| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Ferranti, A Parlapiano, A Malorni, P Pucci, G Marino, G Cossu, L Manca, B Masal. Hemoglobin Ozieri: a new alpha-chain variant (alpha 71(E20)Ala-->Val). Characterization using FAB- and electrospray-mass spectrometric techniques. Biochimica et biophysica acta. vol 1162. issue 1-2. 1993-04-13. PMID:8448185. |
a new silent hemoglobin variant, hb ozieri (alpha 71(e20)ala-->val), was observed in five apparently unrelated newborn babies during a screening for hemoglobinopathies on the island of sardinia. |
1993-04-13 |
2023-08-12 |
Not clear |
| B Landin, M Astro. Unstable haemoglobin causing haemolytic anaemia: de novo mutation in Sweden identified by PCR. Journal of internal medicine. vol 233. issue 3. 1993-04-12. PMID:8450301. |
direct nucleotide sequencing of this material revealed heterozygosity for a substitution corresponding to the haemoglobin variant alpha 2 beta 2 135(h13)ala-->pro. |
1993-04-12 |
2023-08-12 |
Not clear |
| M Valli, A Sangalli, A Rossi, M Mottes, A Forlino, R Tenni, P F Pignatti, G Cett. Osteogenesis imperfecta and type-I collagen mutations. A lethal variant caused by a Gly910-->Ala substitution in the alpha 1 (I) chain. European journal of biochemistry. vol 211. issue 3. 1993-03-23. PMID:7679635. |
a lethal variant caused by a gly910-->ala substitution in the alpha 1 (i) chain. |
1993-03-23 |
2023-08-12 |
Not clear |
| S Bolt, E Routledge, I Lloyd, L Chatenoud, H Pope, S D Gorman, M Clark, H Waldman. The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties. European journal of immunology. vol 23. issue 2. 1993-03-22. PMID:8436176. |
an aglycosyl version of the gamma 1 cd3 mab, produced by site-directed mutagenesis (asn297 to ala), still had considerable activity in this assay (intermediate to the gamma 1 and alpha 2 cd3 mab), albeit at a level approximately 10-fold lower than that of the parental gamma 1 form. |
1993-03-22 |
2023-08-12 |
mouse |
| Y Goshima, S Ohsako, T Yamauch. Overexpression of Ca2+/calmodulin-dependent protein kinase II in Neuro2a and NG108-15 neuroblastoma cell lines promotes neurite outgrowth and growth cone motility. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 2. 1993-03-04. PMID:8381167. |
to elucidate the functional role of ca2+/calmodulin-dependent protein kinase ii (cam kinase ii) in neuronal cells, we studied the phenotypic effects of overexpression of the cam kinase ii wild-type alpha subunit and a mutant enzyme alpha isoform (ala-286), in which formation of the ca(2+)-independent form by autophosphorylation is markedly suppressed by replacement of thr-286 with ala, using neuro2a (nb2a) and ng108-15 neuroblastoma cell lines. |
1993-03-04 |
2023-08-12 |
Not clear |
| S Negri Arjona, J Maldonado Eloy-Garcia, T P Molchanova, J B Wilson, L H Gu, T H Huisma. Hb Brockton [alpha 2 beta 2(138)(H16)Ala-->Pro] observed in a Spanish girl. Hemoglobin. vol 16. issue 6. 1993-02-19. PMID:1487422. |
hb brockton [alpha 2 beta 2(138)(h16)ala-->pro] observed in a spanish girl. |
1993-02-19 |
2023-08-11 |
Not clear |
| J R Spencer, V V Antonenko, N G Delaet, M Goodma. Comparative study of methods to couple hindered peptides. International journal of peptide and protein research. vol 40. issue 3-4. 1993-02-05. PMID:1478786. |
yields of the target tripeptide boc-phe-xaa-phe-obzl (xaa = (nme)ala, (nme)aib, or (nme) alpha ac5c) were compared. |
1993-02-05 |
2023-08-11 |
Not clear |
| C M Graham, A P Warren, D B Thoma. Do antigenic drift residues in influenza hemagglutinins of the H3 subtype qualify as contact sites for MHC class II interaction? International immunology. vol 4. issue 8. 1992-12-21. PMID:1358189. |
