| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mousumi Tania, Md Asaduzzaman Khan, Junjiang F. Epithelial to mesenchymal transition inducing transcription factors and metastatic cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 8. 2015-01-13. PMID:24880591. |
a number of studies have reported that emt-inducing transcription factors (emt-tfs), such as twist, snail, slug, and zeb, are directly or indirectly involved in cancer cell metastasis through a different signaling cascades, including the akt, signal transducer and activator of transcription 3 (stat3), mitogen-activated protein kinase (mapk) and wnt pathways, with the ultimate consequence of the downregulation of e-cadherin and upregulation of metastatic proteins, such as n-cadherin, vimentin, matrix metalloproteinase (mmp)-2, etc. |
2015-01-13 |
2023-08-13 |
Not clear |
| Robert Eves, Robyn Oldham, Lilly Jia, Alan S Ma. The roles of akt isoforms in the regulation of podosome formation in fibroblasts and extracellular matrix invasion. Cancers. vol 7. issue 1. 2015-01-10. PMID:25575302. |
the roles of akt isoforms in the regulation of podosome formation in fibroblasts and extracellular matrix invasion. |
2015-01-10 |
2023-08-13 |
mouse |
| Robert Eves, Robyn Oldham, Lilly Jia, Alan S Ma. The roles of akt isoforms in the regulation of podosome formation in fibroblasts and extracellular matrix invasion. Cancers. vol 7. issue 1. 2015-01-10. PMID:25575302. |
in this study, we have used akt1 and/or akt2 knockout mouse embryonic fibroblasts and akt3-targeted shrna to determine the roles of the three akt isoforms in src and phorbol ester-induced podosome formation, and extracellular matrix (ecm) digestion. |
2015-01-10 |
2023-08-13 |
mouse |
| Bo Liu, Yi Wu, Yu Zhou, Dan Pen. Endothelin A receptor antagonism enhances inhibitory effects of anti-ganglioside GD2 monoclonal antibody on invasiveness and viability of human osteosarcoma cells. PloS one. vol 9. issue 4. 2014-12-31. PMID:24727660. |
our results showed that bq123, etar-shrna and 14g2a mab individually decreased cell invasion and viability, matrix metalloproteinase-2 (mmp-2) expression and activity, pi3k activity, and phosphorylation at serine 473 (ser473) of akt in os cells. |
2014-12-31 |
2023-08-13 |
human |
| Chuan Lv, Can Wu, Yue-Hong Zhou, Ying Shao, Guan Wang, Qiu-Yue Wan. Alpha Lipoic Acid Modulated High Glucose-Induced Rat Mesangial Cell Dysfunction via mTOR/p70S6K/4E-BP1 Pathway. International journal of endocrinology. vol 2014. 2014-12-22. PMID:25530759. |
la at a relatively low concentration (0.25 mmol/l) acted as a growth factor in rat mesangial cells, promoted entry of cell cycle into s phase, extracellular matrix formation, and phosphorylated akt, mtor, p70s6k, and 4e-bp1. |
2014-12-22 |
2023-08-13 |
rat |
| Yan Bi, Dhriti Mukhopadhyay, Mary Drinane, Baoan Ji, Xing Li, Sheng Cao, Vijay H Sha. Endocytosis of collagen by hepatic stellate cells regulates extracellular matrix dynamics. American journal of physiology. Cell physiology. vol 307. issue 7. 2014-11-28. PMID:25080486. |
wortmannin and akt inhibitor blocked collagen internalization by 70% and 89%, respectively, indicating that matrix macropinocytosis requires phosphoinositide-3-kinase (pi3k)/akt signaling. |
2014-11-28 |
2023-08-13 |
mouse |
| X C Xu, X Abuduhadeer, W B Zhang, T Li, H Gao, Y H Wan. Knockdown of RAGE inhibits growth and invasion of gastric cancer cells. European journal of histochemistry : EJH. vol 57. issue 4. 2014-10-22. PMID:24441189. |
the expression of akt, proliferating cell nuclear antigen (pcna) and matrix metallopeptidase-2 (mmp-2) was detected by real-time pcr and western blot assays. |
2014-10-22 |
2023-08-12 |
human |
| Anisur Rahman Khuda-Bukhsh, Sreemanti Das, Santu Kumar Sah. Molecular approaches toward targeted cancer prevention with some food plants and their products: inflammatory and other signal pathways. Nutrition and cancer. vol 66. issue 2. 2014-10-15. PMID:24377653. |
