| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qian-Wen Wang, Yun Su, Jiang-Tao Sheng, Li-Ming Gu, Ying Zhao, Xiao-Xuan Chen, Cheng Chen, Wei-Zhong Li, Kang-Sheng Li, Jian-Ping Da. Anti-influenza A virus activity of rhein through regulating oxidative stress, TLR4, Akt, MAPK, and NF-κB signal pathways. PloS one. vol 13. issue 1. 2018-03-12. PMID:29385192. |
the results showed that rhein could significantly inhibit iav adsorption and replication, decrease iav-induced oxidative stress, activations of tlr4, akt, p38, jnk mapk, and nf-κb pathways, and production of inflammatory cytokines and matrix metalloproteinases in vitro. |
2018-03-12 |
2023-08-13 |
mouse |
| Mohamad Elbaz, Dinesh Ahirwar, Janani Ravi, Mohd W Nasser, Ramesh K Ganj. Novel role of cannabinoid receptor 2 in inhibiting EGF/EGFR and IGF-I/IGF-IR pathways in breast cancer. Oncotarget. vol 8. issue 18. 2018-03-05. PMID:27213582. |
at the molecular level, jwh-015 inhibited egfr and igf-ir activation and their downstream targets stat3, akt, erk, nf-kb and matrix metalloproteinases (mmps). |
2018-03-05 |
2023-08-13 |
mouse |
| Fulvia Farabegoli, Marzia Govoni, Enzo Spisni, Alessio Pap. EGFR inhibition by (-)-epigallocatechin-3-gallate and IIF treatments reduces breast cancer cell invasion. Bioscience reports. vol 37. issue 3. 2018-02-27. PMID:28465354. |
egfr and akt activation and molecular markers of cell motility and migration (cd44, extracellular matrix metalloproteinase (mmp) inducer (emmprin), mmp-2, mmp-9 and tissue inhibitor of metalloproteinases (timps)) were studied after egcg and iif treatments. |
2018-02-27 |
2023-08-13 |
Not clear |
| Zhouhua Hou, Jun Qua. Hepatitis B virus X protein increases microRNA‑21 expression and accelerates the development of hepatoma via the phosphatase and tensin homolog/phosphoinositide 3‑kinase/protein kinase B signaling pathway. Molecular medicine reports. vol 15. issue 5. 2018-01-22. PMID:28339072. |
western blot analysis demonstrated that mir‑21 inhibitors and hbx‑sirna treatment led to the upregulation of phosphatase and tensin homolog (pten), and decreased levels of phosphoinositide 3‑kinase (pi3k), phosphorylated protein kinase b (akt) and matrix metalloproteinase (mmp)‑2. |
2018-01-22 |
2023-08-13 |
Not clear |
| Zhikui Liu, Changwei Dou, Bowen Yao, Meng Xu, Linglong Ding, Yufeng Wang, Yuli Jia, Qing Li, Hongyong Zhang, Kangsheng Tu, Tao Song, Qingguang Li. Methylation-mediated repression of microRNA-129-2 suppresses cell aggressiveness by inhibiting high mobility group box 1 in human hepatocellular carcinoma. Oncotarget. vol 7. issue 24. 2018-01-12. PMID:27191994. |
mechanistic investigations showed that mir-129-2 overexpression inhibited akt phosphorylation at ser473 and decreased the expression of matrix metalloproteinase2/9 (mmp2/9). |
2018-01-12 |
2023-08-13 |
human |
| Tianhui Liu, Ping Wang, Min Cong, Dong Zhang, Lin Liu, Hongyi Li, Qingling Zhai, Zhuo Li, Jidong Jia, Hong Yo. Matrix metalloproteinase-1 induction by diethyldithiocarbamate is regulated via Akt and ERK/miR222/ETS-1 pathways in hepatic stellate cells. Bioscience reports. vol 36. issue 4. 2017-12-06. PMID:27412967. |
matrix metalloproteinase-1 induction by diethyldithiocarbamate is regulated via akt and erk/mir222/ets-1 pathways in hepatic stellate cells. |
2017-12-06 |
2023-08-13 |
Not clear |
| Min Xu, Guoying Wang, Hailang Zhou, Jing Cai, Ping Li, Meng Zhou, Ying Lu, Xiaomeng Jiang, Hongmei Huang, Youli Zhang, Aihua Gon. TGF-β1-miR-200a-PTEN induces epithelial-mesenchymal transition and fibrosis of pancreatic stellate cells. Molecular and cellular biochemistry. vol 431. issue 1-2. 2017-12-04. PMID:28281184. |
