| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard Van Krieken, Neel Mehta, Tony Wang, Mengyu Zheng, Renzhong Li, Bo Gao, Ehab Ayaub, Kjetil Ask, James C Paton, Adrienne W Paton, Richard C Austin, Joan C Krepinsk. Cell surface expression of 78-kDa glucose-regulated protein (GRP78) mediates diabetic nephropathy. The Journal of biological chemistry. vol 294. issue 19. 2019-12-09. PMID:30914477. |
here we explored the role of csgrp78 in regulating high glucose (hg)-induced profibrotic akt ser/thr kinase (akt) signaling and up-regulation of extracellular matrix proteins. |
2019-12-09 |
2023-08-13 |
mouse |
| Candace Miethe, Megan Zamora, Linda Torres, Kelsie G Raign, Curissa J Groll, Ramona S Pric. Characterizing the differential physiological effects of adipocytokines visfatin and resistin in liver cancer cells. Hormone molecular biology and clinical investigation. vol 38. issue 2. 2019-11-21. PMID:30917102. |
cells exposed to visfatin and resistin were analyzed for fatty acid synthase protein, and phosphorylation of akt and erk tumorigenic signaling pathways, cell viability, lipogenesis, reactive oxygen species (ros), matrix metallopeptidase 9 (mmp-9) enzyme activity and invasion. |
2019-11-21 |
2023-08-13 |
Not clear |
| Heguo Cai, Ning Qu, Xiaolei Chen, Yang Zhou, Xinpeng Zheng, Bing Zhang, Chun Xi. The inhibition of PLCγ1 protects chondrocytes against osteoarthritis, implicating its binding to Akt. Oncotarget. vol 9. issue 4. 2019-11-20. PMID:29435116. |
here, through local intra-articular injection of plcγ or akt inhibitor in a rat oa model induced by anterior cruciate ligament transaction plus medial meniscus resection, the architecture of chondrocyte and matrix organization of articular cartilage were observed using histopathological assays and aggrecan, col2, plcγ1, and akt levels were detected using immunohistochemistry assays. |
2019-11-20 |
2023-08-13 |
human |
| Mitsuru Imamura, Jong-Seok Moon, Kuei-Pin Chung, Kiichi Nakahira, Thangamani Muthukumar, Roman Shingarev, Stefan W Ryter, Augustine Mk Choi, Mary E Cho. RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase. JCI insight. vol 3. issue 3. 2019-10-28. PMID:29415885. |
inhibition of akt or acl suppressed tgf-β1-dependent extracellular matrix production and myofibroblast differentiation in fibroblasts. |
2019-10-28 |
2023-08-13 |
mouse |
| J G Silvestre, I L Baptista, W J Silva, A Cruz, M T Silva, E H Miyabara, S Labeit, A S Morisco. The E3 ligase MuRF2 plays a key role in the functional capacity of skeletal muscle fibroblasts. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 52. issue 9. 2019-09-18. PMID:31482977. |
our results indicated that murf2 was necessary to maintain the actin cytoskeleton functionality in skeletal muscle fibroblasts via akt activity and exerted an important role in extracellular matrix remodeling in the skeletal muscle tissue. |
2019-09-18 |
2023-08-13 |
Not clear |
| Youjun Luo, Lin Zha, Lumeng Luo, Xue Chen, Qi Zhang, Caixia Gao, Xibing Zhuang, Sujuan Yuan, Tiankui Qia. [6]-Gingerol enhances the cisplatin sensitivity of gastric cancer cells through inhibition of proliferation and invasion via PI3K/AKT signaling pathway. Phytotherapy research : PTR. vol 33. issue 5. 2019-08-12. PMID:30811726. |
the combination treatment inhibited cell migration and invasion ability and decreased cyclin d1, cyclin a2, matrix metalloproteinase-9, p-pi3k, akt, and p-akt protein expressions and increased p21 and p27 mrna levels. |
2019-08-12 |
2023-08-13 |
Not clear |
| Zhiyong Wang, Huan Xu, Junai Zhang, Hua Jin, Pei We. Basic fibroblast growth factor blockade enhances lung cancer cell invasion by activating the AKT/MMP-2/VEGF pathway. Basic & clinical pharmacology & toxicology. 2019-08-09. PMID:31314153. |
furthermore, bfgf blockade activated the akt pathway and enhanced the expression levels of matrix metalloproteinase (mmp)-2 and vascular endothelial growth factor (vegf) in a549 cells. |
2019-08-09 |
2023-08-13 |
Not clear |
