| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akanksha Kushwaha, Mahendra Kumar Thaku. Increase in hippocampal histone H3K9me3 is negatively correlated with memory in old male mice. Biogerontology. vol 21. issue 2. 2021-01-12. PMID:31760560. |
with advancing age, memory declines through different mechanisms including dysregulation of expression of synaptic plasticity genes in hippocampus. |
2021-01-12 |
2023-08-13 |
mouse |
| Yuehan Li, Xue Lu, Jiaxun Nie, Panpan Hu, Feifei Ge, Ti-Fei Yuan, Xiaowei Gua. MicroRNA134 of Ventral Hippocampus Is Involved in Cocaine Extinction-Induced Anxiety-like and Depression-like Behaviors in Mice. Molecular therapy. Nucleic acids. vol 19. 2021-01-10. PMID:32004865. |
in this study, using the cocaine-induced conditioned place preference (cpp) mice model, we found that mice exhibit enhanced anxiety-like and depression-like behaviors during the cocaine extinction (ce) period of cpp, accompanied by obviously increased mir134 levels and decreased levels of 19 genes that are associated with synaptic plasticity, glia activity, and neurochemical microenvironments, in the ventral hippocampus (vhp). |
2021-01-10 |
2023-08-13 |
mouse |
| Sylvia Badurek, Marilena Griguoli, Aman Asif-Malik, Barbara Zonta, Fei Guo, Silvia Middei, Laura Lagostena, Maria Teresa Jurado-Parras, Thomas H Gillingwater, Agnès Gruart, José María Delgado-García, Enrico Cherubini, Liliana Minichiell. Immature Dentate Granule Cells Require Ntrk2/Trkb for the Formation of Functional Hippocampal Circuitry. iScience. vol 23. issue 5. 2021-01-10. PMID:32361506. |
these changes lead to the disruption of early synchronized neuronal activity at the network level and impaired morphological maturation of ca3 pyramidal neurons, ultimately contributing to altered adult hippocampal synaptic plasticity and cognitive processes. |
2021-01-10 |
2023-08-13 |
mouse |
| Jianhua Zhao, Anna Li, Molly Rajsombath, Yifan Dang, Dennis J Selkoe, Shaomin L. Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region. iScience. vol 6. 2021-01-09. PMID:30240608. |
nearly all studies of the effects of oaβs on hippocampal synaptic plasticity have only examined homosynaptic plasticity. |
2021-01-09 |
2023-08-13 |
Not clear |
| Guoxin Guo, Lin Kang, Dandan Geng, Shuo Han, Sha Li, Juan Du, Chang Wang, Huixian Cu. Testosterone modulates structural synaptic plasticity of primary cultured hippocampal neurons through ERK - CREB signalling pathways. Molecular and cellular endocrinology. vol 503. 2021-01-06. PMID:31805308. |
testosterone modulates structural synaptic plasticity of primary cultured hippocampal neurons through erk - creb signalling pathways. |
2021-01-06 |
2023-08-13 |
rat |
| Guoxin Guo, Lin Kang, Dandan Geng, Shuo Han, Sha Li, Juan Du, Chang Wang, Huixian Cu. Testosterone modulates structural synaptic plasticity of primary cultured hippocampal neurons through ERK - CREB signalling pathways. Molecular and cellular endocrinology. vol 503. 2021-01-06. PMID:31805308. |
although hippocampus-derived androgens play an important role in hippocampal synaptic plasticity, studies at the cellular level have received relatively less attention. |
2021-01-06 |
2023-08-13 |
rat |
| Xin Zhao, Frank R Castelli, Ruyi Wang, Anthony P Auger, Catherine A Marle. Testosterone-related behavioral and neural mechanisms associated with location preferences: A model for territorial establishment. Hormones and behavior. vol 121. 2021-01-06. PMID:32007517. |
