| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard Seonghun Nho, Hong Xia, Judy Kahm, Jill Kleidon, Deanna Diebold, Craig A Henk. Role of integrin-linked kinase in regulating phosphorylation of Akt and fibroblast survival in type I collagen matrices through a beta1 integrin viability signaling pathway. The Journal of biological chemistry. vol 280. issue 28. 2005-09-12. PMID:15905178. |
in contrast, enforced activation of beta1 integrin by activating antibody preserved ilk and akt activity during collagen matrix contraction, and this is associated with protection from collagen contraction-induced apoptosis. |
2005-09-12 |
2023-08-12 |
Not clear |
| Yoko Tanimura, Toshio Kokuryo, Nobuyuki Tsunoda, Yukiko Yamazaki, Koji Oda, Yuji Nimura, Naing Naing Mon, Pengyu Huang, Yasuni Nakanuma, Min-Fu Chen, Yi-Yin Jan, Ta-Sen Yeh, Cheng-Taug Chiu, Ling-Ling Hsieh, Michinari Hamaguch. Tumor necrosis factor alpha promotes invasiveness of cholangiocarcinoma cells via its receptor, TNFR2. Cancer letters. vol 219. issue 2. 2005-04-15. PMID:15723721. |
treatment of ccks1 with tnf-alpha substantially activated nfkappab, mapk and akt signalings which in turn activated matrix metalloproteinase-9 (mmp-9) secretion and in vitro invasiveness of ccks1. |
2005-04-15 |
2023-08-12 |
Not clear |
| Amy Meyer, Cynthia M van Golen, Madanamohan Boyanapalli, Bhumsoo Kim, Mary E Soules, Eva L Feldma. Integrin-linked kinase complexes with caveolin-1 in human neuroblastoma cells. Biochemistry. vol 44. issue 3. 2005-04-12. PMID:15654749. |
overexpression of ilk leads to altered expression of cell cycle regulators, a decreased level of cell adhesion to the extracellular matrix, a decreased level of apoptosis, in vitro phosphorylation of akt, and tumor formation in nude mice. |
2005-04-12 |
2023-08-12 |
mouse |
| Jena J Steinle, David O Zamora, James T Rosenbaum, Harris J Grange. Beta 3-adrenergic receptors mediate choroidal endothelial cell invasion, proliferation, and cell elongation. Experimental eye research. vol 80. issue 1. 2005-03-28. PMID:15652529. |
brl37344 treatment also increased choroidal endothelial cell invasion by 103% above control values; the invasion response was inhibited by pp2 (src inhibitor), ly294002 (pi3k inhibitor), akt inhibitor (akt-i), and matrix metalloproteinase 2/9 inhibitor (mmp-i). |
2005-03-28 |
2023-08-12 |
human |
| Marcin Wysoczynski, Ryan Reca, Janina Ratajczak, Magda Kucia, Neeta Shirvaikar, Marek Honczarenko, Michael Mills, Jens Wanzeck, Anna Janowska-Wieczorek, Mariusz Z Ratajcza. Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient. Blood. vol 105. issue 1. 2005-02-10. PMID:15328152. |
we observed that slps increased calcium flux, phosphorylation of mitogen-activated protein kinase (mapk) p42/44 and akt, secretion of matrix metalloproteinases, and adhesion to endothelium in cd34+ cells. |
2005-02-10 |
2023-08-12 |
mouse |
| Erika Suzuki, Kazuko Handa, Marcos S Toledo, Senitiroh Hakomor. Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 41. 2004-12-02. PMID:15466700. |
in addition, sph induces apoptosis through a separate process: the blocking of "survival signal" through the akt kinase pathway induced by alpha3beta1-mediated cell adhesion to laminin 10/11 in extracellular matrix. |
2004-12-02 |
2023-08-12 |
Not clear |
| Carmen G Lechuga, Zamira H Hernández-Nazara, José-Alfredo Domínguez Rosales, Elena R Morris, Ana Rosa Rincón, Ana María Rivas-Estilla, Andrés Esteban-Gamboa, Marcos Rojkin. TGF-beta1 modulates matrix metalloproteinase-13 expression in hepatic stellate cells by complex mechanisms involving p38MAPK, PI3-kinase, AKT, and p70S6k. American journal of physiology. Gastrointestinal and liver physiology. vol 287. issue 5. 2004-11-24. PMID:15246963. |
tgf-beta1 modulates matrix metalloproteinase-13 expression in hepatic stellate cells by complex mechanisms involving p38mapk, pi3-kinase, akt, and p70s6k. |
