| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marta U Wołoszynowska-Fraser, Azita Kouchmeshky, Peter McCaffer. Vitamin A and Retinoic Acid in Cognition and Cognitive Disease. Annual review of nutrition. vol 40. 2021-09-17. PMID:32966186. |
controlled synthesis of ra is essential for regulating synaptic plasticity in regions of the brain involved in learning and memory, such as the hippocampus. |
2021-09-17 |
2023-08-13 |
Not clear |
| Shanbo Ma, Rui Zhang, Long Li, Hui Qu, Jin Wang, Qian Yang, Chao Guo, Shan Miao, Xiaopeng Sh. Xanthohumol protect cognitive performance in diabetic model rats by inhibiting protein kinase B/nuclear factor kappa-B pathway. Neuroreport. vol 32. issue 8. 2021-09-17. PMID:33913932. |
in further research, we found xn increased synaptic plasticity and dendritic spine density, while decreased reactive oxygen species in hippocampus slices from diabetic rats. |
2021-09-17 |
2023-08-13 |
rat |
| Isabel Espadas, Oscar Ortiz, Patricia García-Sanz, Adrián Sanz-Magro, Samuel Alberquilla, Oscar Solis, José María Delgado-García, Agnès Gruart, Rosario Moratall. Dopamine D2R is Required for Hippocampal-dependent Memory and Plasticity at the CA3-CA1 Synapse. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 4. 2021-09-16. PMID:33264389. |
similarly, deletion of d2r reduced the activity-dependent synaptic plasticity in the hippocampal ca1-ca3 synapse. |
2021-09-16 |
2023-08-13 |
mouse |
| Anne-Sophie Racine, François-Xavier Michon, Isabel Laplante, Jean-Claude Lacaill. Somatostatin contributes to long-term potentiation at excitatory synapses onto hippocampal somatostatinergic interneurons. Molecular brain. vol 14. issue 1. 2021-09-15. PMID:34429141. |
the neuropeptide somatostatin (sst) is also critical for hippocampal long-term synaptic plasticity, as well as learning and memory. |
2021-09-15 |
2023-08-13 |
mouse |
| Abdallah Ahnaou, Kobe Heleven, Ria Biermans, Nikolay V Manyakov, Wilhelmus H Drinkenbur. NMDARs Containing NR2B Subunit Do Not Contribute to the LTP Form of Hippocampal Plasticity: In Vivo Pharmacological Evidence in Rats. International journal of molecular sciences. vol 22. issue 16. 2021-09-15. PMID:34445376. |
this work confirms the role of nmdar in the ltp form of synaptic plasticity, whereas specific blockade of the nr2b subunit was not sufficient to modify hippocampal ltp. |
2021-09-15 |
2023-08-13 |
rat |
| Ivan Goussakov, Sylvia Synowiec, Daniil P Aksenov, Alexander Drobyshevsk. Occlusion of activity dependent synaptic plasticity by late hypoxic long term potentiation after neonatal intermittent hypoxia. Experimental neurology. vol 337. 2021-09-13. PMID:33358869. |
since prior studies in this model did not demonstrate increased cell death, our primary hypothesis was that ih causes a functional disruption of synaptic plasticity in hippocampal neurons. |
2021-09-13 |
2023-08-13 |
mouse |
| Tatyana Y Postnikova, Alexandra V Griflyuk, Dmitry V Amakhin, Anna A Kovalenko, Elena B Soboleva, Olga E Zubareva, Aleksey V Zaitse. Early Life Febrile Seizures Impair Hippocampal Synaptic Plasticity in Young Rats. International journal of molecular sciences. vol 22. issue 15. 2021-09-10. PMID:34360983. |
early life febrile seizures impair hippocampal synaptic plasticity in young rats. |
2021-09-10 |
2023-08-13 |
rat |