also, single housing increased markers of synaptic plasticity in the nucleus accumbens, ventral and dorsal hippocampus, neural changes that may be associated with dispersal, reproduction and territory establishment. |
2021-01-06 |
2023-08-13 |
mouse |
| Xin-Ya Qin, Hui Fang, Qing-Hong Shan, Cong-Cong Qi, Jiang-Ning Zho. All-trans Retinoic Acid-induced Abnormal Hippocampal Expression of Synaptic Genes International journal of molecular sciences. vol 21. issue 8. 2021-01-05. PMID:32290523. |
the hippocampus seems to be a major target of retinoids, and abnormal synaptic plasticity of the hippocampus is involved in depression. |
2021-01-05 |
2023-08-13 |
Not clear |
| Sebastiano A Torrisi, Gianluca Lavanco, Oriana M Maurel, Walter Gulisano, Samuele Laudani, Federica Geraci, Margherita Grasso, Cristina Barbagallo, Filippo Caraci, Claudio Bucolo, Marco Ragusa, Francesco Papaleo, Patrizia Campolongo, Daniela Puzzo, Filippo Drago, Salvatore Salomone, Gian Marco Leggi. A novel arousal-based individual screening reveals susceptibility and resilience to PTSD-like phenotypes in mice. Neurobiology of stress. vol 14. 2021-01-05. PMID:33392367. |
impaired hippocampal synaptic plasticity was also observed in susceptible mice. |
2021-01-05 |
2023-08-13 |
mouse |
| Daiane B Fraga, Ana Paula Costa, Gislaine Olescowicz, Anderson Camargo, Francis L Pazini, Andiara E Freitas, Morgana Moretti, Patricia S Brocardo, Ana Lúcia S Rodrigue. Ascorbic acid presents rapid behavioral and hippocampal synaptic plasticity effects. Progress in neuro-psychopharmacology & biological psychiatry. vol 96. 2021-01-04. PMID:31476335. |
ascorbic acid presents rapid behavioral and hippocampal synaptic plasticity effects. |
2021-01-04 |
2023-08-13 |
mouse |
| Craig T Werner, Swarup Mitra, Benjamin D Auerbach, Zi-Jun Wang, Jennifer A Martin, Andrew F Stewart, Pedro H Gobira, Madoka Iida, Chunna An, Moriah M Cobb, Aaron Caccamise, Richard J Salvi, Rachael L Neve, Amy M Gancarz, David M Diet. Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 42. 2021-01-04. PMID:33020308. |
activin a and glun2b-containing nmdars have both previously been implicated in hippocampal synaptic plasticity. |
2021-01-04 |
2023-08-13 |
rat |
| Anfeng Wang, Xiaojuan Zou, Jiajia Wu, Qingyu Ma, Naijun Yuan, Fengmin Ding, Xiaojuan Li, Jiaxu Che. Early-Life Stress Alters Synaptic Plasticity and mTOR Signaling: Correlation With Anxiety-Like and Cognition-Related Behavior. Frontiers in genetics. vol 11. 2021-01-01. PMID:33381149. |
developmental deficits in hippocampal synaptic plasticity are among the primary detrimental alterations in brain function induced by els. |
2021-01-01 |
2023-08-13 |
mouse |
| Anfeng Wang, Xiaojuan Zou, Jiajia Wu, Qingyu Ma, Naijun Yuan, Fengmin Ding, Xiaojuan Li, Jiaxu Che. Early-Life Stress Alters Synaptic Plasticity and mTOR Signaling: Correlation With Anxiety-Like and Cognition-Related Behavior. Frontiers in genetics. vol 11. 2021-01-01. PMID:33381149. |
psd95 and synaptophysin mrna and protein expression levels were decreased in the hippocampus, and phosphorylated mtor and phosphorylated s6 were significantly decreased in maternally separated mice vs. those not exposed to ms. our data demonstrate that ms impairs synaptic plasticity and inhibits mtor signaling, specifically via s6. |
