| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hak Joo Lee, Meenalakshmi M Mariappan, Luke Norton, Terry Bakewell, Denis Feliers, Sae Byeol Oh, Andrew Donati, Cherubina S Rubannelsonkumar, Manjeri A Venkatachalam, Stephen E Harris, Isabelle Rubera, Michel Tauc, Goutam Ghosh Choudhury, C Ronald Kahn, Kumar Sharma, Ralph A DeFronzo, Balakuntalam S Kasinat. Proximal tubular epithelial insulin receptor mediates high-fat diet-induced kidney injury. JCI insight. vol 6. issue 3. 2021-05-28. PMID:33400689. |
hfd increased the following parameters in the male control mice: renal cortical contents of phosphorylated ir and akt, matrix proteins, urinary acr, urinary kidney injury molecule-1-to-creatinine ratio, and systolic blood pressure. |
2021-05-28 |
2023-08-13 |
mouse |
| Shengli Zhao, Jing Xie, Changhua Zhao, Wen Cao, Yangping Y. Ultrasound-Targeted Microbubble Destruction Enhances the Inhibitive Efficacy of miR-21 Silencing in HeLa Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-05-28. PMID:33606670. |
in addition, mir-21 overexpression significantly increased the expression of p-akt, akt, bcl-2, wnt, ß-catenin, matrix metalloprotein-9 (mmp-9), and epidermal growth factor (egfr) levels, and decreased bax expression. |
2021-05-28 |
2023-08-13 |
Not clear |
| Yidan Yan, Jianmin Xu, Guoxin Ma. Honokiol Suppression of Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Gastric Cancer Cell Biological Activity and Its Mechanism. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-26. PMID:32862190. |
phosphatidylinositol 3-kinase (pi3k), protein kinase b (akt), p21, and matrix metalloproteinase (mmp)-9 proteins and messenger ribonucleic acid (mrna) expression were measured by wb and rt-qpcr assay. |
2021-05-26 |
2023-08-13 |
human |
| Junwei Yan, Xuejiao Yang, Xuefei Jiao, Xian Yang, Mingjin Guo, Yunqing Chen, Lu Zhan, Wenshi Che. Integrative transcriptomic and proteomic analysis reveals CD9/ITGA4/PI3K-Akt axis mediates trabecular meshwork cell apoptosis in human glaucoma. Journal of cellular and molecular medicine. vol 24. issue 1. 2021-05-10. PMID:31680442. |
previous studies found that some pathways were related to glaucoma, such as extracellular matrix (ecm)-receptor interaction, phosphatidylinositol 3-kinase (pi3k)-protein kinase b (akt) and apoptosis. |
2021-05-10 |
2023-08-13 |
human |
| Mi-Kyung Song, Dong Im Kim, Kyuhong Le. Kathon Induces Fibrotic Inflammation in Lungs: The First Animal Study Revealing a Causal Relationship between Humidifier Disinfectant Exposure and Eosinophil and Th2-Mediated Fibrosis Induction. Molecules (Basel, Switzerland). vol 25. issue 20. 2021-04-29. PMID:33066398. |
additionally, kathon exposure modulated the expression of genes related to fibrotic inflammation, including the phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt) signaling pathway, extracellular signal regulated kinase (erk)1 and erk2 cascade, extracellular matrix (ecm)-receptor interaction pathway, transforming growth factor beta receptor signaling pathway, cellular response to tumor necrosis factor, and collagen fibril organization. |
2021-04-29 |
2023-08-13 |
mouse |
| Isabel Fuentes-Calvo, Carlos Martinez-Salgad. Sos1 Modulates Extracellular Matrix Synthesis, Proliferation, and Migration in Fibroblasts. Frontiers in physiology. vol 12. 2021-04-24. PMID:33889087. |
for this purpose, we isolated and cultured sos1 knock-out (ko) mouse embryonic fibroblasts, the main extracellular matrix proteins (ecm)-producing cells, and we analyzed ecm synthesis, cell proliferation and migration in the absence of sos1, as well as the role of the main sos1-ras effectors, erk1/2 and akt, in these processes. |
2021-04-24 |
2023-08-13 |
mouse |
| Jing Zhu, Leilei Zhou, Bin Wei, Zhaoye Qian, Jiru Wang, Hongxia Hui, Yuan Su. miR‑142‑5p inhibits pancreatic cancer cell migration and invasion by targeting PIK3CA. Molecular medicine reports. vol 22. issue 3. 2021-04-21. PMID:32705244. |