they act through one or more signaling pathways like nuclear factor kappa b, cyclooxygenase-2, signal transducer and activator of transcription 3, akt, mitogen activated protein kinase/extracellular regulated kinase, bcl-2, caspases, poly (adp-ribose) polymerase, matrix metalloproteinase 2/9, and cyclin d1. |
2014-10-15 |
2023-08-12 |
Not clear |
| S P Yun, S-J Lee, Y H Jung, H J Ha. Galectin-1 stimulates motility of human umbilical cord blood-derived mesenchymal stem cells by downregulation of smad2/3-dependent collagen 3/5 and upregulation of NF-κB-dependent fibronectin/laminin 5 expression. Cell death & disease. vol 5. 2014-09-02. PMID:24503541. |
reconstructing gal-1-induced genetic changes by replacing it with sirna specific for col-3 or col-5, or treatment of the cells with fn and lm-5 proteins, increased motility and its related proteins such as focal adhesion kinase, akt, erk, integrins, and matrix metalloproteinase-2. |
2014-09-02 |
2023-08-12 |
human |
| Ying Zheng, Xuemei Wang, Haidong Wang, Wei Yan, Quan Zhang, Xin Chan. Bone morphogenetic protein 2 inhibits hepatocellular carcinoma growth and migration through downregulation of the PI3K/AKT pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 6. 2014-08-19. PMID:24573607. |
we also investigated the effects of bmp-2 overexpression and knockdown on the expression of proliferating cell nuclear antigen (pcna), matrix metallopeptidase-2 (mmp-2), phosphorylated akt (p-akt), phosphoinositide 3-kinase p85α (pi3kp85α), bax, bcl-2, caspase-3, cleaved caspase-3, p21, and cyclin e. as a result, we observed that bmp-2 inhibited the proliferation of hcc cells. |
2014-08-19 |
2023-08-12 |
Not clear |
| Abhijit Ghosh, Guanyi Lu, Gang Su, Brendan McEvoy, Omar Sadiq, Paul D DiMusto, Adriana Laser, John S Futchko, Peter K Henke, Jonathan L Eliason, Gilbert R Upchurc. Phosphorylation of AKT and abdominal aortic aneurysm formation. The American journal of pathology. vol 184. issue 1. 2014-08-18. PMID:24332015. |
elastase-treated raw cells produced increased p308 and significant amounts of matrix metalloproteinase 9 (mmp-9), and these effects were suppressed by ly294002 treatment, a known akt inhibitor. |
2014-08-18 |
2023-08-12 |
mouse |
| Ying Jiang, Yan Zou, Shaoqiong Chen, Cansheng Zhu, Aimin Wu, Yingying Liu, Lili Ma, Dongliang Zhu, Xiaomeng Ma, Mei Liu, Zhuang Kang, Rongbiao Pi, Fuhua Peng, Qing Wang, Xiaohong Che. The anti-inflammatory effect of donepezil on experimental autoimmune encephalomyelitis in C57 BL/6 mice. Neuropharmacology. vol 73. 2014-08-13. PMID:23831366. |
blood-brain barrier (bbb) permeability was detected by evan's blue content, the expression of matrix metalloproteinase-2 (mmp-2) and mmp-9, akt and phosphorylated akt (p-akt) as well as nerve growth factor (ngf) and its precursor form (prongf) in the brains of eae mice were detected by western blot, and the levels of interferon-γ and interleukin-4 in the splenocytes culture supernatants and brains of eae mice were evaluated by elisa. |
2014-08-13 |
2023-08-12 |
mouse |
| Kati Rasanen, Sira Sriswasdi, Alexander Valiga, Hsin-Yao Tang, Gao Zhang, Michela Perego, Rajasekharan Somasundaram, Ling Li, Kaye Speicher, Andres J Klein-Szanto, Devraj Basu, Anil K Rustgi, David W Speicher, Meenhard Herly. Comparative secretome analysis of epithelial and mesenchymal subpopulations of head and neck squamous cell carcinoma identifies S100A4 as a potential therapeutic target. Molecular & cellular proteomics : MCP. vol 12. issue 12. 2014-07-31. PMID:24037664. |
key nodes in affected networks included nfκb, akt, and erk, and most implicated cellular components involved various aspects of the extracellular matrix. |
2014-07-31 |
2023-08-12 |
Not clear |
| Su-Zhen Wu, Fang-Fang Peng, Jia-Lin Li, Feng Ye, Shao-Qing Lei, Bai-Fang Zhan. Akt and RhoA activation in response to high glucose require caveolin-1 phosphorylation in mesangial cells. American journal of physiology. Renal physiology. vol 306. issue 11. 2014-07-31. PMID:24694591. |