the structural basis for the loss of recognition of a major antigenic site, ha1 120-139, was investigated by (i) comparing the effects of amino acid substitutions in mutant hemagglutinins (ha1 129 gly----glu; 132 gln----glu; 135 gly----arg) with the corresponding substitutions in synthetic peptides or (ii) by assessing the effects of single amino acid substitutions (to ala) in the alpha k chain (residues 50-79) on the ability of ak transfectants to present peptides. |
1992-12-21 |
2023-08-11 |
Not clear |
| K Fujisawa, Y Hattori, Y Ohba, S And. Hb Yuda or alpha 130(H13)Ala----Asp; a new alpha chain variant with low oxygen affinity. Hemoglobin. vol 16. issue 5. 1992-12-14. PMID:1428950. |
hb yuda or alpha 130(h13)ala----asp; a new alpha chain variant with low oxygen affinity. |
1992-12-14 |
2023-08-11 |
Not clear |
| Y Takada, J Ylänne, D Mandelman, W Puzon, M H Ginsber. A point mutation of integrin beta 1 subunit blocks binding of alpha 5 beta 1 to fibronectin and invasin but not recruitment to adhesion plaques. The Journal of cell biology. vol 119. issue 4. 1992-12-04. PMID:1385446. |
a point mutation in a highly conserved region of the beta 1 subunit, asp130 to ala (d130a) substitution, abrogates the arg-gly-asp (rgd)-dependent binding of alpha 5 beta 1 to fibronectin (fn) without disrupting gross structure or heterodimer assembly. |
1992-12-04 |
2023-08-11 |
Not clear |
| T Ikezu, T Okamoto, E Ogata, I Nishimot. Amino acids 356-372 constitute a Gi-activator sequence of the alpha 2-adrenergic receptor and have a Phe substitute in the G protein-activator sequence motif. FEBS letters. vol 311. issue 1. 1992-11-20. PMID:1327875. |
furthermore, the substitution of the c-terminal phe of peptide alpha 2-f with arg, trp, and tyr (but not ala or asp) did not appreciably affect the gi-activating potency. |
1992-11-20 |
2023-08-11 |
human |
| M L Doyle, G Lew, A De Young, L Kwiatkowski, A Wierzba, R W Noble, G K Acker. Functional properties of human hemoglobins synthesized from recombinant mutant beta-globins. Biochemistry. vol 31. issue 36. 1992-10-26. PMID:1390647. |
the previous and following articles in this issue describe the recombinant synthesis of three mutant beta-globins (beta 1 val----ala, beta 1 val----met, and the addition mutation beta 1 + met), their assembly with heme and natural alpha chains into alpha 2 beta 2 tetramers, and their x-ray crystallographic structures. |
1992-10-26 |
2023-08-11 |
human |
| T P Kline, L Muelle. NMR study on solution structure of the site-specific mutant Leu48----Ala transforming growth factor alpha. International journal of peptide and protein research. vol 39. issue 2. 1992-10-07. PMID:1517010. |
nmr study on solution structure of the site-specific mutant leu48----ala transforming growth factor alpha. |
1992-10-07 |
2023-08-11 |
human |
| T P Kline, L Muelle. NMR study on solution structure of the site-specific mutant Leu48----Ala transforming growth factor alpha. International journal of peptide and protein research. vol 39. issue 2. 1992-10-07. PMID:1517010. |
the nmr spectra of the leu48----ala mutant of human transforming growth factor alpha were compared to that of the wild-type. |
1992-10-07 |
2023-08-11 |
human |
