| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dae Hyung Lee, In-Hye Lim, Eon-Gi Sung, Joo-Young Kim, In-Hwan Song, Yoon Ki Park, Tae-Jin Le. Withaferin A inhibits matrix metalloproteinase-9 activity by suppressing the Akt signaling pathway. Oncology reports. vol 30. issue 2. 2014-02-27. PMID:23708780. |
withaferin a inhibits matrix metalloproteinase-9 activity by suppressing the akt signaling pathway. |
2014-02-27 |
2023-08-12 |
human |
| Pengnan Zhang, Pengfei Zhang, Min Zhou, Hua Jiang, Haiyan Zhang, Bizhi Shi, Xiaorong Pan, Huiping Gao, Hong Sun, Zonghai L. Exon 4 deletion variant of epidermal growth factor receptor enhances invasiveness and cisplatin resistance in epithelial ovarian cancer. Carcinogenesis. vol 34. issue 11. 2014-01-22. PMID:23764753. |
mechanistically, de4 egfr significantly upregulated the extracellular regulated protein kinase, akt, focal adhesion kinase (fak) and src phosphorylation and matrix metalloproteinase-9 expression while downregulated the expression of e-cadherin. |
2014-01-22 |
2023-08-12 |
Not clear |
| Ya-Dong Dong, Long Cui, Cheng-Hong Peng, Dong-Feng Cheng, Bao-San Han, Fang Huan. Expression and clinical significance of HMGB1 in human liver cancer: Knockdown inhibits tumor growth and metastasis in vitro and in vivo. Oncology reports. vol 29. issue 1. 2014-01-09. PMID:23042506. |
the expression of hmgb1, phosphorylated akt (p-akt), ki-67 and matrix metallopeptidase-2 (mmp-2) was detected by real-pcr and western blot assays. |
2014-01-09 |
2023-08-12 |
human |
| Mann-Jen Hour, Shih-Chang Tsai, Hsi-Chin Wu, Meng-Wei Lin, Jing-Gung Chung, Jin-Bin Wu, Jo-Hua Chiang, Minoru Tsuzuki, Jai-Sing Yan. Antitumor effects of the novel quinazolinone MJ-33: inhibition of metastasis through the MAPK, AKT, NF-κB and AP-1 signaling pathways in DU145 human prostate cancer cells. International journal of oncology. vol 41. issue 4. 2013-12-31. PMID:22825655. |
collectively, our data showed that mj-33 decreased protein levels of mapks (mitogen-activated protein kinases), akt, ap-1 and nf-κb, resulting in the inhibition of matrix metalloproteinases. |
2013-12-31 |
2023-08-12 |
human |
| Choya Yoon, Erna A Van Niekerk, Kenneth Henry, Tetsuhiro Ishikawa, Sumihisa Orita, Mark H Tuszynski, W Marie Campan. Low-density lipoprotein receptor-related protein 1 (LRP1)-dependent cell signaling promotes axonal regeneration. The Journal of biological chemistry. vol 288. issue 37. 2013-12-17. PMID:23867460. |
we now find that treatment of adult rat dorsal root ganglion neurons in vitro with lrp1 agonists (the receptor binding domain of α-2-macroglobulin or the hemopexin domain of matrix metalloproteinase 9) induces trkc, akt, and erk activation; significantly increases neurite outgrowth (p < 0.01); and overcomes myelin inhibition (p < 0.05). |
2013-12-17 |
2023-08-12 |
rat |
| Sung Mi Kim, Chae Hwa Kwon, Nari Shin, Do Youn Park, Hyun Jung Moon, Gwang Ha Kim, Tae Yong Jeo. Decreased Muc5AC expression is associated with poor prognosis in gastric cancer. International journal of cancer. vol 134. issue 1. 2013-12-04. PMID:23801416. |
silencing of muc5ac by using a small hairpin rna-containing lentivirus increased the invasion and migration of snu216 and ags cells as well as akt phosphorylation and the expression of vascular endothelial growth factor and matrix metalloproteinase-7, which were blocked by inhibitors of the phosphatidylinositol 3-kinase/akt pathway. |
2013-12-04 |
2023-08-12 |
Not clear |
| Jia-Ying Yang, Wu Deng, Yumay Chen, Weiwei Fan, Kenneth M Baldwin, Richard S Jope, Douglas C Wallace, Ping H Wan. Impaired translocation and activation of mitochondrial Akt1 mitigated mitochondrial oxidative phosphorylation Complex V activity in diabetic myocardium. Journal of molecular and cellular cardiology. vol 59. 2013-10-29. PMID:23500391. |
the translocated akt sequentially localized to the mitochondrial intermembrane space, inner membrane, and matrix. |
