| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fernando Gomez-Pinilla, Natosha M Mercad. How to boost the effects of exercise to favor traumatic brain injury outcome. Sports medicine and health science. vol 4. issue 3. 2022-09-12. PMID:36090919. |
exercise influences dha function by normalizing dha content in the brain, such that the collaborative action of exercise and dha can be instrumental to boost bdnf function with strong therapeutic potential for reducing the deleterious effects of tbi on synaptic plasticity and cognition. |
2022-09-12 |
2023-08-14 |
Not clear |
| Keith H Nuechterlein, Sarah C McEwen, Joseph Ventura, Kenneth L Subotnik, Luana R Turner, Michael Boucher, Laurie R Casaus, Margaret G Distler, Jacqueline N Hayat. Aerobic exercise enhances cognitive training effects in first-episode schizophrenia: randomized clinical trial demonstrates cognitive and functional gains. Psychological medicine. 2022-09-01. PMID:36047035. |
aerobic exercise is hypothesized to increase brain-derived neurotrophic factor (bdnf) and thereby synaptic plasticity, leading to increased learning capacity. |
2022-09-01 |
2023-08-14 |
Not clear |
| Ignacio L Ibarra, Vikram S Ratnu, Lucia Gordillo, In-Young Hwang, Luca Mariani, Kathryn Weinand, Henrik M Hammarén, Jennifer Heck, Martha L Bulyk, Mikhail M Savitski, Judith B Zaugg, Kyung-Min No. Comparative chromatin accessibility upon BDNF stimulation delineates neuronal regulatory elements. Molecular systems biology. vol 18. issue 8. 2022-08-23. PMID:35996956. |
neuronal stimulation induced by the brain-derived neurotrophic factor (bdnf) triggers gene expression, which is crucial for neuronal survival, differentiation, synaptic plasticity, memory formation, and neurocognitive health. |
2022-08-23 |
2023-08-14 |
mouse |
| Ishitha Reddy, Yamini Yadav, Chinmoy Sankar De. Cellular and Molecular Regulation of Exercise-A Neuronal Perspective. Cellular and molecular neurobiology. 2022-08-20. PMID:35986789. |
exerkines such as fndc5/irisin, cathepsin b, adiponectin, and il-6 circulate through the bloodstream, cross the blood-brain barrier, and modulate the expression of important signaling molecules such as ampk, sirt1, pgc1α, bdnf, igf-1, and vegf which further contribute to improved energy metabolism, glucose homeostasis, insulin sensitivity, neurogenesis, synaptic plasticity, and overall well-being of the body and brain. |
2022-08-20 |
2023-08-14 |
Not clear |
| Ying Xing, Yuqian Zhang, Congqin Li, Lu Luo, Yan Hua, Jian Hu, Yulong Ba. Repetitive Transcranial Magnetic Stimulation of the Brain After Ischemic Stroke: Mechanisms from Animal Models. Cellular and molecular neurobiology. 2022-08-02. PMID:35917043. |
rtms can prompt synaptic plasticity by increasing nmdar, ampar and bdnf expression; rtms can inhibit pro-inflammatory cytokines tnf and facilitate the expression of anti-inflammatory cytokines il-10 by shifting astrocytic phenotypes from a1 to a2, and shifting microglial phenotypes from m1 to m2; rtms facilitated the release of angiogenesis-related factors tgfβ and vegf in a2 astrocytes, which can contribute to vasculogenesis and angiogenesis; rtms can suppress apoptosis by increasing bcl-2 expression and inhibiting bax, caspase-3 expression; rtms can also suppress pyroptosis by decreasing caspase-1, il-1β, asc, gsdmd and nlrp1 expression. |
2022-08-02 |
2023-08-14 |
Not clear |
| Medhat Taha, Sara T Elazab, Alaa M Badawy, Abdullah A Saati, Naeem F Qusty, Abdullah G Al-Kushi, Anas Sarhan, Amira Osman, Amira E Farag. Activation of SIRT-1 Pathway by Nanoceria Sheds Light on Its Ameliorative Effect on Doxorubicin-Induced Cognitive Impairment (Chemobrain): Restraining Its Neuroinflammation, Synaptic Dysplasticity and Apoptosis. Pharmaceuticals (Basel, Switzerland). vol 15. issue 8. 2022-07-27. PMID:35893742. |
cenps improved synaptic plasticity via acting on the bdnf. |
2022-07-27 |
2023-08-14 |
rat |