in addition, mir‑142‑5p suppressed the expression of focal adhesion kinase (fak) and matrix metalloproteinase (mmp)9, as well as phosphorylated protein kinase b (akt) protein level, while pik3ca reversed the suppression induced by mir‑142‑5p. |
2021-04-21 |
2023-08-13 |
Not clear |
| Peng Shen, Yanfeng Chen. Long noncoding RNA lncARSR confers resistance to Adriamycin and promotes osteosarcoma progression. Cell death & disease. vol 11. issue 5. 2021-04-07. PMID:32404870. |
further investigation revealed that the upregulation of lncarsr enhanced multidrug resistance-associated protein-1 (mrp1), apoptosis inhibitor survivin, and matrix metalloproteinase-2 (mmp2) through activating akt. |
2021-04-07 |
2023-08-13 |
mouse |
| Mona G Elhadidy, Eman Mohamad El Nashar, Mansour A Alghamdi, Shereen M Sami. A novel gastroprotective effect of zeaxanthin against stress-induced gastritis in male rats targeting the expression of HIF-1α, TFF-1 and MMP-9 through PI3K/Akt/JNK signaling pathway. Life sciences. vol 273. 2021-04-07. PMID:33689686. |
moreover, in the untreated was-induced gastritis group, gastrin and corticosterone levels were significantly increased together with upregulation of the gene expression of hypoxia inducible factor-1α (hif-1α), matrix metalloproteinase-9 (mmp-9), pi3k, akt and jnk in the gastric tissues, which significantly improved by ze administration. |
2021-04-07 |
2023-08-13 |
rat |
| Miaomiao Wang, Yuqing Xu, Peng Wang, Yanfei Xu, Pengzhen Jin, Zaigui Wu, Yeqing Qian, Long Bai, Minyue Don. Galectin-14 Promotes Trophoblast Migration and Invasion by Upregulating the Expression of MMP-9 and N-Cadherin. Frontiers in cell and developmental biology. vol 9. 2021-04-03. PMID:33796532. |
knockdown of galectin-14 in primary trophoblasts inhibited cell migration and invasion, downregulated the expression of matrix metalloproteinase (mmp)-9 and n-cadherin, the activity of mmp-9, and decreased the phosphorylation of akt. |
2021-04-03 |
2023-08-13 |
human |
| Yong Liu, Hui Wang, Xiao-Zhe Zhou, Ning Li, Yi-Chao Guo, Tao-Ping Che. Pentraxin 3 promotes the osteoblastic differentiation of MC3T3-E1 cells through the PI3K/Akt signaling pathway. Bioscience reports. vol 40. issue 6. 2021-03-30. PMID:32436939. |
mechanistically, we show that the action of ptx3 requires the activation of pi3k and akt, and deactivation of pi3k by its inhibitor ly294002 weakens the ptx3-mediated induction of osteoblast signature genes, alp and matrix mineralization. |
2021-03-30 |
2023-08-13 |
mouse |
| Yuan Chen, Chengkun Qin, Xianping Cui, Wenmao Geng, Guozhe Xian, Zhiyi Wan. miR-4510 acts as a tumor suppressor in gastrointestinal stromal tumor by targeting APOC2. Journal of cellular physiology. vol 235. issue 7-8. 2021-03-10. PMID:31975384. |
overexpression of mir-4510 also inhibited the phosphorylation of akt and erk1/2, reduced the expression of matrix metallopeptidase 2 (mmp2) and mmp9. |
2021-03-10 |
2023-08-13 |
Not clear |
| Ali H El-Far, Grazyna Sroga, Soad K Al Jaouni, Shaker A Mous. Role and Mechanisms of RAGE-Ligand Complexes and RAGE-Inhibitors in Cancer Progression. International journal of molecular sciences. vol 21. issue 10. 2021-02-16. PMID:32443845. |
some rage-ligands displayed effects on anti- and pro-apoptotic proteins through upregulation of the phosphatidylinositide 3-kinase (pi3k)/protein kinase b (akt)/mammalian target of rapamycin (mtor), mitogen-activated protein kinases (mapks), matrix metalloproteinases (mmps), vascular endothelial growth factor (vegf), and nuclear factor kappa b (nf- |
2021-02-16 |
2023-08-13 |
Not clear |
| Jason J Northey, Alexander S Barrett, Irene Acerbi, Mary-Kate Hayward, Stephanie Talamantes, Ivory S Dean, Janna K Mouw, Suzanne M Ponik, Jonathon N Lakins, Po-Jui Huang, Junmin Wu, Quanming Shi, Susan Samson, Patricia J Keely, Rita A Mukhtar, Jan T Liphardt, John A Shepherd, E Shelley Hwang, Yunn-Yi Chen, Kirk C Hansen, Laurie E Littlepage, Valerie M Weave. Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217. The Journal of clinical investigation. vol 130. issue 11. 2021-02-16. PMID:32721948. |
