| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V D Myneni, G Melino, M T Kaartine. Transglutaminase 2--a novel inhibitor of adipogenesis. Cell death & disease. vol 6. 2016-04-12. PMID:26313919. |
tg2 deficiency also resulted in reduced rock kinase activity, actin stress fiber formation and increased akt phosphorylation in mefs, but did not alter fibronectin matrix levels or solubility. |
2016-04-12 |
2023-08-13 |
mouse |
| Li Ying, Ziwei Zhu, Zhiyun Xu, Tianrui He, Encheng Li, Zhe Guo, Fen Liu, Chunmeng Jiang, Qi Wan. Cancer Associated Fibroblast-Derived Hepatocyte Growth Factor Inhibits the Paclitaxel-Induced Apoptosis of Lung Cancer A549 Cells by Up-Regulating the PI3K/Akt and GRP78 Signaling on a Microfluidic Platform. PloS one. vol 10. issue 6. 2016-04-06. PMID:26115510. |
we found high levels of hgf in the supernatants of caf and the caf matrix from the supernatants of activated hfl1 fibroblasts or hgf enhanced the levels of met, pi3k and akt phosphorylation and grp78 expression in a549 cells cultured in a 3d cell chamber, which was abrogated by anti-hgf. |
2016-04-06 |
2023-08-13 |
Not clear |
| Dmitry L Aminin, Ekaterina S Menchinskaya, Evgeny A Pisliagin, Alexandra S Silchenko, Sergey A Avilov, Vladimir I Kalini. Anticancer activity of sea cucumber triterpene glycosides. Marine drugs. vol 13. issue 3. 2016-03-03. PMID:25756523. |
the anticancer molecular mechanisms include the induction of tumor cell apoptosis through the activation of intracellular caspase cell death pathways, arrest of the cell cycle at s or g2/m phases, influence on nuclear factors, nf-κb, and up-down regulation of certain cellular receptors and enzymes participating in cancerogenesis, such as egfr (epidermal growth factor receptor), akt (protein kinase b), erk (extracellular signal-regulated kinases), fak (focal adhesion kinase), mmp-9 (matrix metalloproteinase-9) and others. |
2016-03-03 |
2023-08-13 |
human |
| Riccardo Dolcetti, Cinzia Giagulli, Wangxiao He, Marina Selleri, Francesca Caccuri, Lindsay M Eyzaguirre, Pietro Mazzuca, Silvia Corbellini, Federica Campilongo, Stefania Marsico, Emanuela Giombini, Elena Muraro, Gabriella Rozera, Paolo De Paoli, Antonino Carbone, Maria Rosaria Capobianchi, Giuseppe Ippolito, Simona Fiorentini, William A Blattner, Wuyuan Lu, Robert C Gallo, Arnaldo Carus. Role of HIV-1 matrix protein p17 variants in lymphoma pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 46. 2016-02-25. PMID:26578780. |
the hiv-1 matrix protein p17 persists in germinal centers long after hiv-1 drug suppression, and some p17 variants (vp17s) activate akt signaling and promote growth of transformed b cells. |
2016-02-25 |
2023-08-13 |
human |
| Liang Cheng, Guoqing Zeng, Zejun Liu, Bing Zhang, Xu Cui, Honghai Zhao, Xinpeng Zheng, Gang Song, Jian Kang, Chun Xi. Protein kinase B and extracellular signal-regulated kinase contribute to the chondroprotective effect of morroniside on osteoarthritis chondrocytes. Journal of cellular and molecular medicine. vol 19. issue 8. 2016-02-22. PMID:25754021. |
in addition, the intra-articular injection of morroniside elevated the level of proteoglycans in cartilage matrix and the thickness of articular cartilage in a rat experimental model of oa, with the increase of akt and erk activation. |
2016-02-22 |
2023-08-13 |
human |
| Javier A García-Vilas, Ana R Quesada, Miguel A Medin. Damnacanthal, a noni anthraquinone, inhibits c-Met and is a potent antitumor compound against Hep G2 human hepatocellular carcinoma cells. Scientific reports. vol 5. 2016-02-16. PMID:25620570. |
on the other hand, damnacanthal also decreases the phosphorylation levels of akt and targets matrix metalloproteinase-2 secretion in hep g2 cells. |