| Kornrawee Suwannakot, Nataya Sritawan, Salinee Naewla, Anusara Aranarochana, Apiwat Sirichoat, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welba. Melatonin Attenuates Methotrexate-Induced Reduction of Antioxidant Activity Related to Decreases of Neurogenesis in Adult Rat Hippocampus and Prefrontal Cortex. Oxidative medicine and cellular longevity. vol 2022. 2022-07-25. PMID:35873801. |
in the melatonin+mtx group, the protein expression results showed that melatonin treatment significantly upregulated synaptic plasticity and an immature neuron marker through enhancing brain derived neurotrophic factor (bdnf) and doublecortin (dcx), respectively. |
2022-07-25 |
2023-08-14 |
rat |
| Gunnar Nordvall, Pontus Forsell, Johan Sandi. Neurotrophin-targeted therapeutics: a gateway to cognition and more? Drug discovery today. 2022-07-19. PMID:35850433. |
neurotrophins, such as brain-derived neurotrophic factor (bdnf) and neural growth factor (ngf), are small proteins expressed in the brain and peripheral tissues, which regulate several aspects of neuronal function, including not only neurogenesis, synaptic plasticity, neuroprotection but also programmed cell death. |
2022-07-19 |
2023-08-14 |
Not clear |
| Diego Incontri-Abraham, Felipe J Esparza-Salazar, Antonio Ibarr. Copolymer-1 as a potential therapy for mild cognitive impairment. Brain and cognition. vol 162. 2022-07-16. PMID:35841771. |
therefore, cop-1 immunization might promote synaptic plasticity and memory consolidation by increasing bdnf production in patients with mci. |
2022-07-16 |
2023-08-14 |
Not clear |
| Ruike Wang, Mingzhi Yang, Yingying Wu, Rundong Liu, Mengchen Liu, Qiong Li, Xiao Su, Yongjuan Xin, Wenqian Huo, Qihong Deng, Yue Ba, Hui Huan. SIRT1 modifies DNA methylation linked to synaptic deficits induced by Pb in vitro and in vivo. International journal of biological macromolecules. 2022-07-15. PMID:35839949. |
in vivo results demonstrated that pb exposure increased the expression of dnmts, mecp2, pp1 and cleaved caspase3, decreased the expression of sirt1, bdnf and relin and altered dna methylation levels of synaptic plasticity genes. |
2022-07-15 |
2023-08-14 |
rat |
| Riley A Williams, Kenneth W Johnson, Francis S Lee, Hugh C Hemmings, Jimcy Plathol. A Common Human Brain-Derived Neurotrophic Factor Polymorphism Leads to Prolonged Depression of Excitatory Synaptic Transmission by Isoflurane in Hippocampal Cultures. Frontiers in molecular neuroscience. vol 15. 2022-07-11. PMID:35813074. |
here, we show that brain-derived neurotrophic factor (bdnf), a growth factor implicated in synaptic plasticity and dysfunction, enhances glutamate synaptic vesicle exocytosis, and that attenuation of vesicular bdnf release by isoflurane contributes to transient depression of excitatory synaptic transmission in mice. |
2022-07-11 |
2023-08-14 |
mouse |
| T N Dong, E A Kramár, J H Beardwood, A Al-Shammari, M A Wood, A A Keise. Temporal endurance of exercise-induced benefits on hippocampus-dependent memory and synaptic plasticity in female mice. Neurobiology of learning and memory. 2022-07-10. PMID:35811066. |
previous studies have proposed exercise-induced bdnf upregulation as the mechanism underlying exercise-mediated benefits on synaptic plasticity and cognition. |
2022-07-10 |
2023-08-14 |
mouse |
| Laura Boi, Sabrina Petralla, Barbara Monti, Giuseppe Talani, Enrico Sanna, Maria Giuseppina Pisu, Giulia Calderisi, Elisabetta Maciocco, Mariangela Serra, Alessandra Concas, Patrizia Porc. Chronic treatment with hormonal contraceptives alters hippocampal BDNF and histone H3 post-translational modifications but not learning and memory in female rats. Hormones and behavior. vol 144. 2022-07-05. PMID:35785712. |
thus, decreased bdnf content does not affect synaptic plasticity and cognitive performance; rather it might be relevant for the occurrence of certain psychiatric symptoms, reported by some women using hormonal contraceptives. |
2022-07-05 |
2023-08-14 |
rat |
