| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pauline Latzer, Olena Shchyglo, Tim Hartl, Veronika Matschke, Uwe Schlegel, Denise Manahan-Vaughan, Carsten Theis. Blocking VEGF by Bevacizumab Compromises Electrophysiological and Morphological Properties of Hippocampal Neurons. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:30971896. |
vegf inhibition resulted in profound impairments in hippocampal synaptic plasticity as well as reductions in dendritic spine number and length. |
2020-09-30 |
2023-08-13 |
rat |
| Sergey Neyman, Karl-Heinz Braunewell, Kara E O'Connell, Kumlesh K Dev, Denise Manahan-Vaugha. Inhibition of the Interaction Between Group I Metabotropic Glutamate Receptors and PDZ-Domain Proteins Prevents Hippocampal Long-Term Depression, but Not Long-Term Potentiation. Frontiers in synaptic neuroscience. vol 11. 2020-09-30. PMID:31057390. |
the group i metabotropic glutamate (mglu) receptor subtypes, mglu1 and mglu5, strongly regulate hippocampal synaptic plasticity. |
2020-09-30 |
2023-08-13 |
rat |
| Rongrong Han, Zeyue Liu, Nannan Sun, Shu Liu, Lanlan Li, Yan Shen, Jianbo Xiu, Qi X. BDNF Alleviates Neuroinflammation in the Hippocampus of Type 1 Diabetic Mice via Blocking the Aberrant HMGB1/RAGE/NF-κB Pathway. Aging and disease. vol 10. issue 3. 2020-09-30. PMID:31165005. |
we found that bdnf overexpression in the hippocampus significantly rescued stz-induced decreases in mrna and protein expression of two synaptic plasticity markers, spinophilin and synaptophysin. |
2020-09-30 |
2023-08-13 |
mouse |
| Débora Serrenho, Sandra D Santos, Ana Luísa Carvalh. The Role of Ghrelin in Regulating Synaptic Function and Plasticity of Feeding-Associated Circuits. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31191250. |
in this review, we discuss the neuromodulatory mechanisms induced by ghrelin in regulating synaptic plasticity in three main neuronal circuits previously associated with feeding behaviors, namely hypothalamic (homeostatic feeding), ventral tegmental (hedonic and motivational feeding) and hippocampal (cognitive) circuits. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yan Hu, Tie-Cheng Guo, Xiang-Yu Zhang, Jun Tian, Yin-Shan L. Paired associative stimulation improves synaptic plasticity and functional outcomes after cerebral ischemia. Neural regeneration research. vol 14. issue 11. 2020-09-30. PMID:31290455. |
the observed effect may be mediated by increases in the mrna and protein expression of brain-derived neurotrophic factor and n-methyl-d-aspartate receptor 1, and by enhanced synaptic plasticity in the ca1 area of the hippocampus. |
2020-09-30 |
2023-08-13 |
rat |
| Man-Man Zong, Zhi-Qiang Zhou, Mu-Huo Ji, Min Jia, Hui Tang, Jian-Jun Yan. Activation of β2-Adrenoceptor Attenuates Sepsis-Induced Hippocampus-Dependent Cognitive Impairments by Reversing Neuroinflammation and Synaptic Abnormalities. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31354429. |
sepsis-associated encephalopathy induces cognitive dysfunction via mechanisms that commonly involve neuroinflammation and synaptic plasticity impairment of the hippocampus. |
2020-09-30 |
2023-08-13 |
mouse |
| Xue Li, Lu Wang, Shuling Zhang, Xiang Hu, Huijun Yang, Lei X. Timing-Dependent Protection of Swimming Exercise against d-Galactose-Induced Aging-Like Impairments in Spatial Learning/Memory in Rats. Brain sciences. vol 9. issue 9. 2020-09-30. PMID:31540073. |