2016-02-16 |
2023-08-13 |
human |
| Nirmalya Dey, Amit Bera, Falguni Das, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression. Cellular signalling. vol 27. issue 7. 2016-02-16. PMID:25797045. |
high glucose milieu inhibits pten expression to activate akt kinase and induces glomerular mesangial cell hypertrophy and matrix protein expression in diabetic nephropathy. |
2016-02-16 |
2023-08-13 |
Not clear |
| Ying-Yu Kuo, Wai-Tim Jim, Liang-Cheng Su, Chi-Jung Chung, Ching-Yu Lin, Chieh Huo, Jen-Chih Tseng, Shih-Han Huang, Chih-Jen Lai, Bo-Chih Chen, Bi-Juan Wang, Tzu-Min Chan, Hui-Ping Lin, Wun-Shaing Wayne Chang, Chuang-Rung Chang, Chih-Pin Chu. Caffeic Acid phenethyl ester is a potential therapeutic agent for oral cancer. International journal of molecular sciences. vol 16. issue 5. 2016-01-18. PMID:25984601. |
cape treatment inhibits akt signaling, cell cycle regulatory proteins, nf-κb function, as well as activity of matrix metalloproteinase (mmps), epidermal growth factor receptor (egfr), and cyclooxygenase-2 (cox-2). |
2016-01-18 |
2023-08-13 |
Not clear |
| Xin Lian, Yu Jiao, Yu Yang, Zhipeng Wang, Qijia Xuan, Hang Liu, Shan Lu, Zunxian Wang, Yue Liu, Shuo Li, Yuguang Yang, Li Guo, Ling Zhao, Qingyuan Zhan. CrkL regulates SDF-1-induced breast cancer biology through balancing Erk1/2 and PI3K/Akt pathways. Medical oncology (Northwood, London, England). vol 32. issue 1. 2016-01-15. PMID:25476480. |
in vitro studies revealed that sdf-1 induced the activation of crkl, erk1/2, akt and matrix metallopeptidase 9 (mmp9) in mda-mb-231 cells. |
2016-01-15 |
2023-08-13 |
human |
| Itay Israel Shemesh, Benaya Rozen-Zvi, Yona Kalechman, Uzi Gafter, Benjamin Sredn. AS101 prevents diabetic nephropathy progression and mesangial cell dysfunction: regulation of the AKT downstream pathway. PloS one. vol 9. issue 12. 2015-12-14. PMID:25474550. |
previous data have cross-linked pkb (akt) to tgfβ induced matrix modulation. |
2015-12-14 |
2023-08-13 |
rat |
| Z Wang, D Xu, H-F Ding, J Kim, J Zhang, T Hai, C Ya. Loss of ATF3 promotes Akt activation and prostate cancer development in a Pten knockout mouse model. Oncogene. vol 34. issue 38. 2015-12-07. PMID:25531328. |
in line with these in vivo results, knockdown of atf3 expression in human prostate cancer cells by single guided rna-mediated targeting activated akt and increased matrix metalloproteinase-9 expression. |
2015-12-07 |
2023-08-13 |
mouse |
| Cun Wang, Guangzhi Jin, Haojie Jin, Ning Wang, Qin Luo, Yurong Zhang, Dongmei Gao, Kai Jiang, Dishui Gu, Qiujing Shen, Xisong Huo, Fangyuan Hu, Tianxiang Ge, Fangyu Zhao, Wei Chu, Huiqun Shu, Ming Yao, Wenming Cong, Wenxin Qi. Clusterin facilitates metastasis by EIF3I/Akt/MMP13 signaling in hepatocellular carcinoma. Oncotarget. vol 6. issue 5. 2015-11-25. PMID:25609201. |
we also revealed that clu activated akt signaling through complexing with eukaryotic translation initiation factor 3 subunit i (eif3i), which in turn promoted matrix metalloproteinase 13 (mmp13) expression and hcc metastasis. |
2015-11-25 |
2023-08-13 |
Not clear |
| Youming Guo, Pengfei Li, Grant Bledsoe, Zhi-Rong Yang, Lee Chao, Julie Cha. Kallistatin inhibits TGF-β-induced endothelial-mesenchymal transition by differential regulation of microRNA-21 and eNOS expression. Experimental cell research. vol 337. issue 1. 2015-11-20. PMID:26156753. |
moreover, kallistatin antagonized tgf-β-induced mir-21 and snail1 synthesis, akt phosphorylation, nf-κb activation, and matrix metalloproteinase 2 (mmp2) synthesis and activation. |
2015-11-20 |
2023-08-13 |
human |
