| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Asha Eapen, Anne Georg. Dentin phosphophoryn in the matrix activates AKT and mTOR signaling pathway to promote preodontoblast survival and differentiation. Frontiers in physiology. vol 6. 2015-08-24. PMID:26300786. |
dentin phosphophoryn in the matrix activates akt and mtor signaling pathway to promote preodontoblast survival and differentiation. |
2015-08-24 |
2023-08-13 |
Not clear |
| Fuhai Wang, Xiaofeng Dong, Peng Xiu, Jingtao Zhong, Honglong Wei, Zongzhen Xu, Tao Li, Feng Liu, Xueying Sun, Jie L. T7 peptide inhibits angiogenesis via downregulation of angiopoietin-2 and autophagy. Oncology reports. vol 33. issue 2. 2015-08-20. PMID:25483829. |
in conclusion, the t7 peptide inhibited angiogenesis and exerted its antitumor effects by inhibition of ang2, phosphorylation of akt and matrix metalloproteinase-2 (mmp-2) regulated by ang2. |
2015-08-20 |
2023-08-13 |
mouse |
| Yi Hu, Xing Lin, Ping Wang, Yi-Xue Xue, Zhen Li, Li-Bo Liu, Bo Yu, Tian-Da Feng, Yun-Hui Li. CRM197 in Combination With shRNA Interference of VCAM-1 Displays Enhanced Inhibitory Effects on Human Glioblastoma Cells. Journal of cellular physiology. vol 230. issue 8. 2015-07-15. PMID:25201410. |
activation of cleaved caspase-3, 8, and 9, activity of matrix metalloproteinase-2/9 (mmp-2/9), and expression of phosphorylated akt (p-akt) were also checked. |
2015-07-15 |
2023-08-13 |
human |
| Y Zhen, L Guanghui, Z Xief. Knockdown of EGFR inhibits growth and invasion of gastric cancer cells. Cancer gene therapy. vol 21. issue 11. 2015-07-15. PMID:25394504. |
the expression of akt, proliferating cell nuclear antigen (pcna) and matrix metallopeptidase-9 (mmp-9) was detected by real-time pcr and western blotting assays. |
2015-07-15 |
2023-08-13 |
human |
| Wei Zhang, Qianyi Li, Chao Song, Lifeng La. Knockdown of autophagy-related protein 6, Beclin-1, decreases cell growth, invasion, and metastasis and has a positive effect on chemotherapy-induced cytotoxicity in osteosarcoma cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 4. 2015-07-09. PMID:25427639. |
furthermore, we determine the functional relevance of beclin-1 knockdown to osteosarcoma cell growth, migration, and invasion, and investigate the expression levels of matrix metallopeptidase-2 (mmp-2), mmp-9, phosphoinositide 3-kinase p85α (pi3kp85α), and phosphorylated akt (p-akt). |
2015-07-09 |
2023-08-13 |
mouse |
| Takamitsu Sasaki, Hiroki Kuniyas. Significance of AKT in gastric cancer (Review). International journal of oncology. vol 45. issue 6. 2015-06-29. PMID:25270272. |
akt is a serine/threonine kinase activated downstream of integrin, which is a receptor for various pro-proliferation and bioactive substances as well as the extracellular matrix receptor. |
2015-06-29 |
2023-08-13 |
Not clear |
| Richard E Kast, Georg Karpel-Massler, Marc-Eric Halatsc. CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide. Oncotarget. vol 5. issue 18. 2015-06-25. PMID:25211298. |
the combined action of this suite of drugs blocks signaling at, or the activity of, akt phosphorylation, aldehyde dehydrogenase, angiotensin converting enzyme, carbonic anhydrase -2,- 9, -12, cyclooxygenase-1 and -2, cathepsin b, hedgehog, interleukin-6, 5-lipoxygenase, matrix metalloproteinase -2 and -9, mammalian target of rapamycin, neurokinin-1, p-gp efflux pump, thioredoxin reductase, tissue factor, 20 kda translationally controlled tumor protein, and vascular endothelial growth factor. |
2015-06-25 |
2023-08-13 |
Not clear |
| Longhui Han, Wenru Su, Jingwen Huang, Jingwen Zhou, Sujuan Qiu, Dan Lian. Doxycycline inhibits inflammation-induced lymphangiogenesis in mouse cornea by multiple mechanisms. PloS one. vol 9. issue 9. 2015-06-16. PMID:25268699. |
