| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seung-Ae Kim, Hyo-Jeong Lee, Kwang Seok Ahn, Hyo-Jung Lee, Eun-Ok Lee, Kyoo-Seok Ahn, Seung-Hoon Choi, Soo-Jin Jung, Ji Young Kim, Namin Baek, Sung-Hoon Ki. Paeonol exerts anti-angiogenic and anti-metastatic activities through downmodulation of Akt activation and inactivation of matrix metalloproteinases. Biological & pharmaceutical bulletin. vol 32. issue 7. 2009-10-08. PMID:19571375. |
taken together, these findings suggest that paeonol can be a potent suppressor of angiogenesis and metastasis partially through inhibition of akt signaling pathway and matrix metalloproteinase activity. |
2009-10-08 |
2023-08-12 |
human |
| Mohammad Athar, Jung Ho Back, Levy Kopelovich, David R Bickers, Arianna L Ki. Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms. Archives of biochemistry and biophysics. vol 486. issue 2. 2009-07-08. PMID:19514131. |
these include tumor suppressors p53 and rb; cell cycle regulators, cyclins, cdks, p21waf1, p27kip and ink and the checkpoint kinases atm/atr; transcription factors nf-kappab, ap-1, c-jun, and c-fos; angiogenic and metastatic factors, vegf and matrix metalloprotease 2/9; cyclooxygenases for inflammation; and apoptotic and survival regulators, bax, bak, puma, noxa, trail, apaf, survivin, akt, bcl2 and bcl-x(l). |
2009-07-08 |
2023-08-12 |
Not clear |
| Guei-Jane Wang, Yeh-Jeng Huang, Deng-Hai Chen, Yun-Lian Li. Ganoderma lucidum extract attenuates the proliferation of hepatic stellate cells by blocking the PDGF receptor. Phytotherapy research : PTR. vol 23. issue 6. 2009-06-17. PMID:19107744. |
alpha-smooth muscle actin (alpha-sma) was used to evaluate extracellular matrix deposition, and western blotting was performed to measure cyclins d1 and d2, and phosphorylation of the pdgfbeta-receptor (pdgfbetar), akt and jnk. |
2009-06-17 |
2023-08-12 |
rat |
| Letícia Abel Penedo, Priscilla Oliveira-Silva, Ericka M C Gonzalez, Rafaela Maciel, Patricia B Jurgilas, Adriana da Cunha Faria Melibeu, Paula Campello-Costa, Claudio Alberto Serfat. Nutritional tryptophan restriction impairs plasticity of retinotectal axons during the critical period. Experimental neurology. vol 217. issue 1. 2009-05-26. PMID:19416666. |
tryptophan-restricted animals showed a reduced activity of matrix metalloproteinase-9 and altered expressions of phosphorylated forms of erk1/2 and akt. |
2009-05-26 |
2023-08-12 |
rat |
| Yiyun Zhang, Huiping Zhao, Szilard Asztalos, Michael Chisamore, Yasmin Sitabkhan, Debra A Tonett. Estradiol-induced regression in T47D:A18/PKCalpha tumors requires the estrogen receptor and interaction with the extracellular matrix. Molecular cancer research : MCR. vol 7. issue 4. 2009-05-14. PMID:19372579. |
we conclude that e(2)-induced t47d:a18/pkcalpha tumor regression requires participation of er-alpha, the extracellular matrix, fasl/fasl ligand, and akt pathways, allowing the opportunity to explore new predictive markers and therapeutic targets. |
2009-05-14 |
2023-08-12 |
Not clear |
| Satoshi Rokutanda, Takashi Fujita, Naoko Kanatani, Carolina A Yoshida, Hisato Komori, Wenguang Liu, Akio Mizuno, Toshihisa Komor. Akt regulates skeletal development through GSK3, mTOR, and FoxOs. Developmental biology. vol 328. issue 1. 2009-05-12. PMID:19389373. |
by analyzing transgenic embryos that expressed constitutively active akt (myrakt) or dominant-negative akt in chondrocytes, we found that akt positively regulated the four processes of chondrocyte maturation, chondrocyte proliferation, cartilage matrix production, and cell growth in skeletal development. |
2009-05-12 |
2023-08-12 |
mouse |
| Zhiyong Mi, Hongtao Guo, M Benjamin Russell, Yingmiao Liu, Bruce A Sullenger, Paul C Ku. RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cells. Molecular therapy : the journal of the American Society of Gene Therapy. vol 17. issue 1. 2009-05-05. PMID:18985031. |
