| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Goc, Mrunal Choudhary, Tatiana V Byzova, Payaningal R Somanat. TGFβ- and bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR). Journal of cellular physiology. vol 226. issue 11. 2011-11-15. PMID:21302298. |
a number of pro-fibrogenic stimuli, such as growth factors, cytokines, and extracellular matrix (ecm) proteins, involve akt and its downstream substrates in mediating their effects. |
2011-11-15 |
2023-08-12 |
Not clear |
| Drew Kuraitis, Chenchen Hou, Yan Zhang, Branka Vulesevic, Tanja Sofrenovic, Daniel McKee, Zahra Sharif, Marc Ruel, Erik J Suurone. Ex vivo generation of a highly potent population of circulating angiogenic cells using a collagen matrix. Journal of molecular and cellular cardiology. vol 51. issue 2. 2011-10-25. PMID:21569777. |
when subjected to serum starvation, the matrix conferred a resistance to cell death for cd34(+) and cd133(+) progenitors and increased phosphorylation of akt. |
2011-10-25 |
2023-08-12 |
mouse |
| Pu Wang, Xiaodong Wang, Peixing Wu, Jinghai Zhang, Toshinori Sato, Sadako Yamagata, Tatsuya Yamagat. GM3 Upregulation of matrix metalloproteinase-9 possibly through PI3K, AKT, RICTOR, RHOGDI-2, and TNF-A pathways in mouse melanoma B16 cells. Advances in experimental medicine and biology. vol 705. 2011-10-14. PMID:21618116. |
gm3 upregulation of matrix metalloproteinase-9 possibly through pi3k, akt, rictor, rhogdi-2, and tnf-a pathways in mouse melanoma b16 cells. |
2011-10-14 |
2023-08-12 |
mouse |
| Bruna Romana-Souza, Marcela Otranto, Taís Fontoura Almeida, Luis Cristóvão Porto, Andréa Monte-Alto-Cost. Stress-induced epinephrine levels compromise murine dermal fibroblast activity through β-adrenoceptors. Experimental dermatology. vol 20. issue 5. 2011-09-16. PMID:21366703. |
in addition, the blockade of β3-adrenoceptors reversed the increase in fibroblast proliferation and nitric oxide synthesis as well as the reduction of fibroblast migration, akt phosphorylation and active matrix metalloproteinase-2 expression induced by epinephrine. |
2011-09-16 |
2023-08-12 |
mouse |
| Jin-Hong Kim, Anand R Asthagir. Matrix stiffening sensitizes epithelial cells to EGF and enables the loss of contact inhibition of proliferation. Journal of cell science. vol 124. issue Pt 8. 2011-09-02. PMID:21429934. |
contact inhibition on soft substrates requires e-cadherin, and the loss of contact inhibition upon matrix stiffening is accompanied by the disruption of cell-cell contacts, changes in the localization of the egf receptor and zo-1, and selective attenuation of erk, but not akt, signaling. |
2011-09-02 |
2023-08-12 |
Not clear |
| Kung-Wen Lu, Jung-Chou Chen, Tung-Yuan Lai, Jai-Sing Yang, Shu-Wen Weng, Yi-Shih Ma, Pei-Jung Lu, Jing-Ru Weng, Fu-Shin Chueh, W Gibson Wood, Jing-Gung Chun. Gypenosides inhibits migration and invasion of human oral cancer SAS cells through the inhibition of matrix metalloproteinase-2 -9 and urokinase-plasminogen by ERK1/2 and NF-kappa B signaling pathways. Human & experimental toxicology. vol 30. issue 5. 2011-08-29. PMID:20511288. |
gyp decreased the abundance of several proteins, including nuclear factor-kappa b (nf-κb), cyclooxygenase-2 (cox-2), extracellular signal-regulated kinase 1/2 (erk1/ 2), matrix metalloproteinase-9, -2 (mmp-9, -2), sevenless homolog (sos), ras, urokinase-type plasminogen activator (upa), focal adhesion kinase (fak) and rac-alpha serine/threonine-protein kinase (akt), in a time-dependent manner. |
2011-08-29 |
2023-08-12 |
human |