serine/threonine kinase pkc-β1 mediates glucose-induced akt s473 phosphorylation, rhoa activation, and transforming growth factor (tgf)-β1 upregulation and finally leads to matrix upregulation in mesangial cells (mcs). |
2014-07-31 |
2023-08-13 |
rat |
| Honghai Zhao, Tongen Zhang, Chun Xia, Lei Shi, Shaojie Wang, Xinpeng Zheng, Tianhui Hu, Bing Zhan. Berberine ameliorates cartilage degeneration in interleukin-1β-stimulated rat chondrocytes and in a rat model of osteoarthritis via Akt signalling. Journal of cellular and molecular medicine. vol 18. issue 2. 2014-06-30. PMID:24286347. |
the data thus strongly suggest that berberine may ameliorate cartilage degeneration from oa by promoting cell survival and matrix production of chondrocytes, which was partly attributed to the activation of akt in il-1β-stimulated articular chondrocytes and in a rat oa model. |
2014-06-30 |
2023-08-12 |
rat |
| Safinur Atay, Andrew K Godwi. Tumor-derived exosomes: A message delivery system for tumor progression. Communicative & integrative biology. vol 7. issue 1. 2014-06-24. PMID:24778765. |
these exosomes contain oncogenic kit and their transfer and uptake by surrounding smooth muscle cells lead to enhanced akt and mapk signaling and phenotypic modulation of several cellular processes, including morphological changes, expression of tumor-associated markers, secretion of matrix metalloproteinases, and enhanced tumor cell invasion. |
2014-06-24 |
2023-08-13 |
Not clear |
| Myoung-Gwi Ryou, Gourav Roy Choudhury, Ali Winters, Luokun Xie, Robert T Mallet, Shao-Hua Yan. Pyruvate minimizes rtPA toxicity from in vitro oxygen-glucose deprivation and reoxygenation. Brain research. vol 1530. 2014-04-23. PMID:23891792. |
measured variables included cellular viability (calcein am and annexin-v/propidium iodide), reactive oxygen species (ros; mitosox red and 2',7'-dichlorofluorescein diacetate), nadph, nadp(+) and atp contents (spectrophotometry), matrix metalloproteinase-2 (mmp2) activities (gelatin zymography), and cellular contents of mmp2, tissue inhibitor of metalloproteinase-2 (timp2), and phosphor-activation of anti-apoptotic p70s6 kinase, akt and erk (immunoblot). |
2014-04-23 |
2023-08-12 |
Not clear |
| Kuei-Chuan Chan, Ming-Cheng Lin, Chien-Ning Huang, Wen-Chun Chang, Chau-Jong Wan. Mulberry 1-deoxynojirimycin pleiotropically inhibits glucose-stimulated vascular smooth muscle cell migration by activation of AMPK/RhoB and down-regulation of FAK. Journal of agricultural and food chemistry. vol 61. issue 41. 2014-04-01. PMID:24050301. |
the first involved ampk activation to inhibit fatty acid synthase (fasn) and akt activity and then rhob activation to inhibit nuclear factor-κb (nf-κb) and matrix metalloproteinase-2 (mmp) activity. |
2014-04-01 |
2023-08-12 |
Not clear |
| Xiaohong Chen, Shaoqiong Chen, Ying Jiang, Cansheng Zhu, Aimin Wu, Xiaomeng Ma, Fuhua Peng, Lili Ma, Dongliang Zhu, Qing Wang, Rongbiao P. Minocycline reduces oxygen-glucose deprivation-induced PC12 cell cytotoxicity via matrix metalloproteinase-9, integrin β1 and phosphorylated Akt modulation. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 8. 2014-03-20. PMID:23224583. |
minocycline reduces oxygen-glucose deprivation-induced pc12 cell cytotoxicity via matrix metalloproteinase-9, integrin β1 and phosphorylated akt modulation. |
2014-03-20 |
2023-08-12 |
human |
| Xiaohong Chen, Shaoqiong Chen, Ying Jiang, Cansheng Zhu, Aimin Wu, Xiaomeng Ma, Fuhua Peng, Lili Ma, Dongliang Zhu, Qing Wang, Rongbiao P. Minocycline reduces oxygen-glucose deprivation-induced PC12 cell cytotoxicity via matrix metalloproteinase-9, integrin β1 and phosphorylated Akt modulation. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 8. 2014-03-20. PMID:23224583. |
our results showed that minocycline could ameliorate oxygen-glucose deprivation-induced pc12 cell cytotoxicity at concentrations of 20 nm-20 μm, down-regulate the production and activity of matrix metalloproteinase-9, inhibit the degradation of integrin β1, and up-regulate akt phosphorylation at optimal concentration of 200 nm. |
2014-03-20 |
2023-08-12 |
human |