| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wataru Ohwada, Masaya Tanno, Toshiyuki Yano, Sang-Bing Ong, Koki Abe, Tatsuya Sato, Atsushi Kuno, Takayuki Miki, Hirohito Sugawara, Yusuke Igaki, Tetsuji Miur. Distinct intra-mitochondrial localizations of pro-survival kinases and regulation of their functions by DUSP5 and PHLPP-1. Biochimica et biophysica acta. Molecular basis of disease. vol 1866. issue 10. 2020-12-07. PMID:32480039. |
treatment with igf-1 increased the protein level of akt in the matrix, while erk and gsk-3β protein levels were increased in om. |
2020-12-07 |
2023-08-13 |
Not clear |
| Hongzao Ni, Daofei Ji, Zhixiong Huang, Jing L. SMAGP knockdown inhibits the malignant phenotypes of glioblastoma cells by inactivating the PI3K/Akt pathway. Archives of biochemistry and biophysics. vol 695. 2020-12-07. PMID:33049294. |
western blot was applied to detect the expression of smagp, matrix metalloproteinase (mmp)-2, and mmp-9 and analyze the changes of phosphoinositide 3-kinase (pi3k)/protein kinase b (akt) signaling. |
2020-12-07 |
2023-08-13 |
Not clear |
| Jian Lei, Abebe Feyissa Amhare, Liyun Wang, Yizhen Lv, Huan Deng, Hang Gao, Xiong Guo, Jing Han, Mikko J Lamm. Proteomic analysis of knee cartilage reveals potential signaling pathways in pathological mechanism of Kashin-Beck disease compared with osteoarthritis. Scientific reports. vol 10. issue 1. 2020-11-30. PMID:32322000. |
kegg pathways enrichment and ppi network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (pi3k)-protein kinase b (akt), and ras signaling pathways were involved in the degeneration of cartilage. |
2020-11-30 |
2023-08-13 |
Not clear |
| L Zhang, Y Wang, H S. Long non-coding RNA LINC00152/miR-613/CD164 axis regulates cell proliferation, apoptosis, migration and invasion in glioma via PI3K/AKT pathway. Neoplasma. vol 67. issue 4. 2020-11-16. PMID:32726126. |
western blot was used to detect the expression of cd164, phosphatidylinositol 3' -kinase (pi3k), phosphorylated pi3k (p-pi3k), protein kinase b (akt), phosphorylated akt (p-akt), matrix metalloproteinase 9 (mmp9), bcl2-associated x (bax) and c-myc. |
2020-11-16 |
2023-08-13 |
Not clear |
| Meredith Mihalopoulos, Zachary Dovey, Maddison Archer, Talia G Korn, Kennedy E Okhawere, William Nkemdirim, Hassan Funchess, Ami Rambhia, Nihal Mohamed, Steven A Kaplan, Reza Mehrazin, Dara Lundon, Che-Kai Tsao, Ketan K Badani, Natasha Kypriano. Repurposing of α1-Adrenoceptor Antagonists: Impact in Renal Cancer. Cancers. vol 12. issue 9. 2020-10-27. PMID:32872127. |
mechanistically these drugs overcome anoikis resistance in tumor cells by targeting cell survival regulators akt and fak, disrupting integrin adhesion (α5β1 and α2β1) and engaging extracellular matrix (ecm)-associated tumor suppressors. |
2020-10-27 |
2023-08-13 |
human |
| Hye-Jeong Cho, Mi-Ock Baek, Sana Abdul Khaliq, Seung Joo Chon, Kuk Hui Son, Sung Ho Lee, Mee-Sup Yoo. Microgravity inhibits decidualization via decreasing Akt activity and FOXO3a expression in human endometrial stromal cells. Scientific reports. vol 9. issue 1. 2020-10-23. PMID:31431660. |
the phosphorylation of akt decreased under sm conditions in human escs, accompanied by a simultaneous decrease in the level of matrix metalloproteinase (mmp)-2 and foxo3a. |
2020-10-23 |
2023-08-13 |
human |
| Hardeep Singh Tuli, Vaishali Aggarwal, Jagjit Kaur, Diwakar Aggarwal, Gaurav Parashar, Nidarshana Chaturvedi Parashar, Muobarak Tuorkey, Ginpreet Kaur, Raj Savla, Katrin Sak, Manoj Kuma. Baicalein: A metabolite with promising antineoplastic activity. Life sciences. vol 259. 2020-10-15. PMID:32781058. |
