| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ronald S Duman, Satoshi Deyama, Manoela Viar Fogaç. Role of BDNF in the pathophysiology and treatment of depression: Activity-dependent effects distinguish rapid-acting antidepressants. The European journal of neuroscience. vol 53. issue 1. 2021-06-28. PMID:31811669. |
the role of neurotrophic factors, particularly brain-derived neurotrophic factor (bdnf), has been of particular interest as these factors play a key role in activity-dependent regulation of synaptic plasticity. |
2021-06-28 |
2023-08-13 |
Not clear |
| Chiara Lanzillotta, Antonella Tramutola, Graziella Di Giacomo, Federico Marini, D Allan Butterfield, Fabio Di Domenico, Marzia Perluigi, Eugenio Baron. Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: A harmful synergistic path in down syndrome. Free radical biology & medicine. vol 165. 2021-06-28. PMID:33516914. |
furthermore, we analyzed whether changes of brain insulin signaling were associated with alterations of: (i) proteins regulating brain energy metabolism (mitochondrial complexes, hexokinase-ii, sirt1); (ii) oxidative stress (os) markers (iii) app cleavage; and (iv) proteins mediating synaptic plasticity mechanisms (psd95, syntaxin-1 and bdnf). |
2021-06-28 |
2023-08-13 |
mouse |
| Thomas Andreska, Patrick Lüningschrör, Michael Sendtne. Regulation of TrkB cell surface expression-a mechanism for modulation of neuronal responsiveness to brain-derived neurotrophic factor. Cell and tissue research. vol 382. issue 1. 2021-06-23. PMID:32556728. |
this process can occur in very short time periods and the resulting rapid modulation of target cell sensitivity to bdnf could represent a mechanism for fine-tuning of synaptic plasticity and communication in complex neuronal networks. |
2021-06-23 |
2023-08-13 |
Not clear |
| Susanne Meis, Thomas Endres, Volkmar Lessman. Neurotrophin signalling in amygdala-dependent cued fear learning. Cell and tissue research. vol 382. issue 1. 2021-06-23. PMID:32845430. |
the neurotrophin brain-derived neurotrophic factor (bdnf) is known to regulate synaptic plasticity and memory formation in many areas of the mammalian brain including the amygdala, where bdnf signalling via tropomyosin-related kinase b (trkb) receptors is prominently involved in fear learning. |
2021-06-23 |
2023-08-13 |
Not clear |
| Wu Zhou, Zhiping Xie, Chengcai Li, Zelong Xing, Shenke Xie, Meihua Li, Jianguo Ya. Driving effect of BDNF in the spinal dorsal horn on neuropathic pain. Neuroscience letters. vol 756. 2021-06-22. PMID:34022262. |
bdnf is an important regulator of neuronal development, synaptic transmission, and cellular and synaptic plasticity, which are essential for nerve maintenance and repair. |
2021-06-22 |
2023-08-13 |
Not clear |
| Tadahiro Numakawa, Haruki Odak. Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer's Disease: Beneficial Effects of Flavonoids for Neuroprotection. International journal of molecular sciences. vol 22. issue 11. 2021-06-22. PMID:34071978. |
the function of the brain-derived neurotrophic factor (bdnf) via activation through its high-affinity receptor tropomyosin receptor kinase b (trkb) has a pivotal role in cell differentiation, cell survival, synaptic plasticity, and both embryonic and adult neurogenesis in central nervous system neurons. |
2021-06-22 |
2023-08-13 |
Not clear |
| Erin Wosnitzka, Xinsheng Nan, Jeff Nan, Pedro Chacón-Fernández, Lothar Kussmaul, Michael Schuler, Bastian Hengerer, Yves-Alain Bard. A New Mouse Line Reporting the Translation of Brain-Derived Neurotrophic Factor Using Green Fluorescent Protein. eNeuro. vol 7. issue 1. 2021-06-18. PMID:31882533. |
while bdnf is receiving considerable attention for its role in synaptic plasticity and in nervous system dysfunction, identifying brain circuits involving bdnf-expressing neurons has been challenging. |
2021-06-18 |
2023-08-13 |
mouse |