2013-10-29 |
2023-08-12 |
Not clear |
| Ying-Bin Wang, Yi Hu, Zhen Li, Ping Wang, Yi-Xue Xue, Yi-Long Yao, Bo Yu, Yun-Hui Li. Artemether combined with shRNA interference of vascular cell adhesion molecule-1 significantly inhibited the malignant biological behavior of human glioma cells. PloS one. vol 8. issue 4. 2013-10-17. PMID:23593320. |
the expression of matrix metalloproteinase-2 (mmp-2), matrix metalloproteinase-9 (mmp-9) and phosphorylated akt (p-akt) was checked by western blot assay. |
2013-10-17 |
2023-08-12 |
human |
| Keith R Brunt, Jun Wu, Zhilin Chen, Daniel Poeckel, Ryan A Dercho, Luis G Melo, Colin D Funk, Christopher A Ward, Ren-Ke L. Ex vivo Akt/HO-1 gene therapy to human endothelial progenitor cells enhances myocardial infarction recovery. Cell transplantation. vol 21. issue 7. 2013-08-08. PMID:22776314. |
late outgrowth epcs transduced ex vivo with akt and ho-1 demonstrate improved adhesion to extracellular matrix, improved migration toward human cardiomyocytes, and an improved paracrine profile under stress. |
2013-08-08 |
2023-08-12 |
mouse |
| Ching-Fen Wu, Yun-Lian Lin, Yi-Tsau Huan. Hepatitis C virus core protein stimulates fibrogenesis in hepatic stellate cells involving the obese receptor. Journal of cellular biochemistry. vol 114. issue 3. 2013-07-09. PMID:22961938. |
furthermore, knockdown of ob-rb down-regulated hcvcp-induced stat3, akt, and ampkα phosphorylation, and reversed hcvcp-suppressed mrna expression of matrix metalloproteinase (mmp)-1, peroxisome proliferator-activated receptor (ppar)γ and sterol regulatory element binding protein-1c (srebp-1c) genes. |
2013-07-09 |
2023-08-12 |
human |
| Mikhail Konoplyannikov, Khawaja Husnain Haider, Vien Khach Lai, Rafeeq P H Ahmed, Shujia Jiang, Muhammad Ashra. Activation of diverse signaling pathways by ex-vivo delivery of multiple cytokines for myocardial repair. Stem cells and development. vol 22. issue 2. 2013-07-02. PMID:22873203. |
using our custom-made growth factor array and western blotting, multiple angiogenic and prosurvival factors were detected in (trans)sm, including secreted frizzled related protein-1,2,4,5, matrix metalloproteinases-3 and 9, connexin-43, netrin-1, nos-2, wnt-3, akt, mapk42/44, stat3, nuclear factor kappa b (nfκb), hypoxia-inducible factor 1 (hif-1α), and protein kinase c (pkc). |
2013-07-02 |
2023-08-12 |
human |
| Elizabeth W Bradley, Lomeli R Carpio, Jennifer J Westendor. Histone deacetylase 3 suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt signaling and matrix secretion. The Journal of biological chemistry. vol 288. issue 14. 2013-05-31. PMID:23408427. |
histone deacetylase 3 suppression increases ph domain and leucine-rich repeat phosphatase (phlpp)1 expression in chondrocytes to suppress akt signaling and matrix secretion. |
2013-05-31 |
2023-08-12 |
mouse |
| Elizabeth W Bradley, Lomeli R Carpio, Jennifer J Westendor. Histone deacetylase 3 suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt signaling and matrix secretion. The Journal of biological chemistry. vol 288. issue 14. 2013-05-31. PMID:23408427. |
these phenotypes led to the hypothesis that the akt/mtor pathway was repressed in these hdac3-deficient chondrocytes because akt promotes hypertrophy and matrix production in many tissues. |
2013-05-31 |
2023-08-12 |
mouse |
| Elizabeth W Bradley, Lomeli R Carpio, Jennifer J Westendor. Histone deacetylase 3 suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt signaling and matrix secretion. The Journal of biological chemistry. vol 288. issue 14. 2013-05-31. PMID:23408427. |
expression of constitutively active akt restored phosphorylation of mtor and p70 s6k and matrix gene expression levels. |
2013-05-31 |
2023-08-12 |
mouse |
| Elizabeth W Bradley, Lomeli R Carpio, Jennifer J Westendor. Histone deacetylase 3 suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt signaling and matrix secretion. The Journal of biological chemistry. vol 288. issue 14. 2013-05-31. PMID:23408427. |
