| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K P Rücknagel, H Wiesner, G Braunitze. Carnivora: the primary structure of the beach marten (Martes foina, Mustelidae) hemoglobin. Biological chemistry Hoppe-Seyler. vol 371. issue 6. 1990-10-04. PMID:2390216. |
the differences concerning heme and interchain contact sites as well as the substitution alpha 77 (ef6)pro----ala are discussed. |
1990-10-04 |
2023-08-11 |
human |
| S H Lin, N T Yu, J Tame, D Shih, J P Renaud, J Pagnier, K Naga. Effect of the distal residues on the vibrational modes of the Fe-CO bond in hemoglobin studied by protein engineering. Biochemistry. vol 29. issue 23. 1990-09-27. PMID:2201408. |
the replacement of val-e11 by ala, leu, ile, and met has no effect on the v(c-o), v(fe-co) stretching or delta(fe-c-o) bending frequencies in both the alpha and beta subunits of hb, although some of these mutations affect the co affinity as much as 40-fold. |
1990-09-27 |
2023-08-11 |
human |
| T M elAttar, H S Lin, R D Plat. Comparison of the inhibitory effect of polyunsaturated fatty acids on prostaglandin synthesis. II. Fibroblasts. Prostaglandins, leukotrienes, and essential fatty acids. vol 39. issue 2. 1990-06-26. PMID:1971442. |
it was found that a combination of epa + dcha (6:4), dcha and ala caused significant reduction in synthesis of pge2 (10.1-87.8%) and pgf2 alpha (14.0-54.6%) at the four dose levels studied. |
1990-06-26 |
2023-08-11 |
human |
| b' S L Grokhovski\\xc4\\xad, A N Surovaia, N Iu Sidorova, G V Gurski\\xc4\\xa. [Synthesis of nonlinear DNA-binding peptide with binding specificity determinants close to those of 434 Cro-repressor]. Molekuliarnaia biologiia. vol 23. issue 6. 1990-05-21. PMID:2633035.' |
a difference in binding specificity shown by the peptide and 434 cro protein could be attributed to a flexibility of the connecting chains between dna-binding domains in the peptide molecule as well as to a replacement of thr - ala in the alpha 2 helix. |
1990-05-21 |
2023-08-11 |
Not clear |
| M Zam. Codon usage pattern in alpha 2(I) chain domain of chicken type I collagen and its implications for the secondary structure of the mRNA and the synthesis pauses of the collagen. Biochemical and biophysical research communications. vol 167. issue 2. 1990-05-07. PMID:2322250. |
the codon usage pattern of each of the three major amino acids of the alpha-chain domain of the collagen, gly, pro and ala, fluctuates considerably along the base sequence segments of the mrna and a deviation of the pattern from that of the average of the whole alpha 2(i) chain domain mrna, particularly for gly codons, leads to a loss of the stability of the local secondary structure of the mrna. |
1990-05-07 |
2023-08-11 |
chicken |
| M D Holmes, M L Brantly, D T Curiel, S Weidinger, R G Crysta. Characterization of the normal alpha 1-antitrypsin allele Vmunich: a variant associated with a unique protein isoelectric focusing pattern. American journal of human genetics. vol 46. issue 4. 1990-04-23. PMID:2316526. |
the vmunich allele differed from the common normal m1(val213) alpha 1at allele by a single nucleotide substitution of cytosine for adenosine, with the resultant amino acid change asp2 gat----ala gct. |
1990-04-23 |
2023-08-11 |
Not clear |
| P Charnet, C Labarca, R J Leonard, N J Vogelaar, L Czyzyk, A Gouin, N Davidson, H A Leste. An open-channel blocker interacts with adjacent turns of alpha-helices in the nicotinic acetylcholine receptor. Neuron. vol 4. issue 1. 1990-04-19. PMID:1690017. |
at position 10' (alpha s252, beta t263, gamma a261, delta a266), ala residues yield stronger and longer binding of qx-222 than ser or thr residues. |
1990-04-19 |
2023-08-11 |
mouse |
| C Sultana, A Abbasi, Z H Zaid. Primary structure of hemoglobin alpha-chain of Columba livia (gray wild pigeon). Journal of protein chemistry. vol 8. issue 5. 1990-03-08. PMID:2610857. |
among different exchanges, positions alpha 24 (tyr----leu), alpha 26 (ala----gly), alpha 32 (met----leu), alpha 64 (asp----glu), alpha 113 (leu----phe), and alpha 129 (leu----val) are unique to pigeon hemoglobin. |
1990-03-08 |
2023-08-11 |
pigeon |
| E M Price, D A Rice, J B Lingre. Site-directed mutagenesis of a conserved, extracellular aspartic acid residue affects the ouabain sensitivity of sheep Na,K-ATPase. The Journal of biological chemistry. vol 264. issue 36. 1990-02-01. PMID:2557344. |
four of the five mutant alpha subunits, containing either asn, ala, glu, or ser in place of asp-121, conferred ouabain resistance to hela cells when expressed in those cells. |