| P Ferranti, A Di Luccia, A Malorni, P Pucci, M Ruoppolo, G Marino, L Ferrar. River buffalo (Bubalus bubalis L.) AA phenotype haemoglobins: characterization by immobiline polyacrylamide gel electrophoresis and high performance liquid chromatography and determination of the primary structure of the constitutive chains by mass spectrometry. Comparative biochemistry and physiology. B, Comparative biochemistry. vol 101. issue 1-2. 1992-09-17. PMID:1499282. |
two amino acid replacements (lys 18----his and asn 116----his) were present in the beta chain with respect to the bovine (a phenotype) chain, whereas the alpha 1 and alpha 3 globins were found to contain four amino acid replacements compared to the bovine alpha, three of which were identical (glu 23----asp, glu 71----gly and phe 117----cys) and, notably, an insertion of ala at position 123-124. |
1992-09-17 |
2023-08-11 |
cattle |
| P Ferranti, A Di Luccia, A Malorni, P Pucci, M Ruoppolo, G Marino, L Ferrar. River buffalo (Bubalus bubalis L.) AA phenotype haemoglobins: characterization by immobiline polyacrylamide gel electrophoresis and high performance liquid chromatography and determination of the primary structure of the constitutive chains by mass spectrometry. Comparative biochemistry and physiology. B, Comparative biochemistry. vol 101. issue 1-2. 1992-09-17. PMID:1499282. |
furthermore, alpha 1 contains phe at position 130 whereas alpha 3 contains ser at position 132 (following the modified numbering as a consequence of the ala insertion). |
1992-09-17 |
2023-08-11 |
cattle |
| Y Tagawa, S Fujinami, Y Kadota, T Nakagawa, T Seki, Y Shiozaki, K Inoue, T Harano, K Harano, S Ued. Hb Olomouc [alpha 2 beta 2(86)(F2)Ala----Asp] found in a Japanese family. Hemoglobin. vol 16. issue 1-2. 1992-08-25. PMID:1634364. |
hb olomouc [alpha 2 beta 2(86)(f2)ala----asp] found in a japanese family. |
1992-08-25 |
2023-08-11 |
Not clear |
| D R Light, M S Dennis, I J Forsythe, C C Liu, D W Green, D A Kratzer, B V Plap. Alpha-isoenzyme of alcohol dehydrogenase from monkey liver. Cloning, expression, mechanism, coenzyme, and substrate specificity. The Journal of biological chemistry. vol 267. issue 18. 1992-08-06. PMID:1618764. |
molecular modeling suggests that the differences between mmadh alpha and eqadh are a result of the substitution of ala for phe93 and thr for ser48. |
1992-08-06 |
2023-08-11 |
human |
| S Adachi, N Sunohara, K Ishimori, I Morishim. Structure and ligand binding properties of leucine 29(B10) mutants of human myoglobin. The Journal of biological chemistry. vol 267. issue 18. 1992-08-06. PMID:1618766. |
on the basis of these results, replacement of leu29(b10) by ala or ile appears to allow bound co to rotate from a conformation pointing toward the beta meso carbon of the heme group to the one pointing toward the alpha meso carbon atom, presumably filling the space left by removal of the delta 2 carbon atom of leu29(b10). |
1992-08-06 |
2023-08-11 |
human |
| M J Anderson, C M Milner, R G Cotton, R D Campbel. The coding sequence of the hemolytically inactive C4A6 allotype of human complement component C4 reveals that a single arginine to tryptophan substitution at beta-chain residue 458 is the likely cause of the defect. Journal of immunology (Baltimore, Md. : 1950). vol 148. issue 9. 1992-06-02. PMID:1573268. |
direct sequencing of a 4.4-kb region of the gene covering exons 17 to 31 and encoding the c4d fragment and most of the rest of the alpha chain of c4 revealed that the c4a6 allele encodes the a isotypic residues pro cys-leu asp at positions 1101, 1102, 1105, and 1106 and the same residues as the c4a3 alpha gene at the polymorphic positions 1054 (asp), 1157 (asn), 1182 (thr), 1188 (val), 1191 (leu) and 1267 (ala). |
1992-06-02 |
2023-08-11 |
human |