| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaojun Zhu, Qianqian Cao, Xia Li, Zhengping Wan. Knockdown of TACC3 inhibits trophoblast cell migration and invasion through the PI3K/Akt signaling pathway. Molecular medicine reports. vol 14. issue 4. 2017-04-17. PMID:27572091. |
the expression levels of tacc3, matrix metalloproteinase (mmp)‑2, mmp‑9, tissue inhibitor of metalloproteinase (timp)‑1, timp‑2, phosphoinositide 3‑kinase (pi3k), phosphorylated (p)‑pi3k, akt and p‑akt were detected by western blotting. |
2017-04-17 |
2023-08-13 |
human |
| Hui Liu, Yonghui Dong, Yutong Gao, Zhipeng Du, Yuting Wang, Peng Cheng, Anmin Chen, Hui Huan. The Fascinating Effects of Baicalein on Cancer: A Review. International journal of molecular sciences. vol 17. issue 10. 2017-03-31. PMID:27735841. |
the anti-tumor functions of baicalein are mainly due to its capacities to inhibit complexes of cyclins to regulate the cell cycle, to scavenge oxidative radicals, to attenuate mitogen activated protein kinase (mapk), protein kinase b (akt) or mammalian target of rapamycin (mtor) activities, to induce apoptosis by activating caspase-9/-3 and to inhibit tumorinvasion and metastasis by reducing the expression of matrix metalloproteinase-2/-9 (mmp-2/-9). |
2017-03-31 |
2023-08-13 |
Not clear |
| Pu Li, Chenkui Miao, Chao Liang, Pengfei Shao, Zengjun Wang, Jie L. Silencing CAPN2 Expression Inhibited Castration-Resistant Prostate Cancer Cells Proliferation and Invasion via AKT/mTOR Signal Pathway. BioMed research international. vol 2017. 2017-03-20. PMID:28280729. |
knockdown of cpan2 level suppressed the migration and invasion capacity of crpc cells by reducing matrix metalloproteinase-2 (mmp-2) and mmp-9 activation, as well as repressing the phosphorylation protein expression of akt and mtor. |
2017-03-20 |
2023-08-13 |
Not clear |
| H-B Zhao, X-F Zhang, H-B Wang, M-Z Zhan. Migration and invasion enhancer 1 (MIEN1) is overexpressed in breast cancer and is a potential new therapeutic molecular target. Genetics and molecular research : GMR. vol 16. issue 1. 2017-03-16. PMID:28198505. |
downregulation of mien1 suppressed the expression of matrix metallopeptidase 9 by downregulating the expression of protein kinase b (also known as akt) in breast cancer cells. |
2017-03-16 |
2023-08-13 |
human |
| Xiangling Xiao, Zhongwei He, Wei Cao, Fen Cai, Liang Zhang, Qiuyue Huang, Chunsheng Fan, Chao Duan, Xiaobo Wang, Jiu Wang, Ying Li. Oridonin inhibits gefitinib-resistant lung cancer cells by suppressing EGFR/ERK/MMP-12 and CIP2A/Akt signaling pathways. International journal of oncology. vol 48. issue 6. 2017-03-10. PMID:27082429. |
ori also significantly downregulated the phosphorylation of egfr, erk, akt, expression levels of matrix metalloproteinase-12 (mmp-12), and the cancerous inhibitor of protein phosphatase 2a (cip2a). |
2017-03-10 |
2023-08-13 |
Not clear |
| Xiaoli Zhu, Qianming Bai, Yongming Lu, Yiqiong Lu, Linlin Zhu, Xiaoyan Zhou, Lijing W. Expression and function of CXCL12/CXCR4/CXCR7 in thyroid cancer. International journal of oncology. vol 48. issue 6. 2017-03-06. PMID:27082011. |
overexpression of cxcr4 in k1 cells significantly increased akt and erk phosphorylation and markedly induced the expression and activity of matrix metalloproteinase-2 (mmp‑2). |
2017-03-06 |
2023-08-13 |
human |
| Bo-Yun Choi, Chul-Hong Park, Yun Hee Na, Hyoung-Woo Bai, Jae-Young Cho, Byung Yeoup Chun. Inhibition of RANKL-induced osteoclast differentiation through the downregulation of c-Fos and NFATc1 by Eremochloa ophiuroides (centipedegrass) extract. Molecular medicine reports. vol 13. issue 5. 2017-02-16. PMID:27035226. |