these data demonstrate that hdac3 controls chondrocyte hypertrophy and matrix content by repressing phlpp1 expression and facilitating akt activity. |
2013-05-31 |
2023-08-12 |
mouse |
| Boban M Erovic, Luke Harris, Mina Jamali, David P Goldstein, Jonathan C Irish, Sylvia L Asa, Ozgur Met. Biomarkers of parathyroid carcinoma. Endocrine pathology. vol 23. issue 4. 2013-05-23. PMID:23001705. |
we constructed a tissue microarray of parathyroid carcinomas from 10 patients as well as parathyroid adenomas from 25 patients and stained the slides for 34 proteins involved in angiogenesis (platelet-derived growth factor receptor (pdgfr)-α, pdgfr-β, vascular endothelial growth factor receptor-2 (vegfr-2), and epidermal growth factor receptor (egfr)), inflammation (cyclooxygenase (cox)-1 and cox-2), cell adhesion (matrix metalloproteinase (mmp)-1, cd9, and keratin 7), cell cycle (cdc2p34, cyclin d1, retinoblastoma (rb), p27, p21, parafibromin, bmi-1, 14-3-3σ, and p53), and apoptosis (bcl-2a, mcl-1, bcl-xl, and glutathione-s-transferase-isoenzyme π (gst-π)) along with some markers of the sonic hedgehog (smo, shh, gli-1, gli-2, gli-3, and patched), mtor (akt, mammalian target of rapamycin (mtor), and forkhead box o (foxo)-1), and wnt (wisp-1, wisp-2, and β-catenin) signal transduction pathways. |
2013-05-23 |
2023-08-12 |
Not clear |
| David S Hong, Udai Banerji, Bahareh Tavana, Goldy C George, Joann Aaron, Razelle Kurzroc. Targeting the molecular chaperone heat shock protein 90 (HSP90): lessons learned and future directions. Cancer treatment reviews. vol 39. issue 4. 2013-05-10. PMID:23199899. |
in cancer cells, hsp90 client proteins play a major role in oncogenic signal transduction (i.e., mutant epidermal growth factor receptor), angiogenesis (i.e., vascular endothelial growth factor), anti-apoptosis (i.e., akt), and metastasis (i.e., matrix metalloproteinase 2 and cd91), processes central to maintaining the cancer phenotype. |
2013-05-10 |
2023-08-12 |
Not clear |
| X-Y Ye, X-M Niu, N-W Tang, Y-H Xu, Z-M Li, Y-F Yu, S Lu, S-W Che. Adenovirus mediated knockdown of bone morphogenetic protein 2 inhibits human lung cancer growth and invasion in vitro and in vivo. International journal of immunopathology and pharmacology. vol 25. issue 4. 2013-04-23. PMID:23298487. |
adenovirus vector-mediated bmp-2 small hairpin rna (shbmp-2) was used to transfect into a549 lac cells to determine the functional relevance of bmp-2 and tumor growth and invasion in vitro and in vivo, and further investigate the expression levels of bmp-2, vascular endothelial growth factor (vegf), matrix metallopeptidase-9 (mmp-9), phosphatidylinositol 3-kinase p85alpha (pi3kp85alpha) and phosphorylated akt (p-akt). |
2013-04-23 |
2023-08-12 |
mouse |
| Maitham A Khajah, Sanaa Al Saleh, Princy M Mathew, Yunus A Luqman. Differential effect of growth factors on invasion and proliferation of endocrine resistant breast cancer cells. PloS one. vol 7. issue 7. 2013-04-11. PMID:22860018. |
differential effects were observed on activation of akt and erk1/2 suggesting their involvement as intracellular mediators of egf induced invasion, in part through the regulation of matrix metalloproteinase activity. |
2013-04-11 |
2023-08-12 |
Not clear |
| Christopher R Daniels, Cerrone R Foster, Sana Yakoob, Suman Dalal, William L Joyner, Mahipal Singh, Krishna Sing. Exogenous ubiquitin modulates chronic β-adrenergic receptor-stimulated myocardial remodeling: role in Akt activity and matrix metalloproteinase expression. American journal of physiology. Heart and circulatory physiology. vol 303. issue 12. 2013-04-09. PMID:23042947. |
exogenous ubiquitin modulates chronic β-adrenergic receptor-stimulated myocardial remodeling: role in akt activity and matrix metalloproteinase expression. |
2013-04-09 |
2023-08-12 |
mouse |