| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ping Huang, Yuejuan Zhang, Tao Jiang, Wenjiao Zeng, Nong Zhan. Role of aldose reductase in the high glucose induced expression of fibronectin in human mesangial cells. Molecular biology reports. vol 37. issue 6. 2010-10-25. PMID:19821053. |
these results show that inhibition of ar may be useful to prevented extracellular matrix (ecm) deposition in diabetic nephropathy, which is regulated by jnk and akt. |
2010-10-25 |
2023-08-12 |
human |
| Bingqing Deng, Xiao Yang, Jianshe Liu, Fangfang He, Zhonghua Zhu, Chun Zhan. Focal adhesion kinase mediates TGF-beta1-induced renal tubular epithelial-to-mesenchymal transition in vitro. Molecular and cellular biochemistry. vol 340. issue 1-2. 2010-09-21. PMID:20177740. |
the expression of fak, alpha-smooth muscle actin (alpha-sma),e-cadherin, akt, matrix metallopeptidase-9 (mmp-9),tissue inhibitor of metalloproteinase-1 (timp-1), and collagen iv were detected by rt-pcr, western blot and immunofluorescence methods, respectively. |
2010-09-21 |
2023-08-12 |
Not clear |
| Jin-Nyoung Ho, Ga Young Kang, Seung-Sook Lee, Jongdoo Kim, In Hwa Bae, Sang-Gu Hwang, Hong-Duck U. Bcl-XL and STAT3 mediate malignant actions of gamma-irradiation in lung cancer cells. Cancer science. vol 101. issue 6. 2010-09-14. PMID:20331635. |
here, we demonstrate that this activity of ir in lung cancer cells is mediated by a signaling pathway involving p38 kinase, phosphoinositide 3-kinase, akt, and matrix metalloproteinase (mmp-2). |
2010-09-14 |
2023-08-12 |
Not clear |
| Judith V M G Bovée, Pancras C W Hogendoorn, Jay S Wunder, Benjamin A Alma. Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. Nature reviews. Cancer. vol 10. issue 7. 2010-07-27. PMID:20535132. |
cytogenetic studies and mouse models are beginning to identify genes and signalling pathways that have roles in tumour progression, such as hedgehog, p53, insulin-like growth factor, cyclin-dependent kinase 4, hypoxia-inducible factor, matrix metalloproteinases, src and akt, suggesting potential new therapeutic approaches. |
2010-07-27 |
2023-08-12 |
mouse |
| Y Xu, Q Chen, W Li, X Su, T Chen, Y Liu, Y Zhao, C Y. Overexpression of transcriptional coactivator AIB1 promotes hepatocellular carcinoma progression by enhancing cell proliferation and invasiveness. Oncogene. vol 29. issue 23. 2010-06-22. PMID:20305690. |
these phenotypic changes caused by aib1 knockdown correlated with increased expression of the cell cycle inhibitor p21(cip1/waf1) and decreased akt activation and the expression of proliferating cell nuclear antigen (pcna) and matrix metallopeptidase mmp-9. |
2010-06-22 |
2023-08-12 |
mouse |
| Toru Akiyama, Peter F M Choong, Crispin R Das. RANK-Fc inhibits malignancy via inhibiting ERK activation and evoking caspase-3-mediated anoikis in human osteosarcoma cells. Clinical & experimental metastasis. vol 27. issue 4. 2010-06-10. PMID:20383567. |
the anti-invasion and anti-metastasis capability of rank-fc is attributed to reduced extracellular signal-regulated protein kinase (erk) signaling via rank-fc, though activation of nfkappab, and altered expression of akt, p38, jnk, and matrix metalloproteinase (mmp)-2 and -9 were ruled out. |
2010-06-10 |
2023-08-12 |
human |
| Yuxi Zhang, Chuize Kong, Yu Zeng, Linhui Wang, Zhenhua Li, Huiqing Wang, Chuanliang Xu, Yinghao Su. Ursolic acid induces PC-3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro. Molecular carcinogenesis. vol 49. issue 4. 2010-05-12. PMID:20146252. |
ua also inhibited cell invasion by downregulating matrix metalloproteinase-9 via inhibition of akt in pc-3 cells. |
2010-05-12 |
2023-08-12 |
human |