in the process of understanding the underlying signaling cascades, the role of mitogen activated protein kinase (mapk), mammalian target of rapamycin (mtor), akt serine/threonine protein kinase b (akt), poly(adp-ribose) polymerase (parp), matrix metalloproteinases-2 (mmp-2), matrix metalloproteinases-9 (mmp-9) and caspase-3/-8,-9 have been highlighted as the major players for baicalein anti-malignant potential. |
2020-10-15 |
2023-08-13 |
Not clear |
| Yunhua Tang, Xiangyang Zhang, Fan Qi, Mingfeng Chen, Yuan Li, Longfei Liu, Wei He, Zhuo Li, Xiongbing Z. Afatinib inhibits proliferation and invasion and promotes apoptosis of the T24 bladder cancer cell line. Experimental and therapeutic medicine. vol 9. issue 5. 2020-10-01. PMID:26136904. |
mtt assay was used to estimate the proliferation of the t24 cells; flow cytometric analysis was used to estimate the effect of afatinib on t24 cell apoptosis; cell invasion ability was assessed by a transwell invasion assay; and western blot analysis was used to detect the expression of bcl-2, bax, akt, extracellular-signal-regulated kinase (erk)1/2, matrix metalloproteinase (mmp)-2 and mmp-9. |
2020-10-01 |
2023-08-13 |
human |
| Jian-Jun Gu, Jian-He Zhang, Hong-Jie Chen, Shou-Sen Wan. TPX2 promotes glioma cell proliferation and invasion via activation of the AKT signaling pathway. Oncology letters. vol 12. issue 6. 2020-10-01. PMID:28105208. |
overexpression of tpx2 also significantly enhanced the phosphorylation of akt, decreased the expression of p21, and increased the expression of cyclin d1 and matrix metallopeptidase (mmp)-9. |
2020-10-01 |
2023-08-13 |
human |
| Yan Chen, Jin Sun, Junyan M. Proliferation and invasion of ovarian cancer cells are suppressed by knockdown of TRIM11. Oncology letters. vol 14. issue 2. 2020-10-01. PMID:28781653. |
knockdown of trim11 not only affects the expression of cell apoptosis-related (bcl-2 and bax) and invasion-related proteins [matrix metalloproteinase (mmp)-2 and mmp-9], but also reduced the phosphorylation levels of erk and akt. |
2020-10-01 |
2023-08-13 |
Not clear |
| Wencai Sun, Yintai Li, Suizhuan We. miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis. Experimental and therapeutic medicine. vol 15. issue 1. 2020-10-01. PMID:29434702. |
furthermore, cell viability, cell apoptosis, cell autophagy and matrix synthesis, as well as the expressions of proteins associated with the phosphoinositide 3-kinase (pi3k)/protein kinase b (akt)/mammalian target of rapamycin (mtor) signaling pathway were detected. |
2020-10-01 |
2023-08-13 |
rat |
| Yingying Zhang, Jinfeng Liu, Yan Lv, Chao Zhang, Shuai Gu. LncRNA meg3 suppresses hepatocellular carcinoma in vitro and vivo studies. American journal of translational research. vol 11. issue 7. 2020-10-01. PMID:31396320. |
furthermore, overexpression of meg3 (a) decreased proliferation, migration, and invasion of hepg2 cells; (b) enhanced apoptosis and the proportion of hepg2 cells in g1 of the cell cycle; (c) increased the expression of phosphatase and tensin homolog (pten), bcl2-associated x (bax), and p53 proteins; and (d) decreased the expression of mirna-10a-5p, akt, p-akt, bcl-2, and the matrix metalloproteinases (mmps)-2 and -9. |
2020-10-01 |
2023-08-13 |
Not clear |
| Zailong Zhou, Jian M. Gambogic acid suppresses colon cancer cell activity Experimental and therapeutic medicine. vol 18. issue 4. 2020-10-01. PMID:31555380. |
western blotting was used to analyze relative protein expression levels of phosphoinositide 3-kinase (pi3k), protein kinase b (akt), p21, and matrix metalloprotease (mmp)-2 and -9 between groups. |
2020-10-01 |
2023-08-13 |
human |
| Kenneth Maies. Picking a bone with WISP1 (CCN4): new strategies against degenerative joint disease. Journal of translational science. vol 1. issue 3. 2020-09-30. PMID:26893943. |
