| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Zhang, J Li, R Luo, J Jiang, J-A Wan. Bone marrow mesenchymal stem cells induce angiogenesis and attenuate the remodeling of diabetic cardiomyopathy. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 116. issue 2. 2008-05-15. PMID:18286426. |
studies have demonstrated mscs transplantation can prevent apoptosis of ischemic heart via upregulation of akt and enos and inhibit myocardial fibrosis of dilated cardiomyopathy by decreasing the expression of matrix metalloproteinase (mmp) in rat models. |
2008-05-15 |
2023-08-12 |
rat |
| Chang Seok Ki, Sook Young Park, Hyun Jeong Kim, Hong-Moon Jung, Kyung Mi Woo, Jung Weon Lee, Young Hwan Par. Development of 3-D nanofibrous fibroin scaffold with high porosity by electrospinning: implications for bone regeneration. Biotechnology letters. vol 30. issue 3. 2008-05-01. PMID:17973083. |
western immunoblotting for activated paxillin, fak, akt, c-src, and erk1/2 antibodies showed signals from the extracellular matrix were significantly increased in 3-d nfs. |
2008-05-01 |
2023-08-12 |
Not clear |
| Beatriz Martínez-Poveda, Ramón Muñoz-Chápuli, Salvador Rodríguez-Nieto, José M Quintela, Antonio Fernández, Miguel-Angel Medina, Ana R Quesad. IB05204, a dichloropyridodithienotriazine, inhibits angiogenesis in vitro and in vivo. Molecular cancer therapeutics. vol 6. issue 10. 2008-02-07. PMID:17938261. |
ib05204 treatment inhibits matrix metalloproteinase-2 (mmp-2) production in endothelial and tumor cells, down-regulates endothelial cyclooxygenase-2 expression, and represses phosphorylation of endothelial akt in response to serum stimulation, suggesting that ib05204 interferes with molecular mechanisms of cell migration and survival. |
2008-02-07 |
2023-08-12 |
mouse |
| D Wu, F Peng, B Zhang, A J Ingram, B Gao, J C Krepinsk. Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells. Diabetologia. vol 50. issue 9. 2008-01-07. PMID:17622510. |
recent data have linked the serine/threonine kinase protein kinase b (akt) to matrix modulation. |
2008-01-07 |
2023-08-12 |
Not clear |
| Gretchen A Repasky, Yixing Zhou, Staeci Morita, Channing J De. Ras-mediated intestinal epithelial cell transformation requires cyclooxygenase-2-induced prostaglandin E2 signaling. Molecular carcinogenesis. vol 46. issue 12. 2007-12-20. PMID:17477350. |
finally, we found that pge2 stimulated the activation of ras and erk, but not akt, and reduced matrix deprivation-induced apoptosis, in untransformed epithelial cells. |
2007-12-20 |
2023-08-12 |
Not clear |
| A R M Ruhul Amin, M Helal Uddin Biswas, Takeshi Senga, Gen-Sheng Feng, Reiji Kannagi, Munna L Agarwal, Michinari Hamaguch. A role for SHPS-1/SIRPalpha in Concanavalin A-dependent production of MMP-9. Genes to cells : devoted to molecular & cellular mechanisms. vol 12. issue 9. 2007-11-27. PMID:17825046. |
treatment of mouse embryonic fibroblasts (mefs) with con a induces secretion of matrix metalloproteinase (mmp)-9, a phenomenon that is inhibited in cells expressing yf mutant of shps-1, a dominant negative form of akt or in cells pre-treated with an akt inhibitor, ly294002 or extracellular-signal regulated kinase (erk) inhibitor, u0126. |
2007-11-27 |
2023-08-12 |
mouse |
| Sanjeev Shukla, Gregory T Maclennan, Douglas J Hartman, Pingfu Fu, Martin I Resnick, Sanjay Gupt. Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion. International journal of cancer. vol 121. issue 7. 2007-11-07. PMID:17551921. |