| Gyeong-Hun Park, Ki-young Park, Hong-il Cho, Sang-Min Lee, Ji Su Han, Chong Hyun Won, Sung Eun Chang, Mi Woo Lee, Jee Ho Choi, Kee Chan Moon, Hyoseung Shin, Yong Jung Kang, Dong Hun Le. Red ginseng extract promotes the hair growth in cultured human hair follicles. Journal of medicinal food. vol 18. issue 3. 2015-11-16. PMID:25396716. |
in conclusion, rge and its ginsenosides may enhance hdpc proliferation, activate erk and akt signaling pathways in hdpcs, upregulate hair matrix keratinocyte proliferation, and inhibit the dht-induced androgen receptor transcription. |
2015-11-16 |
2023-08-13 |
mouse |
| Yi Zhang, Tiecheng Pan, Xiaoxuan Zhong, Cai Chen. Androgen receptor promotes esophageal cancer cell migration and proliferation via matrix metalloproteinase 2. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 8. 2015-11-16. PMID:25724186. |
furthermore, ar knockdown led to substantial reductions in matrix metalloproteinase 2 (mmp2) and p-akt levels in escc cell lines, but no significant change in akt and mmp9 expression. |
2015-11-16 |
2023-08-13 |
Not clear |
| Xinkui Xiong, Daoyi Sun, Hao Chai, Wengang Shan, Yue Yu, Liyong Pu, Feng Chen. MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma. Biochemical and biophysical research communications. vol 465. issue 2. 2015-11-12. PMID:26255969. |
the overexpression of mir-145 in icc cell lines inhibited proliferation, growth, and invasion by suppressing nuak1 expression, which was associated with a decrease in akt signaling and matrix metalloproteinase protein expression. |
2015-11-12 |
2023-08-13 |
human |
| Yong Zhang, Chao-Qun Yang, Yang Gao, Ce Wang, Cheng-Lin Zhang, Xu-Hui Zho. Knockdown of CXCR7 inhibits proliferation and invasion of osteosarcoma cells through inhibition of the PI3K/Akt and β-arrestin pathways. Oncology reports. vol 32. issue 3. 2015-11-03. PMID:24969680. |
knockdown of cxcr7 suppressed proliferation and invasion of os cells through decreased expression of pi3k, akt, β-arrestin, proliferating cell nuclear antigen (pcna), and matrix metalloproteinase-9 (mmp-9). |
2015-11-03 |
2023-08-13 |
human |
| Chih-Chung Lin, Wei-Ning Lin, Wei-Chen Hou, Li-Der Hsiao, Chuen-Mao Yan. Endothelin-1 induces VCAM-1 expression-mediated inflammation via receptor tyrosine kinases and Elk/p300 in human tracheal smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. vol 309. issue 3. 2015-10-15. PMID:26071554. |
here we reported that et-1 stimulated expression of vcam-1 gene on htsmcs, which was blocked by pretreatment with the inhibitors of et receptors, src, matrix metalloproteinases (mmps), epidermal growth factor receptor (egfr), platelet-derived growth factor receptor (pdgfr), phosphatidylinositol 3-kinase (pi3k), akt, mek1/2, and p300, suggesting the participation of these signaling components in et-1-regulated htsmc responses. |
2015-10-15 |
2023-08-13 |
human |
| Wennan Zhao, Wenzhi Guo, Qianxiang Zhou, Sheng-Nan Ma, Ran Wang, Yuling Qiu, Meihua Jin, Hong-Quan Duan, Dexin Kon. In vitro antimetastatic effect of phosphatidylinositol 3-kinase inhibitor ZSTK474 on prostate cancer PC3 cells. International journal of molecular sciences. vol 14. issue 7. 2015-10-01. PMID:23812078. |
furthermore, zstk474 inhibited phosphorylation of akt substrate-girdin, and the secretion of matrix metalloproteinase (mmp), both of which were reported to be closely involved in migration and invasion. |
2015-10-01 |
2023-08-12 |
human |
| Bao-gui Zhang, Tao Du, Ming-de Zang, Qing Chang, Zhi-yuan Fan, Jian-fang Li, Bei-qin Yu, Li-ping Su, Chen Li, Chao Yan, Qin-long Gu, Zheng-gang Zhu, Min Yan, Bingya Li. Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9. Oncotarget. vol 5. issue 21. 2015-08-31. PMID:25301736. |
these findings were accompanied by activation of akt and upregulation of matrix metalloproteinase 9 (mmp9). |
2015-08-31 |
2023-08-13 |
Not clear |