| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiaofeng Zhou, Xiying Guo, Tu Chen, Yumin Liu, Huimin Ji, Yixuan Sun, Xiaosong Yang, Changhan Ouyang, Xiufen Liu, Min Le. The neuroprotective role of celastrol on hippocampus in diabetic rats by inflammation restraint, insulin signaling adjustment, Aβ reduction and synaptic plasticity alternation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 179. 2024-09-04. PMID:39232386. |
the neuroprotective role of celastrol on hippocampus in diabetic rats by inflammation restraint, insulin signaling adjustment, aβ reduction and synaptic plasticity alternation. |
2024-09-04 |
2024-09-08 |
rat |
| Daniel Wolf, Maurilyn Ayon-Olivas, Michael Sendtne. BDNF-Regulated Modulation of Striatal Circuits and Implications for Parkinson's Disease and Dystonia. Biomedicines. vol 12. issue 8. 2024-08-29. PMID:39200225. |
activation of tropomyosin receptor kinase b (trkb) by bdnf is necessary for the induction of long-term potentiation (ltp), a form of synaptic plasticity, in the hippocampus and striatum. |
2024-08-29 |
2024-09-01 |
Not clear |
| Ruth A Singer, Veronika Rajchin, Kwanghoon Park, Nathaniel Heintz, Robert B Darnel. Opto-CLIP reveals dynamic FMRP regulation of mRNAs upon CA1 neuronal activation. bioRxiv : the preprint server for biology. 2024-08-26. PMID:39185177. |
since molecular studies have demonstrated that synaptic plasticity in ca1 excitatory hippocampal neurons is protein-synthesis dependent, together these observations have suggested a potential role for fmrp in synaptic plasticity in fxs. |
2024-08-26 |
2024-08-28 |
Not clear |
| Federico Tesler, Roberta Maria Lorenzi, Adam Ponzi, Claudia Casellato, Fulvia Palesi, Daniela Gandolfi, Claudia A M Gandini Wheeler Kingshott, Jonathan Mapelli, Egidio D'Angelo, Michele Migliore, Alain Destexh. Multiscale modeling of neuronal dynamics in hippocampus CA1. Frontiers in computational neuroscience. vol 18. 2024-08-21. PMID:39165754. |
then, we analyze the implementation of synaptic plasticity within our framework, a key aspect to study the role of hippocampus in learning and memory consolidation, and we demonstrate the capability of our framework to incorporate the variations at synaptic level. |
2024-08-21 |
2024-08-23 |
Not clear |
| Calvin Wong, Luis David Rodriguez-Hernandez, Kevin C Lister, Ning Gu, Weihua Cai, Mehdi Hooshmandi, Jonathan Fan, Nicole Brown, Vivienne Nguyen, Alfredo Ribeiro-da-Silva, Robert P Bonin, Arkady Khoutorsk. Targeting spinal mechanistic target of rapamycin complex 2 alleviates inflammatory and neuropathic pain. Brain : a journal of neurology. 2024-08-21. PMID:39167538. |
the mechanistic target of rapamycin complex 2 (mtorc2), a central signaling hub that modulates both actin-dependent structural changes and mtorc1-dependent mrna translation, plays key roles in hippocampal synaptic plasticity and memory formation. |
2024-08-21 |
2024-08-24 |
Not clear |
| Zixun Wang, Xinyu Hu, Zhongyi Wang, Jiaming Chen, Ling Wang, Changjiang Li, Jing Deng, Kuitao Yue, Lizhuo Wang, Yujia Kong, Lin Su. Ketamine alleviates PTSD-like effect and improves hippocampal synaptic plasticity via regulation of GSK-3β/GR signaling of rats. Journal of psychiatric research. vol 178. 2024-08-21. PMID:39167905. |
ketamine alleviates ptsd-like effect and improves hippocampal synaptic plasticity via regulation of gsk-3β/gr signaling of rats. |
2024-08-21 |
2024-08-24 |
rat |
| Al-Hassan Soliman Wadan, Muhammad Liaquat Raza, Nasrollah Moradiko. Synaptic modulation by coffee compounds: Insights into neural plasticity. Progress in brain research. vol 289. 2024-08-21. PMID:39168580. |
this chapter investigates how caffeine affects fluctuations in structure and function in the hippocampus formation and neocortical structure, regions known for their high synaptic plasticity profile. |
