| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroko Ida-Yonemochi, Keishi Otsu, Hayato Ohshima, Hidemitsu Harad. The glycogen metabolism via Akt signaling is important for the secretion of enamel matrix in tooth development. Mechanisms of development. vol 139. 2016-12-13. PMID:26809144. |
these results suggested that the activation of akt signaling via igf is linked to the onset of both glycogen metabolism and enamel matrix deposition. |
2016-12-13 |
2023-08-13 |
mouse |
| Hiroko Ida-Yonemochi, Keishi Otsu, Hayato Ohshima, Hidemitsu Harad. The glycogen metabolism via Akt signaling is important for the secretion of enamel matrix in tooth development. Mechanisms of development. vol 139. 2016-12-13. PMID:26809144. |
in contrast, some inhibitors of akt signals and glycogen synthesis/degradation down-regulated enamel matrix secretion. |
2016-12-13 |
2023-08-13 |
mouse |
| Hiroko Ida-Yonemochi, Keishi Otsu, Hayato Ohshima, Hidemitsu Harad. The glycogen metabolism via Akt signaling is important for the secretion of enamel matrix in tooth development. Mechanisms of development. vol 139. 2016-12-13. PMID:26809144. |
taking these findings together, glycogen metabolism via akt signaling is an essential system for the secretion of enamel matrix in ameloblast differentiation. |
2016-12-13 |
2023-08-13 |
mouse |
| Ke Xu, Qizhi Shuai, Xiaoning Li, Yan Zhang, Chao Gao, Lei Cao, Feifei Hu, Toshihiro Akaike, Jian-xi Wang, Zhongwei Gu, Jun Yan. Human VE-Cadherin Fusion Protein as an Artificial Extracellular Matrix Enhancing the Proliferation and Differentiation Functions of Endothelial Cell. Biomacromolecules. vol 17. issue 3. 2016-12-13. PMID:26859785. |
furthermore, the hve-cad-fc matrix activated endogenous ve-cadherin/β-catenin proteins and effectively triggered the intracellular signals such as f-actin stress fiber, p-fak, akt, and bcl-2. |
2016-12-13 |
2023-08-13 |
human |
| Ahmed Malki, Mona Mohsen, Hassan Aziz, Ola Rizk, Omima Shaban, Mohamed El-Sayed, Zaki A Sherif, Hayam Ashou. New 3-Cyano-2-Substituted Pyridines Induce Apoptosis in MCF 7 Breast Cancer Cells. Molecules (Basel, Switzerland). vol 21. issue 2. 2016-10-24. PMID:26901182. |
furthermore, 9a reduced the expression of phospho akt and β-catenin in dose dependent manner while inhibiting the expression of migration-related genes such as matrix metalloproteinase (mmp)-9 and vascular endothelial growth factor (vegf). |
2016-10-24 |
2023-08-13 |
human |
| Ping Li, Li Ying Xiao, Hong Ta. Muc-1 promotes migration and invasion of oral squamous cell carcinoma cells via PI3K-Akt signaling. International journal of clinical and experimental pathology. vol 8. issue 9. 2016-10-05. PMID:26617744. |
moreover, silenced cells present defects in phosphatidylinositol 3-kinase (pi3k)-serine/threonine kinase (akt) signaling, and reduced expression/activity of matrix metallopeptidase (mmp)-2/9. |
2016-10-05 |
2023-08-13 |
mouse |
| Wen Jie Wang, Kun Mou, Xi Feng Wu, Jin Zhong Zhang, Gang Ren, Jiu De Qi, Yi-Fu Xu, Xin Ya. Grb2-associated binder 2 silencing impairs growth and migration of H1975 cells via modulation of PI3K-Akt signaling. International journal of clinical and experimental pathology. vol 8. issue 9. 2016-09-26. PMID:26617767. |
moreover, silenced cells present defects in phosphatidylinositol 3-kinase (pi3k)-serine/threonine kinase (akt) signaling, and reduced expression/activity of matrix metallopeptidase (mmp)-2/9. |
2016-09-26 |
2023-08-13 |
mouse |
