| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunfeng Liu, Hao Wang, Mo Yang, Yiheng Liang, Li Jiang, Siman Sun, Shangrong Fa. Downregulation of cAMP-Dependent Protein Kinase Inhibitor-b Promotes Preeclampsia by Decreasing Phosphorylated Akt. Reproductive sciences (Thousand Oaks, Calif.). vol 28. issue 1. 2021-11-23. PMID:32676926. |
downregulation of pkib leaded to a decrease in phosphorylated akt, as well as downstream proteins such as matrix metalloproteinase 2, matrix metalloproteinase 9, and glycogen synthase kinase 3β, which are related to migration and invasion. |
2021-11-23 |
2023-08-13 |
human |
| Sajad Fakhri, Mohammad Mehdi Gravandi, Sadaf Abdian, Esra Küpeli Akkol, Mohammad Hosein Farzaei, Eduardo Sobarzo-Sánche. The Neuroprotective Role of Polydatin: Neuropharmacological Mechanisms, Molecular Targets, Therapeutic Potentials, and Clinical Perspective. Molecules (Basel, Switzerland). vol 26. issue 19. 2021-11-18. PMID:34641529. |
it is considered an auspicious phytochemical in modulating neuroinflammatory/apoptotic/autophagy/oxidative stress signaling mediators such as nuclear factor-κb (nf-κb), nf-e2-related factor 2 (nrf2)/antioxidant response elements (are), matrix metalloproteinase (mmps), interleukins (ils), phosphoinositide 3-kinases (pi3k)/protein kinase b (akt), and the extracellular regulated kinase (erk)/mitogen-activated protein kinase (mapk). |
2021-11-18 |
2023-08-13 |
Not clear |
| Rafał Pingwara, Daria Kosmala, Natalia Woźniak, Arkadiusz Orzechowski, Joanna Much. IFN-λ Modulates the Migratory Capacity of Canine Mammary Tumor Cells via Regulation of the Expression of Matrix Metalloproteinases and Their Inhibitors. Cells. vol 10. issue 5. 2021-11-08. PMID:33922837. |
moreover, we demonstrated that this process is related to the expression of extracellular matrix metalloproteinases and their inhibitors; furthermore, it is independent of akt and erk signaling pathways. |
2021-11-08 |
2023-08-13 |
Not clear |
| Jan M Leerink, Mabel van de Ruit, Elizabeth A M Feijen, Leontien C M Kremer, Annelies M C Mavinkurve-Groothuis, Yigal M Pinto, Esther E Creemers, Wouter E M Ko. Extracellular matrix remodeling in animal models of anthracycline-induced cardiomyopathy: a meta-analysis. Journal of molecular medicine (Berlin, Germany). vol 99. issue 9. 2021-10-29. PMID:34052857. |
collagens, matrix metalloproteinases (mmps), inflammation markers, transforming growth factor ß signaling markers, and markers for cardiac hypertrophy were upregulated, whereas the protein kinase b (akt) pro-survival pathway was downregulated. |
2021-10-29 |
2023-08-13 |
mouse |
| Hao Wu, Liang Yang, Daguang Liao, Yudan Chen, Wei Wang, Jiasheng Fan. Podocalyxin regulates astrocytoma cell invasion and survival against temozolomide. Experimental and therapeutic medicine. vol 5. issue 4. 2021-10-21. PMID:23596468. |
podxl overexpression in sw1783 cells significantly increased cell invasion, matrix metalloproteinase-9 (mmp-9) expression, cell survival against temozolomide-induced apoptotic stress, and phosphorylation of akt at serine 473 (ser473), which was abolished by the selective phosphatidylinositol 3-kinase (pi3k) inhibitor ly294002 (ly). |
2021-10-21 |
2023-08-12 |
Not clear |
| Miao Mo, Fenghua Peng, Lu Wang, Longkai Peng, Gongbin Lan, Shaojie Y. Roles of mitochondrial transcription factor A and microRNA-590-3p in the development of bladder cancer. Oncology letters. vol 6. issue 2. 2021-10-21. PMID:24137381. |
furthermore, cell proliferation- and migration-related genes, including phosphoinositide-3-kinase (pi3k), akt, matrix metalloproteinase (mmp)-2 and mmp9, were significantly downregulated in the mirna-590-3p-overex-pressing 5637 cells, but upregulated in the tfam-overexpressing cells. |
2021-10-21 |
2023-08-12 |
Not clear |
| Jian Li, Li Jiang, Zhu Liu, Yanguo Li, Yang Xu, Hongwei Li. Oncogenic pseudogene DUXAP10 knockdown suppresses proliferation and invasion and induces apoptosis of papillary thyroid carcinoma cells by inhibition of Akt/mTOR pathway. Clinical and experimental pharmacology & physiology. vol 47. issue 8. 2021-10-12. PMID:32215944. |