| Liping Feng, Jiahang Su, Rongxiang Chi, Qiao Zhu, Shuguang Lv, Wenjing Lian. Effect of amlodipine besylate combined with acupoint application of traditional Chinese medicine nursing on the treatment of renal failure and hypertension by the PI3K/AKT pathway. International journal of molecular medicine. vol 43. issue 4. 2019-07-30. PMID:30816438. |
the expression of vegf and matrix metallopeptidase 9 protein were significantly decreased, but the expression of pi3k, akt mrna and p‑pi3k/pi3k, p‑akt/akt protein were significantly increased. |
2019-07-30 |
2023-08-13 |
rat |
| David Romeo-Guitart, Joaquim Forés, Xavier Navarro, Caty Casa. Boosted Regeneration and Reduced Denervated Muscle Atrophy by NeuroHeal in a Pre-clinical Model of Lumbar Root Avulsion with Delayed Reimplantation. Scientific reports. vol 7. issue 1. 2019-07-16. PMID:28931824. |
chronic treatment (up to 6 months) with neuroheal, a new combination drug therapy identified using a systems biology approach, exerted long-lasting neuroprotection, reduced gliosis and matrix proteoglycan content, accelerated nerve regeneration by activating the akt pathway, promoted the formation of functional neuromuscular junctions, and reduced denervation-induced muscular atrophy. |
2019-07-16 |
2023-08-13 |
Not clear |
| Yi Xu, Wei Zhou, Yuan Ji, Jian Shen, Xiaxia Zhu, Huijun Yu, Jingchun Guo, Zhi Pang, Wenxiang We. Elongator promotes the migration and invasion of hepatocellular carcinoma cell by the phosphorylation of AKT. International journal of biological sciences. vol 14. issue 5. 2019-07-15. PMID:29805303. |
the expression of matrix metalloproteinase-2 (mmp-2) and mmp-9 were enhanced by phosphorylation of akt. |
2019-07-15 |
2023-08-13 |
Not clear |
| Jianjun Han, Jingjing Yu, Yu'na Dai, Jumei Li, Meiyan Guo, Jingzhen Song, Xuefeng Zho. Overexpression of miR-361-5p in triple-negative breast cancer (TNBC) inhibits migration and invasion by targeting RQCD1 and inhibiting the EGFR/PI3K/Akt pathway. Bosnian journal of basic medical sciences. vol 19. issue 1. 2019-06-10. PMID:29924958. |
expression of mir-361-5p, mrna and protein expression of pi3k, akt, egfr, phosphorylated (p)-egfr/pi3k/akt, and protein expression of rqcd1 and matrix metallopeptidase 9 (mmp-9) in mda-mb-231 were measured by qrt-pcr/western blot after transfection. |
2019-06-10 |
2023-08-13 |
Not clear |
| Lei Fang, Xinggang Wang, Qingzhu Sun, Eleni Papakonstantinou, Chongteck S'ng, Michael Tamm, Daiana Stolz, Michael Rot. IgE Downregulates PTEN through MicroRNA-21-5p and Stimulates Airway Smooth Muscle Cell Remodeling. International journal of molecular sciences. vol 20. issue 4. 2019-05-31. PMID:30781615. |
non-immune ige activated two signaling pathways: (i) signal transducer and activator of transcription 3 (stat3)→mir-21-5p→downregulating phosphatase and tensin homolog (pten) expression, and (ii) phosphatidylinositol 3-kinases (pi3k)→protein kinase b (akt)→mammalian target of rapamycin (mtor)→ribosomal protein s6 kinase beta-1 (p70s6k)→peroxisome proliferator-activated receptor gamma coactivator 1-α (pgc1-α)→peroxisome proliferator-activated receptor-γ (ppar-γ)→cyclooxygenase-2 (cox-2)→mitochondrial activity, proliferation, migration, and extracellular matrix deposition. |
2019-05-31 |
2023-08-13 |
human |
| Manipa Saha, Saurav Kumar, Shoiab Bukhari, Sai A Balaji, Prashant Kumar, Sravanth K Hindupur, Annapoorni Rangaraja. AMPK-Akt Double-Negative Feedback Loop in Breast Cancer Cells Regulates Their Adaptation to Matrix Deprivation. Cancer research. vol 78. issue 6. 2019-05-20. PMID:29339542. |
matrix deprival triggered ampk activity and concomitantly inhibited akt activity by upregulating the akt phosphatase phlpp2. |
2019-05-20 |
2023-08-13 |
Not clear |
| Jie Yin, Weiwei Xia, Mengying Wu, Yue Zhang, Songming Huang, Aihua Zhang, Zhanjun Ji. Inhibition of mitochondrial complex I activity attenuates neointimal hyperplasia by inhibiting smooth muscle cell proliferation and migration. Chemico-biological interactions. vol 304. 2019-05-13. PMID:30857887. |