1990-02-01 |
2023-08-11 |
human |
| E M Price, D A Rice, J B Lingre. Site-directed mutagenesis of a conserved, extracellular aspartic acid residue affects the ouabain sensitivity of sheep Na,K-ATPase. The Journal of biological chemistry. vol 264. issue 36. 1990-02-01. PMID:2557344. |
the cells expressing the mutant na,k-atpase alpha subunit containing either asn, ala, glu, or ser in place of asp-121 contained a component of na,k-atpase activity that was nearly 100-times more resistant to ouabain than the endogenous hela (human) or sheep enzyme. |
1990-02-01 |
2023-08-11 |
human |
| M Freissmuth, A G Gilma. Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity. The Journal of biological chemistry. vol 264. issue 36. 1990-02-01. PMID:2557345. |
the arginine residue (arg187) that is the presumed site of adp-ribosylation of gs alpha by cholera toxin has been changed to ala, glu, or lys. |
1990-02-01 |
2023-08-11 |
Not clear |
| H Wajcman, Y Blouquit, G Gombaud-Saintonge, J Riou, F Galactero. Hb Fontainebleau [alpha 21(B2)Ala----pro], a new silent mutant hemoglobin. Hemoglobin. vol 13. issue 5. 1990-02-01. PMID:2599878. |
hb fontainebleau [alpha 21(b2)ala----pro], a new silent mutant hemoglobin. |
1990-02-01 |
2023-08-11 |
Not clear |
| H Wajcman, Y Blouquit, G Gombaud-Saintonge, J Riou, F Galactero. Hb Fontainebleau [alpha 21(B2)Ala----pro], a new silent mutant hemoglobin. Hemoglobin. vol 13. issue 5. 1990-02-01. PMID:2599878. |
hb fontainebleau [alpha 21(b2)ala----pro] was found in a family of italian origin. |
1990-02-01 |
2023-08-11 |
Not clear |
| L Ulukutlu, H Ozsahin, J B Wilson, B B Webber, H Hu, A Kutlar, F Kutlar, T H Huisma. Hb Brockton [alpha 2 beta 2138(H16)Ala----Pro] observed in a Turkish girl. Hemoglobin. vol 13. issue 5. 1990-02-01. PMID:2599887. |
hb brockton [alpha 2 beta 2138(h16)ala----pro] observed in a turkish girl. |
1990-02-01 |
2023-08-11 |
Not clear |
| A J Mathews, R J Rohlfs, J S Olson, J Tame, J P Renaud, K Naga. The effects of E7 and E11 mutations on the kinetics of ligand binding to R state human hemoglobin. The Journal of biological chemistry. vol 264. issue 28. 1989-10-25. PMID:2777799. |
the val-e11 side chain in alpha chains also appears to be part of the kinetic barrier to o2 and co binding since substitution with ala causes approximately 10-fold increases in the association rate constants for the binding of these diatomic ligands. |
1989-10-25 |
2023-08-11 |
human |
| Y J Avissar, J G Ormerod, S I Beal. Distribution of delta-aminolevulinic acid biosynthetic pathways among phototrophic bacterial groups. Archives of microbiology. vol 151. issue 6. 1989-10-03. PMID:2789025. |
the five-carbon pathway is apparently the more widely utilized one among bacteria, while the ala synthase pathway seems to be limited to the alpha subgroup of purple bacteria. |
1989-10-03 |
2023-08-11 |
Not clear |
| G Brignon, M F Mahé, F Grosclaude, B Ribadeau-Duma. Sequence of caprine alpha s1-casein and characterization of those of its genetic variants which are synthesized at a high level, alpha s1-CnA, B and C. Protein sequences & data analysis. vol 2. issue 3. 1989-09-01. PMID:2755948. |
variant alpha s1-cnc differs from alpha s1-cnb by three substitutions, 8 his (b)----ile (c), 100 arg (b)----lys (c) and 195 thr (b)----ala (c). |
1989-09-01 |
2023-08-11 |
cattle |
| M C Martins, L Rosado, J B Wilson, A Kutlar, H Hu, T H Huisma. Hb Himeji or alpha 2 beta 2(140)(H18)Ala----Asp in a Portuguese family. Hemoglobin. vol 13. issue 4. 1989-08-29. PMID:2753739. |
hb himeji or alpha 2 beta 2(140)(h18)ala----asp in a portuguese family. |
1989-08-29 |
2023-08-11 |
Not clear |
| F Ni, Y C Meinwald, M Vásquez, H A Scherag. High-resolution NMR studies of fibrinogen-like peptides in solution: structure of a thrombin-bound peptide corresponding to residues 7-16 of the A alpha chain of human fibrinogen. Biochemistry. vol 28. issue 7. 1989-08-25. PMID:2742827. |
medium- and long-range noe interactions were found between the nh proton of asp(7) and the c beta h protons of ala(10), between the c alpha h proton of glu(11) and the nh proton of gly(13), and between the ring protons of phe(8) and the c alpha h protons of gly(14) and the c gamma h protons of val(15). |
1989-08-25 |
2023-08-11 |
human |
| T Harano, K Harano, K Imai, H Yunoki, H Yagi, K Nagashima, T Kuroum. Hb J-Meerut [alpha 120(H3)Ala----Glu] found in a Japanese family. Hemoglobin. vol 13. issue 2. 1989-08-04. PMID:2737912. |
hb j-meerut [alpha 120(h3)ala----glu] found in a japanese family. |
1989-08-04 |
2023-08-11 |
Not clear |