2004-11-24 |
2023-08-12 |
Not clear |
| Toshihiro Ichiki, Tomotake Tokunou, Kae Fukuyama, Naoko Iino, Satoko Masuda, Akira Takeshit. 15-Deoxy-Delta12,14-prostaglandin J2 and thiazolidinediones transactivate epidermal growth factor and platelet-derived growth factor receptors in vascular smooth muscle cells. Biochemical and biophysical research communications. vol 323. issue 2. 2004-11-16. PMID:15369766. |
15-d-pgj2-induced phosphorylation of both egf-r and pdgf-r. gm6001, a matrix metalloproteinase inhibitor, and pp2, a src family protein kinase inhibitor, suppressed 15-d-pgj2- and tzds-induced phosphorylation of egf-r and pdgfbeta-r as well as activation of erk1/2 and akt. |
2004-11-16 |
2023-08-12 |
Not clear |
| Young-Ae Choi, Hyung-Kyu Lim, Jae-Ryong Kim, Chu-Hee Lee, Young-Jo Kim, Shin-Sung Kang, Suk-Hwan Bae. Group IB secretory phospholipase A2 promotes matrix metalloproteinase-2-mediated cell migration via the phosphatidylinositol 3-kinase and Akt pathway. The Journal of biological chemistry. vol 279. issue 35. 2004-10-06. PMID:15220345. |
group ib secretory phospholipase a2 promotes matrix metalloproteinase-2-mediated cell migration via the phosphatidylinositol 3-kinase and akt pathway. |
2004-10-06 |
2023-08-12 |
Not clear |
| Mark A Carlson, Michael T Longaker, Jon S Thompso. Modulation of FAK, Akt, and p53 by stress release of the fibroblast-populated collagen matrix. The Journal of surgical research. vol 121. issue 1. 2004-09-20. PMID:15372728. |
modulation of fak, akt, and p53 by stress release of the fibroblast-populated collagen matrix. |
2004-09-20 |
2023-08-12 |
Not clear |
| Eva Hammar, Géraldine Parnaud, Domenico Bosco, Nadja Perriraz, Kathrin Maedler, Marc Donath, Dominique G Rouiller, Philippe A Halba. Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways. Diabetes. vol 53. issue 8. 2004-09-17. PMID:15277383. |
caspase-8 activity was reduced in cells cultured on matrix, whereas focal adhesion kinase (fak), protein kinase b (pkb, or akt), and extracellular signal-regulated kinase (erk) phosphorylation was augmented. |
2004-09-17 |
2023-08-12 |
rat |
| Mark S Duxbury, Hiromichi Ito, Eric Benoit, Michael J Zinner, Stanley W Ashley, Edward E Whan. Overexpression of CEACAM6 promotes insulin-like growth factor I-induced pancreatic adenocarcinoma cellular invasiveness. Oncogene. vol 23. issue 34. 2004-09-02. PMID:15208677. |
ceacam6-overexpressing clones exhibited increased akt and c-src kinase activities, as well as higher levels of matrix metalloproteinase-2 (mmp-2) expression and activity in the presence of igf-i. |
2004-09-02 |
2023-08-12 |
human |
| Mark A Carlson, Michael T Longaker, Jon S Thompso. Modulation of FAK, Akt, and p53 by stress release of the fibroblast-populated collagen matrix. The Journal of surgical research. vol 120. issue 2. 2004-08-11. PMID:15234210. |
modulation of fak, akt, and p53 by stress release of the fibroblast-populated collagen matrix. |
2004-08-11 |
2023-08-12 |
Not clear |
| Mark A Carlson, Michael T Longaker, Jon S Thompso. Modulation of FAK, Akt, and p53 by stress release of the fibroblast-populated collagen matrix. The Journal of surgical research. vol 120. issue 2. 2004-08-11. PMID:15234210. |
we hypothesized that focal adhesion kinase (fak) and protein kinase b (akt) would be activated and that the p53 level would be low in the rigidly anchored (attached) collagen matrix; loss of anchorage (detachment) was hypothesized to have the opposite effects. |
2004-08-11 |
2023-08-12 |
Not clear |
| Stephen Gately, William W L. Multiple roles of COX-2 in tumor angiogenesis: a target for antiangiogenic therapy. Seminars in oncology. vol 31. issue 2 Suppl 7. 2004-07-29. PMID:15179620. |
