| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dajiang Wu, Hao Zhang, Fang Ji, Wenbin Din. MicroRNA-17 promotes osteosarcoma cells proliferation and migration and inhibits apoptosis by regulating SASH1 expression. Pathology, research and practice. vol 215. issue 1. 2019-02-05. PMID:30396754. |
in this study, quantitative real-time pcr (qrt-pcr) was used to measure the expression of mir-17, and western blotting assay was performed to measure the expressions of sam and sh3 domain containing 1 (sash1), phosphoinoinositide-3 kinase (pi3k), protein kinase b (akt), caspase3, bcl-2 gene family (bcl-2, bax) and matrix metalloprotein (mmp-2, mmp-9) in mg-63 cells. |
2019-02-05 |
2023-08-13 |
Not clear |
| Shuxian Yang, Yonghong Liao, Liyong Li, Xudong Xu, Li Ca. Zeylenone Induces Mitochondrial Apoptosis and Inhibits Migration and Invasion in Gastric Cancer. Molecules (Basel, Switzerland). vol 23. issue 9. 2018-11-12. PMID:30150551. |
we found that zey downregulated the expression of matrix metalloproteinase 2/9 (mmp 2/9) and inhibited the phosphorylation of akt and erk. |
2018-11-12 |
2023-08-13 |
mouse |
| Meng-Hsun Yu, Ming-Cheng Lin, Chien-Ning Huang, Kuei-Chuan Chan, Chau-Jong Wan. Acarbose inhibits the proliferation and migration of vascular smooth muscle cells via targeting Ras signaling. Vascular pharmacology. vol 103-105. 2018-09-20. PMID:29432898. |
acarbose also inhibited the phosphorylation of focal adhesion kinase (fak) and akt, activities of the matrix metalloproteinases (mmps) mmp-2 and mmp-9, and protein expressions of small g proteins (ras, cdc42, rhoa, and rac1) in a dose-dependent manner. |
2018-09-20 |
2023-08-13 |
Not clear |
| Bin Sun, Changxian Dong, Hongzhao Lei, Yubin Gong, Miaomiao Li, Yuanfang Zhang, Hongyu Zhang, Longlong Su. Propranolol inhibits proliferation and invasion of hemangioma-derived endothelial cells by suppressing the DLL4/Notch1/Akt pathway. Chemico-biological interactions. vol 294. 2018-09-14. PMID:30130526. |
the expressions of matrix metalloproteinase (mmp)-2, mmp-9, delta-like 4 (dll4), notch1, akt, p-akt, and vascular endothelial growth factor (vegf) were detected using western blot. |
2018-09-14 |
2023-08-13 |
human |
| Yuan Zeng, Ying Yan. Piperine depresses the migration progression via downregulating the Akt/mTOR/MMP‑9 signaling pathway in DU145 cells. Molecular medicine reports. vol 17. issue 5. 2018-09-13. PMID:29488612. |
in addition, ly294002, an protein kinase b (akt) inhibitor, greatly suppressed the expression level of phospho (p)‑akt, matrix metalloproteinase (mmp)‑9 and p‑mammalian target of rapamycin (mtor), suggesting that the activation of the akt/mtor/mmp‑9 signaling pathway may participate in regulating cell migration in pca. |
2018-09-13 |
2023-08-13 |
Not clear |
| Xiaoling Zhu, Yuzhen Li, Qinggang Men. Islet-1 promotes the proliferation and invasion, and inhibits the apoptosis of A375 human melanoma cells. International journal of molecular medicine. vol 41. issue 6. 2018-09-10. PMID:29568936. |
the expression levels of matrix metalloproteinase (mmp)-2 and mmp-9 were measured by qpcr and western blot analysis; the expression levels of akt and p-akt were measured in the cells treated with vascular endothelial growth factor (vegf) and the pi3k/akt inhibitor, ly294002, by western blot analysis. |
2018-09-10 |
2023-08-13 |
human |
| Dapeng Li, Ye Hua, Lu Jiang, Yonghui Huang, Jiawei Yue, Yan Wu, Yongchang Che. Cyclic Guanosine Monophosphate (cGMP)-Dependent Protein Kinase II Blocks Epidermal Growth Factor (EGF)/Epidermal Growth Factor Receptor (EGFR)-Induced Biological Effects on Osteosarcoma Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-09-10. PMID:29617357. |
transwell assay was used to examine mg-63 cell migration; and western blot analysis was used to detect expression of matrix metalloproteinase 9 (mmp-9) and activation of erk and akt. |
2018-09-10 |
2023-08-13 |
