| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Keiichi Kadoyama, Kenji Matsuura, Masaoki Takano, Koji Maekura, Yukari Inoue, Shogo Matsuyam. Changes in the expression of prefoldin subunit 5 depending on synaptic plasticity in the mouse hippocampus. Neuroscience letters. vol 712. 2020-09-23. PMID:31505240. |
in transgenic mice overexpressing human tau with n279 k mutation as a model of alzheimer's disease that showed impaired synaptic plasticity, the levels of pfdn5 mrna and protein in the hippocampus were significantly decreased in an age-dependent manner as compared with age-matched control. |
2020-09-23 |
2023-08-13 |
mouse |
| Keiichi Kadoyama, Kenji Matsuura, Masaoki Takano, Koji Maekura, Yukari Inoue, Shogo Matsuyam. Changes in the expression of prefoldin subunit 5 depending on synaptic plasticity in the mouse hippocampus. Neuroscience letters. vol 712. 2020-09-23. PMID:31505240. |
the findings demonstrated that the level of pfdn5 protein in the hippocampus was changed depending on the situation of synaptic plasticity. |
2020-09-23 |
2023-08-13 |
mouse |
| Hadi Zarif, Agnès Paquet, Kevin Lebrigand, Marie-Jeanne Arguel, Catherine Heurteaux, Nicolas Glaichenhaus, Joëlle Chabry, Alice Guyon, Agnès Petit-Paite. CD4+ T Cells Affect the Thyroid Hormone Transport at the Choroid Plexus in Mice Raised in Enriched Environment. Neuroimmunomodulation. vol 26. issue 2. 2020-09-22. PMID:30703773. |
others and we have shown that t cells have an important role in hippocampal synaptic plasticity, including neurogenesis in the dentate gyrus, spinogenesis, and glutamatergic synaptic function in the ca of the hippocampus. |
2020-09-22 |
2023-08-13 |
mouse |
| Jianxing Lian, Kai Li, Jing Gao, Xiaoyue Tan, Zhuo Yan. Legumain acts on neuroinflammatory to affect CUS-induced cognitive impairment. Behavioural brain research. vol 376. 2020-09-22. PMID:31509774. |
in conclusion, our results suggested that legumain may be an effective therapeutic target for cognitive impairment as was seen within the cus model and legumain ko reduced the level of neuroinflammation, thereby improving the hippocampal synaptic plasticity and cognitive impairment of stressed mice. |
2020-09-22 |
2023-08-13 |
mouse |
| James E Orfila, Robert M Dietz, Krista M Rodgers, Andra Dingman, Olivia P Patsos, Ivelisse Cruz-Torres, Himmat Grewal, Frank Strnad, Christian Schroeder, Paco S Herso. Experimental pediatric stroke shows age-specific recovery of cognition and role of hippocampal Nogo-A receptor signaling. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 40. issue 3. 2020-09-21. PMID:30762478. |
juvenile and adult mice subjected to 45-min mcao, and extracellular field recordings of ca1 neurons were performed to assess hippocampal synaptic plasticity changes after mcao, and contextual fear conditioning was performed to evaluate memory and biochemistry used to analyze nogo-a expression. |
2020-09-21 |
2023-08-13 |
mouse |
| Anna Yu-Szu Huang, Junsung Woo, Debosmita Sardar, Brittney Lozzi, Navish A Bosquez Huerta, Chia-Ching John Lin, Daniela Felice, Antrix Jain, Adriana Paulucci-Holthauzen, Benjamin Denee. Region-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit Activities. Neuron. vol 106. issue 6. 2020-09-21. PMID:32320644. |
these changes in hippocampal astrocytes did not affect basal neuronal properties but specifically inhibited synaptic plasticity, which is regulated by nfia in astrocytes through calcium-dependent mechanisms. |
2020-09-21 |
2023-08-13 |
Not clear |