| Minyoung Lee, Jung-Jin Park, Yun-Sil Le. Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin beta1-mediated paxillin and AKT activation. Oncology reports. vol 23. issue 3. 2010-04-29. PMID:20127017. |
in this study, we examined ir-induced cell adhesion to the extracellular matrix and evaluated the role of integrin beta1-associated downstream signaling molecules, such as paxillin and akt. |
2010-04-29 |
2023-08-12 |
human |
| Byung-Chul Jeong, Hyun-Joo Kim, In-Ho Bae, Kkot-Nim Lee, Kwang-Youl Lee, Won-Mann Oh, Sun-Hun Kim, In-Chol Kang, Shee-Eun Lee, Gou-Young Koh, Kyung-Keun Kim, Jeong-Tae Ko. COMP-Ang1, a chimeric form of Angiopoietin 1, enhances BMP2-induced osteoblast differentiation and bone formation. Bone. vol 46. issue 2. 2010-04-22. PMID:19782780. |
recently cartilage oligomeric matrix protein (comp)-ang1, an ang1 variant which is more potent than native ang1 in phosphorylating tie2 receptor and akt, was developed. |
2010-04-22 |
2023-08-12 |
Not clear |
| Anguraj Sadanandam, Erin G Rosenbaugh, Seema Singh, Michelle Varney, Rakesh K Sing. Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis. Microvascular research. vol 79. issue 1. 2010-04-12. PMID:19850054. |
in addition, our data suggest that sema5a decreases apoptosis through activation of akt, increases migration through activating met tyrosine kinases and extracellular matrix degradation through matrix metalloproteinase 9. |
2010-04-12 |
2023-08-12 |
mouse |
| Eo-Jin Lee, Dong-Il Kim, Wun-Jae Kim, Sung-Kwon Moo. Naringin inhibits matrix metalloproteinase-9 expression and AKT phosphorylation in tumor necrosis factor-alpha-induced vascular smooth muscle cells. Molecular nutrition & food research. vol 53. issue 12. 2010-03-23. PMID:19810018. |
naringin inhibits matrix metalloproteinase-9 expression and akt phosphorylation in tumor necrosis factor-alpha-induced vascular smooth muscle cells. |
2010-03-23 |
2023-08-12 |
Not clear |
| Kuei-Chuan Chan, Hsieh-Hsun Ho, Chien-Ning Huang, Ming-Cheng Lin, Hsiang-Mei Chen, Chau-Jong Wan. Mulberry leaf extract inhibits vascular smooth muscle cell migration involving a block of small GTPase and Akt/NF-kappaB signals. Journal of agricultural and food chemistry. vol 57. issue 19. 2010-01-28. PMID:19761240. |
mle also inhibited the activities of matrix metalloproteinases (mmps) mmp-2 and mmp-9, protein expressions, and phosphorylation of fak and akt, and protein expressions of small guanosine triphosphatases (gtpases: c-raf, ras, rac1, cdc42, and rhoa) in a dose-dependent manner. |
2010-01-28 |
2023-08-12 |
Not clear |
| Aaron P Petty, Stephen E Wright, Kathleen A Rewers-Felkins, Michelle A Yenderrozos, Beth A Vorderstrasse, J Suzanne Lindse. Targeting migration inducting gene-7 inhibits carcinoma cell invasion, early primary tumor growth, and stimulates monocyte oncolytic activity. Molecular cancer therapeutics. vol 8. issue 8. 2010-01-19. PMID:19671748. |
reduced phosphorylation of erk1/2, akt, and s6 kinase as well as decreased membrane-type 1 matrix metalloproteinase activity were mechanisms through which mig-7 protein caused these effects. |
2010-01-19 |
2023-08-12 |
mouse |
| Youngmi Kim, Dooil Jeoun. The cancer/testis antigen CAGE induces MMP-2 through the activation of NF-kappaB and AP-1. BMB reports. vol 42. issue 11. 2009-12-29. PMID:19944019. |
cancer-associated antigen (cage) induces the expression of matrix metalloproteinase-2 (mmp-2) by activating akt, which in turn interacts with inhibitory kappa kinase beta (ikappakbeta) to activate nuclear factor kappab (nf-kappab). |
2009-12-29 |
2023-08-12 |
Not clear |
| Weihong Yin, Jong-In Park, Richard F Loese. Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. The Journal of biological chemistry. vol 284. issue 46. 2009-12-24. PMID:19762915. |