cge decreased the expression levels of osteoclast‑specific genes, including matrix metalloproteinase‑9, osteoclast‑associated immunoglobulin‑like receptor and cathepsin k, however, cge had no inhibitory effect on the expression levels of mitogen‑activated protein kinases, nuclear factor‑κb and akt. |
2017-02-16 |
2023-08-13 |
mouse |
| Li-Qian Zhang, Su-Qing Yang, Ying Wang, Qiao Fang, Xian-Jun Chen, Hong-Sheng Lu, Ling-Ping Zha. Long Noncoding RNA MIR4697HG Promotes Cell Growth and Metastasis in Human Ovarian Cancer. Analytical cellular pathology (Amsterdam). vol 2017. 2017-02-13. PMID:28168162. |
mir4697hg knockdown also caused a decrease in matrix metalloprotease-9, phosphorylated erk, and phosphorylated akt. |
2017-02-13 |
2023-08-13 |
human |
| Dao-Fu Shen, Xin Liu, Xue-Feng Yang, Lei Fang, Yang Gao, Shuang Zhao, Ji-Cheng Wu, Shuai Shi, Jun-Jun Li, Xiang-Xuan Zhao, Wen-Feng Gou, Hua-Chuan Zhen. The roles of parafibromin expression in ovarian epithelial carcinomas: a marker for differentiation and prognosis and a target for gene therapy. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 3. 2017-02-07. PMID:26409451. |
the transfectants showed the hypoexpression of phosphoinositide 3-kinase (pi3k), akt, p70 ribosomal protein s6 kinase (p70s6k), wnt5a, b cell lymphoma-extra large (bcl-xl), survivin, vascular endothelial growth factor (vegf) and matrix metallopeptidase 9 (mmp-9) than the mock and control at both mrna and protein levels (p < 0.05). |
2017-02-07 |
2023-08-13 |
Not clear |
| Xue Liu, Qian Chen, Xu-Gang Hu, Xian-Chao Zhang, Ti-Wei Fu, Qing Liu, Yan Liang, Xi-Long Zhao, Xia Zhang, Yi-Fang Ping, Xiu-Wu Bia. PTP1B promotes aggressiveness of breast cancer cells by regulating PTEN but not EMT. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 10. 2017-02-07. PMID:27465552. |
mechanistically, ptp1b knockdown upregulated pten, accompanied with an abatement of akt phosphorylation and the expression of matrix metalloproteinase 2 (mmp2) and mmp7. |
2017-02-07 |
2023-08-13 |
Not clear |
| Alfredo Conti, Sara G Romeo, Annamaria Cama, Domenico La Torre, Valeria Barresi, Gaetana Pezzino, Chiara Tomasello, Salvatore Cardali, Filippo F Angileri, Francesca Polito, Guido Ferlazzo, Rosamaria Di Giorgio, Antonino Germanò, M'hammed Aguennou. MiRNA expression profiling in human gliomas: upregulated miR-363 increases cell survival and proliferation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 10. 2017-02-07. PMID:27495233. |
furthermore, mirna-363 inhibition induced the downregulation of akt, cyclin-d1, matrix metalloproteinase (mmp)-2, mmp-9, and bcl-2 and upregulation of caspase 3. |
2017-02-07 |
2023-08-13 |
human |
| Shinichiro Tahara, Satoshi Nojima, Kenji Ohshima, Yumiko Hori, Masako Kurashige, Naoki Wada, Jun-Ichiro Ikeda, Eiichi Mori. S100A4 accelerates the proliferation and invasion of endometrioid carcinoma and is associated with the "MELF" pattern. Cancer science. vol 107. issue 9. 2017-02-06. PMID:27348205. |
these cells showed impaired akt phosphorylation and matrix metalloproteinase-2 activation, accounting for their impaired proliferation and invasion, respectively. |
2017-02-06 |
2023-08-13 |
Not clear |
| Baosong Xie, Guanying Zheng, Hongru Li, Xiujuan Yao, Rujun Hong, Ruihui Li, Wenxiang Yue, Yusheng Che. Effects of the tumor suppressor PTEN on the pathogenesis of idiopathic pulmonary fibrosis in Chinese patients. Molecular medicine reports. vol 13. issue 3. 2017-01-03. PMID:26846484. |
overexpression of pten also suppressed phosphorylation of akt and smad3, and decreased the expression levels of numerous proteins with critical roles in tgf‑β1‑induced fibrosis, including α‑smooth muscle actin, matrix metalloproteinase (mmp)‑2 and mmp‑9. |
2017-01-03 |
