| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anfeng Wang, Xiaojuan Zou, Jiajia Wu, Qingyu Ma, Naijun Yuan, Fengmin Ding, Xiaojuan Li, Jiaxu Che. Early-Life Stress Alters Synaptic Plasticity and mTOR Signaling: Correlation With Anxiety-Like and Cognition-Related Behavior. Frontiers in genetics. vol 11. 2021-01-01. PMID:33381149. |
therefore, we speculate that els decreased synaptic plasticity via the inhibition of the mtor pathway in the hippocampus, which may underlie vulnerability to stress and mental disorders in adulthood. |
2021-01-01 |
2023-08-13 |
mouse |
| Wenzhu Wang, Xu Liu, Zhengyi Yang, Hui Shen, Lixu Liu, Yan Yu, Tong Zhan. Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats. Frontiers in neuroscience. vol 14. 2020-12-18. PMID:33328857. |
levodopa improves cognitive function and the deficits of structural synaptic plasticity in hippocampus induced by global cerebral ischemia/reperfusion injury in rats. |
2020-12-18 |
2023-08-13 |
rat |
| Wenzhu Wang, Xu Liu, Zhengyi Yang, Hui Shen, Lixu Liu, Yan Yu, Tong Zhan. Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats. Frontiers in neuroscience. vol 14. 2020-12-18. PMID:33328857. |
in conclusion, levodopa can improve cognitive function after global cerebral ischemia/reperfusion injury by enhancing the synaptic plasticity in the hippocampus. |
2020-12-18 |
2023-08-13 |
rat |
| Blake L Elliott, Chris Blais, Samuel M McClure, Gene A Brewe. Neural correlates underlying the effect of reward value on recognition memory. NeuroImage. vol 206. 2020-12-14. PMID:31648002. |
a second hypothesis is that value acts through the reward-related midbrain dopamine system to modulate synaptic plasticity in hippocampal and cortical efferents, thereby benefiting memory encoding. |
2020-12-14 |
2023-08-13 |
human |
| Zhengjun Wang, Qian Ge, Yuwei Wu, Jinming Zhang, Qiaofen Gu, Jing Ha. Impairment of Long-term Memory by a Short-term High-fat Diet via Hippocampal Oxidative Stress and Alterations in Synaptic Plasticity. Neuroscience. vol 424. 2020-12-10. PMID:31711814. |
impairment of long-term memory by a short-term high-fat diet via hippocampal oxidative stress and alterations in synaptic plasticity. |
2020-12-10 |
2023-08-13 |
mouse |
| Jiandong Sun, Yan Liu, Guoqi Zhu, Caleb Cato, Xiaoning Hao, Li Qian, Weiju Lin, Rachana Adhikari, Yun Luo, Michel Baudry, Xiaoning B. PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome. Scientific reports. vol 10. issue 1. 2020-12-10. PMID:32555345. |
pka and ube3a regulate sk2 channel trafficking to promote synaptic plasticity in hippocampus: implications for angelman syndrome. |
2020-12-10 |
2023-08-13 |
Not clear |
| Tushar Arora, Pablo Caviedes, Shiv Kumar Sharm. Effects of a Tripeptide on Mitogen-Activated Protein Kinase and Glycogen Synthase Kinase Activation in a Cell Line Derived from the Foetal Hippocampus of a Trisomy 16 Mouse: an Animal Model of Down Syndrome. Neurotoxicity research. vol 37. issue 3. 2020-12-04. PMID:31802378. |
here, we show enhanced activation of the extracellular signal-regulated kinase (erk), a kinase that critically regulates synaptic plasticity and memory, in a hippocampal cell line derived from trisomy 16 mouse foetus. |
2020-12-04 |
2023-08-13 |
mouse |
| Ivani Credidio Trombetta, José Roberto DeMoura, Cleber Rene Alves, Renato Carbonari-Brito, Felipe Xerez Cepeda, José Ribeiro Lemo. Serum Levels of BDNF in Cardiovascular Protection and in Response to Exercise. Arquivos brasileiros de cardiologia. vol 115. issue 2. 2020-12-04. PMID:32876194. |
bdnf is a neurotrophin found at high concentrations in the hippocampus and cerebral cortex and is considered a key molecule for the maintenance of synaptic plasticity and survival of neuronal cells. |