protein expression of matrix metalloproteinase (mmp)-2, mmp-9, protein kinase b (akt), phosphorylated akt, mammalian target of rapamycin (mtor), and phosphorylated mtor was examined by western blot. |
2021-10-12 |
2023-08-13 |
Not clear |
| Mingming Qi, Xiaojin Chen, Liqun Bian, Han Zhang, Jian M. Honokiol combined with curcumin sensitizes multidrug-resistant human lung adenocarcinoma A549/DDP cells to cisplatin. Experimental and therapeutic medicine. vol 22. issue 5. 2021-10-12. PMID:34630656. |
the mrna expression levels of akt, erk1/2, cyclin-dependent kinase inhibitor 1 (p21), caspase 3, cleaved caspase 3, caspase 9, cleaved caspase 9, poly (adp-ribose) polymerase (parp), cleaved parp, matrix metalloproteinase (mmp)-2 and mmp-9 were examined by reverse transcription-quantitative (rt-q) pcr assay, and the protein expression levels of phosphorylated (p)-akt, p-erk1/2, p21, caspase 3, cleaved caspase 3, caspase 9, cleaved caspase 9, parp, cleaved parp, mmp-2 and mmp-9 proteins expression by western blot assay. |
2021-10-12 |
2023-08-13 |
human |
| Chuanbao Lin, Pengfei Qian, Yan Zhang, Zhihui Liu, Kun Dai, Dawei Su. Plac1 promotes nasopharyngeal carcinoma cells proliferation, migration and invasion via Furin/NICD/PTEN pathway. Tissue & cell. vol 69. 2021-10-07. PMID:33418237. |
relative expressions of plac1 and proteins related to migration and invasion (e-cadherin, n-cadherin, matrix metalloproteinase2 (mmp2), and mmp9), furin/notch1 intracellular domain (nicd)/phosphate and tension homology (pten) pathway (nicd, pten, phosphorylated-akt (p-akt), akt) were quantified by quantitative real-time polymerase chain reaction (qrt-pcr) and western blot as needed. |
2021-10-07 |
2023-08-13 |
human |
| Lan Sun, Xu-Xian Wu, Yu-Fen Pen. [Effect of resveratrol on PTEN expression and fibrosis of renal tubular epithelial cells in a high-glucose environment]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 18. 2021-09-29. PMID:34581090. |
although the pten inhibitor did not affect pten, the expression changes of the other proteins were opposite to the results after res treatment and the fibrosis was aggravated, which suggested that sf1670 promoted the fibrosis by inhibiting pten, activating akt and increasing the synthesis of collagen Ⅳ and other extracellular matrix. |
2021-09-29 |
2023-08-13 |
rat |
| Ji-Ming Bao, Qiang Dang, Chun-Jung Lin, U-Ging Lo, Boris Feldkoren, Andrew Dang, Elizabeth Hernandez, Fei Li, Vandana Panwar, Cheng-Fan Lee, Jun-Jie Cen, Bing Guan, Vitaly Margulis, Payal Kapur, Rolf A Brekken, Jun-Hang Luo, Jer-Tsong Hsieh, Wan-Long Ta. SPARC is a key mediator of TGF-β-induced renal cancer metastasis. Journal of cellular physiology. vol 236. issue 3. 2021-09-14. PMID:32780451. |
mechanistically, sparc activates protein kinase b (akt) pathway leading to elevated expression of matrix metalloproteinase-2 that can facilitate rcc invasion. |
2021-09-14 |
2023-08-13 |
Not clear |
| Zhiqiang Hu, Hui Wang, Yan Fu, Kang Ma, Xiaoyan Ma, Jing Wan. Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways. Nutrition and cancer. vol 73. issue 8. 2021-09-08. PMID:32762372. |
more significantly, gps dramatically inhibited the migration of hela cells and regulated the matrix metalloproteinase expression through the mapk and akt signaling pathways, of which mapk1 was an underlying target in gps against hela cells. |
2021-09-08 |
2023-08-13 |
Not clear |
| Chunhua Li, Qing L. Circular RNA circ_0111277 Serves as ceRNA, Targeting the miR-424-5p/NFAT5 Axis to Regulate the Proliferation, Migration, and Invasion of Trophoblast Cells in Preeclampsia. Reproductive sciences (Thousand Oaks, Calif.). 2021-08-31. PMID:34462874. |
protein levels of matrix metallopeptidase 2 (mmp2), vascular endothelial growth factor-a (vegf-a), nfat5, phospho-phosphatidylinositol 3 kinase (p-pi3k), pi3k, phospho-protein kinase b (p-akt), and akt were examined by western blot assay. |
2021-08-31 |
2023-08-13 |
Not clear |
| Muhebaier Abuduer, Er Zi Gu . LINC00665 promotes the viability, migration and invasion of T cell acute lymphoblastic leukemia cells by targeting miR-101 via modulating PI3K/Akt pathway. Tissue & cell. vol 71. 2021-08-09. PMID:34171521. |
