| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katarzyna Korybalska, Edyta Kawka, Angelika Kusch, Fabienne Aregger, Duska Dragun, Achim Jörres, Andrzej Bręborowicz, Janusz Witowsk. Recovery of senescent endothelial cells from injury. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 68. issue 3. 2013-04-05. PMID:22904099. |
compared with young ec, senescent cells displayed increased expression of senescence-associated β-galactosidase, nitric oxide synthase (enos), and akt kinase, and secreted increased amounts of growth factors (vegf, tgf-β), cytokines (il-6, il-8, mcp-1), adhesion molecules (sicam-1), and matrix proteins (fibronectin). |
2013-04-05 |
2023-08-12 |
Not clear |
| Swadesh K Das, Sujit K Bhutia, Belal Azab, Timothy P Kegelman, Leyla Peachy, Prasanna K Santhekadur, Santanu Dasgupta, Rupesh Dash, Paul Dent, Steven Grant, Luni Emdad, Maurizio Pellecchia, Devanand Sarkar, Paul B Fishe. MDA-9/syntenin and IGFBP-2 promote angiogenesis in human melanoma. Cancer research. vol 73. issue 2. 2013-03-26. PMID:23233738. |
experimental evidence is provided for a model of angiogenesis induction by mda-9/syntenin in which mda-9/syntenin interacts with the extracellular matrix (ecm), activating src and fak resulting in activation by phosphorylation of akt, which induces hypoxia inducible factor 1-α (hif-1α). |
2013-03-26 |
2023-08-12 |
human |
| Bo Li, Yuehua Yang, Shengdan Jiang, Binbin Ni, Ke Chen, Leisheng Jian. Adenovirus-mediated overexpression of BMP-9 inhibits human osteosarcoma cell growth and migration through downregulation of the PI3K/AKT pathway. International journal of oncology. vol 41. issue 5. 2013-03-22. PMID:22948234. |
we used a recombinant adenovirus expressing bmp-9 (adbmp-9) to infect osteosarcoma cell lines with relatively low endogenous bmp-9 expression to determine the functional relevance of bmp-9 overexpression to osteosarcoma cell growth and migration in vitro and in vivo, and further investigated the expression levels of ki-67, matrix metallopeptidase-9 (mmp-9), phosphoinositide 3-kinase p85α (pi3kp85α) and phosphorylated akt (p-akt). |
2013-03-22 |
2023-08-12 |
mouse |
| Helan Xiao, Xiao-Hui Bai, Yingchun Wang, Hyunhee Kim, Alan S Mak, Mingyao Li. MEK/ERK pathway mediates PKC activation-induced recruitment of PKCζ and MMP-9 to podosomes. Journal of cellular physiology. vol 228. issue 2. 2013-01-24. PMID:22740332. |
inhibitors for pi3k, akt, and src suppressed pdbu-induced podosome formation and matrix degradation. |
2013-01-24 |
2023-08-12 |
human |
| Jianguo Li, J Li, Funian Li, F Li, Haibo Wang, H Wang, Xingang Wang, X Wang, Yao Jiang, Y Jiang, Dongxiao Li, D L. Wortmannin reduces metastasis and angiogenesis of human breast cancer cells via nuclear factor-κB-dependent matrix metalloproteinase-9 and interleukin-8 pathways. The Journal of international medical research. vol 40. issue 3. 2013-01-03. PMID:22906259. |
to investigate whether inhibition of akt phosphorylation by the phosphatidylinositol 3-kinase (pi3k) inhibitor, wortmannin, reduces metastasis and angiogenesis in a human breast cancer cell line via nuclear factor (nf)-κb-dependent matrix metalloproteinase (mmp)-9 and interleukin (il)-8 pathways. |
2013-01-03 |
2023-08-12 |
human |
| Nv Yan, Shuang Zhang, Yang Yang, Lin Cheng, Can Li, Lixia Dai, Lei Dai, Xiaomei Zhang, Ping Fan, Hongwei Tian, Ruibo Wang, Xiaolei Chen, Xiaolan Su, Yiming Li, Junfeng Zhang, Tao Du, Yuquan Wei, Hongxin Den. Therapeutic upregulation of Class A scavenger receptor member 5 inhibits tumor growth and metastasis. Cancer science. vol 103. issue 9. 2012-11-06. PMID:22642751. |
interestingly, upregulation of scara5 inactivated signal transducer and activator of transcription 3, as well as downstream signaling including cyclinb1, cyclind1, akt, survivin, matrix metalloproteinase-9 and vascular endothelial growth factor-a. |
2012-11-06 |
2023-08-12 |
mouse |
| Zhonghai Chen, Dong Chen, Thomas L McCarthy, Michael Centrella, Yuning Zhang, Gilbert W Moecke. Inorganic phosphate stimulates fibronectin expression in renal fibroblasts. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 30. issue 1. 2012-10-22. PMID:22759963. |