in addition, overexpression of mir-200a promotes the expression of pten and decreases the expression of matrix proteins and attenuates phosphorylation of akt and mtor. |
2017-12-04 |
2023-08-13 |
Not clear |
| Hui Jin, Cynthia St Hilaire, Yuting Huang, Dan Yang, Natalia I Dmitrieva, Alejandra Negro, Robin Schwartzbeck, Yangtengyu Liu, Zhen Yu, Avram Walts, Jean-Michel Davaine, Duck-Yeon Lee, Danielle Donahue, Kevin S Hsu, Jessica Chen, Tao Cheng, William Gahl, Guibin Chen, Manfred Boeh. Increased activity of TNAP compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease ACDC. Science signaling. vol 9. issue 458. 2017-11-20. PMID:27965423. |
in response to osteogenic stimulation, acdc patient-derived imscs had decreased amounts of the tnap substrate ppi, an inhibitor of extracellular matrix calcification, and exhibited increased activation of akt, mechanistic target of rapamycin (mtor), and the 70-kda ribosomal protein s6 kinase (p70s6k), a pathway that promotes calcification. |
2017-11-20 |
2023-08-13 |
mouse |
| Zhongping Zhou, Miaomiao Tang, Yi Liu, Zhuyi Zhang, Rongzhu Lu, Jian L. Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line. Anti-cancer drugs. vol 28. issue 4. 2017-11-16. PMID:28125432. |
furthermore, the results indicated that apg not only suppressed phosphorylation of akt, thereby preventing its activation, but also inhibited its downstream gene expression of matrix metalloproteinases-9, glycogen synthase kinase-3β, and hef1. |
2017-11-16 |
2023-08-13 |
human |
| Fujun Dai, Wubei Yu, Jia Song, Qian Li, Chaojie Wang, Songqiang Xi. Extracellular polyamines-induced proliferation and migration of cancer cells by ODC, SSAT, and Akt1-mediated pathway. Anti-cancer drugs. vol 28. issue 4. 2017-11-16. PMID:28157137. |
polyamines upregulated the expression of ornithine decarboxylase (odc), ssat, akt1, akt, hypoxia-inducible factors-1α, vascular endothelial growth factor, and matrix metalloproteinases, and downregulated p27 expression. |
2017-11-16 |
2023-08-13 |
Not clear |
| Hui Cheng, Qingzhou Yao, Rui Song, Yufeng Zhai, Wei Wang, David A Fullerton, Xianzhong Men. Lysophosphatidylcholine activates the Akt pathway to upregulate extracellular matrix protein production in human aortic valve cells. The Journal of surgical research. vol 213. 2017-09-19. PMID:28601321. |
lysophosphatidylcholine activates the akt pathway to upregulate extracellular matrix protein production in human aortic valve cells. |
2017-09-19 |
2023-08-13 |
human |
| Rong Wang, Weiping Wang, Lin Ao, Zhi Wang, Xianglin Hao, Huidong Zhan. Benzo[a]pyrene-7,8-diol-9,10-epoxide suppresses the migration and invasion of human extravillous trophoblast HTR-8/SVneo cells by down-regulating MMP2 through inhibition of FAK/SRC/PI3K/AKT pathway. Toxicology. vol 386. 2017-08-22. PMID:28529061. |
the protein and mrna levels of fak, src, pi3k, p-pi3k, akt, p-akt, endothelial nitric oxide synthase (enos) and its activity, and matrix metalloproteinase 2 (mmp2) significantly decreased with increasing bpde concentration. |
2017-08-22 |
2023-08-13 |
human |
| Shurui Chen, Wei Liu, Ke Wang, Yizeng Fan, Jiaqi Chen, Jianbin Ma, Xinyang Wang, Dalin He, Jin Zeng, Lei L. Tetrandrine inhibits migration and invasion of human renal cell carcinoma by regulating Akt/NF-κB/MMP-9 signaling. PloS one. vol 12. issue 3. 2017-08-17. PMID:28288190. |
mechanistically, the protein levels of matrix metalloproteinases 9 (mmp-9), phosphorylated pi3k, pdk1, akt and nf-κb were markedly reduced after tet treatment. |
2017-08-17 |
2023-08-13 |
human |