this study was designed to investigate beneficial effects of swimming exercise training on learning/memory, synaptic plasticity and creb (camp response element binding protein) expression in hippocampus in a rat model of d-galactose-induced aging (dga). |
2020-09-30 |
2023-08-13 |
rat |
| Ju Zeng, Bin Cheng, Yan Huang, Xiaorui Zhang, Chen Wang, Na Sun, Gang Liu, Xiaorui Cheng, Yongxiang Zhang, Wenxia Zho. Active Fraction Combination from Liuwei Dihuang Decoction (LW-AFC) Alleviated the LPS-Induced Long-Term Potentiation Impairment and Glial Cells Activation in Hippocampus of Mice by Modulating Immune Responses. Evidence-based complementary and alternative medicine : eCAM. vol 2019. 2020-09-30. PMID:31636681. |
neuroinflammation is known as a typical feature associated with many neurodegenerative diseases including alzheimer's disease (ad) and impairs the synaptic plasticity of the hippocampus. |
2020-09-30 |
2023-08-13 |
mouse |
| Valentyna Dubovyk, Denise Manahan-Vaugha. Gradient of Expression of Dopamine D2 Receptors Along the Dorso-Ventral Axis of the Hippocampus. Frontiers in synaptic neuroscience. vol 11. 2020-09-30. PMID:31680927. |
dopamine d2-like receptors (d2r) play an important role in the regulation of hippocampal neuronal excitability and contribute to the regulation of synaptic plasticity, the encoding of hippocampus-dependent memories and the regulation of affective state. |
2020-09-30 |
2023-08-13 |
Not clear |
| Valentyna Dubovyk, Denise Manahan-Vaugha. Gradient of Expression of Dopamine D2 Receptors Along the Dorso-Ventral Axis of the Hippocampus. Frontiers in synaptic neuroscience. vol 11. 2020-09-30. PMID:31680927. |
taken together, our study suggests that the higher d2r expression levels of the ventral hippocampus may contribute to reported gradients in the degree of expression of synaptic plasticity along the dorso-ventral hippocampal axis, and may support behavioral information processing by the ventral hippocampus. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jim R Fadel, Lawrence P Reaga. Stop signs in hippocampal insulin signaling: the role of insulin resistance in structural, functional and behavioral deficits. Current opinion in behavioral sciences. vol 9. 2020-09-29. PMID:26955646. |
while insulin appears to play a minor role in the regulation of glucose uptake in the central nervous system (cns), insulin is known to play a major role in regulating synaptic plasticity in brain regions like the hippocampus. |
2020-09-29 |
2023-08-13 |
Not clear |
| Wensen Pan, Shuo Han, Lin Kang, Sha Li, Juan Du, Huixian Cu. Effects of dihydrotestosterone on synaptic plasticity of the hippocampus in mild cognitive impairment male SAMP8 mice. Experimental and therapeutic medicine. vol 12. issue 3. 2020-09-29. PMID:27588067. |
effects of dihydrotestosterone on synaptic plasticity of the hippocampus in mild cognitive impairment male samp8 mice. |
2020-09-29 |
2023-08-13 |
mouse |
| Wensen Pan, Shuo Han, Lin Kang, Sha Li, Juan Du, Huixian Cu. Effects of dihydrotestosterone on synaptic plasticity of the hippocampus in mild cognitive impairment male SAMP8 mice. Experimental and therapeutic medicine. vol 12. issue 3. 2020-09-29. PMID:27588067. |
the current study focused on how dihydrotestosterone (dht) regulates synaptic plasticity in the hippocampus of mild cognitive impairment male senescence-accelerated mouse prone 8 (samp8) mice. |
2020-09-29 |
2023-08-13 |
mouse |