critical enzymatic components of the opn signal transduction pathways, pi3k, jnk1/2, src and akt, and mediators of extracellular matrix degradation, matrix metalloproteinase 2 (mmp2) and uroplasminogen activator (upa), are significantly decreased following exposure to opn-r3. |
2009-05-05 |
2023-08-12 |
human |
| Keri A Barksdale, Gautam N Biju. The basal flux of Akt in the mitochondria is mediated by heat shock protein 90. Journal of neurochemistry. vol 108. issue 5. 2009-04-22. PMID:19187436. |
interestingly, incubation of isolated mitochondria with constitutively active akt caused visible alterations in mitochondrial morphology, including pronounced remodeling of the mitochondrial matrix. |
2009-04-22 |
2023-08-12 |
mouse |
| Huixin Wang, Vyomesh Patel, Hiroshi Miyazaki, J Silvio Gutkind, W Andrew Yeudal. Role for EPS8 in squamous carcinogenesis. Carcinogenesis. vol 30. issue 1. 2009-02-12. PMID:19008210. |
hn4/eps8 cells showed increased proliferation and migration compared with controls, together with elevated expression and activity of matrix metalloprotease (mmp)-9, which was dependent on protein kinase b (akt) activity. |
2009-02-12 |
2023-08-12 |
Not clear |
| Yuqing Liu, Eric Lik Hang Lui, Scott L Friedman, Lei Li, Tao Ye, Yongjun Chen, Ronnie T Poon, Jana Wo, Tsz Wai Kok, Sheung Tat Fa. PTK787/ZK22258 attenuates stellate cell activation and hepatic fibrosis in vivo by inhibiting VEGF signaling. Laboratory investigation; a journal of technical methods and pathology. vol 89. issue 2. 2009-02-12. PMID:19114984. |
these beneficial effects were associated with reduced phosphorylation of akt and suppressed mrna expression of procollagen-(i), timp-1, matrix metalloproteinase-9 and cd31. |
2009-02-12 |
2023-08-12 |
Not clear |
| Myung Hee Kim, Shi Yong Ryu, Myung Ae Bae, Joon-Sig Choi, Yong Ki Min, Seong Hwan Ki. Baicalein inhibits osteoclast differentiation and induces mature osteoclast apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 46. issue 11. 2009-01-06. PMID:18786594. |
interestingly, baicalein inhibited rankl-induced activation of signaling molecules (akt, erk/map kinase and nf-kappab) and mrna expression of osteoclast-associated genes (trap, matrix metalloproteinase 9 and c-src) and another transcription factors (c-fos, fra-2 and nfatc1). |
2009-01-06 |
2023-08-12 |
mouse |
| Hojin Kang, Kayla J Bayless, Roland Kauna. Fluid shear stress modulates endothelial cell invasion into three-dimensional collagen matrices. American journal of physiology. Heart and circulatory physiology. vol 295. issue 5. 2008-12-22. PMID:18805898. |
the enhancement of invasion by 5.3 dyn/cm2 shear stress coincided with elevated phosphorylation of akt and matrix metalloproteinase (mmp)-2 activation. |
2008-12-22 |
2023-08-12 |
human |
| Hideshi Okada, Genzou Takemura, Yiwen Li, Takamasa Ohno, Longhu Li, Rumi Maruyama, Masayasu Esaki, Shusaku Miyata, Hiromitsu Kanamori, Atsushi Ogino, Munehiro Nakagawa, Shinya Minatoguchi, Takako Fujiwara, Hisayoshi Fujiwar. Effect of a long-term treatment with a low-dose granulocyte colony-stimulating factor on post-infarction process in the heart. Journal of cellular and molecular medicine. vol 12. issue 4. 2008-11-13. PMID:18298650. |
these effects were accompanied by activation of signal transducer and activator of transcription 3 (stat3) and akt and also by up-regulation of gata-4, myosin heavy chain and matrix metalloproteinases-2 and -9. |
2008-11-13 |
2023-08-12 |
mouse |
| Christina Magkou, Lydia Nakopoulou, Christina Zoubouli, Kanelina Karali, Irene Theohari, Panagiotis Bakarakos, Ioanna Giannopoulo. Expression of the epidermal growth factor receptor (EGFR) and the phosphorylated EGFR in invasive breast carcinomas. Breast cancer research : BCR. vol 10. issue 3. 2008-11-12. PMID:18522728. |
