium and kinetic studies of the unfolding-refolding induced by guanidine hydrochloride for six mutant alpha subunits (pro-->ala) were carried out by peptidyl circular dichroism and aromatic fluorescence measurements at ph 7 and 25 degrees c. these results were analyzed assuming the presence of one intermediate (i) state in the denaturation process. |
1997-03-13 |
2023-08-12 |
Not clear |
| E Maruya, Y Ishikawa, L Lin, K Tokunaga, A Kimura, H Nita, S Yokoyama, H Saj. Allele typing of HLA-A10 group by nested-PCR-low ionic strength single stranded conformation polymorphism and a novel A26 allele (A26KY, A*2605). Human immunology. vol 50. issue 2. 1997-02-27. PMID:8891738. |
d50068) revealed that the allele differs from a*2601 by a single nucleotide substitution at position 299, which leads to an amino acid substitution ala-->glu at position 76 in the alpha helix loop of the alpha 1 domain. |
1997-02-27 |
2023-08-12 |
Not clear |
| K R Rajashankar, S Ramakuma. Pi-turns in proteins and peptides: Classification, conformation, occurrence, hydration and sequence. Protein science : a publication of the Protein Society. vol 5. issue 5. 1997-02-21. PMID:8732765. |
poor helix formers, such as his, tyr, and asn, also were found to be preferred for pi alpha r-turns, whereas good helix former ala is not preferred. |
1997-02-21 |
2023-08-12 |
Not clear |
| P Dupuis-Williams, C Klotz, H Mazarguil, J Beisso. The tubulin gene family of Paramecium: characterization and expression of the alpha PT1 and alpha PT2 genes which code for alpha-tubulins with unusual C-terminal amino acids, GLY and ALA. Biology of the cell. vol 87. issue 1-2. 1997-02-20. PMID:9004490. |
the tubulin gene family of paramecium: characterization and expression of the alpha pt1 and alpha pt2 genes which code for alpha-tubulins with unusual c-terminal amino acids, gly and ala. |
1997-02-20 |
2023-08-12 |
Not clear |
| P Dupuis-Williams, C Klotz, H Mazarguil, J Beisso. The tubulin gene family of Paramecium: characterization and expression of the alpha PT1 and alpha PT2 genes which code for alpha-tubulins with unusual C-terminal amino acids, GLY and ALA. Biology of the cell. vol 87. issue 1-2. 1997-02-20. PMID:9004490. |
we show that p tetraurelia possesses four alpha- and three beta-genes and we report the cloning and sequencing of two intronless alpha-genes, alpha pt1 and alpha pt2, which code for very similar polypeptides, differing only by their unusual c-terminal amino acids, respectively gly and ala. |
1997-02-20 |
2023-08-12 |
Not clear |
| V Baudin, J Kister, G Caron, V Jonval, C Poyart, J Pagnie. The role of proline beta 5(A2) in the functional properties of human adult hemoglobin. Hemoglobin. vol 20. issue 1. 1997-02-19. PMID:8745432. |
to clarify the role of this portion of the molecule involved in oxygen-linked anion binding, we have engineered the recombinant hemoglobin alpha 2 beta (2)5(a2)pro-->ala[rhb beta 5(a2)pro-->ala]. |
1997-02-19 |
2023-08-12 |
human |
| A C Papageorgiou, C P Quinn, D Beer, R D Brehm, H S Tranter, P F Bonventre, K R Achary. Crystal structure of a biologically inactive mutant of toxic shock syndrome toxin-1 at 2.5 A resolution. Protein science : a publication of the Protein Society. vol 5. issue 8. 1997-02-06. PMID:8844860. |
in the molecular structure of the mutant toxin, the helix alpha 2 remains unaltered, but the his to ala modification causes perturbations on the neighboring helix alpha 1 by disrupting helix-helix interactions. |
1997-02-06 |
2023-08-12 |
Not clear |
| N Kieffer, C Melchior, J M Guinet, S Michels, V Gouon, N Bro. Serine 752 in the cytoplasmic domain of the beta 3 integrin subunit is not required for alpha v beta 3 postreceptor signaling events. Cell adhesion and communication. vol 4. issue 1. 1997-02-05. PMID:8870971. |