2024-08-21 |
2024-08-24 |
Not clear |
| Sergio López-García, Esperanza López-Merino, Alba Fernández-Rodrigo, Pablo Zamorano-González, Silvia Gutiérrez-Eisman, Raquel Jiménez-Sánchez, José A Esteba. PI3K couples long-term synaptic potentiation with cofilin recruitment and actin polymerization in dendritic spines via its regulatory subunit p85α. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-08-19. PMID:39158722. |
to investigate this issue, we targeted individual regulatory subunits of type i pi3ks in hippocampal neurons and employed a combination of electrophysiological, biochemical and imaging techniques to assess their role in synaptic plasticity. |
2024-08-19 |
2024-08-21 |
Not clear |
| Yucai Ye, Chaojing Fu, Yan Li, Junli Sun, Xinru Li, Shifan Chai, Shuo Li, Meng Hou, Hongyan Cai, Meina Wu, Zhaojun Wan. Alternate-day fasting improves cognitive and brain energy deficits by promoting ketone metabolism in the 3xTg mouse model of Alzheimer's disease. Experimental neurology. 2024-08-14. PMID:39142368. |
we found that adf increased circulating βohb concentrations in 3xtg mice, improved cognitive function, reduced anxiety-like behaviors, improved hippocampal synaptic plasticity, and reduced neuronal loss, aβ oligomers and tau hyperphosphorylation. |
2024-08-14 |
2024-08-17 |
mouse |
| Ana Belén Sanz-Martos, María Roca, Adrián Plaza, Beatriz Merino, Mariano Ruiz-Gayo, Nuria Del Olm. LONG-TERM SATURATED FAT-ENRICHED DIETS IMPAIR HIPPOCAMPAL LEARNING AND MEMORY PROCESSES IN A SEX-DEPENDENT MANNER. Neuropharmacology. 2024-08-11. PMID:39128582. |
consumption of saturated fat-enriched diets during adolescence has been closely associated with the reduction of hippocampal synaptic plasticity and the impairment of cognitive function. |
2024-08-11 |
2024-08-14 |
mouse |
| Ju-Young Oh, Hyowon Lee, Sun-Young Jang, Hyunjin Kim, Geunhong Park, Almas Serikov, Jae-Hwan Jang, Junyeop Kim, Seulkee Yang, Moonsun Sa, Sung Eun Lee, Young-Eun Han, Tae-Yeon Hwang, Sharon Jiyoon Jung, Hee Young Kim, Seung Eun Lee, Soo-Jin Oh, Jeongjin Kim, Jeongyeon Kim, Jongpil Kim, Thomas J McHugh, C Justin Lee, Min-Ho Nam, Hi-Joon Par. Central Role of Hypothalamic Circuits for Acupuncture's Anti-Parkinsonian Effects. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-08-09. PMID:39119926. |
through chemogenetic manipulation specifically targeting these mch projections, their respective roles in mediating the acupuncture-induced motor recovery and memory improvements following pd onset are demonstrated, as well as the underlying mechanisms mediating recovery from dopaminergic neurodegeneration, reactive gliosis, and impaired hippocampal synaptic plasticity. |
2024-08-09 |
2024-08-12 |
mouse |
| Shi Bai, Zhong-Ming Ying, Jia-Kang Ying, Qin-Ying Zhang, Yu-Hang Lv, Zhong-Min W. Inhibition of 5-HT alleviates PTSD-like behaviors and promotes hippocampal neuroplasticity by modulating hippocampal autophagy in rats. Journal of neurophysiology. 2024-08-07. PMID:39110517. |
the current study demonstrates that sh-sert exhibits significant anti-ptsd effects, potentially mediated in part through the reduction of cellular autophagy to enhance hippocampal synaptic plasticity. |
2024-08-07 |
2024-08-10 |
rat |
| Andrea Scolz, Elena Vezzoli, Michela Villa, Francesca Talpo, Jessica Cazzola, Francesca Raffin, Chiara Cordiglieri, Andrea Falqui, Giuseppe Pepe, Vittorio Maglione, Dario Besusso, Gerardo Biella, Chiara Zuccat. Neuroprotection by ADAM10 inhibition requires TrkB signaling in the Huntington's disease hippocampus. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-08-07. PMID:39112663. |
we provide evidence that active adam10 is increased in the hippocampus of two mouse models of hd, leading to extensive proteolysis of n-cadherin, which has a widely recognized role in spine morphology and synaptic plasticity. |