| Domenico Del Turco, Mandy H Paul, Jessica Schlaudraff, Meike Hick, Kristina Endres, Ulrike C Müller, Thomas Delle. Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus. Frontiers in molecular neuroscience. vol 9. 2020-09-29. PMID:27965537. |
intriguingly, however, studies focusing on the role of app in synaptic plasticity have reported diverging results and considerable differences in effect size between the dentate gyrus (dg) and area ca1 of the mouse hippocampus. |
2020-09-29 |
2023-08-13 |
mouse |
| Caroline Fasano, Jill Rocchetti, Katarzyna Pietrajtis, Johannes-Friedrich Zander, Frédéric Manseau, Diana Y Sakae, Maya Marcus-Sells, Lauriane Ramet, Lydie J Morel, Damien Carrel, Sylvie Dumas, Susanne Bolte, Véronique Bernard, Erika Vigneault, Romain Goutagny, Gudrun Ahnert-Hilger, Bruno Giros, Stéphanie Daumas, Sylvain Williams, Salah El Mestikaw. Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells. Frontiers in cellular neuroscience. vol 11. 2020-09-29. PMID:28559797. |
hippocampal interneurons release the inhibitory transmitter gaba to regulate excitation, rhythm generation and synaptic plasticity. |
2020-09-29 |
2023-08-13 |
mouse |
| Chang-Lu Tao, Yun-Tao Liu, Z Hong Zhou, Pak-Ming Lau, Guo-Qiang B. Accumulation of Dense Core Vesicles in Hippocampal Synapses Following Chronic Inactivity. Frontiers in neuroanatomy. vol 12. 2020-09-29. PMID:29942253. |
here we employed cryo-electron tomography (cryo-et) to visualize synaptic ultrastructure in cultured hippocampal neurons and investigated changes in subcellular features in response to chronic inactivity, a paradigm often used for the induction of homeostatic synaptic plasticity. |
2020-09-29 |
2023-08-13 |
Not clear |
| Lu Yu, Yanhong Duan, Zheng Zhao, Wendi He, Ming Xia, Qiujuan Zhang, Xiaohua Ca. Hydroxysafflor Yellow A (HSYA) Improves Learning and Memory in Cerebral Ischemia Reperfusion-Injured Rats via Recovering Synaptic Plasticity in the Hippocampus. Frontiers in cellular neuroscience. vol 12. 2020-09-29. PMID:30405354. |
hydroxysafflor yellow a (hsya) improves learning and memory in cerebral ischemia reperfusion-injured rats via recovering synaptic plasticity in the hippocampus. |
2020-09-29 |
2023-08-13 |
rat |
| Dongxue Li, Dongqing Jing, Ziyang Liu, Ying Chen, Fang Huang, Thomas Behnisc. Enhanced Expression of Secreted α-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31001090. |
moreover, α-klotho overexpression increased hippocampal synaptic transmission in response to standardized stimulation strengths, altered paired-pulse facilitation of synaptic transmission, and enhanced activity-dependent synaptic plasticity. |
2020-09-29 |
2023-08-13 |
mouse |
| Hye Jin Park, Huiyoung Kwon, Ji Hye Lee, Eunbi Cho, Young Choon Lee, Minho Moon, Mira Jun, Dong Hyun Kim, Ji Wook Jun. β-Amyrin Ameliorates Alzheimer's Disease-Like Aberrant Synaptic Plasticity in the Mouse Hippocampus. Biomolecules & therapeutics. vol 28. issue 1. 2020-09-28. PMID:31357749. |
β-amyrin ameliorates alzheimer's disease-like aberrant synaptic plasticity in the mouse hippocampus. |
2020-09-28 |
2023-08-13 |
mouse |
| Mudan Cai, Inho Jung, Huiyoung Kwon, Eunbi Cho, Jieun Jeon, Jeanho Yun, Young Choon Lee, Dong Hyun Kim, Jong Hoon Ry. Spinosin Attenuates Alzheimer's Disease-Associated Synaptic Dysfunction via Regulation of Plasmin Activity. Biomolecules & therapeutics. vol 28. issue 2. 2020-09-28. PMID:31791115. |
many agents regulating hippocampal synaptic plasticity show an ameliorative effect on ad pathology, making them potential candidates for ad therapy. |
2020-09-28 |
2023-08-13 |
mouse |