Not clear |
| Xiaohui Ma, Hairong Yao, Yuhong Yang, Long Jin, Yu Wang, Lina Wu, Shengli Yang, Kang Chen. miR-195 suppresses abdominal aortic aneurysm through the TNF-α/NF-κB and VEGF/PI3K/Akt pathway. International journal of molecular medicine. vol 41. issue 4. 2018-08-23. PMID:29393364. |
the present study also used mir‑195 mimics to increase the expression of mir‑195, and elisa kits and western blot analysis were used to analyze the levels of interleukin (il)‑1β and il‑6, and the protein expression levels of matrix metalloproteinase (mmp)‑2, mmp‑9, tumor necrosis factor (tnf)‑α, nuclear factor (nf)‑κb, vascular endothelial growth factor (vegf), phosphoinositide 3‑kinase (pi3k) and phosphorylated (p‑)akt. |
2018-08-23 |
2023-08-13 |
Not clear |
| Shipin Zhang, Shang Jiunn Chuah, Ruenn Chai Lai, James Hoi Po Hui, Sai Kiang Lim, Wei Seong To. MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity. Biomaterials. vol 156. 2018-08-03. PMID:29182933. |
inhibitors of akt or erk phosphorylation suppressed exosome-mediated increase in cell proliferation and migration but not matrix synthesis. |
2018-08-03 |
2023-08-13 |
rat |
| M Ito, T Yurube, K Kakutani, K Maeno, T Takada, Y Terashima, Y Kakiuchi, Y Takeoka, S Miyazaki, R Kuroda, K Nishid. Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction. Osteoarthritis and cartilage. vol 25. issue 12. 2018-07-18. PMID:28888905. |
selective interference of mtorc1/raptor protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with akt and autophagy induction. |
2018-07-18 |
2023-08-13 |
human |
| Jian-Jun Gu, Kai-Chun Fan, Jian-He Zhang, Hong-Jie Chen, Shou-Sen Wan. Suppression of microRNA-130b inhibits glioma cell proliferation and invasion, and induces apoptosis by PTEN/AKT signaling. International journal of molecular medicine. vol 41. issue 1. 2018-07-09. PMID:29115407. |
western blotting revealed that the mir-130b inhibitor upregulated the expression of pten, inhibited akt pathway activation, upregulated the tumor suppressor gene p27, and suppressed cyclin d1, matrix metalloproteinase 2 and 9 expression. |
2018-07-09 |
2023-08-13 |
mouse |
| Ting-Ting Liu, Xi-Sheng Liu, Meng Zhang, Xue-Ni Liu, Fu-Xiang Zhu, Fang-Ming Zhu, Si-Wen Ouyang, Shan-Bao Li, Chen-Long Song, Hui-Min Sun, Su Lu, Yu Zhang, Jun Lin, Hua-Mei Tang, Zhi-Hai Pen. Cartilage oligomeric matrix protein is a prognostic factor and biomarker of colon cancer and promotes cell proliferation by activating the Akt pathway. Journal of cancer research and clinical oncology. vol 144. issue 6. 2018-06-12. PMID:29560517. |
cartilage oligomeric matrix protein is a prognostic factor and biomarker of colon cancer and promotes cell proliferation by activating the akt pathway. |
2018-06-12 |
2023-08-13 |
Not clear |
| Yunjuan Nie, Yaoyao Yang, Jian Zhang, Guowei Cai, Yanhua Chang, Gaoshang Chai, Chongyong Gu. Shikonin suppresses pulmonary fibroblasts proliferation and activation by regulating Akt and p38 MAPK signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 95. 2018-06-11. PMID:28922731. |
collectively, these data indicate that shi has a strong cytotoxicity in pulmonary fibroblast via inhibiting akt activation signaling pathway, and attenuates tgf-β induced extracellular matrix genes production in pulmonary fibroblasts via modulating the activities of p38 mapk and akt. |
2018-06-11 |
2023-08-13 |
Not clear |
| Xiaoqing Yan, Xiaozhen Dai, Luqing He, Xiao Ling, Minglong Shao, Chi Zhang, Yuehui Wang, Jian Xiao, Lu Cai, Xiaokun Li, Yi Ta. A Novel CXCR4 antagonist enhances angiogenesis via modifying the ischaemic tissue environment. Journal of cellular and molecular medicine. vol 21. issue 10. 2018-06-05. PMID:28374486. |