2021-01-01 |
2023-08-13 |
mouse |
| Anfeng Wang, Xiaojuan Zou, Jiajia Wu, Qingyu Ma, Naijun Yuan, Fengmin Ding, Xiaojuan Li, Jiaxu Che. Early-Life Stress Alters Synaptic Plasticity and mTOR Signaling: Correlation With Anxiety-Like and Cognition-Related Behavior. Frontiers in genetics. vol 11. 2021-01-01. PMID:33381149. |
therefore, we speculate that els decreased synaptic plasticity via the inhibition of the mtor pathway in the hippocampus, which may underlie vulnerability to stress and mental disorders in adulthood. |
2021-01-01 |
2023-08-13 |
mouse |
| Wenzhu Wang, Xu Liu, Zhengyi Yang, Hui Shen, Lixu Liu, Yan Yu, Tong Zhan. Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats. Frontiers in neuroscience. vol 14. 2020-12-18. PMID:33328857. |
levodopa improves cognitive function and the deficits of structural synaptic plasticity in hippocampus induced by global cerebral ischemia/reperfusion injury in rats. |
2020-12-18 |
2023-08-13 |
rat |
| Wenzhu Wang, Xu Liu, Zhengyi Yang, Hui Shen, Lixu Liu, Yan Yu, Tong Zhan. Levodopa Improves Cognitive Function and the Deficits of Structural Synaptic Plasticity in Hippocampus Induced by Global Cerebral Ischemia/Reperfusion Injury in Rats. Frontiers in neuroscience. vol 14. 2020-12-18. PMID:33328857. |
in conclusion, levodopa can improve cognitive function after global cerebral ischemia/reperfusion injury by enhancing the synaptic plasticity in the hippocampus. |
2020-12-18 |
2023-08-13 |
rat |
| Blake L Elliott, Chris Blais, Samuel M McClure, Gene A Brewe. Neural correlates underlying the effect of reward value on recognition memory. NeuroImage. vol 206. 2020-12-14. PMID:31648002. |
a second hypothesis is that value acts through the reward-related midbrain dopamine system to modulate synaptic plasticity in hippocampal and cortical efferents, thereby benefiting memory encoding. |
2020-12-14 |
2023-08-13 |
human |
| Zhengjun Wang, Qian Ge, Yuwei Wu, Jinming Zhang, Qiaofen Gu, Jing Ha. Impairment of Long-term Memory by a Short-term High-fat Diet via Hippocampal Oxidative Stress and Alterations in Synaptic Plasticity. Neuroscience. vol 424. 2020-12-10. PMID:31711814. |
impairment of long-term memory by a short-term high-fat diet via hippocampal oxidative stress and alterations in synaptic plasticity. |
2020-12-10 |
2023-08-13 |
mouse |
| Jiandong Sun, Yan Liu, Guoqi Zhu, Caleb Cato, Xiaoning Hao, Li Qian, Weiju Lin, Rachana Adhikari, Yun Luo, Michel Baudry, Xiaoning B. PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome. Scientific reports. vol 10. issue 1. 2020-12-10. PMID:32555345. |
pka and ube3a regulate sk2 channel trafficking to promote synaptic plasticity in hippocampus: implications for angelman syndrome. |
2020-12-10 |
2023-08-13 |
Not clear |
| Tushar Arora, Pablo Caviedes, Shiv Kumar Sharm. Effects of a Tripeptide on Mitogen-Activated Protein Kinase and Glycogen Synthase Kinase Activation in a Cell Line Derived from the Foetal Hippocampus of a Trisomy 16 Mouse: an Animal Model of Down Syndrome. Neurotoxicity research. vol 37. issue 3. 2020-12-04. PMID:31802378. |
here, we show enhanced activation of the extracellular signal-regulated kinase (erk), a kinase that critically regulates synaptic plasticity and memory, in a hippocampal cell line derived from trisomy 16 mouse foetus. |
2020-12-04 |
2023-08-13 |
mouse |