restoration of the pten gene to highly invasive prostate cancer pc-3 cells or expression of a dominant negative version of the pi3k target, akt also significantly inhibited invasion and downregulated protein expression of urokinase-type plasminogen activator (upa) and matrix metalloproteinase (mmp)-9, markers for cell invasion, indicating a central role of the pi3k-akt pathway in this process. |
2007-11-07 |
2023-08-12 |
human |
| Chung-Chen Su, Yu-Ping Lin, Yu-Jung Cheng, Jyun-Yuan Huang, Woei-Jer Chuang, Yan-Shen Shan, Bei-Chang Yan. Phosphatidylinositol 3-kinase/Akt activation by integrin-tumor matrix interaction suppresses Fas-mediated apoptosis in T cells. Journal of immunology (Baltimore, Md. : 1950). vol 179. issue 7. 2007-11-06. PMID:17878356. |
in jurkat cells, cell matrix contact reduced the assembly of the fas death-inducing signaling complex and bcl-x(l) cleavage, but enhanced the phosphorylation of erk1/2, p38 mapk, and akt. |
2007-11-06 |
2023-08-12 |
Not clear |
| Sutima Luangdilok, Carol Box, Lisa Patterson, William Court, Kevin Harrington, Lisa Pitkin, Peter Rhŷs-Evans, Pornchai O-charoenrat, Suzanne Eccle. Syk tyrosine kinase is linked to cell motility and progression in squamous cell carcinomas of the head and neck. Cancer research. vol 67. issue 16. 2007-10-04. PMID:17699797. |
conversely, abrogation of syk activity by pharmacologic inhibition or small interfering rna in hn6 cells with high levels of endogenous expression inhibited migration, haptotaxis, and engagement with matrix proteins; this was accompanied by decreased levels of phosphorylated akt. |
2007-10-04 |
2023-08-12 |
Not clear |
| Payaningal R Somanath, Eugene S Kandel, Nissim Hay, Tatiana V Byzov. Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly. The Journal of biological chemistry. vol 282. issue 31. 2007-09-13. PMID:17562714. |
we have previously documented that akt activates integrins and akt1 deficiency results in matrix abnormalities in skin and blood vessels in vivo. |
2007-09-13 |
2023-08-12 |
human |
| Hamid Yaqoob Qureshi, Rasheed Ahmad, Judith Sylvester, Muhammad Zafarulla. Requirement of phosphatidylinositol 3-kinase/Akt signaling pathway for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in human chondrocytes. Cellular signalling. vol 19. issue 8. 2007-09-12. PMID:17376651. |
tgf-beta induction of pro-survival akt cascade and timp-3 may be related to strengthening of cartilage extracellular matrix, increased chondrocyte viability and maintenance of joint tissue integrity. |
2007-09-12 |
2023-08-12 |
human |
| N Kimura, Y Hoshino, K Totsukawa, E Sat. Cellular and molecular events during oocyte maturation in mammals: molecules of cumulus-oocyte complex matrix and signalling pathways regulating meiotic progression. Society of Reproduction and Fertility supplement. vol 63. 2007-08-15. PMID:17566282. |
recent studies by our group imply that i) the interaction of ha-cd44 identified in the porcine coc matrix is likely to participate in gap junctional communication and meiotic progression, and that ii) phosphatidylinositol 3-kinase (p13-k) and akt contribute to the progress of follicle stimulating hormone (fsh)-induced meiosis in mice. |
2007-08-15 |
2023-08-12 |
mouse |
| Isis C Sroka, Raymond B Nagle, G Tim Bowde. Membrane-type 1 matrix metalloproteinase is regulated by sp1 through the differential activation of AKT, JNK, and ERK pathways in human prostate tumor cells. Neoplasia (New York, N.Y.). vol 9. issue 5. 2007-06-29. PMID:17534446. |
membrane-type 1 matrix metalloproteinase is regulated by sp1 through the differential activation of akt, jnk, and erk pathways in human prostate tumor cells. |
2007-06-29 |
2023-08-12 |
human |
