| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael Ratcliff, Daniel Rees, Scott McGrady, Luke Buntwal, Amanda K E Hornsby, Jaqueline Bayliss, Brianne A Kent, Timothy Bussey, Lisa Saksida, Amy L Beynon, Owain W Howell, Alwena H Morgan, Yuxiang Sun, Zane B Andrews, Timothy Wells, Jeffrey S Davie. Calorie restriction activates new adult born olfactory-bulb neurones in a ghrelin-dependent manner but acyl-ghrelin does not enhance subventricular zone neurogenesis. Journal of neuroendocrinology. vol 31. issue 7. 2020-09-18. PMID:31179562. |
emerging evidence suggests that the gut hormone ghrelin plays an important role in protecting neurones, promoting synaptic plasticity and increasing hippocampal neurogenesis in the adult brain. |
2020-09-18 |
2023-08-13 |
mouse |
| Kaiyu Xu, Ying Zhang, Wandi Xiong, Zhongyu Zhang, Zhengbo Wang, Longbao Lv, Chao Liu, Zhengfei Hu, Yong-Tang Zheng, Lin Lu, Xin-Tian Hu, Jiali L. CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis. Nature communications. vol 11. issue 1. 2020-09-18. PMID:32681011. |
knockdown of circgria1 results in an age-related improvement of synaptogenesis, and glur1 activity-dependent synaptic plasticity in the hippocampal neurons in males. |
2020-09-18 |
2023-08-13 |
monkey |
| Mi Li, Kai Li, Ning Ding, Yi-Qiang Xie, Kun Niu, Hong Zhan. [Effect of electroacupuncture on expression of CREB and its ability to bind to synaptic proteins in amygdala and hippocampus of rats with post-traumatic stress disorder]. Zhen ci yan jiu = Acupuncture research. vol 45. issue 7. 2020-09-16. PMID:32705823. |
to observe the effect of electroacupuncture (ea) on the expression of camp-response element binding protein (creb, a key protein for bdnf-trkb signaling) and it's blinding ability to synaptic key protein in the amygdala and hippocampus of rats with post-traumatic stress disorder (ptsd), so as to lay a foundation for further study of the interaction mechanism between bdnf-trkb signaling and synaptic plasticity. |
2020-09-16 |
2023-08-13 |
rat |
| Adrián Martín-Segura, Tariq Ahmed, Álvaro Casadomé-Perales, Irene Palomares-Perez, Ernest Palomer, Axelle Kerstens, Sebastian Munck, Detlef Balschun, Carlos G Dott. Age-associated cholesterol reduction triggers brain insulin resistance by facilitating ligand-independent receptor activation and pathway desensitization. Aging cell. vol 18. issue 3. 2020-09-14. PMID:30884121. |
in recent studies, we reported that the mild and gradual loss of cholesterol in the synaptic fraction of hippocampal neurons during aging leads to a decrease in synaptic plasticity evoked by glutamate receptor activation and also by receptor tyrosine kinase (rtk) signaling. |
2020-09-14 |
2023-08-13 |
mouse |
| Ying Yu, Dan Xu, Siyuan Cheng, Li Zhang, Zhaokun Shi, Jun Qin, Zhaohui Zhang, Hui Wan. Prenatal ethanol exposure enhances the susceptibility to depressive behavior of adult offspring rats fed a high‑fat diet by affecting BDNF‑associated pathway. International journal of molecular medicine. vol 45. issue 2. 2020-09-11. PMID:31894308. |
multigene rt‑qpcr also revealed that the mrna expression levels for bdnf pathway‑associated genes and synaptic plasticity genes were decreased in the hippocampus of fetal offspring rats in the pee group. |
2020-09-11 |
2023-08-13 |
rat |
| Yuyoung Joo, Yutong Xue, Yue Wang, Ross A McDevitt, Nirnath Sah, Simone Bossi, Shuaikun Su, Seung Kyu Lee, Wei Peng, Aoji Xie, Yongqing Zhang, Yi Ding, Wai Lim Ku, Soumita Ghosh, Kenneth Fishbein, Weiping Shen, Richard Spencer, Kevin Becker, Keji Zhao, Mark P Mattson, Henriette van Praag, Alexei Sharov, Weidong Wan. Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity. Nature communications. vol 11. issue 1. 2020-08-28. PMID:32561719. |