in summary we show that even mildly elevated serum phosphate levels can induce synthesis of the interstitial matrix protein fibronectin through activation of erk1/2 and akt signaling pathways in kidney fibroblasts and that the synthesis of fibronectin is mediated by a transcriptional complex consisting of nfatc1, osterix and c-fos. |
2012-10-22 |
2023-08-12 |
Not clear |
| Nelly Blaes, Christiane Pécher, Marion Mehrenberger, Eric Cellier, Françoise Praddaude, Jacques Chevalier, Ivan Tack, Réjean Couture, Jean-Pierre Girolam. Bradykinin inhibits high glucose- and growth factor-induced collagen synthesis in mesangial cells through the B2-kinin receptor. American journal of physiology. Renal physiology. vol 303. issue 2. 2012-10-02. PMID:22573379. |
in conclusion, deficient b2r activation aggravated mesangial matrix expansion in diabetic rodents whereas b2r activation reduced mc collagen synthesis by a mechanism targeting erk1/2 and akt, common pathways activated by egf and tgf-β. |
2012-10-02 |
2023-08-12 |
mouse |
| Min-Hsiung Pan, Ying-Ting Lin, Chih-Li Lin, Chi-Shiang Wei, Chi-Tang Ho, Wei-Jen Che. Suppression of Heregulin-β1/HER2-Modulated Invasive and Aggressive Phenotype of Breast Carcinoma by Pterostilbene via Inhibition of Matrix Metalloproteinase-9, p38 Kinase Cascade and Akt Activation. Evidence-based complementary and alternative medicine : eCAM. vol 2011. 2012-08-23. PMID:19617202. |
suppression of heregulin-β1/her2-modulated invasive and aggressive phenotype of breast carcinoma by pterostilbene via inhibition of matrix metalloproteinase-9, p38 kinase cascade and akt activation. |
2012-08-23 |
2023-08-12 |
human |
| Jing Zhang, Jin-Shui Zhu, Zhou Zhou, Wei-Xiong Chen, Ni-Wei Che. Inhibitory effects of ethyl pyruvate administration on human gastric cancer growth via regulation of the HMGB1-RAGE and Akt pathways in vitro and in vivo. Oncology reports. vol 27. issue 5. 2012-07-23. PMID:22246223. |
ep decreased the expression of hmgb1, rage, akt, p-akt, ki-67 and matrix metallopeptidase-9 (mmp‑9), and increased the expression of p53. |
2012-07-23 |
2023-08-12 |
human |
| Shujing Wang, Shengjin Yu, Wei Shi, Liang Ge, Xiao Yu, Jianhui Fan, Jianing Zhan. Curcumin inhibits the migration and invasion of mouse hepatoma Hca-F cells through down-regulating caveolin-1 expression and epidermal growth factor receptor signaling. IUBMB life. vol 63. issue 9. 2012-07-09. PMID:22362715. |
curcumin down-regulated the expression of cluster of differntiation (cd)147, matrix metalloproteinase 2, and matrix metalloproteinase 9 and inhibited the phosphorylation of epidermal growth factor receptor (egfr), the phosphoinositilde 3-kinase (pi3k)/protein kinase b (akt), p38 mitogen-activated protein kinase (mapk), and p44/42mapk in hca-f cells. |
2012-07-09 |
2023-08-12 |
mouse |
| Bonnie H Y Yeung, Chris K C Won. Stanniocalcin-1 regulates re-epithelialization in human keratinocytes. PloS one. vol 6. issue 11. 2012-03-16. PMID:22069492. |
in this study, staurosporine (sts) treatment induced human keratinocyte (hacat) e-lam formation on fibronectin matrix and migration via the activation of focal adhesion kinase (fak), the surge of intracellular calcium level [ca²⁺]i and the inactivation of akt. |
2012-03-16 |
2023-08-12 |
human |
| Li Dong, Lina Kang, Liang Ding, Qin Chen, Jian Bai, Rong Gu, Lixin Li, Biao X. Insulin modulates ischemia-induced endothelial progenitor cell mobilization and neovascularization in diabetic mice. Microvascular research. vol 82. issue 3. 2012-03-13. PMID:21964072. |
insulin treatment restored ischemia-induced release of stromal-derived growth factor 1α and vascular endothelial growth factor (vegf), and consequently enhanced the activity of akt and endothelial nitric oxide synthase (enos) as well as matrix metalloproteinase-9 in bone marrow. |
2012-03-13 |
2023-08-12 |
mouse |
| Xin-Yun Duan, Ping-Li Xie, Yu-Lin Ma, Si-Yuan Tan. Omentin inhibits osteoblastic differentiation of calcifying vascular smooth muscle cells through the PI3K/Akt pathway. Amino acids. vol 41. issue 5. 2012-03-12. PMID:21082206. |