| Takashi Hoshiba, Hikaru Nagahara, Chong-Su Cho, Yoh-ichi Tagawa, Toshihiro Akaik. Primary hepatocyte survival on non-integrin-recognizable matrices without the activation of Akt signaling. Biomaterials. vol 28. issue 6. 2007-03-05. PMID:17081603. |
to prolong the viability of hepatocytes in the adherent culture on pvla matrix on which hepatocytes maintain their functions for longer period than those on pll matrix, it might be a good approach to activate akt signaling pathway. |
2007-03-05 |
2023-08-12 |
mouse |
| Genzou Takemura, Shusaku Miyata, Yukinori Kawase, Hideshi Okada, Rumi Maruyama, Hisayoshi Fujiwar. Autophagic degeneration and death of cardiomyocytes in heart failure. Autophagy. vol 2. issue 3. 2007-02-12. PMID:16874110. |
g-csf-induced changes in molecular signaling included activation of akt and stat3 (signal transducer and activator of transcription-3), a reduction in the level of myocardial tumor necrosis factor-alpha, and an increase in those of matrix metalloproteinases. |
2007-02-12 |
2023-08-12 |
human |
| Siong-Seng Liau, Amarsanaa Jazag, Edward E Whan. HMGA1 is a determinant of cellular invasiveness and in vivo metastatic potential in pancreatic adenocarcinoma. Cancer research. vol 66. issue 24. 2007-01-25. PMID:17178855. |
hmga1 silencing resulted in significant reductions in cellular invasiveness through matrigel; in cellular matrix metalloproteinase-9 (mmp-9) activity, mrna levels, and gene promoter activity; and in akt phosphorylation at ser(473). |
2007-01-25 |
2023-08-12 |
human |
| Richard Seonghun Nho, Hong Xia, Deanna Diebold, Judy Kahm, Jill Kleidon, Eric White, Craig A Henk. PTEN regulates fibroblast elimination during collagen matrix contraction. The Journal of biological chemistry. vol 281. issue 44. 2006-12-11. PMID:16963781. |
however, during subsequent collagen matrix contraction, the level of phosphorylated akt progressively declines, triggering apoptosis. |
2006-12-11 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Hong Xia, Deanna Diebold, Judy Kahm, Jill Kleidon, Eric White, Craig A Henk. PTEN regulates fibroblast elimination during collagen matrix contraction. The Journal of biological chemistry. vol 281. issue 44. 2006-12-11. PMID:16963781. |
here we show that pten phosphatase becomes activated during collagen matrix contraction and is responsible for antagonizing phosphatidylinositol 3-kinase activity and promoting a decline in phosphorylated akt and fibroblast apoptosis in response to collagen contraction. |
2006-12-11 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Hong Xia, Deanna Diebold, Judy Kahm, Jill Kleidon, Eric White, Craig A Henk. PTEN regulates fibroblast elimination during collagen matrix contraction. The Journal of biological chemistry. vol 281. issue 44. 2006-12-11. PMID:16963781. |
pten null fibroblasts displayed enhanced levels of phosphorylated akt and were resistant to collagen matrix contraction-induced apoptosis. |
2006-12-11 |
2023-08-12 |
Not clear |
| Arthur J Chu, Ta-Hsu Chou, Ben D Che. Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications. Frontiers in bioscience : a journal and virtual library. vol 9. 2006-09-28. PMID:15353307. |
pge2 induced by cox-2 exerts several biological properties that may be advantageous for tumorigenesis: 1) promoting angiogenesis (increased vegf, bfgf, and pdgf production), 2) anti-apoptosis mechanism (via increased bcl-2 and akt activity), 3) stimulating tumor metastasis (by increasing matrix metalloproteinases) and 4) decreased immune surveillance (decreased cytokine production and nk activity). |
2006-09-28 |
2023-08-12 |
human |