| Kirtiman Srivastava, Adam Pickard, Simon McDade, Dennis J McCanc. p63 drives invasion in keratinocytes expressing HPV16 E6/E7 genes through regulation of Src-FAK signalling. Oncotarget. vol 8. issue 10. 2017-07-07. PMID:26001294. |
depletion of src, fak or akt in the invasive cells normalised the expression/activity of c-jun and mmp14, thus implicating the src-fak/akt/ap-1 signalling in mmp14-mediated extra-cellular matrix remodelling. |
2017-07-07 |
2023-08-13 |
human |
| Xue Liu, Ershun Liang, Xiuhui Song, Zhanhui Du, Yun Zhang, Yuxia Zha. Inhibition of Pin1 alleviates myocardial fibrosis and dysfunction in STZ-induced diabetic mice. Biochemical and biophysical research communications. vol 479. issue 1. 2017-06-13. PMID:27634219. |
our results indicate that pin1 inhibition attenuates cardiac extracellular matrix deposition by regulating the phosphorylation of akt, tgf-β1/smads, mmp activities, and α-sma expression in diabetic mice. |
2017-06-13 |
2023-08-13 |
mouse |
| Malatee Tayeh, Sirinun Nilwarangoon, Wilawan Mahabusarakum, Ramida Watanapokasi. Anti-metastatic effect of rhodomyrtone from Rhodomyrtus tomentosa on human skin cancer cells. International journal of oncology. vol 50. issue 3. 2017-06-13. PMID:28075447. |
data demonstrated that rhodomyrtone could inhibit the focal adhesion kinase (fak) and phosphorylation of protein kinase b (akt), c-raf, extracellular signal-regulated kinase 1/2 (erk1/2) and p38 mapk involved in the downregulation the enzyme activities and protein expression of matrix metalloproteinase-2 (mmp-2) and mmp-9. |
2017-06-13 |
2023-08-13 |
human |
| Zhiyong Zhang, Louis F Amorosa, Susette M Coyle, Marie A Macor, Morris J Birnbaum, Leonard Y Lee, Beatrice Haimovic. Insulin-Dependent Regulation of mTORC2-Akt-FoxO Suppresses TLR4 Signaling in Human Leukocytes: Relevance to Type 2 Diabetes. Diabetes. vol 65. issue 8. 2017-06-05. PMID:27207509. |
we extend this work to show that in addition to matrix metalloproteinase 9, hypoxia-inducible factor 1α, and cleaved ampkα, patient leukocytes also express irs-1 phosphorylated on ser(312), akt phosphorylated on thr(308), and elevated tlr4 expression. |
2017-06-05 |
2023-08-13 |
human |
| Ning Chen, Jun Hao, Lisha Li, Fan Li, Shuxia Liu, Huijun Dua. Carboxy-terminal modulator protein attenuated extracellular matrix deposit by inhibiting phospho-Akt, TGF-β1 and α-SMA in kidneys of diabetic mice. Biochemical and biophysical research communications. vol 474. issue 4. 2017-05-10. PMID:27166156. |
our results indicate that ctmp attenuates renal extracellular matrix deposit by regulating the phosphorylation of akt, tgf-β1 and α-sma expression in diabetic mice. |
2017-05-10 |
2023-08-13 |
mouse |
| Jintaek Im, Kyutae Kim, Polla Hergert, Richard Seonghun Nh. Idiopathic pulmonary fibrosis fibroblasts become resistant to Fas ligand-dependent apoptosis via the alteration of decoy receptor 3. The Journal of pathology. vol 240. issue 1. 2017-05-04. PMID:27218286. |
ipf patients' lung fibroblasts express inappropriately high akt activity, protecting them in response to an apoptosis-inducing type i collagen matrix. |
2017-05-04 |
2023-08-13 |
human |
| Jintaek Im, Kyutae Kim, Polla Hergert, Richard Seonghun Nh. Idiopathic pulmonary fibrosis fibroblasts become resistant to Fas ligand-dependent apoptosis via the alteration of decoy receptor 3. The Journal of pathology. vol 240. issue 1. 2017-05-04. PMID:27218286. |
our results showed that when ipf cells interact with collagen matrix, aberrantly activated akt increases dcr3 expression via gsk-3β-nfatc1 and protects ipf cells from the fasl-dependent apoptotic pathway. |
2017-05-04 |
2023-08-13 |
human |