| Karen Man-Fong Sze, Kris Lai-Ting Wong, Glanice Kin-Yan Chu, Joyce Man-Fong Lee, Tai-On Yau, Irene Oi-Lin N. Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance. Hepatology (Baltimore, Md.). vol 53. issue 5. 2011-07-19. PMID:21520171. |
in addition to activation of akt, there was up-regulation of the sp1 transcription factor (sp1) and matrix metalloproteinase 2 (mmp2), as well as mmp2 activation in pten-knockdown hcc cells and pten(-/-) mefs. |
2011-07-19 |
2023-08-12 |
mouse |
| Li Zhang, Joseph M Valdez, Boyu Zhang, Lei Wei, Jiang Chang, Li Xi. ROCK inhibitor Y-27632 suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells and increases their cloning efficiency. PloS one. vol 6. issue 3. 2011-07-18. PMID:21464902. |
dissociation of prostate epithelial cells from extracellular matrix increases pten activity and attenuates akt activity. |
2011-07-18 |
2023-08-12 |
Not clear |
| Marta Palomo, Maribel Diaz-Ricart, Montserrat Rovira, Ginés Escolar, Enric Carrera. Defibrotide prevents the activation of macrovascular and microvascular endothelia caused by soluble factors released to blood by autologous hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. vol 17. issue 4. 2011-06-30. PMID:21126597. |
interestingly, this observation correlated with a higher increase in the expression of both tissue factor and von willebrand factor on the extracellular matrix, together with activation of intracellular p38 mapk and akt. |
2011-06-30 |
2023-08-12 |
Not clear |
| Yu Shi, Rui Liu, Si Zhang, Yin-Yan Xia, Hai-Jie Yang, Ke Guo, Qi Zeng, Zhi-Wei Fen. Neural cell adhesion molecule potentiates invasion and metastasis of melanoma cells through CAMP-dependent protein kinase and phosphatidylinositol 3-kinase pathways. The international journal of biochemistry & cell biology. vol 43. issue 4. 2011-06-03. PMID:21277992. |
furthermore, attenuation of either pka or akt activity in ncam kd cells is shown to affect their common downstream target, transcription factor camp response element binding protein (creb), which in turn down-regulates mrna expression of matrix metalloproteinase-2 (mmp-2), thus contributes to impaired cellular invasion and metastasis of melanoma cells. |
2011-06-03 |
2023-08-12 |
mouse |
| Anju Preet, Zahida Qamri, Mohd W Nasser, Anil Prasad, Konstantin Shilo, Xianghong Zou, Jerome E Groopman, Ramesh K Ganj. Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 1. 2011-04-28. PMID:21097714. |
upon further elucidation into the molecular mechanism, we observed that both cb1 and cb2 agonists inhibited phosphorylation of akt, a key signaling molecule controlling cell survival, migration, and apoptosis, and reduced matrix metalloproteinase 9 expression and activity. |
2011-04-28 |
2023-08-12 |
Not clear |
| C-H Lee, C-H Hong, H-S Yu, G-S Chen, K-C Yan. Transforming growth factor-β enhances matrix metalloproteinase-2 expression and activity through AKT in fibroblasts derived from angiofibromas in patients with tuberous sclerosis complex. The British journal of dermatology. vol 163. issue 6. 2011-04-11. PMID:20698845. |
transforming growth factor-β enhances matrix metalloproteinase-2 expression and activity through akt in fibroblasts derived from angiofibromas in patients with tuberous sclerosis complex. |
2011-04-11 |
2023-08-12 |
Not clear |
| Ajanta Chakraborty, Pramod Kumar, Kaushik Ghosh, Partha Ro. Evaluation of a Schiff base copper complex compound as potent anticancer molecule with multiple targets of action. European journal of pharmacology. vol 647. issue 1-3. 2011-04-01. PMID:20797395. |
it caused apoptosis within the tumor by the up regulation of caspase pathway and inhibition of the akt, matrix metalloproteinase 9 and α-methyl acyl coa racemase. |
2011-04-01 |