the mice also display impairments in hippocampal neurogenesis and synaptic plasticity. |
2020-08-28 |
2023-08-13 |
mouse |
| Pengyou Zhou, Boxuan Pu, Yang Liu, Xiaohong Zhang, Xiao Liu, Jingjing Bian, Xinru Wang, Shoufang Jian. [Effects of PM_(2. 5) exposure on synaptic plasticity and Wnt/β-catenin pathway in rat hippocampus]. Wei sheng yan jiu = Journal of hygiene research. vol 49. issue 3. 2020-08-26. PMID:32693900. |
5) exposure on synaptic plasticity and wnt/β-catenin pathway in rat hippocampus]. |
2020-08-26 |
2023-08-13 |
rat |
| Pengyou Zhou, Boxuan Pu, Yang Liu, Xiaohong Zhang, Xiao Liu, Jingjing Bian, Xinru Wang, Shoufang Jian. [Effects of PM_(2. 5) exposure on synaptic plasticity and Wnt/β-catenin pathway in rat hippocampus]. Wei sheng yan jiu = Journal of hygiene research. vol 49. issue 3. 2020-08-26. PMID:32693900. |
5) exposure on the development of synaptic plasticity and wnt/β-catenin pathway in hippocampus of offspring rats. |
2020-08-26 |
2023-08-13 |
rat |
| Zahra Gholamnezhad, Mohammad Hossien Boskabady, Zahra Jahangir. Exercise and Dementia. Advances in experimental medicine and biology. vol 1228. 2020-08-12. PMID:32342466. |
the main positive effects suggested for exercise are less cognitive and behavioral impairment or decline, development of health-associated conditions (stress, sleep), reduction of dementia risk factors including chronic non-communicable disease (diabetes, cardiovascular disease), increase in neurotrophins, enhancement of brain blood flow, angiogenesis, neurogenesis, synaptogenesis and synaptic plasticity in the brain memory-related region (e.g., hippocampus), and reduction of neuroinflammation and apoptosis. |
2020-08-12 |
2023-08-13 |
human |
| Paula Adler, Janice Mayne, Krystal Walker, Zhibin Ning, Daniel Figey. Therapeutic Targeting of Casein Kinase 1δ/ε in an Alzheimer's Disease Mouse Model. Journal of proteome research. vol 18. issue 9. 2020-08-11. PMID:31334659. |
mass spectrometry-based proteomic analyses revealed that pf-670462 administration in 3xtg-ad mice reversed hippocampal proteomic alterations in several ad-related and clock-regulated pathways, including synaptic plasticity and amyloid precursor protein processing. |
2020-08-11 |
2023-08-13 |
mouse |
| Ang Li, Suk-Yu Yau, Sergio Machado, Pingjie Wang, Ti-Fei Yuan, Kwok-Fai S. Enhancement of Hippocampal Plasticity by Physical Exercise as a Polypill for Stress and Depression: A Review. CNS & neurological disorders drug targets. vol 18. issue 4. 2020-08-05. PMID:30848219. |
here, we review recent discoveries on the potential mechanisms concerning how physical exercise mitigates the stressrelated depressive disorders, with a focus on the perspective of modulation on hippocampal neurogenesis, dendritic remodeling and synaptic plasticity. |
2020-08-05 |
2023-08-13 |
Not clear |
| Pengfei Xu, Xiaohao Zhang, Qian Liu, Yi Xie, Xiaolei Shi, Jingjing Chen, Yunzi Li, Hongquan Guo, Rui Sun, Ye Hong, Xinfeng Liu, Gelin X. Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke. Cell death & disease. vol 10. issue 8. 2020-08-03. PMID:31324751. |
moreover, blockade of trem-1 can potentiate cellular proliferation and synaptic plasticity in hippocampus, resulting in long-term functional improvement. |
2020-08-03 |
2023-08-13 |
Not clear |
| Yue Li, Minjie Shen, Michael E Stockton, Xinyu Zha. Hippocampal deficits in neurodevelopmental disorders. Neurobiology of learning and memory. vol 165. 2020-07-30. PMID:30321651. |
in addition, with its high levels of activity-dependent synaptic plasticity and lifelong neurogenesis, the hippocampus is sensitive to experience and exposure and susceptible to disease and injury. |
2020-07-30 |
2023-08-13 |
human |