additionally, doxycycline treatment dramatically reduced the phosphorylation of nf-κbp65, akt and enos in ila and significantly inhibited matrix metalloproteinases (mmps) activity in vitro and in ila. |
2015-06-16 |
2023-08-13 |
mouse |
| Yongqiang Dong, Guojun Liang, Bo Yuan, Chaoqun Yang, Rui Gao, Xuhui Zho. MALAT1 promotes the proliferation and metastasis of osteosarcoma cells by activating the PI3K/Akt pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 3. 2015-06-15. PMID:25431257. |
at the same time, the proliferating cell nuclear antigen (pcna), matrix metallopeptidase 9 (mmp-9), phosphorylated pi3kp85α, and akt expressions were significantly inhibited in malat1-deleted cells. |
2015-06-15 |
2023-08-13 |
human |
| Zhaolong Liu, Gang Han, Yu Cao, Yidong Wang, Hangjun Gon. Calcium/calmodulin‑dependent protein kinase II enhances metastasis of human gastric cancer by upregulating nuclear factor‑κB and Akt‑mediated matrix metalloproteinase‑9 production. Molecular medicine reports. vol 10. issue 5. 2015-06-09. PMID:25174603. |
furthermore, h282r upregulated matrix metalloproteinase‑9 (mmp‑9) expression and production, which were dependent on camkii‑mediated increase in nuclear factor (nf)‑κb and akt activation. |
2015-06-09 |
2023-08-13 |
human |
| Young-Rak Cho, Jae Hyeon Kim, Jin-Kyu Kim, Eun-Kyung Ahn, Hye-Jin Ko, Jae Kyung In, Sang-Jin Lee, Gyu-Un Bae, Yong Kee Kim, Joa Sub Oh, Dong-Wan Se. Broussonetia kazinoki modulates the expression of VEGFR-2 and MMP-2 through the inhibition of ERK, Akt and p70S6K‑dependent signaling pathways: Its implication in endothelial cell proliferation, migration and tubular formation. Oncology reports. vol 32. issue 4. 2015-06-01. PMID:25109823. |
these anti-angiogenic activities of bk were associated with the inactivation of mitogenic signaling pathways including extracellular signal-regulated kinase, akt and p70s6k, and the subsequent downregulation of vegfr-2 and matrix metalloproteinase-2. |
2015-06-01 |
2023-08-13 |
human |
| Hai Lin, Li-Hua Sun, Wei Han, Tie-Ying He, Xin-Jian Xu, Kun Cheng, Cheng Geng, Li-Dan Su, Hao Wen, Xi-Yan Wang, Qi-Long Che. Knockdown of OCT4 suppresses the growth and invasion of pancreatic cancer cells through inhibition of the AKT pathway. Molecular medicine reports. vol 10. issue 3. 2015-05-13. PMID:25017645. |
the knockdown of oct4 inhibited the proliferation and invasion of pancreatic cancer cells (panc‑1) expressing high levels of oct4, accompanied with decreased expression of akt, proliferating cell nuclear antigen (pcna) and matrix metalloproteinase‑2 (mmp‑2). |
2015-05-13 |
2023-08-13 |
human |
| Yuan Wang, Lin Yuan, Xiang-Min Yang, Ding Wei, Bin Wang, Xiu-Xuan Sun, Fei Feng, Gang Nan, Ye Wang, Zhi-Nan Chen, Huijie Bia. A chimeric antibody targeting CD147 inhibits hepatocellular carcinoma cell motility via FAK-PI3K-Akt-Girdin signaling pathway. Clinical & experimental metastasis. vol 32. issue 1. 2015-04-24. PMID:25424030. |
except for the depression of matrix metalloproteinase-2 and matrix metalloproteinase-9 expressions, chab18 antibody suppressed cell motility by rearrangement of actin cytoskeleton, which was probably induced by decreasing the phosphorylation of focal adhesion kinase, phosphatidylinositide-3 kinase (pi3k), akt, and girdin in the integrin signaling pathway. |
2015-04-24 |
2023-08-13 |
mouse |
| Jun Iwashita, Yuho Ito, Mari Yokoo, Sunao Takahashi, Jun Murat. Akt induces down regulation of MUC5AC production in NCI-H292 human airway epithelial cells cultured on extracellular matrix. Bioscience, biotechnology, and biochemistry. vol 78. issue 2. 2015-03-30. PMID:25036673. |
akt induces down regulation of muc5ac production in nci-h292 human airway epithelial cells cultured on extracellular matrix. |
2015-03-30 |
2023-08-13 |
human |