| Yan Wang, Guo-Hua Su, Fang Zhang, Jing-Xue Chu, Yun-Shan Wan. Cyclic GMP-AMP Synthase Is Required for Cell Proliferation and Inflammatory Responses in Rheumatoid Arthritis Synoviocytes. Mediators of inflammation. vol 2015. 2016-09-26. PMID:26819496. |
cgas overexpression enhanced the production of proinflammatory cytokines and matrix metalloproteinases (mmps) as well as akt and erk phosphorylation in tnfα-stimulated fls. |
2016-09-26 |
2023-08-13 |
human |
| Yan Wang, Guo-Hua Su, Fang Zhang, Jing-Xue Chu, Yun-Shan Wan. Cyclic GMP-AMP Synthase Is Required for Cell Proliferation and Inflammatory Responses in Rheumatoid Arthritis Synoviocytes. Mediators of inflammation. vol 2015. 2016-09-26. PMID:26819496. |
in contrast, cgas silencing inhibited production of proinflammatory cytokines and matrix metalloproteinases (mmps) as well as akt and erk phosphorylation in tnfα-stimulated fls. |
2016-09-26 |
2023-08-13 |
human |
| Xueying Chen, Guoliang Liu, Wei Zhang, Jianing Zhang, Yugang Yan, Wenqian Dong, Ershun Liang, Yun Zhang, Mingxiang Zhan. Inhibition of MEF2A prevents hyperglycemia-induced extracellular matrix accumulation by blocking Akt and TGF-β1/Smad activation in cardiac fibroblasts. The international journal of biochemistry & cell biology. vol 69. 2016-09-19. PMID:26482596. |
inhibition of mef2a prevents hyperglycemia-induced extracellular matrix accumulation by blocking akt and tgf-β1/smad activation in cardiac fibroblasts. |
2016-09-19 |
2023-08-13 |
mouse |
| Xueying Chen, Guoliang Liu, Wei Zhang, Jianing Zhang, Yugang Yan, Wenqian Dong, Ershun Liang, Yun Zhang, Mingxiang Zhan. Inhibition of MEF2A prevents hyperglycemia-induced extracellular matrix accumulation by blocking Akt and TGF-β1/Smad activation in cardiac fibroblasts. The international journal of biochemistry & cell biology. vol 69. 2016-09-19. PMID:26482596. |
our study suggests that inhibition of mef2a could alleviate hg-induced extracellular matrix accumulation by blocking the activation of akt and tgf-β1/smad signaling pathway in cfs. |
2016-09-19 |
2023-08-13 |
mouse |
| Hai-Ying Peng, Wei Gao, Fa-Rong Chong, Hong-Yan Liu, J I Zhan. Semaphorin 4A enhances lung fibrosis through activation of Akt via PlexinD1 receptor. Journal of biosciences. vol 40. issue 5. 2016-09-15. PMID:26648031. |
western blot analysis showed that sema4a activated the akt pathway in lung fibroblasts, and the specific inhibitor of akt pathway, akt inhibitor iii, blocked the ability of sema4a to promote the ability of lung fibroblasts to contract a collagen gel matrix. |
2016-09-15 |
2023-08-13 |
Not clear |
| Rui Liu, Wenjie Wang, Bingling Dai, Yanping Liu, Yanmin Zhan. Taspine derivative TAS9 regulates cell growth and metastasis of human hepatocellular carcinoma. Molecular medicine reports. vol 12. issue 5. 2016-08-15. PMID:26459497. |
the results indicated that tas9 inhibited smmc‑7721 cell growth by downregulating the signaling molecules protein kinase cβ (pkcβ), akt, mammalian target of rapamycin, mitogen‑activated protein kinase kinase 2, raf and c‑jun n‑terminal kinase‑1, and inhibiting smmc‑7721 cell migration by suppressing the expression of matrix metalloproteinase (mmp)‑2, mmp‑9, chemokine (c‑x‑c motif) receptor 4, nuclear factor κb, p38 and p53. |
2016-08-15 |
2023-08-13 |
human |
| Yufu Tang, Pengfei Lv, Zhongyi Sun, Lei Han, Wenping Zho. 14-3-3β Promotes Migration and Invasion of Human Hepatocellular Carcinoma Cells by Modulating Expression of MMP2 and MMP9 through PI3K/Akt/NF-κB Pathway. PloS one. vol 11. issue 1. 2016-08-10. PMID:26730736. |