2023-08-13 |
human |
| Bo Kou, Wei Liu, Wenbo He, Yuanyuan Zhang, Jianjie Zheng, Yang Yan, Yongjian Zhang, Suochun Xu, Haichen Wan. Tetrandrine suppresses metastatic phenotype of prostate cancer cells by regulating Akt/mTOR/MMP-9 signaling pathway. Oncology reports. vol 35. issue 5. 2016-12-27. PMID:26935264. |
the protein expression of akt, phosphorylated akt, the mammalian target of rapamycin (mtor), phosphorylated mtor and matrix metalloproteinases 9 (mmp-9) was detected by western blot in the presence or absence of tetrandrine or in the group tetrandrine combination with ly294002 (inhibitor of akt) and rapamycin (inhibitor of mtor). |
2016-12-27 |
2023-08-13 |
Not clear |
| Bing He, Ting Li, Lei Guan, Fang-E Liu, Xue-Mei Chen, Jing Zhao, Song Lin, Zhi-Zhen Liu, Hu-Qin Zhan. CTNNA3 is a tumor suppressor in hepatocellular carcinomas and is inhibited by miR-425. Oncotarget. vol 7. issue 7. 2016-12-20. PMID:26882563. |
in these cells, ctnna3 inhibited akt signal, and in turn decreased the proliferating cell nuclear antigen (pcna) and the matrix metallopeptidase mmp-9, and increased the cell cycle inhibitor p21(cip1/waf1). |
2016-12-20 |
2023-08-13 |
mouse |
| Feng Guo, Qingzhu Wang, Yingni Zhou, Lina Wu, Xiaojun Ma, Fei Liu, Fengjuan Huang, Guijun Qi. Lentiviral Vector-Mediated FoxO1 Overexpression Inhibits Extracellular Matrix Protein Secretion Under High Glucose Conditions in Mesangial Cells. Journal of cellular biochemistry. vol 117. issue 1. 2016-12-13. PMID:26052839. |
by contrast, overexpression of nucleus-localized foxo1 (insensitive to akt phosphorylation) directly up-regulated the expressions of anti-oxidative enzymes, accompanied with inactivation of tgf-β/smad3 pathway, as well as decreases of extracellular matrix proteins. |
2016-12-13 |
2023-08-13 |
cat |
| Sujeenthar Tharmalingam, Chiping Wu, David R Hampso. The calcium-sensing receptor and integrins modulate cerebellar granule cell precursor differentiation and migration. Developmental neurobiology. vol 76. issue 4. 2016-12-13. PMID:26138678. |
analysis of cell-surface proteins demonstrated that activation of the casr by positive allosteric modulators promoted plasma membrane expression of β1 integrins via erk2 and akt phosphorylation and resulted in increased gcp migration toward an extracellular matrix protein. |
2016-12-13 |
2023-08-13 |
Not clear |
| Lin Zhu, Song Zhao, Shuxia Liu, Qingjuan Liu, Fan Li, Jun Ha. PTEN Regulates Renal Extracellular Matrix Deposit via Increased CTGF in Diabetes Mellitus. Journal of cellular biochemistry. vol 117. issue 5. 2016-12-13. PMID:26447680. |
in the end our study suggests that pten regulates renal extracellular matrix production via activated akt and increased ctgf in diabetes mellitus. |
2016-12-13 |
2023-08-13 |
mouse |
| Yong Zhang, Bo Zhan. Trichostatin A, an Inhibitor of Histone Deacetylase, Inhibits the Viability and Invasiveness of Hypoxic Rheumatoid Arthritis Fibroblast-Like Synoviocytes via PI3K/Akt Signaling. Journal of biochemical and molecular toxicology. vol 30. issue 4. 2016-12-13. PMID:26509796. |
tsa blocked hypoxia-induced invasion of ra flss during matrigel invasion assays and reduced the expression of matrix metalloproteinases (mmp-2 and mmp-9) and pi3k and phosphorylation of akt. |
2016-12-13 |
2023-08-13 |
Not clear |
| Hiroko Ida-Yonemochi, Keishi Otsu, Hayato Ohshima, Hidemitsu Harad. The glycogen metabolism via Akt signaling is important for the secretion of enamel matrix in tooth development. Mechanisms of development. vol 139. 2016-12-13. PMID:26809144. |
the glycogen metabolism via akt signaling is important for the secretion of enamel matrix in tooth development. |
2016-12-13 |
2023-08-13 |
mouse |