| Lei Wu, Liang Yang, Yu Xiong, Hua Guo, Xiaoli Shen, Zujue Cheng, Yan Zhang, Ziyun Gao, Xingen Zh. Annexin A5 promotes invasion and chemoresistance to temozolomide in glioblastoma multiforme cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 12. 2015-03-10. PMID:25245332. |
overexpression of annexin a5 in both cell lines significantly increased cell invasion, matrix metalloproteinase-2 (mmp-2) expression/activity, akt phosphorylation at serine 473, and the half maximal inhibitory concentration (ic50) values of temozolomide and markedly decreased temozolomide-induced apoptosis, all of which were abolished by selective pi3k inhibitor bkm120. |
2015-03-10 |
2023-08-13 |
human |
| Hui Xia, Yong-Fu Ma, Chang-Hai Yu, Ying-Jie Li, Jian Tang, Jing-Bo Li, Ying-Nan Zhao, Yang Li. Aquaporin 3 knockdown suppresses tumour growth and angiogenesis in experimental non-small cell lung cancer. Experimental physiology. vol 99. issue 7. 2015-02-20. PMID:24803527. |
aquaporin 3 knockdown in vitro significantly suppressed activities of matrix metalloproteinases mmp2 and mmp9, reduced akt phosphorylation and decreased cell invasiveness of a549 and h1299 cells. |
2015-02-20 |
2023-08-13 |
mouse |
| Falguni Das, Nandini Ghosh-Choudhury, Nirmalya Dey, Amit Bera, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose forces a positive feedback loop connecting Akt kinase and FoxO1 transcription factor to activate mTORC1 kinase for mesangial cell hypertrophy and matrix protein expression. The Journal of biological chemistry. vol 289. issue 47. 2015-02-12. PMID:25288788. |
high glucose forces a positive feedback loop connecting akt kinase and foxo1 transcription factor to activate mtorc1 kinase for mesangial cell hypertrophy and matrix protein expression. |
2015-02-12 |
2023-08-13 |
mouse |
| Falguni Das, Nandini Ghosh-Choudhury, Nirmalya Dey, Amit Bera, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose forces a positive feedback loop connecting Akt kinase and FoxO1 transcription factor to activate mTORC1 kinase for mesangial cell hypertrophy and matrix protein expression. The Journal of biological chemistry. vol 289. issue 47. 2015-02-12. PMID:25288788. |
high glucose-induced akt acts as a signaling hub for mesangial cell hypertrophy and matrix expansion, which are recognized as cardinal signatures for the development of diabetic nephropathy. |
2015-02-12 |
2023-08-13 |
mouse |
| Falguni Das, Nandini Ghosh-Choudhury, Nirmalya Dey, Amit Bera, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose forces a positive feedback loop connecting Akt kinase and FoxO1 transcription factor to activate mTORC1 kinase for mesangial cell hypertrophy and matrix protein expression. The Journal of biological chemistry. vol 289. issue 47. 2015-02-12. PMID:25288788. |
together, our results provide the first evidence for the presence of a positive feedback loop for the sustained activation of akt involving inactivated foxo1 and a decrease in catalase expression, leading to increased ros and mesangial cell hypertrophy and matrix protein expression. |
2015-02-12 |
2023-08-13 |
mouse |
| Alphonse E Sirica, Jorge A Almenara, Chao L. Periostin in intrahepatic cholangiocarcinoma: pathobiological insights and clinical implications. Experimental and molecular pathology. vol 97. issue 3. 2015-02-04. PMID:25446840. |
through its interaction with specific components of the extracellular tumor matrix, particularly collagen type i and tenascin-c, and with cell surface receptors, notably integrins leading to activation of the akt and fak signaling pathways, this tgf-β family-inducible matricellular protein appears to be functioning as a key extracellular matrix molecule regulating such critically important and diverse malignant tumor behaviors as tumor fibrogenesis and desmoplasia, invasive malignant cell growth, chemoresistance, and metastatic colonization. |
2015-02-04 |
2023-08-13 |
Not clear |