culture studies demonstrated that znf217 mediates a matrix stiffness- and collagen density-induced increase in akt activity and mammary epithelial cell proliferation. |
2021-02-16 |
2023-08-13 |
mouse |
| Jie Ding, Wei Jia, Yangang Cui, Juan Jin, Yongqing Zhang, Lingchuan Xu, Yuhong Li. Anti-angiogenic effect of a chemically sulfated polysaccharide from Phellinus ribis by inhibiting VEGF/VEGFR pathway. International journal of biological macromolecules. vol 154. 2021-02-15. PMID:32171839. |
western blotting also detected decreased phosphorylated (p)-vegfr-1, p-vegfr-2, hypoxia-inducible factor-1α (hif-1α), protein kinase b (akt), and matrix metalloproteinases-9 (mmp-9). |
2021-02-15 |
2023-08-13 |
mouse |
| Ping Xie, Vinay K Kondeti, Sun Lin, Yoshisuke Haruna, Kirtee Raparia, Yashpal S Kanwa. Withdrawal: Role of extracellular matrix renal tubulo-interstitial nephritis antigen (TINag) in cell survival utilizing integrin αvβ3/focal adhesion kinase (FAK)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B-serine/threonine kinase (AKT) signaling pathway. The Journal of biological chemistry. vol 294. issue 26. 2021-02-08. PMID:31253687. |
withdrawal: role of extracellular matrix renal tubulo-interstitial nephritis antigen (tinag) in cell survival utilizing integrin αvβ3/focal adhesion kinase (fak)/phosphatidylinositol 3-kinase (pi3k)/protein kinase b-serine/threonine kinase (akt) signaling pathway. |
2021-02-08 |
2023-08-13 |
Not clear |
| Ying Liu, Xi Chen, Yeon Ja Choi, Ning Yang, Zhongya Song, Elizabeth R Snedecor, Wei Liang, Elaine Lai-Han Leung, Lianfeng Zhang, Chuan Qin, Jiang Che. GORAB promotes embryonic lung maturation through antagonizing AKT phosphorylation, versican expression, and mesenchymal cell migration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 4. 2021-01-19. PMID:32067289. |
these findings suggest a role of gorab in negatively regulating akt phosphorylation, the expression of vcan, and the migration of lung mesenchyme fibroblasts, and suggest that alveolar sac formation resembles a patterning event that is orchestrated by molecular signaling and the extracellular matrix in the mesenchyme. |
2021-01-19 |
2023-08-13 |
mouse |
| Jun Yeon Park, Myoung-Sook Shi. Inhibitory Effects of Pectic Polysaccharide Isolated from Polymers. vol 13. issue 1. 2021-01-12. PMID:33375243. |
matrix metalloproteinase (mmp-9), vascular endothelial growth factor (vegf), pi3k, akt, and p38 phosphorylation levels were determined using western blotting; vegf and mmp-9 transcript levels were measured using sybr green qrt-pcr. |
2021-01-12 |
2023-08-13 |
human |
| Hongwei Chen, Chuan He, Yan Liu, Xiaolin Li, Chaoju Zhang, Qunyan Qin, Qixiong Pan. LncRNA-GAS5 Inhibits Expression of miR 103 and Ameliorates the Articular Cartilage in Adjuvant-Induced Arthritis in Obese Mice. Dose-response : a publication of International Hormesis Society. vol 18. issue 4. 2020-12-22. PMID:33343265. |
we measured the expression levels of matrix metalloproteinases (mmp)-13, nf-κb, fibroblast growth factor (fgf) 21, p38, akt, and pi3k in cartilage via western blotting and quantitative reverse transcription pcr. |
2020-12-22 |
2023-08-13 |
mouse |
| Wataru Ohwada, Masaya Tanno, Toshiyuki Yano, Sang-Bing Ong, Koki Abe, Tatsuya Sato, Atsushi Kuno, Takayuki Miki, Hirohito Sugawara, Yusuke Igaki, Tetsuji Miur. Distinct intra-mitochondrial localizations of pro-survival kinases and regulation of their functions by DUSP5 and PHLPP-1. Biochimica et biophysica acta. Molecular basis of disease. vol 1866. issue 10. 2020-12-07. PMID:32480039. |
stepwise trypsin digestion of mitochondria isolated from hek293 or h9c2 cells was performed, and immunoblotting revealed that gsk-3β and erk localized dominantly in the outer membrane (om), while akt resided at comparable levels in om, the inner membrane (im) and the matrix. |
2020-12-07 |
2023-08-13 |
Not clear |