| Peiyun Yan, Zhancheng Xue, Dezhu Li, Saiqi Ni, Chuang Wang, Xinchun Jin, Dongsheng Zhou, Xingxing Li, Xin Zhao, Xiaowei Chen, Wei Cui, Dingli Xu, Wenhua Zhou, Junfang Zhan. Dysregulated CRTC1-BDNF signaling pathway in the hippocampus contributes to Aβ oligomer-induced long-term synaptic plasticity and memory impairment. Experimental neurology. vol 345. 2021-09-07. PMID:34274327. |
dysregulated crtc1-bdnf signaling pathway in the hippocampus contributes to aβ oligomer-induced long-term synaptic plasticity and memory impairment. |
2021-09-07 |
2023-08-13 |
rat |
| Katarzyna Głombik, Jan Detka, Bartosz Bobula, Joanna Bąk, Magdalena Kusek, Krzysztof Tokarski, Bogusława Budziszewsk. Contribution of Hypothyroidism to Cognitive Impairment and Hippocampal Synaptic Plasticity Regulation in an Animal Model of Depression. International journal of molecular sciences. vol 22. issue 4. 2021-09-06. PMID:33562494. |
contribution of hypothyroidism to cognitive impairment and hippocampal synaptic plasticity regulation in an animal model of depression. |
2021-09-06 |
2023-08-13 |
rat |
| Ji-Ren An, Jia-Nan Su, Gui-Yan Sun, Qing-Feng Wang, Ya-Dong Fan, Nan Jiang, Yu-Feng Yang, Yan Sh. Liraglutide Alleviates Cognitive Deficit in db/db Mice: Involvement in Oxidative Stress, Iron Overload, and Ferroptosis. Neurochemical research. 2021-09-04. PMID:34480710. |
lira can reduce oxidative stress, lipid peroxidation and iron overload in diabetic cognitive disorders and further inhibit ferroptosis, thereby weakening the damage to hippocampal neurons and synaptic plasticity and ultimately restoring cognitive function. |
2021-09-04 |
2023-08-13 |
mouse |
| Sachie Sasaki-Hamada, Ayumu Fujiwara, Show Satoh, Takashi Iwai, Jun-Ichiro Ok. GLP-2 restores impairments in spatial working memory and hippocampal LTD via the MEK/ERK pathway in juvenile-onset diabetes rats. Behavioural brain research. vol 406. 2021-09-02. PMID:33716118. |
we previously reported that juvenile-onset diabetes mellitus (jdm) rats, which were prepared by administering stz to 17-day-old rats, developed cognitive impairments and hippocampal synaptic plasticity deficiencies, which were restored by glucagon-like peptide-1 (glp-1). |
2021-09-02 |
2023-08-13 |
rat |
| Soomaayeh Heysieattalab, Jafar Doostmohammadi, Mahgol Darvishmolla, Negin Saeedi, Narges Hosseinmardi, Masoumeh Gholami, Mahyar Janahmadi, Samira Choopan. Non-selective COX inhibitors impair memory formation and short-term but not long-term synaptic plasticity. Naunyn-Schmiedeberg's archives of pharmacology. vol 394. issue 9. 2021-09-02. PMID:33937935. |
the present study was designed to investigate the effects of long-term low-dose (equivalent to prophylactic dose) and short-term high-dose (equivalent to analgesic dose) administration of asa and ss respectively, on spatial learning and memory and hippocampal synaptic plasticity. |
2021-09-02 |
2023-08-13 |
Not clear |
| Radu Gugustea, Renee J Tamming, Nicole Martin-Kenny, Nathalie G Bérubé, L Stan Leun. Inactivation of ATRX in forebrain excitatory neurons affects hippocampal synaptic plasticity. Hippocampus. vol 30. issue 6. 2021-09-01. PMID:31713968. |
inactivation of atrx in forebrain excitatory neurons affects hippocampal synaptic plasticity. |
2021-09-01 |
2023-08-13 |
mouse |
| Su-Youne Chang, Christopher DeVera, Zhihua Yang, Tao Yang, Lina Song, Arthur McDowell, Zhi-Gang Xiong, Roger Simon, An Zho. Hippocampal changes in mice lacking an active prohormone convertase 2. Hippocampus. vol 30. issue 7. 2021-09-01. PMID:32057164. |
taken together, our results suggest that pc2 is involved in regulating hippocampal synaptic plasticity, learning, and memory behaviors, as well as the hippocampal response to stresses originating in other regions of the brain. |