2020-12-04 |
2023-08-13 |
Not clear |
| E Segabinazi, N F Gasperini, A M Faustino, R Centeno, A S Dos Santos, W de Almeida, L P Bronauth, S Marcuzzo, L O Pereir. Comparative overview of the effects of aerobic and resistance exercise on anxiety-like behavior, cognitive flexibility, and hippocampal synaptic plasticity parameters in healthy rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 53. issue 11. 2020-12-01. PMID:33053097. |
comparative overview of the effects of aerobic and resistance exercise on anxiety-like behavior, cognitive flexibility, and hippocampal synaptic plasticity parameters in healthy rats. |
2020-12-01 |
2023-08-13 |
rat |
| Javed Iqbal, Zhi-Nei Tan, Min-Xing Li, Hui-Bin Chen, Boyu Ma, Xin Zhou, Xin-Ming M. Estradiol Alters Hippocampal Gene Expression during the Estrous Cycle. Endocrine research. vol 45. issue 2. 2020-11-25. PMID:31608702. |
estrogen (e2) modulates a wide range of neural functions such as spine formation, synaptic plasticity, and neurotransmission in the hippocampus. |
2020-11-25 |
2023-08-13 |
rat |
| Shan Shi, Ke Ma, Na-Ryum Bin, Hidekiyo Harada, Xiaoyu Xie, Mengjia Huang, Haiyu Liu, Soomin Lee, Xue Fan Wang, Roberto Adachi, Philippe P Monnier, Liang Zhang, Shuzo Sugit. Syntaxin-3 is dispensable for basal neurotransmission and synaptic plasticity in postsynaptic hippocampal CA1 neurons. Scientific reports. vol 10. issue 1. 2020-11-25. PMID:31959797. |
together, our data suggest that syntaxin-3 is dispensable for hippocampal basal neurotransmission and synaptic plasticity, and further supports the notion that syntaxin-4 is the major isoform mediating these processes. |
2020-11-25 |
2023-08-13 |
mouse |
| Cleiton Lopes-Aguiar, Rafael N Ruggiero, Matheus T Rossignoli, Ingrid de Miranda Esteves, José Eduardo Peixoto-Santos, Rodrigo N Romcy-Pereira, João P Leit. Long-term potentiation prevents ketamine-induced aberrant neurophysiological dynamics in the hippocampus-prefrontal cortex pathway in vivo. Scientific reports. vol 10. issue 1. 2020-11-25. PMID:32346044. |
nmdar hypofunction affects normal oscillatory dynamics and synaptic plasticity in key brain regions related to schizophrenia, particularly in the hippocampus and the prefrontal cortex. |
2020-11-25 |
2023-08-13 |
rat |
| b' Marta Rolland, Rebecca Powell, Muriel Jacquier-Sarlin, Sylvie Boisseau, Robin Reynaud-Dulaurier, Jose Martinez-Hernandez, Louise Andr\\xc3\\xa9, Eve Borel, Alain Buisson, Fabien Lant\\xc3\\xa. Effect of A\\xce\\xb2 Oligomers on Neuronal APP Triggers a Vicious Cycle Leading to the Propagation of Synaptic Plasticity Alterations to Healthy Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 27. 2020-11-23. PMID:32444385.' |
we used complementary techniques ranging from electrophysiological recordings and molecular biology to confocal microscopy in primary cortical cultures, and from acute hippocampal and cortical slices from male wild-type and amyloid precursor protein (app) knock-out (ko) mice to assess the effects of aβos on glutamatergic transmission, synaptic plasticity, and dendritic spine structure. |
2020-11-23 |
2023-08-13 |
mouse |
| Xiumin Zhang, Fang Zhao, Chenfang Wang, Jun Zhang, Yu Bai, Fang Zhou, Zhaojun Wang, Meina Wu, Wei Yang, Junhong Guo, Jinshun Q. AVP(4-8) Improves Cognitive Behaviors and Hippocampal Synaptic Plasticity in the APP/PS1 Mouse Model of Alzheimer's Disease. Neuroscience bulletin. vol 36. issue 3. 2020-11-20. PMID:31605298. |
avp(4-8) improves cognitive behaviors and hippocampal synaptic plasticity in the app/ps1 mouse model of alzheimer's disease. |