downstream proangiogenic actions of these eicosanoid products include: (1) production of vascular endothelial growth factor; (2) promotion of vascular sprouting, migration, and tube formation; (3) enhanced endothelial cell survival via bcl-2 expression and akt signaling; (4) induction of matrix metalloproteinases; (5) activation of epidermal growth factor receptor-mediated angiogenesis; and (6) suppression of interleukin-12 production. |
2004-07-29 |
2023-08-12 |
Not clear |
| Katherine Conant, Coryse St Hillaire, Hideaki Nagase, Rob Visse, Devin Gary, Norman Haughey, Carol Anderson, Jadwiga Turchan, Avindra Nat. Matrix metalloproteinase 1 interacts with neuronal integrins and stimulates dephosphorylation of Akt. The Journal of biological chemistry. vol 279. issue 9. 2004-05-03. PMID:14679206. |
matrix metalloproteinase 1 interacts with neuronal integrins and stimulates dephosphorylation of akt. |
2004-05-03 |
2023-08-12 |
human |
| Hiroshi Kobayashi, Mika Suzuki, Naohiro Kanayama, Toshihiko Tera. Genetic down-regulation of phosphoinositide 3-kinase by bikunin correlates with suppression of invasion and metastasis in human ovarian cancer HRA cells. The Journal of biological chemistry. vol 279. issue 8. 2004-04-30. PMID:14597629. |
here, we show that 1) tgf-beta1 induced a rapid increase of the pi3k activity that was accompanied by increased expression (5-fold) of the upa mrna; 2) pharmacological inhibition of pi3k or as-pi3k odn transfection inhibited tgf-beta1-stimulated akt phosphorylation; 3) both pi3k pharmacological inhibitors and forced expression of as-pi3k odn reduced tgf-beta1-stimulated upa mrna and protein expression by approximately 70% compared with controls; 4) concentrations of pi3k inhibitors, sufficient to inhibit upa up-regulation, inhibited tgf-beta1-dependent hra cell invasion; 5) the as-pi3k odn cells had a decreased ability to invade the extracellular matrix layer as compared with controls; and 6) when the as-pi3k odn cells were injected intraperitoneally into nude mice, the mice developed smaller intraperitoneal tumors and showed longer survival. |
2004-04-30 |
2023-08-12 |
mouse |
| A R M Ruhul Amin, Takeshi Senga, Myat Lin Oo, Aye Aye Thant, Michinari Hamaguch. Secretion of matrix metalloproteinase-9 by the proinflammatory cytokine, IL-1beta: a role for the dual signalling pathways, Akt and Erk. Genes to cells : devoted to molecular & cellular mechanisms. vol 8. issue 6. 2004-02-19. PMID:12786942. |
secretion of matrix metalloproteinase-9 by the proinflammatory cytokine, il-1beta: a role for the dual signalling pathways, akt and erk. |
2004-02-19 |
2023-08-12 |
Not clear |
| V Cenni, A Sirri, M Riccio, G Lattanzi, S Santi, A de Pol, N M Maraldi, S Marmirol. Targeting of the Akt/PKB kinase to the actin skeleton. Cellular and molecular life sciences : CMLS. vol 60. issue 12. 2004-02-11. PMID:14685694. |
here we show that akt is bound to the actin skeleton in in situ cytoskeletal matrix preparations from pdgf-treated saos2 cells, suggesting an interaction between the two proteins. |
2004-02-11 |
2023-08-12 |
Not clear |
| Kacper Jankowski, Magda Kucia, Marcin Wysoczynski, Ryan Reca, Dongling Zhao, Ela Trzyna, John Trent, Stephen Peiper, Marek Zembala, Janina Ratajczak, Peter Houghton, Anna Janowska-Wieczorek, Mariusz Z Ratajcza. Both hepatocyte growth factor (HGF) and stromal-derived factor-1 regulate the metastatic behavior of human rhabdomyosarcoma cells, but only HGF enhances their resistance to radiochemotherapy. Cancer research. vol 63. issue 22. 2004-02-09. PMID:14633723. |
we found that although hgf, similar to sdf-1, did not affect the proliferation of rms cells, it induced in several of them: (a) locomotion; (b) stress fiber formation; (c) chemotaxis; (d) adhesion to human umbilical vein endothelial cells; (e) trans-matrigel invasion and matrix metalloproteinase secretion; and (f) phosphorylation of mitogen-activated protein kinase p42/44 and akt. |
2004-02-09 |
2023-08-12 |
mouse |