2021-09-01 |
2023-08-13 |
mouse |
| Maria Gomis-González, Lorena Galera-López, Marc Ten-Blanco, Arnau Busquets-Garcia, Thomas Cox, Rafael Maldonado, Andrés Ozait. Protein Kinase C-Gamma Knockout Mice Show Impaired Hippocampal Short-Term Memory While Preserved Long-Term Memory. Molecular neurobiology. vol 58. issue 2. 2021-09-01. PMID:32996086. |
within the different pkc isoforms, pkc-gamma has been specifically associated with learning and memory since mice lacking this isoform (pkc-gamma ko mice) showed mild cognitive impairment and deficits in hippocampal synaptic plasticity. |
2021-09-01 |
2023-08-13 |
mouse |
| Dan-Dan Tian, Min Wang, An Liu, Mei-Rong Gao, Chen Qiu, Wen Yu, Wen-Ju Wang, Kun Zhang, Le Yang, Yan-Yan Jia, Chang-Bin Yang, Yu-Mei W. Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway. Molecular neurobiology. vol 58. issue 2. 2021-09-01. PMID:33025508. |
here, we provide evidence that paeoniflorin (pf), a monoterpene glycoside compound derived from paeonia lactiflora, ameliorated reserpine-induced mouse depression-like behaviors, characterized as increased mobility time in tail suspension test and forced swimming test, as well as the abnormal alteration of synaptic plasticity in the depressive hippocampus. |
2021-09-01 |
2023-08-13 |
mouse |
| Jian Hu, Ce Li, Yan Hua, Peile Liu, Beiyao Gao, Yuyuan Wang, Yulong Ba. Constraint-induced movement therapy improves functional recovery after ischemic stroke and its impacts on synaptic plasticity in sensorimotor cortex and hippocampus. Brain research bulletin. vol 160. 2021-08-31. PMID:32298779. |
constraint-induced movement therapy improves functional recovery after ischemic stroke and its impacts on synaptic plasticity in sensorimotor cortex and hippocampus. |
2021-08-31 |
2023-08-13 |
human |
| N M Weston, A T Rolfe, A H Freelin, T M Reeves, D Su. Traumatic brain injury modifies synaptic plasticity in newly-generated granule cells of the adult hippocampus. Experimental neurology. vol 336. 2021-08-30. PMID:33188818. |
traumatic brain injury modifies synaptic plasticity in newly-generated granule cells of the adult hippocampus. |
2021-08-30 |
2023-08-13 |
rat |
| Katherine E Squires, Kyle J Gerber, Matthew C Tillman, Daniel J Lustberg, Carolina Montañez-Miranda, Meilan Zhao, Suneela Ramineni, Christopher D Scharer, Ramendra N Saha, Feng-Jue Shu, Jason P Schroeder, Eric A Ortlund, David Weinshenker, Serena M Dudek, John R Heple. Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons. The Journal of biological chemistry. vol 296. 2021-08-27. PMID:33410399. |
rgs14 is a multifunctional signaling protein that suppresses synaptic plasticity in dendritic spines of hippocampal neurons. |
2021-08-27 |
2023-08-13 |
mouse |
| Katherine E Squires, Kyle J Gerber, Matthew C Tillman, Daniel J Lustberg, Carolina Montañez-Miranda, Meilan Zhao, Suneela Ramineni, Christopher D Scharer, Ramendra N Saha, Feng-Jue Shu, Jason P Schroeder, Eric A Ortlund, David Weinshenker, Serena M Dudek, John R Heple. Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons. The Journal of biological chemistry. vol 296. 2021-08-27. PMID:33410399. |
when introduced into mice by crispr/cas9, rgs14-lr protein expression was detected predominantly in the nuclei of neurons within hippocampus, central amygdala, piriform cortex, and striatum, brain regions associated with learning and synaptic plasticity. |
2021-08-27 |
2023-08-13 |
mouse |