2020-11-20 |
2023-08-13 |
mouse |
| Xiumin Zhang, Fang Zhao, Chenfang Wang, Jun Zhang, Yu Bai, Fang Zhou, Zhaojun Wang, Meina Wu, Wei Yang, Junhong Guo, Jinshun Q. AVP(4-8) Improves Cognitive Behaviors and Hippocampal Synaptic Plasticity in the APP/PS1 Mouse Model of Alzheimer's Disease. Neuroscience bulletin. vol 36. issue 3. 2020-11-20. PMID:31605298. |
these results reveal the beneficial effects of avp(4-8) in app/ps1-ad mice, showing that the intranasal administration of avp(4-8) effectively improved the working memory and long-term spatial memory of app/ps1-ad mice, which may be associated with the elevation of psd95 and ngf levels in the brain and the maintenance of hippocampal synaptic plasticity. |
2020-11-20 |
2023-08-13 |
mouse |
| Sheng-Tzung Tsai, Shin-Yuan Chen, Shinn-Zong Lin, Guo-Fang Tsen. Rostral intralaminar thalamic deep brain stimulation ameliorates memory deficits and dendritic regression in β-amyloid-infused rats. Brain structure & function. vol 225. issue 2. 2020-11-20. PMID:32036422. |
spatial memory was tested in the morris water maze (mwm), while structural synaptic plasticity and glutamatergic transmission strength were estimated by measuring dendritic spine densities in dye-injected neurons and tissue expression levels of postsynaptic density protein 95 (psd-95) in medial prefrontal cortex (mpfc) and hippocampus. |
2020-11-20 |
2023-08-13 |
rat |
| Genevieve Saw, Kumar Krishna, Neelima Gupta, Tuck Wah Soong, Karthik Mallilankaraman, Sreedharan Sajikumar, S Thameem Dhee. Epigenetic regulation of microglial phosphatidylinositol 3-kinase pathway involved in long-term potentiation and synaptic plasticity in rats. Glia. vol 68. issue 3. 2020-11-19. PMID:31702864. |
however, ltp was rescued when the same hippocampal slices were treated with active pi3k or bdnf, indicating that microglial pi3k/akt signaling contributes to ltp and synaptic plasticity. |
2020-11-19 |
2023-08-13 |
rat |
| Katisha R Gopaul, Muhammad Irfan, Omid Miry, Linnea R Vose, Alexander Moghadam, Galadu Subah, Tomas Hökfelt, Christina Bark, Patric K Stanto. Developmental Time Course of SNAP-25 Isoforms Regulate Hippocampal Long-Term Synaptic Plasticity and Hippocampus-Dependent Learning. International journal of molecular sciences. vol 21. issue 4. 2020-11-19. PMID:32093363. |
developmental time course of snap-25 isoforms regulate hippocampal long-term synaptic plasticity and hippocampus-dependent learning. |
2020-11-19 |
2023-08-13 |
mouse |
| Wenchong Sun, Jian Wang, Dasheng Cai, Ling Pe. Neuroprotection of the Developing Brain by Dexmedetomidine Is Mediated by Attenuating Single Propofol-induced Hippocampal Apoptosis and Synaptic Plasticity Deficits. Experimental neurobiology. vol 29. issue 5. 2020-11-14. PMID:33154198. |
neuroprotection of the developing brain by dexmedetomidine is mediated by attenuating single propofol-induced hippocampal apoptosis and synaptic plasticity deficits. |
2020-11-14 |
2023-08-13 |
rat |
| Wenchong Sun, Jian Wang, Dasheng Cai, Ling Pe. Neuroprotection of the Developing Brain by Dexmedetomidine Is Mediated by Attenuating Single Propofol-induced Hippocampal Apoptosis and Synaptic Plasticity Deficits. Experimental neurobiology. vol 29. issue 5. 2020-11-14. PMID:33154198. |
after a single propofol exposure to p7 rats, dex pretreatment effectively rescued the profound apoptosis seen in hippocampal neurocytes, and strongly reversed the aberrant expression levels of bcl2-like 1 (bcl2l1), matrix metallopeptidase 9 (mmp-9) and cleaved caspase 3 (cc3), and sharply enhanced synaptic plasticity. |
2020-11-14 |
2023-08-13 |
rat |