| Khairunnuur Fairuz Azman, Rahimah Zakari. Recent Advances on the Role of Brain-Derived Neurotrophic Factor (BDNF) in Neurodegenerative Diseases. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35743271. |
the signaling cascades initiated by bdnf and its receptor are the key regulators of synaptic plasticity, which plays important role in learning and memory formation. |
2022-06-24 |
2023-08-14 |
Not clear |
| Chuanwang Tong, Senyang Ca. Study on the mechanism of visual aging in cats' primary visual cortex based on BDNF-TrkB signal pathway. Scientific reports. vol 12. issue 1. 2022-06-22. PMID:35732706. |
to explore the expression of brain-derived neurotrophic factor (bdnf) and specific receptor tyrosine kinase receptor b (trkb) in the primary visual cortex of young and old cats, especially to reveal the age-related differences in the mediating mechanism of bdnf-trkb signaling pathway in cats' visual cortex and their possible effects on synaptic plasticity, nissl staining was used to display neurons in each layer of cats' primary visual cortex, and immunohistochemical abc method was used to label bdnf and trkb immunopositive cells in each layer of cats' primary visual cortex. |
2022-06-22 |
2023-08-14 |
Not clear |
| Beatriz Gutiérrez-Vera, Alejandro Rivera-Olvera, Martha L Escoba. ENVIRONMENTAL ENRICHMENT ATTENUATES CONDITIONED TASTE AVERSION THROUGH THE RESTORATION OF BDNF LEVELS IN THE INSULAR CORTEX. Behavioural brain research. 2022-06-01. PMID:35644274. |
these changes are known to be related to increased levels of some trophic factors, such as brain-derived neurotrophic factor (bdnf), which has been considered a regulatory protein for synaptic plasticity in the adult brain. |
2022-06-01 |
2023-08-13 |
rat |
| Roberto Bonanni, Ida Cariati, Umberto Tarantino, Giovanna D'Arcangelo, Virginia Tancred. Physical Exercise and Health: A Focus on Its Protective Role in Neurodegenerative Diseases. Journal of functional morphology and kinesiology. vol 7. issue 2. 2022-06-01. PMID:35645300. |
in this regard, neurotrophins, such as brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), glia cell line-derived neurotrophic factor (gdnf), neurotrophin-3 (nt-3), and neurotrophin-4 (nt-4), have been suggested as key mediators of brain health benefits, as they are involved in neurogenesis, neuronal survival, and synaptic plasticity. |
2022-06-01 |
2023-08-13 |
Not clear |
| Abdallah Mohammad Ibrahim, Lalita Chauhan, Aditi Bhardwaj, Anjali Sharma, Faizana Fayaz, Bhumika Kumar, Mohamed Alhashmi, Noora AlHajri, Md Sabir Alam, Faheem Hyder Potto. Brain-Derived Neurotropic Factor in Neurodegenerative Disorders. Biomedicines. vol 10. issue 5. 2022-05-28. PMID:35625880. |
moreover, bdnf has several important roles, such as improving synaptic plasticity and contributing to long-lasting memory formation. |
2022-05-28 |
2023-08-13 |
Not clear |
| Guoli Wang, Tianyue An, Cong Lei, Xiaofeng Zhu, Li Yang, Lianxue Zhang, Ronghua Zhan. Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134-mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression. Journal of ginseng research. vol 46. issue 3. 2022-05-23. PMID:35600767. |
antidepressant-like effect of ginsenoside rb1 on potentiating synaptic plasticity via the mir-134-mediated bdnf signaling pathway in a mouse model of chronic stress-induced depression. |
2022-05-23 |
2023-08-13 |
mouse |
| Maria M Ekblom, E Bojsen-Møller, V Blom, O Tarassova, M Moberg, M Pontén, R Wang, O Ekblo. Acute effects of physical activity patterns on plasma cortisol and brain-derived neurotrophic factor in relation to corticospinal excitability. Behavioural brain research. 2022-05-14. PMID:35568076. |
brain-derived neurotrophic factor (bdnf) and cortisol are both capable of modulating synaptic plasticity, but it is unknown how physical activity-induced changes in their plasma levels relate to corticospinal plasticity in humans. |
2022-05-14 |
2023-08-13 |
Not clear |