these results demonstrate opposing roles for phosphatidylinositol 3-kinase-akt and mek-erk in cartilage matrix synthesis and suggest that elevated levels of reactive oxygen species cause chondrocyte igf-i resistance by altering the balance of akt to erk activity. |
2009-12-24 |
2023-08-12 |
human |
| Feijun Luo, David G Brooks, Hongtao Ye, Rifat Hamoudi, George Poulogiannis, Charles E Patek, Douglas J Winton, Mark J Arend. Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways. International journal of experimental pathology. vol 90. issue 5. 2009-12-14. PMID:19765110. |
k-ras(asp12) increased activation of mapk and akt signalling pathway targets phospho-extracellular signal-regulated kinase (perk) and pakt, and increased relative expression levels of wnt pathway targets vascular endothelial growth factor (vegf), gastrin, cyclo-oxygenase 2 (cox2) and t-cell lymphoma invasion and metastasis 1 (tiam1) in k-ras(asp12)/cre/apc(min/+) adenomas compared with that of apc(min/+) adenomas, although other wnt signalling pathway target genes such as peroxisome proliferator-activated receptor delta (ppard), matrix metalloproteinase 7 (mmp7), protein phosphatase 1 alpha (pp1a) and c-myc remained unchanged. |
2009-12-14 |
2023-08-12 |
mouse |
| Jae Hong Park, Ho Jae Ha. Caveolin-1 plays important role in EGF-induced migration and proliferation of mouse embryonic stem cells: involvement of PI3K/Akt and ERK. American journal of physiology. Cell physiology. vol 297. issue 4. 2009-12-03. PMID:19625610. |
egf also increased matrix metalloproteinase (mmp-2) expression levels and egf-induced mmp2 expression was inhibited by caveolin-1 sirna, fak sirna, ly-294002, akt inhibitor, and pd-98059. |
2009-12-03 |
2023-08-12 |
mouse |
| Yuan-Wei Shih, Jiunn-Min Shieh, Pei-Fen Wu, Yi-Chieh Lee, Yi-Zhi Chen, Tai-An Chian. Alpha-tomatine inactivates PI3K/Akt and ERK signaling pathways in human lung adenocarcinoma A549 cells: effect on metastasis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 47. issue 8. 2009-10-19. PMID:19457446. |
the data also showed alpha-tomatine could inhibit phosphorylation of akt and extracellular signal-regulated kinase 1 and 2 (erk1/2), which is involved in the up-regulating matrix metalloproteinase-2 (mmp-2), matrix metalloproteinase-9 (mmp-9) or urokinase-type plasminogen activator (u-pa), whereas it did not affect phosphorylation of c-jun n-terminal kinase (jnk) and p38. |
2009-10-19 |
2023-08-12 |
human |
| Seung-Ae Kim, Hyo-Jeong Lee, Kwang Seok Ahn, Hyo-Jung Lee, Eun-Ok Lee, Kyoo-Seok Ahn, Seung-Hoon Choi, Soo-Jin Jung, Ji Young Kim, Namin Baek, Sung-Hoon Ki. Paeonol exerts anti-angiogenic and anti-metastatic activities through downmodulation of Akt activation and inactivation of matrix metalloproteinases. Biological & pharmaceutical bulletin. vol 32. issue 7. 2009-10-08. PMID:19571375. |
paeonol exerts anti-angiogenic and anti-metastatic activities through downmodulation of akt activation and inactivation of matrix metalloproteinases. |
2009-10-08 |
2023-08-12 |
human |
| Seung-Ae Kim, Hyo-Jeong Lee, Kwang Seok Ahn, Hyo-Jung Lee, Eun-Ok Lee, Kyoo-Seok Ahn, Seung-Hoon Choi, Soo-Jin Jung, Ji Young Kim, Namin Baek, Sung-Hoon Ki. Paeonol exerts anti-angiogenic and anti-metastatic activities through downmodulation of Akt activation and inactivation of matrix metalloproteinases. Biological & pharmaceutical bulletin. vol 32. issue 7. 2009-10-08. PMID:19571375. |
furthermore, paeonol downregluated akt phosphorylation in bfgf-stimulated huvecs and reduced expression of matrix metalloproteinases-2 and -9 in ht1080 human fibrosarcoma cells. |
2009-10-08 |
2023-08-12 |
human |