| Michael Ratcliff, Daniel Rees, Scott McGrady, Luke Buntwal, Amanda K E Hornsby, Jaqueline Bayliss, Brianne A Kent, Timothy Bussey, Lisa Saksida, Amy L Beynon, Owain W Howell, Alwena H Morgan, Yuxiang Sun, Zane B Andrews, Timothy Wells, Jeffrey S Davie. Calorie restriction activates new adult born olfactory-bulb neurones in a ghrelin-dependent manner but acyl-ghrelin does not enhance subventricular zone neurogenesis. Journal of neuroendocrinology. vol 31. issue 7. 2020-09-18. PMID:31179562. |
emerging evidence suggests that the gut hormone ghrelin plays an important role in protecting neurones, promoting synaptic plasticity and increasing hippocampal neurogenesis in the adult brain. |
2020-09-18 |
2023-08-13 |
mouse |
| Kaiyu Xu, Ying Zhang, Wandi Xiong, Zhongyu Zhang, Zhengbo Wang, Longbao Lv, Chao Liu, Zhengfei Hu, Yong-Tang Zheng, Lin Lu, Xin-Tian Hu, Jiali L. CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis. Nature communications. vol 11. issue 1. 2020-09-18. PMID:32681011. |
knockdown of circgria1 results in an age-related improvement of synaptogenesis, and glur1 activity-dependent synaptic plasticity in the hippocampal neurons in males. |
2020-09-18 |
2023-08-13 |
monkey |
| Mi Li, Kai Li, Ning Ding, Yi-Qiang Xie, Kun Niu, Hong Zhan. [Effect of electroacupuncture on expression of CREB and its ability to bind to synaptic proteins in amygdala and hippocampus of rats with post-traumatic stress disorder]. Zhen ci yan jiu = Acupuncture research. vol 45. issue 7. 2020-09-16. PMID:32705823. |
to observe the effect of electroacupuncture (ea) on the expression of camp-response element binding protein (creb, a key protein for bdnf-trkb signaling) and it's blinding ability to synaptic key protein in the amygdala and hippocampus of rats with post-traumatic stress disorder (ptsd), so as to lay a foundation for further study of the interaction mechanism between bdnf-trkb signaling and synaptic plasticity. |
2020-09-16 |
2023-08-13 |
rat |
| Adrián Martín-Segura, Tariq Ahmed, Álvaro Casadomé-Perales, Irene Palomares-Perez, Ernest Palomer, Axelle Kerstens, Sebastian Munck, Detlef Balschun, Carlos G Dott. Age-associated cholesterol reduction triggers brain insulin resistance by facilitating ligand-independent receptor activation and pathway desensitization. Aging cell. vol 18. issue 3. 2020-09-14. PMID:30884121. |
in recent studies, we reported that the mild and gradual loss of cholesterol in the synaptic fraction of hippocampal neurons during aging leads to a decrease in synaptic plasticity evoked by glutamate receptor activation and also by receptor tyrosine kinase (rtk) signaling. |
2020-09-14 |
2023-08-13 |
mouse |
| Ying Yu, Dan Xu, Siyuan Cheng, Li Zhang, Zhaokun Shi, Jun Qin, Zhaohui Zhang, Hui Wan. Prenatal ethanol exposure enhances the susceptibility to depressive behavior of adult offspring rats fed a high‑fat diet by affecting BDNF‑associated pathway. International journal of molecular medicine. vol 45. issue 2. 2020-09-11. PMID:31894308. |
multigene rt‑qpcr also revealed that the mrna expression levels for bdnf pathway‑associated genes and synaptic plasticity genes were decreased in the hippocampus of fetal offspring rats in the pee group. |
2020-09-11 |
2023-08-13 |
rat |
| Yuyoung Joo, Yutong Xue, Yue Wang, Ross A McDevitt, Nirnath Sah, Simone Bossi, Shuaikun Su, Seung Kyu Lee, Wei Peng, Aoji Xie, Yongqing Zhang, Yi Ding, Wai Lim Ku, Soumita Ghosh, Kenneth Fishbein, Weiping Shen, Richard Spencer, Kevin Becker, Keji Zhao, Mark P Mattson, Henriette van Praag, Alexei Sharov, Weidong Wan. Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity. Nature communications. vol 11. issue 1. 2020-08-28. PMID:32561719. |
the mice also display impairments in hippocampal neurogenesis and synaptic plasticity. |
2020-08-28 |
2023-08-13 |
mouse |
| Pengyou Zhou, Boxuan Pu, Yang Liu, Xiaohong Zhang, Xiao Liu, Jingjing Bian, Xinru Wang, Shoufang Jian. [Effects of PM_(2. 5) exposure on synaptic plasticity and Wnt/β-catenin pathway in rat hippocampus]. Wei sheng yan jiu = Journal of hygiene research. vol 49. issue 3. 2020-08-26. PMID:32693900. |