2023-08-12 |
rat |
| G Martinez, R U de Iong. The lens epithelium in ocular health and disease. The international journal of biochemistry & cell biology. vol 42. issue 12. 2011-04-01. PMID:20883819. |
recent data indicate that normal epithelial phenotype is regulated by several key signalling systems, including receptor tyrosine kinase receptors acting via the mapk and akt pathways, wnt, notch as well as extracellular matrix cues and possibly the sal-warts-hippo pathway. |
2011-04-01 |
2023-08-12 |
Not clear |
| Young-June Jin, Iha Park, In-Kee Hong, Hee-Jung Byun, Jeongsuk Choi, Young-Myeong Kim, Hansoo Le. Fibronectin and vitronectin induce AP-1-mediated matrix metalloproteinase-9 expression through integrin α(5)β(1)/α(v)β(3)-dependent Akt, ERK and JNK signaling pathways in human umbilical vein endothelial cells. Cellular signalling. vol 23. issue 1. 2011-02-08. PMID:20816750. |
fibronectin and vitronectin induce ap-1-mediated matrix metalloproteinase-9 expression through integrin α(5)β(1)/α(v)β(3)-dependent akt, erk and jnk signaling pathways in human umbilical vein endothelial cells. |
2011-02-08 |
2023-08-12 |
human |
| Sarah F Connelly, Beth A Isley, Cheryl H Baker, Gary E Gallick, Justin M Summ. Loss of tyrosine phosphatase-dependent inhibition promotes activation of tyrosine kinase c-Src in detached pancreatic cells. Molecular carcinogenesis. vol 49. issue 12. 2011-01-07. PMID:20945416. |
src family kinase (sfk) dependent increases in akt and jun n-terminal kinase (jnk) phosphorylation were observed in detached cells, indicating the potential for src-dependent activation of survival and stress pathways in pancreatic cancer cells that have detached from the extracellular matrix. |
2011-01-07 |
2023-08-12 |
human |
| J Li, Y S Lee, J-S Choi, H-Y Sung, J-K Kim, S S Lim, Y-H Kan. Roasted licorice extracts dampen high glucose-induced mesangial hyperplasia and matrix deposition through blocking Akt activation and TGF-beta signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 17. issue 10. 2010-12-07. PMID:20382513. |
roasted licorice extracts dampen high glucose-induced mesangial hyperplasia and matrix deposition through blocking akt activation and tgf-beta signaling. |
2010-12-07 |
2023-08-12 |
human |
| Andreea M Bujor, Sashidar Nakerakanti, Erin Morris, Faye N Hant, Maria Trojanowsk. Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts. Experimental dermatology. vol 19. issue 4. 2010-11-15. PMID:20201953. |
akt blockade has dual antifibrotic effects in human dermal fibroblasts, by up-regulating matrix metalloproteinase 1 (mmp1) and down-regulating collagen gene expression (j invest dermatol 2008: 128: 1906). |
2010-11-15 |
2023-08-12 |
human |
| M P Ponnusamy, I Lakshmanan, M Jain, S Das, S Chakraborty, P Dey, S K Batr. MUC4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells. Oncogene. vol 29. issue 42. 2010-11-09. PMID:20697346. |
knockdown of n-cadherin decreased the activation of extracellular signal-regulated kinase-1/2 (erk1/2), akt and matrix metalloproteinase 9 (mmp9), and inhibited the motility in the skov3-muc4 cells. |
2010-11-09 |
2023-08-12 |
human |
| Shireen Hossain, Gabriela Fragoso, Walter E Mushynski, Guillermina Almaza. Regulation of peripheral myelination by Src-like kinases. Experimental neurology. vol 226. issue 1. 2010-10-28. PMID:20696161. |
using phospho-specific antibodies, we showed that addition of extracellular matrix extracts to sc-drgn co-cultures resulted in the activation of erk, akt and p38 mapk, three protein kinases involved in sc proliferation, differentiation and peripheral myelination. |
2010-10-28 |
2023-08-12 |
rat |