2024-08-07 |
2024-08-10 |
mouse |
| Andrea Scolz, Elena Vezzoli, Michela Villa, Francesca Talpo, Jessica Cazzola, Francesca Raffin, Chiara Cordiglieri, Andrea Falqui, Giuseppe Pepe, Vittorio Maglione, Dario Besusso, Gerardo Biella, Chiara Zuccat. Neuroprotection by ADAM10 inhibition requires TrkB signaling in the Huntington's disease hippocampus. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-08-07. PMID:39112663. |
collectively, these findings indicate that adam10 inhibition coupled with trkb signaling represents an efficacious strategy to prevent hippocampal synaptic plasticity defects and cognitive dysfunction in hd. |
2024-08-07 |
2024-08-10 |
mouse |
| Maryam Azarfarin, Tahereh Ghadiri, Masoomeh Dadkhah, Sajad Sahab-Nega. The interaction between cannabinoids and long-term synaptic plasticity: A survey on memory formation and underlying mechanisms. Cell biochemistry and function. vol 42. issue 6. 2024-08-02. PMID:39090824. |
synaptic plasticity consists of gradual changes in the biochemistry and morphology of pre- and postsynaptic neurons, particularly in the hippocampus. |
2024-08-02 |
2024-08-05 |
Not clear |
| Maria Vazquez Pavon, Sheeja Navakkode, Sreedharan Sajikuma. Nogo-A-mediated constraints on activity-dependent synaptic plasticity and associativity in rat hippocampal CA2 synapses. Hippocampus. 2024-08-02. PMID:39091158. |
nogo-a-mediated constraints on activity-dependent synaptic plasticity and associativity in rat hippocampal ca2 synapses. |
2024-08-02 |
2024-08-05 |
rat |
| Mahmoud Hosseini, Fatemeh Seyedi, Mahdiyeh Hedayati-Moghadam, Mohammad Ali-Hassanzadeh, Hedyeh Askarpour, Somaieh Mansouri, Hadi Shafieemojaz, Yousef Baghchegh. The effects of PPARγ agonists on long‑termpotentiation and apoptosis in the hippocampusarea of juvenile hypothyroid rats. Acta neurobiologiae experimentalis. vol 84. issue 2. 2024-08-01. PMID:39087839. |
the aim of the present study was to evaluate the effect of rosiglitazone (rsg) or pioglitazone (pog) on the synaptic plasticity, neuronal apoptosis, brain-derived neurotrophic factor (bdnf), and nitric oxide (no) metabolites in the hippocampus of juvenile hypothyroid rats. |
2024-08-01 |
2024-08-03 |
rat |
| Qian-Yun Wu, Lian-Hong Lin, Kun Lu, Si-Fu Deng, Wei-Min Li, Yuan Xu, Bin Zhang, Ji-Hong Li. Astrocytic 5-HT Experimental & molecular medicine. 2024-07-31. PMID:39085354. |
astrocytic 5-ht nmda receptor-dependent long-term depression (ltd) in the hippocampus is a well-known form of synaptic plasticity that has been linked to different cognitive functions. |
2024-07-31 |
2024-08-03 |
mouse |
| Ashley N Ewens, Alexander Pilski, Shayne D Hastings, Chris Krook-Magnuson, Steven M Graves, Esther Krook-Magnuson, Stanley A Thaye. Levetiracetam prevents neurophysiological changes and preserves cognitive function in the HIV-1 TAT transgenic mouse model of HIV-associated neurocognitive disorder. The Journal of pharmacology and experimental therapeutics. 2024-07-26. PMID:39060163. |
itat mice had an increased frequency of spontaneous excitatory postsynaptic currents in hippocampal slice recordings and impaired long-term potentiation, a form of synaptic plasticity that underlies learning and memory. |
2024-07-26 |
2024-07-29 |
mouse |
| Mansour Azimzadeh, Maryam Noorbakhshni. Maternal linalool treatment protects against radiofrequency wave-induced deteriorations in adolescent rats: A behavioral and electrophysiological study. Scientific reports. vol 14. issue 1. 2024-07-26. PMID:39060318. |
electrophysiological properties and synaptic plasticity of the dorsal hippocampal ca3-ca1 synapse showed a decrease in fepsp amplitude and slope. |
2024-07-26 |
2024-07-29 |
rat |