our results provide evidence that (1) the c-terminal cytoplasmic domain of beta 3 (amino acids 744-762) is essential for alpha v beta 3 integrin postreceptor occupancy events; (2) within this domain, the ser752pro mutation affects alpha v beta 3 postreceptor occupancy events by preventing cell spreading and focal contact localization; (3) the defective receptor function of the vitronectin receptor alpha v beta 3 is due to the presence of pro752, rather than the absence of ser752, as a ser to ala substitution at position 752 restores normal beta 3 integrin cell spreading and adhesive plaque formation. |
1997-02-05 |
2023-08-12 |
human |
| I Artsimovitch, K Murakami, A Ishihama, M M How. Transcription activation by the bacteriophage Mu Mor protein requires the C-terminal regions of both alpha and sigma70 subunits of Escherichia coli RNA polymerase. The Journal of biological chemistry. vol 271. issue 50. 1997-01-17. PMID:8943297. |
reconstituted rna polymerases containing ala substitutions in the alpha c-terminal domain were used to assay mor-dependent transcription from pm in vitro. |
1997-01-17 |
2023-08-12 |
Not clear |
| M K Lee, T H You, A Curtiss, D H Dea. Involvement of two amino acid residues in the loop region of Bacillus thuringiensis Cry1Ab toxin in toxicity and binding to Lymantria dispar. Biochemical and biophysical research communications. vol 229. issue 1. 1997-01-09. PMID:8954096. |
ala and leu residues in cry1ab9-033 were substituted with gly and ser by site-directed mutagenesis to produce mutant cry1ab alpha 8. |
1997-01-09 |
2023-08-12 |
Not clear |
| M Grossmann, M W Szkudlinski, J A Dias, H Xia, R Wong, D Puett, B D Weintrau. Site-directed mutagenesis of amino acids 33-44 of the common alpha-subunit reveals different structural requirements for heterodimer expression among the glycoprotein hormones and suggests that cyclic adenosine 3',5'-monophosphate production and growth promotion are potentially dissociable functions of human thyrotropin. Molecular endocrinology (Baltimore, Md.). vol 10. issue 6. 1996-12-30. PMID:8776737. |
mutating alpha arg35 to ala reduced camp induction but not receptor binding of htsh. |
1996-12-30 |
2023-08-12 |
human |
| P J Ho, J Rochette, D C Rees, C A Fisher, E R Huehns, A M Will, S L Thei. Hb Sun Prairie: diagnostic pitfalls in thalassemic hemoglobinopathies. Hemoglobin. vol 20. issue 2. 1996-12-30. PMID:8811313. |
we report an asian indian family in which two daughters have hb sun prairie, a known unstable alpha 2-globin variant [codon 130, gct-->cct; alpha 2 130(h13)ala-->pro beta 2]. |
1996-12-30 |
2023-08-12 |
Not clear |
| K Kodaira, M Oki, M Kakikawa, H Kimoto, A Taket. The virion proteins encoded by bacteriophage phi K and its host-range mutant phi KhT: host-range determination and DNA binding properties. Journal of biochemistry. vol 119. issue 6. 1996-12-17. PMID:8827438. |
phi kht, a host-range mutant of phi k, can grow on e. coli c and b, besides k12, and is more thermosensitive than the parental phage phi k. sequencing analysis revealed that the genome of phi k and phi kht consists of 6,089 nucleotides (nt), and codes for eleven genes, whose sequences are similar to those of alpha 3, phi x174, and g4 infective to strain c. in phi kht, two nt had changed: one is in the gene g, resulting in replacement of the 75th codon ala with ser, and the other is at 67th codon of the gene h: val to ala. |
1996-12-17 |
2023-08-12 |
Not clear |
| K Hiraga, K Yutan. Study of cysteine residues in the alpha subunit of Escherichia coli tryptophan synthase. 1. Role in conformational stability. Protein engineering. vol 9. issue 5. 1996-12-05. PMID:8795042. |
to eludicate the role in conformational stability of cys residues buried in the interior of a protein, the thermodynamic properties of denaturation of mutant alpha subunit of escherichia coli tryptophan synthase, in which ser, ala, val or gly was substituted for each of the three cys residues, were analyzed using calorimetry. |
1996-12-05 |
2023-08-12 |
Not clear |