in this study, p2g was found to possess a robust capability to promote epc infiltration and incorporation in neo-vessels, enhance the expression and function of pro-angiogenic factors, such as sdf-1, vascular endothelial growth factor and matrix metalloprotein-9, and activate cell signals involved in angiogenesis, such as proliferating cell nuclear antigen, protein kinase b (akt), extracellular regulated protein kinases and mammalian target of rapamycin, in ischaemic tissue. |
2018-06-05 |
2023-08-13 |
Not clear |
| In-A Cho, Sang-Joun You, Kyeong-Rok Kang, Su-Gwan Kim, Ji-Su Oh, Jae-Seek You, Gyeong-Je Lee, Yo-Seob Seo, Do Kyung Kim, Chun Sung Kim, Sook-Young Lee, Jae-Sung Ki. Biochanin-A induces apoptosis and suppresses migration in FaDu human pharynx squamous carcinoma cells. Oncology reports. vol 38. issue 5. 2018-06-04. PMID:28901495. |
biochanin-a also inhibited wound healing migration and proliferation of fadu cells via the downregulation and inactivation of matrix metalloproteinase-2 and -9 that are mediated by the suppression of p38, mitogen activated protein kinase (mapk), nf-κb and akt cellular signaling pathways. |
2018-06-04 |
2023-08-13 |
human |
| Sze Wan Shan, Chi Wai Do, Thomas Chuen Lam, Ricky Pak Wing Kong, King Kit Li, Ka Man Chun, William Daniel Stamer, Chi Ho T. New Insight of Common Regulatory Pathways in Human Trabecular Meshwork Cells in Response to Dexamethasone and Prednisolone Using an Integrated Quantitative Proteomics: SWATH and MRM-HR Mass Spectrometry. Journal of proteome research. vol 16. issue 10. 2018-05-22. PMID:28920441. |
together with other novel proteins identified in the data sets, additional pathways implicated by these regulated proteins were the phosphatidylinositol 3-kinase (pi3k)-protein kinase b (akt) signaling pathway, integrin cell surface interaction, extracellular matrix (ecm) proteoglycans, and ecm-receptor interaction. |
2018-05-22 |
2023-08-13 |
human |
| Lin Li, Ting Xiao, Fang Li, Yan Li, Ou Zeng, Maojun Liu, Biao Liang, Zining Li, Chun Chu, Jun Yan. Hydrogen sulfide reduced renal tissue fibrosis by regulating autophagy in diabetic rats. Molecular medicine reports. vol 16. issue 2. 2018-05-04. PMID:28656209. |
the expression levels of matrix metalloproteinase 9 (mmp9), mmp7, tissue inhibitor of metalloproteinase 1 (timp1), superoxide dismutase (sod), serine/threonine kinase akt, transforming growth factor (tgf)‑β1, nuclear factor (nf)‑κb and several autophagy related proteins were assessed by western blot analysis. |
2018-05-04 |
2023-08-13 |
rat |
| Yatao Jiang, Yuqing Chen, Yanping Che. Knockdown of JARID2 inhibits the viability and migration of placenta trophoblast cells in preeclampsia. Molecular medicine reports. vol 16. issue 3. 2018-04-24. PMID:28714012. |
the expression levels of matrix metallopeptidase 2 (mmp2), mmp9, phosphorylated phosphatidylinositol 3‑kinase (p‑pi3k), pi3k, phosphorylated akt serine/threonine kinase 1 (p‑akt) and akt in htr8/svneo cells were also detected using western blotting. |
2018-04-24 |
2023-08-13 |
human |
| Haomin Zhao, Tao Han, Xin Hong, Dajun Su. Adipose differentiation‑related protein knockdown inhibits vascular smooth muscle cell proliferation and migration and attenuates neointima formation. Molecular medicine reports. vol 16. issue 3. 2018-04-16. PMID:28713961. |
extracellular signal‑regulated kinase (erk), phosphorylated (p)‑erk, akt, p‑akt, proliferating cell nuclear antigen (pcna), matrix metalloproteinase (mmp)‑2 and mmp‑9 protein levels were determined by western blotting. |
2018-04-16 |
2023-08-13 |
mouse |
| Jialin Chen, Peng Chen, Ludvig J Backman, Qingjun Zhou, Patrik Danielso. Ciliary Neurotrophic Factor Promotes the Migration of Corneal Epithelial Stem/progenitor Cells by Up-regulation of MMPs through the Phosphorylation of Akt. Scientific reports. vol 6. 2018-04-10. PMID:27174608. |
this study provides new insights into the role of cntf on the migration of corneal epithelial stem/progenitor cells and its inherent mechanism of up-regulation of matrix metalloproteinases through the akt signalling pathway. |
2018-04-10 |
2023-08-13 |
mouse |