the expressions of linc00665, mir-101, cyclin d1, matrix metalloproteinases (mmp)-2, mmp-9, phosphorylated (p)-phosphatidylinositol 3-kinase (pi3k), pi3k, p-akt, akt were detected by quantitative real-time polymerase chain reaction (qrt-pcr) and western blot. |
2021-08-09 |
2023-08-13 |
Not clear |
| Aihong Wang, Lu Liu, Miao Yuan, Sai Han, Xuewu You, Hui Zhang, Fuhua Lei, Youzhong Zhan. Role and mechanism of FLNa and UCP2 in the development of cervical cancer. Oncology reports. vol 44. issue 6. 2021-08-02. PMID:33125133. |
in addition, the present study investigated the expression of cell‑associated proteins [extracellular signal‑regulated kinase (erk), phosphorylated (p) erk, protein kinase b (akt), p‑akt and b‑cell lymphoma‑2 (bcl‑2)] and the mrna levels of cellular proteins such as ras, matrix metalloproteinase (mmp)‑2 and mmp‑9. |
2021-08-02 |
2023-08-13 |
Not clear |
| Hardeep Singh Tuli, Sonam Mittal, Mariam Loka, Vaishali Aggarwal, Diwakar Aggarwal, Akshara Masurkar, Ginpreet Kaur, Mehmet Varol, Katrin Sak, Manoj Kumar, Gautam Sethi, Anupam Bishaye. Deguelin targets multiple oncogenic signaling pathways to combat human malignancies. Pharmacological research. vol 166. 2021-07-29. PMID:33581287. |
based on initial scientific excerpts, deguelin has been reported to inhibit tumor growth via different signaling pathways, including mitogen-activated protein kinase, phosphoinositide 3-kinase, serine/threonine protein kinase b (also known as akt), mammalian target of rapamycin, nuclear factor-κb, matrix metalloproteinase (mmp)-2, mmp-9 and caspase-3, caspase-8, and caspase-9. |
2021-07-29 |
2023-08-13 |
human |
| Mingxing Fang, Tieling Xu, Shujuan Fan, Na Liu, Luping Li, Junxia Gao, Wenbin L. SOX11 and FAK participate in the stretch‑induced mechanical injury to alveolar type 2 epithelial cells. International journal of molecular medicine. vol 47. issue 1. 2021-07-15. PMID:33236128. |
to further explore the underlying molecular mechanisms, reverse transcription‑quantitative pcr and western blot analysis were used to assess the expression levels of sox11, fak, akt, caspase‑3/8, p65 and matrix metalloproteinase (mmp)7. |
2021-07-15 |
2023-08-13 |
Not clear |
| Shujun Chen, Bo L. MiR-128-3p Post-Transcriptionally Inhibits WISP1 to Suppress Apoptosis and Inflammation in Human Articular Chondrocytes via the PI3K/AKT/NF-κB Signaling Pathway. Cell transplantation. vol 29. 2021-07-09. PMID:32830547. |
overexpression of wisp1 inhibited the proliferation of chondrocytes, which induced apoptosis, degradation of chondrocyte matrix, production of proinflammatory cytokines, and activated the phosphatidylinositol-3-kinase (pi3k)/protein kinase b (akt)/nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb) pathway. |
2021-07-09 |
2023-08-13 |
human |
| Miao Wang, Weihua Tang, Nianjin Gong, Peijun Li. Sodium Danshensu inhibits the progression of lung cancer by regulating PI3K/Akt signaling pathway. Drug development research. 2021-07-01. PMID:34196024. |
moreover, the levels of proliferating cell nuclear antigen (pcna), matrix metalloproteinase 9 (mmp9), b-cell lymphoma-2 (bcl-2) associated x (bax), bcl-2, phosphorylated (p)-phosphoinositide 3-kinase (pi3k), and p-protein kinase b (akt) in lung cancer cells were evaluated using quantitative real-time polymerase chain reaction (qrt-pcr) and/or western blot assays. |
2021-07-01 |
2023-08-13 |
Not clear |
| Zhen Dong, Yidong Liu, Qinghai Wang, Hongyang Wang, Jianlei Ji, Tao Huang, Aashish Khanal, Haitao Niu, Yanwei Ca. The circular RNA-NRIP1 plays oncogenic roles by targeting microRNA-505 in the renal carcinoma cell lines. Journal of cellular biochemistry. vol 121. issue 3. 2021-06-02. PMID:31692056. |
the protein expression levels of bcl-2, bax, cleaved-caspase-3, matrix metalloproteinase (mmp)-2, mmp-9, adenosine 5'-monophosphate (amp)-activated protein kinase (ampk), protein kinase b (akt), phosphatidylinositol 3-kinase (pi3k), and mammalian target of rapamycin (mtor) were individually determined via western blot. |
2021-06-02 |
2023-08-13 |
Not clear |