| Hajime Hirase, Sonam Akther, Xiaowen Wang, Yuki O. Glycogen distribution in mouse hippocampus. Journal of neuroscience research. vol 97. issue 8. 2020-07-28. PMID:30675919. |
in the recent decade, glycogenolysis in the rodent hippocampus has been shown critical for synaptic plasticity and memory formation. |
2020-07-28 |
2023-08-13 |
mouse |
| Xiao-Ying Lin, Ying Cui, Lei Wang, Wen Che. Chronic exercise buffers the cognitive dysfunction and decreases the susceptibility to seizures in PTZ-treated rats. Epilepsy & behavior : E&B. vol 98. issue Pt A. 2020-07-27. PMID:31377659. |
the levels of synaptic-related proteins including psd95 (postsynaptic density 95), synapsin, glua1, and bdnf (brain-derived neurotrophic factor) were measured to evaluate the hippocampal synaptic plasticity. |
2020-07-27 |
2023-08-13 |
rat |
| Mingxing Li, Xuejiao Sun, Qian Li, Yong Li, Can Luo, Hailong Huang, Jing Chen, Chenzi Gong, Yajie Li, Yifeng Zheng, Song Zhang, Xiaolin Huang, Hong Che. Fucoidan exerts antidepressant-like effects in mice via regulating the stability of surface AMPARs. Biochemical and biophysical research communications. vol 521. issue 2. 2020-07-27. PMID:31668812. |
interestingly, chronic fucoidan administration not only dose-dependently reduced stress-induced depressive-like behaviors in the tst, fst, sucrose preference test (spt), and novelty-suppressed feeding test (nsft), but also alleviated the downregulation of brain-derived neurotrophic factor (bdnf)-dependent synaptic plasticity via inhibiting caspase-1-mediated inflammation in the hippocampus of mice. |
2020-07-27 |
2023-08-13 |
mouse |
| Mingxing Li, Xuejiao Sun, Qian Li, Yong Li, Can Luo, Hailong Huang, Jing Chen, Chenzi Gong, Yajie Li, Yifeng Zheng, Song Zhang, Xiaolin Huang, Hong Che. Fucoidan exerts antidepressant-like effects in mice via regulating the stability of surface AMPARs. Biochemical and biophysical research communications. vol 521. issue 2. 2020-07-27. PMID:31668812. |
moreover, fucoidan significantly ameliorated behavioral and synaptic plasticity abnormalities in the overexpression of caspase-1 in the hippocampus of mice. |
2020-07-27 |
2023-08-13 |
mouse |
| Xi Xiao, Xinxin Xu, Fangjuan Li, Guomin Xie, Tao Zhan. Anti-inflammatory treatment with β-asarone improves impairments in social interaction and cognition in MK-801 treated mice. Brain research bulletin. vol 150. 2020-07-24. PMID:31129169. |
moreover, β-asarone alleviated the impairments of hippocampal synaptic plasticity and enhanced the expression of hippocampal synaptophysin (syp) and postsynaptic density protein 95 (psd95) in mk-801-treated mice. |
2020-07-24 |
2023-08-13 |
mouse |
| Kaiyue Zeng, Ying Li, Wushuang Yang, Yunlong Ge, Lanxi Xu, Tong Ren, Huijun Zhang, Rengong Zhuo, Lu Peng, Caixia Chen, Yu Zhou, Yun Zhao, Wen Jun Li, Xin Jin, Lichao Yan. Moringa oleifera seed extract protects against brain damage in both the acute and delayed stages of ischemic stroke. Experimental gerontology. vol 122. 2020-07-23. PMID:31039389. |
the relevant mechanism of protection may occur by promoting hippocampal neurogenesis and synaptic plasticity as well as improving cholinergic function. |
2020-07-23 |
2023-08-13 |
mouse |
| Sergio R Zamudio, Luz A Pichardo-Macías, Verónica Díaz-Villegas, Itzel L Flores-Navarrete, Sonia Guzmán-Velázque. Subchronic cerebrolysin treatment alleviates cognitive impairments and dendritic arborization alterations of granular neurons in the hippocampal dentate gyrus of rats with temporal lobe epilepsy. Epilepsy & behavior : E&B. vol 97. 2020-07-23. PMID:31207446. |
in animal models of tle induced by pilocarpine, learning and memory deficiencies associated with changes in synaptic plasticity of the hippocampus have been reported. |
2020-07-23 |
2023-08-13 |
rat |