moreover, inhibition of pi3k or akt activation reversed the effects of omentin on alp activity and the matrix mineralization. |
2012-03-12 |
2023-08-12 |
human |
| Monika Ivanova, Pavol Janega, Jana Matejikova, Petra Simoncikova, Dezider Pancza, Tanya Ravingerova, Miroslav Baranci. Activation of Akt kinase accompanies increased cardiac resistance to ischemia/reperfusion in rats after short-term feeding with lard-based high-fat diet and increased sucrose intake. Nutrition research (New York, N.Y.). vol 31. issue 8. 2012-02-22. PMID:21925349. |
we investigated the influence of hfs diet on cardiac function and vulnerability to ischemia-reperfusion (i/r) injury in langendorff-perfused rat hearts subjected to 30-minute global ischemia and 120-minute reperfusion as well as on akt kinase and matrix metalloproteinases. |
2012-02-22 |
2023-08-12 |
rat |
| Monika Ivanova, Pavol Janega, Jana Matejikova, Petra Simoncikova, Dezider Pancza, Tanya Ravingerova, Miroslav Baranci. Activation of Akt kinase accompanies increased cardiac resistance to ischemia/reperfusion in rats after short-term feeding with lard-based high-fat diet and increased sucrose intake. Nutrition research (New York, N.Y.). vol 31. issue 8. 2012-02-22. PMID:21925349. |
in addition, there was lower content of collagen i and iii in the left ventricle associated with akt kinase activation and matrix metalloproteinase 9 up-regulation. |
2012-02-22 |
2023-08-12 |
rat |
| Shan Wu, Alan Wells, Linda G Griffith, Douglas A Lauffenburge. Controlling multipotent stromal cell migration by integrating "course-graining" materials and "fine-tuning" small molecules via decision tree signal-response modeling. Biomaterials. vol 32. issue 30. 2011-12-12. PMID:21782235. |
using poly(methyl methacrylate)-graft-poly(ethylene oxide) polymer surfaces tethered with epidermal growth factor (tegf) and systematically adsorbed with fibronectin, vitronectin, or collagen-i to present htert-immortalized human mscs with growth factor and extracellular matrix cues, we measured cell motility properties along with signaling activities of egfr, erk, akt, and fak on 19 different substrate conditions. |
2011-12-12 |
2023-08-12 |
human |
| Stephanie M Wittig-Blaich, Lukasz A Kacprzyk, Thorsten Eismann, Melanie Bewerunge-Hudler, Petra Kruse, Eva Winkler, Wolfgang S L Strauss, Raimund Hibst, Rudolf Steiner, Mark Schrader, Daniel Mertens, Holger Sültmann, Rainer Witti. Matrix-dependent regulation of AKT in Hepsin-overexpressing PC3 prostate cancer cells. Neoplasia (New York, N.Y.). vol 13. issue 7. 2011-12-05. PMID:21750652. |
full expression of hepsin led to cell death and detachment and was specifically associated with reduced phosphorylation of akt at ser(473), which was restored by growth on matrix derived from rwpe1 normal prostatic epithelial cells. |
2011-12-05 |
2023-08-12 |
mouse |
| Ping Xie, Vinay K Kondeti, Sun Lin, Yoshisuke Haruna, Kirtee Raparia, Yashpal S Kanwa. Role of extracellular matrix renal tubulo-interstitial nephritis antigen (TINag) in cell survival utilizing integrin (alpha)vbeta3/focal adhesion kinase (FAK)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B-serine/threonine kinase (AKT) signaling pathway. The Journal of biological chemistry. vol 286. issue 39. 2011-11-22. PMID:21795690. |
role of extracellular matrix renal tubulo-interstitial nephritis antigen (tinag) in cell survival utilizing integrin (alpha)vbeta3/focal adhesion kinase (fak)/phosphatidylinositol 3-kinase (pi3k)/protein kinase b-serine/threonine kinase (akt) signaling pathway. |
2011-11-22 |
2023-08-12 |
rat |
| Anna Goc, Mrunal Choudhary, Tatiana V Byzova, Payaningal R Somanat. TGFβ- and bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR). Journal of cellular physiology. vol 226. issue 11. 2011-11-15. PMID:21302298. |
tgfβ- and bleomycin-induced extracellular matrix synthesis is mediated through akt and mammalian target of rapamycin (mtor). |
2011-11-15 |
2023-08-12 |
Not clear |