the aim of this study was to investigate the expressions of egfr and pegfr and their correlation with overall and disease-free survival, clinicopathological parameters and biological markers of invasion and angiogenesis (phosphorylated akt [pakt], urokinase plasminogen activator receptor [upar], matrix metalloproteinase [mmp]-14, vascular endothelial growth factor receptor [vegfr]-1/flt-1). |
2008-11-12 |
2023-08-12 |
Not clear |
| Sharmila Shankar, Qinghe Chen, Suthakar Ganapathy, Karan P Singh, Rakesh K Srivastav. Diallyl trisulfide increases the effectiveness of TRAIL and inhibits prostate cancer growth in an orthotopic model: molecular mechanisms. Molecular cancer therapeutics. vol 7. issue 8. 2008-10-22. PMID:18723480. |
dats inhibited angiogenesis (as measured by cd31-positive and factor viii-positive blood vessels and hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-6 expression) and metastasis [matrix metalloproteinase (mmp)-2, mmp-7, mmp-9, and mt-1 mmp expression], which were correlated with inhibition in akt and nuclear factor-kappab activation. |
2008-10-22 |
2023-08-12 |
mouse |
| Andreea M Bujor, Jaspreet Pannu, Shizhong Bu, Edwin A Smith, Robin C Muise-Helmericks, Maria Trojanowsk. Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts. The Journal of investigative dermatology. vol 128. issue 8. 2008-08-29. PMID:18323784. |
furthermore, inhibition of akt upregulated basal matrix metalloproteinase 1 (mmp1) production and reversed the inhibitory effect of transforming growth factor-beta (tgf-beta) on mmp1 gene expression. |
2008-08-29 |
2023-08-12 |
human |
| Anna Spániková, Petra Simoncíková, Tána Ravingerová, Olga Pechánová, Miroslav Barancí. The effect of chronic nitric oxide synthases inhibition on regulatory proteins in rat hearts. Molecular and cellular biochemistry. vol 312. issue 1-2. 2008-08-11. PMID:18327702. |
the aim of the present study was to characterize the effects of chronic nitric oxide synthase (nos) inhibition on the alterations of regulatory myocardial proteins of intracellular signaling pathways (mitogen-activated protein kinase (mapk) and akt kinase cascades) and matrix metalloproteinases (mmp). |
2008-08-11 |
2023-08-12 |
rat |
| Ana B Rodríguez-Peña, Maria T Grande, Nélida Eleno, Miguel Arévalo, Carmen Guerrero, Eugerio Santos, José M López-Novo. Activation of Erk1/2 and Akt following unilateral ureteral obstruction. Kidney international. vol 74. issue 2. 2008-08-04. PMID:18449171. |
the use of specific pharmacological inhibitors to either erk1/2 or akt activation led to decreased levels of fibroblast-myofibroblast markers in the interstitium while inhibition of pi3k reduced the number of proliferating cells and the amount of interstitial extracellular matrix deposition. |
2008-08-04 |
2023-08-12 |
Not clear |
| Hongwei Shao, Yaohong Tan, Darwin Eton, Zhe Yang, M Georgina Uberti, Sen Li, Andrew Schulick, Hong Y. Statin and stromal cell-derived factor-1 additively promote angiogenesis by enhancement of progenitor cells incorporation into new vessels. Stem cells (Dayton, Ohio). vol 26. issue 5. 2008-07-28. PMID:18308946. |
in vitro mono-treatment with either fluvastatin (100 nm) or sdf-1 (100 ng/ml) facilitated epc proliferation and migration, inhibited epc apoptosis, enhanced expression of matrix metalloproteinase-2 (mmp-2) and -9 (mmp-9), and increased akt phosphorylation and nitric oxide production. |
2008-07-28 |
2023-08-12 |
mouse |
| Zhiyuan Ma, Aiqiang Dong, Minjian Kong, Jianfang Qia. Silencing of the type 1 insulin-like growth factor receptor increases the sensitivity to apoptosis and inhibits invasion in human lung adenocarcinoma A549 cells. Cellular & molecular biology letters. vol 12. issue 4. 2008-05-28. PMID:17588222. |
moreover, silencing igf-1r decreases the expression of invasive-related genes including matrix metalloproteinase-2 (mmp-2), mmp-9, and urokinase-plasminogen activator (u-pa), and the phosphorylation of akt and erk1/2. |
2008-05-28 |
2023-08-12 |
human |