in addition, ectopic expression of 14-3-3β in hcc cell lines led to enhanced migration ability and invasiveness, as well as up-regulation of matrix metalloproteinase 2 and 9, which could be suppressed by inhibiting the activation of akt and nuclear factor-κb (nf-κb) signaling. |
2016-08-10 |
2023-08-13 |
human |
| Phorl Sophors, Young Mee Kim, Ga Young Seo, Jung-Sik Huh, Yoongho Lim, Dong Soo Koh, Moonjae Ch. A synthetic isoflavone, DCMF, promotes human keratinocyte migration by activating Src/FAK signaling pathway. Biochemical and biophysical research communications. vol 472. issue 2. 2016-08-08. PMID:26923073. |
dcmf-induced src kinase could promote activation of erk, akt, and p38 signaling pathways, and dcmf-induced secretion of matrix metalloproteinase (mmp)-2 and mmp-9 and partial epithelial-mesenchymal transition (emt), whereas src inhibition abolished dcmf-induced emt. |
2016-08-08 |
2023-08-13 |
mouse |
| Bijun Chen, Jinming Li, George F Fellows, Zilin Sun, Rennian Wan. Maintaining human fetal pancreatic stellate cell function and proliferation require β1 integrin and collagen I matrix interactions. Oncotarget. vol 6. issue 16. 2016-05-17. PMID:26062655. |
significant activation of fak/erk and akt signaling pathways, and up-regulation of cyclin d1 protein levels, were observed within pascs cultured on collagen i matrix. |
2016-05-17 |
2023-08-13 |
human |
| Jin Kyeong Choi, Sung-Wan Kim, Duk-Sil Kim, Jong Yeong Lee, Soyoung Lee, Hyun-Mee Oh, Yeong Su Ha, Jeongsoo Yoo, Pil-Hoon Park, Tae-Yong Shin, Taeg Kyu Kwon, Mun-Chual Rho, Sang-Hyun Ki. Oleanolic acid acetate inhibits rheumatoid arthritis by modulating T cell immune responses and matrix-degrading enzymes. Toxicology and applied pharmacology. vol 290. 2016-05-10. PMID:26570984. |
oaa reduced the expression and production of inflammatory mediators, such as cytokines and matrix metalloproteinase (mmp)-1/3, in the ankle joint tissue and ra synovial fibroblasts by down-regulating akt, mitogen-activated protein kinases, and nuclear factor-κb. |
2016-05-10 |
2023-08-13 |
mouse |
| Li Jun Xu, Yu Chang Wang, Hong Wen Lan, Jun Li, Tian Xi. Grb2-associated binder-2 gene promotes migration of non-small cell lung cancer cells via Akt signaling pathway. American journal of translational research. vol 8. issue 2. 2016-05-09. PMID:27158407. |
finally, we found that gab2 promotes nsclc migration through the protein kinase b (akt) signaling pathway and up-regulation the activity of matrix metallopeptidase (mmp)-2/9. |
2016-05-09 |
2023-08-13 |
Not clear |
| Wei Zhang, Jingying Zhu, Zhiyan Du, Jiyun Yu, Yuanji Xu, Fang Wan. Intraarticular gene transfer of SPRY2 suppresses adjuvant-induced arthritis in rats. Applied microbiology and biotechnology. vol 99. issue 16. 2016-04-14. PMID:25935347. |
adspry2 suppressed the production of proinflammatory cytokines and matrix metalloproteinases (mmps), and the activation of erk and akt signals in aia ankle joints. |
2016-04-14 |
2023-08-13 |
human |
| Yang Xu, Zhangxiao Peng, Weidan Ji, Xiang Li, Xuejing Lin, Liqiang Qian, Xiaoya Li, Xiaoyun Chai, Qiuye Wu, Quangen Gao, Changqing S. A Novel Matrine Derivative WM130 Inhibits Activation of Hepatic Stellate Cells and Attenuates Dimethylnitrosamine-Induced Liver Fibrosis in Rats. BioMed research international. vol 2015. 2016-04-14. PMID:26167476. |
on the dmn-induced rat liver fibrosis model, wm130 can effectively reduce the tgf-β1, akt, α-sma, and p-erk levels, decrease the extracellular matrix (ecm) formation, and inhibit rat liver fibrosis progression. |
2016-04-14 |
2023-08-13 |
rat |