wisp1 has an intricate relationship with a number of proliferative and protective pathways that include phosphoinositide 3-kinase (pi 3-k), protein kinase b (akt), nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb), interleukin -6 (il-6), transforming growth factor-β, matrix metalloproteinase, small non-coding ribonucleic acids (rnas), sirtuin silent mating type information regulation 2 homolog 1 (saccharomyces cerevisiae) (sirt1), and the mechanistic target of rapamycin (mtor). |
2020-09-30 |
2023-08-13 |
Not clear |
| Yao Deng, Mengjiao Zhang, Xianchun Chen, Ximing Pu, Xiaoming Liao, Zhongbing Huang, Guangfu Yi. A novel akermanite/poly (lactic-co-glycolic acid) porous composite scaffold fabricated via a solvent casting-particulate leaching method improved by solvent self-proliferating process. Regenerative biomaterials. vol 4. issue 4. 2020-09-30. PMID:28798869. |
in this work, a kind of slightly soluble bioactive ceramic akermanite (akt) powders were aboratively selected and introduced in the plga matrix, a novel l-lactide modified akt/poly (lactic- |
2020-09-30 |
2023-08-13 |
Not clear |
| Haibin Lu, Baolei Wu, Ge Ma, Deyu Zheng, Ruijuan Song, Erjiang Huang, Ming Mao, Bin L. Melatonin represses oral squamous cell carcinoma metastasis by inhibiting tumor-associated neutrophils. American journal of translational research. vol 9. issue 12. 2020-09-30. PMID:29312489. |
mechanistically, mel suppressed the tan release of c-x-c motif chemokine ligand 8, c-c motif chemokine ligand 2 (ccl2), ccl4, and matrix metalloproteinase-9 by blockage of p38 mapk and akt signaling. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jiancheng Xi, Xiaobo Luo, Yipeng Wang, Jinglong Li, Lixin Guo, Guangseng Wu, Qingui L. Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats. Experimental and therapeutic medicine. vol 18. issue 5. 2020-09-30. PMID:31602247. |
tetrahydrocurcumin effectively decreased the gene expression of matrix metalloproteinase-3 and -13, as well as cyclooxygenase-2, promoted the phosphorylation of akt and enhanced the protein expression of forkhead box (fox)o4 in sci rats. |
2020-09-30 |
2023-08-13 |
rat |
| Jia Yun Liu, Xiao Yu Wu, Guan Nan Wu, Fu-Kun Liu, Xue-Quan Ya. FOXQ1 promotes cancer metastasis by PI3K/AKT signaling regulation in colorectal carcinoma. American journal of translational research. vol 9. issue 5. 2020-09-29. PMID:28559972. |
finally, foxq1-dependent inhibition of colorectal cancer cell migration and invasion and down-regulation of focal adhesion kinase (fak), phosphatidyl inositol 3-kinase (pi3k) phosphorylation, akt (v-akt murine thymoma viral oncogene) phosphorylation and matrix metalloproteinase-2/9 (mmp-2/9) expression. |
2020-09-29 |
2023-08-13 |
human |
| Yan Wang, Xuefeng Han, Zhiliang Tan, Jinhe Kang, Zheng Wan. Rumen-Protected Glucose Stimulates the Insulin-Like Growth Factor System and mTOR/AKT Pathway in the Endometrium of Early Postpartum Dairy Cows. Animals : an open access journal from MDPI. vol 10. issue 2. 2020-09-28. PMID:32102173. |
expressions of igf members, the matrix metalloproteinase, protein kinase b (akt)/mechanistic target of rapamycin complex1 (mtor) signaling pathway, and cell proliferation factors (proliferating cell nuclear antigen (pcna) and ki67) were detected using real-time polymerase chain reaction, western blot, immunohistochemistry, and immunofluorescence, respectively. |
2020-09-28 |
2023-08-13 |
Not clear |
| Sujing Zhuang, Li Li, Yuwei Zang, Guangfeng Li, Feng Wan. RRM2 elicits the metastatic potential of breast cancer cells by regulating cell invasion, migration and VEGF expression via the PI3K/AKT signaling. Oncology letters. vol 19. issue 4. 2020-09-28. PMID:32256828. |
moreover, inhibition of rrm2 dampened the activation of phosphatidylinositol 3 kinase (pi3k)/protein kinase b (akt) signaling by decreasing phosphorylated-akt and downstream matrix metalloproteinases-2 expression. |
2020-09-28 |
2023-08-13 |
Not clear |