interestingly, rot inhibited the phosphorylation of protein kinase b (akt), but not extracellular signal-regulated kinase (erk) 1/2, in response to pdgf-bb, accompanied with the blockade of matrix metalloproteinase-9 (mmp-9) upregulation and reactive oxygen species (ros) production. |
2019-05-13 |
2023-08-13 |
mouse |
| Yanni Lv, Wen Liu, Zhaohui Ruan, Zixuan Xu, Longsheng F. Myosin IIA Regulated Tight Junction in Oxygen Glucose-Deprived Brain Endothelial Cells Via Activation of TLR4/PI3K/Akt/JNK1/2/14-3-3ε/NF-κB/MMP9 Signal Transduction Pathway. Cellular and molecular neurobiology. vol 39. issue 2. 2019-04-29. PMID:30666520. |
nmmhc iia participated in regulating downstream transduction pathway tlr4, phosphatidylinositol 3-kinase (pi3k), akt, jnk1/2, 14-3-3ε, nuclear factor kappa b (nf-кb) and matrix metalloprotein 9 (mmp9). |
2019-04-29 |
2023-08-13 |
mouse |
| Maurizio Cutolo, Barbara Ruaro, Paola Montagna, Renata Brizzolara, Emanuela Stratta, Amelia Chiara Trombetta, Stefano Scabini, Pier Paolo Tavilla, Aurora Parodi, Claudio Corallo, Nicola Giordano, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith, Stefano Soldan. Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts. Arthritis research & therapy. vol 20. issue 1. 2019-04-15. PMID:29720235. |
myofibroblasts contribute to fibrosis through the overproduction of extracellular matrix (ecm) proteins, primarily type i collagen (col-1) and fibronectin (fn), a process which is mediated in systemic sclerosis (ssc) by the activation of fibrogenic intracellular signaling transduction molecules, including extracellular signal-regulated kinases 1 and 2 (erk1/2) and protein kinase b (akt). |
2019-04-15 |
2023-08-13 |
Not clear |
| Jiyoon Seok, Soo-Hyun Yoon, Sun-Hee Lee, Jong Hwa Jung, You Mie Le. The oncometabolite d‑2‑hydroxyglutarate induces angiogenic activity through the vascular endothelial growth factor receptor 2 signaling pathway. International journal of oncology. vol 54. issue 2. 2019-04-01. PMID:30483760. |
d‑2hg activated vegf receptor (vegfr)2 and vegfr2 downstream signaling, extracellular signal‑regulated kinase 1/2, focal adhesion kinase, akt and matrix metalloproteinase (mmp)2. |
2019-04-01 |
2023-08-13 |
chicken |
| Fudong Fan, Qing Zhou, Zhenjun Xu, Dongjin Wan. Osteopontin in the Pathogenesis of Aortic Dissection by the Enhancement of MMP Expressions. International heart journal. vol 60. issue 2. 2019-03-28. PMID:30626766. |
transforming growth factor-β (tgf-β), matrix metalloproteinase 1 (mmp-1), mmp-2, mmp-9, timp-1, and timp-2 gene expressions by hvsmc were measured and akt, iκb, smad1/5/8 and erk1/2 signaling pathways were detected. |
2019-03-28 |
2023-08-13 |
human |
| Steven Chapman, Madison Mick, Parker Hall, Camilo Mejia, Stephanie Sue, Bihishta Abdul Wase, Margaret A Nguyen, Evan C Whisenant, Shalene H Wilcox, Duane Winden, Paul R Reynolds, Juan A Arroy. Cigarette smoke extract induces oral squamous cell carcinoma cell invasion in a receptor for advanced glycation end-products-dependent manner. European journal of oral sciences. vol 126. issue 1. 2019-03-18. PMID:29226456. |
treatment of cells with cigarette smoke extract resulted in: (i) increased invasion of oscc; (ii) increased rage expression; (iii) inhibition of cigarette smoke extract-induced oscc cell invasion by sages; (iv) increased ras, increased akt and nf-κb activation, and downregulation by sages; and (v) increased expression of matrix metalloproteinases (mmps) 2, 9, and 14, and downregulation by sages. |
2019-03-18 |
2023-08-13 |
Not clear |
| Shi-Quan Liu, Chun-Yan Xu, Wen-Hong Wu, Zhen-Hua Fu, Si-Wei He, Meng-Bin Qin, Jie-An Huan. Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis. International journal of oncology. vol 54. issue 1. 2019-03-14. PMID:30365116. |
fak knockdown and sphk1 knockdown of human colon cancer rko cells inhibited the emt and migrational potency, along with the expression of p‑fak, p‑protein kinase b (akt) and matrix metalloproteinase (mmp)2/9. |
2019-03-14 |
2023-08-13 |
human |