5) exposure on synaptic plasticity and wnt/β-catenin pathway in rat hippocampus]. |
2020-08-26 |
2023-08-13 |
rat |
| Pengyou Zhou, Boxuan Pu, Yang Liu, Xiaohong Zhang, Xiao Liu, Jingjing Bian, Xinru Wang, Shoufang Jian. [Effects of PM_(2. 5) exposure on synaptic plasticity and Wnt/β-catenin pathway in rat hippocampus]. Wei sheng yan jiu = Journal of hygiene research. vol 49. issue 3. 2020-08-26. PMID:32693900. |
5) exposure on the development of synaptic plasticity and wnt/β-catenin pathway in hippocampus of offspring rats. |
2020-08-26 |
2023-08-13 |
rat |
| Zahra Gholamnezhad, Mohammad Hossien Boskabady, Zahra Jahangir. Exercise and Dementia. Advances in experimental medicine and biology. vol 1228. 2020-08-12. PMID:32342466. |
the main positive effects suggested for exercise are less cognitive and behavioral impairment or decline, development of health-associated conditions (stress, sleep), reduction of dementia risk factors including chronic non-communicable disease (diabetes, cardiovascular disease), increase in neurotrophins, enhancement of brain blood flow, angiogenesis, neurogenesis, synaptogenesis and synaptic plasticity in the brain memory-related region (e.g., hippocampus), and reduction of neuroinflammation and apoptosis. |
2020-08-12 |
2023-08-13 |
human |
| Paula Adler, Janice Mayne, Krystal Walker, Zhibin Ning, Daniel Figey. Therapeutic Targeting of Casein Kinase 1δ/ε in an Alzheimer's Disease Mouse Model. Journal of proteome research. vol 18. issue 9. 2020-08-11. PMID:31334659. |
mass spectrometry-based proteomic analyses revealed that pf-670462 administration in 3xtg-ad mice reversed hippocampal proteomic alterations in several ad-related and clock-regulated pathways, including synaptic plasticity and amyloid precursor protein processing. |
2020-08-11 |
2023-08-13 |
mouse |
| Ang Li, Suk-Yu Yau, Sergio Machado, Pingjie Wang, Ti-Fei Yuan, Kwok-Fai S. Enhancement of Hippocampal Plasticity by Physical Exercise as a Polypill for Stress and Depression: A Review. CNS & neurological disorders drug targets. vol 18. issue 4. 2020-08-05. PMID:30848219. |
here, we review recent discoveries on the potential mechanisms concerning how physical exercise mitigates the stressrelated depressive disorders, with a focus on the perspective of modulation on hippocampal neurogenesis, dendritic remodeling and synaptic plasticity. |
2020-08-05 |
2023-08-13 |
Not clear |
| Pengfei Xu, Xiaohao Zhang, Qian Liu, Yi Xie, Xiaolei Shi, Jingjing Chen, Yunzi Li, Hongquan Guo, Rui Sun, Ye Hong, Xinfeng Liu, Gelin X. Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke. Cell death & disease. vol 10. issue 8. 2020-08-03. PMID:31324751. |
moreover, blockade of trem-1 can potentiate cellular proliferation and synaptic plasticity in hippocampus, resulting in long-term functional improvement. |
2020-08-03 |
2023-08-13 |
Not clear |
| Yue Li, Minjie Shen, Michael E Stockton, Xinyu Zha. Hippocampal deficits in neurodevelopmental disorders. Neurobiology of learning and memory. vol 165. 2020-07-30. PMID:30321651. |
in addition, with its high levels of activity-dependent synaptic plasticity and lifelong neurogenesis, the hippocampus is sensitive to experience and exposure and susceptible to disease and injury. |
2020-07-30 |
2023-08-13 |
human |
| Hajime Hirase, Sonam Akther, Xiaowen Wang, Yuki O. Glycogen distribution in mouse hippocampus. Journal of neuroscience research. vol 97. issue 8. 2020-07-28. PMID:30675919. |
in the recent decade, glycogenolysis in the rodent hippocampus has been shown critical for synaptic plasticity and memory formation. |
2020-07-28 |
2023-08-13 |
mouse |