| Muhammad Asim, Bing Wang, Bo Hao, Xiaoguang Wan. Ketamine for post-traumatic stress disorders and it's possible therapeutic mechanism. Neurochemistry international. vol 146. 2021-06-18. PMID:33862176. |
ketamine seems to have an inimitable mechanism of action entailing glutamate modulation via actions at the n-methyl-d-aspartate (nmda) and α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa) receptors, as well as downstream activation of brain-derived neurotrophic factor (bdnf) and mechanistic target of rapamycin (mtor) signaling pathways to potentiate synaptic plasticity. |
2021-06-18 |
2023-08-13 |
Not clear |
| b' Jessica Le Blanc, Samuel Fleury, Imane Boukhatem, Jean-Christophe B\\xc3\\xa9langer, M\\xc3\\xa9lanie Welman, Marie Lordkipanidz\\xc3\\xa. Platelets Selectively Regulate the Release of BDNF, But Not That of Its Precursor Protein, proBDNF. Frontiers in immunology. vol 11. 2021-06-14. PMID:33324399.' |
brain-derived neurotrophic factor (bdnf) plays a role in synaptic plasticity and neuroprotection. |
2021-06-14 |
2023-08-13 |
human |
| Daniela Moutinho, Sónia Veiga, Jesús R Requen. Human VGF-Derived Antidepressant Neuropeptide TLQP62 Promotes SH-SY5Y Neurite Outgrowth. Journal of molecular neuroscience : MN. vol 70. issue 8. 2021-05-25. PMID:32458204. |
tlqp62 is a neuropeptide derived from the neurotrophin-inducible vgf (non-acronymic) protein with antidepressant-like properties capable of inducing increased memory on the mouse hippocampus by promoting neurogenesis and synaptic plasticity through brain-derived neurotropic factor (bdnf) and its receptor tyrosine receptor kinase b (trkb). |
2021-05-25 |
2023-08-13 |
mouse |
| Hoda Nikookar, Mohammad Haddadi, Mehrnaz Haghi, Raheleh Masoud. DNT1 Downregulation and Increased Ethanol Sensitivity in Transgenic Drosophila Models of Alzheimer's Disease. Archives of gerontology and geriatrics. vol 94. 2021-05-18. PMID:33550108. |
loss of synaptic plasticity and cognitive decline, partly due to decrease in brain derived neurotrophic factor (bdnf), are other hallmarks of ad. |
2021-05-18 |
2023-08-13 |
drosophila_melanogaster |
| Marta Méndez-Couz, Beate Krenzek, Denise Manahan-Vaugha. Genetic Depletion of BDNF Impairs Extinction Learning of a Spatial Appetitive Task in the Presence or Absence of the Acquisition Context. Frontiers in behavioral neuroscience. vol 15. 2021-05-18. PMID:33994970. |
for example, bdnf has been associated with synaptic plasticity needed for spatial learning, and it is involved in acquisition and extinction learning of fear conditioning. |
2021-05-18 |
2023-08-13 |
Not clear |
| Mohammad Abbas Sheikholeslami, Shiva Ghafghazi, Ramin Pouriran, Seyed Erfan Mortazavi, Siavash Parvarde. Attenuating effect of paroxetine on memory impairment following cerebral ischemia-reperfusion injury in rat: The involvement of BDNF and antioxidant capacity. European journal of pharmacology. vol 893. 2021-05-17. PMID:33347827. |
oxidative/nitrosative stress, synaptic plasticity, and brain-derived neurotrophic factor (bdnf) are involved in the physiopathology of brain ischemia-induced memory disorders. |
2021-05-17 |
2023-08-13 |
rat |
| Mohammad Abbas Sheikholeslami, Shiva Ghafghazi, Ramin Pouriran, Seyed Erfan Mortazavi, Siavash Parvarde. Attenuating effect of paroxetine on memory impairment following cerebral ischemia-reperfusion injury in rat: The involvement of BDNF and antioxidant capacity. European journal of pharmacology. vol 893. 2021-05-17. PMID:33347827. |
it was ultimately attained that paroxetine attenuates cerebral ischemia-induced passive avoidance memory dysfunction in rats by the enhancement of hippocampal synaptic plasticity and bdnf content together with the suppression of oxidative/nitrosative stress. |
2021-05-17 |
2023-08-13 |
rat |
| New Fei Ho, Jordon Xin Jie Tng, Mingyuan Wang, Guoyang Chen, Vigneshwaran Subbaraju, Suhailah Shukor, Desiree Si Xian Ng, Bhing-Leet Tan, Shu Juan Puang, Sok-Hong Kho, Rachel Wan En Siew, Gwen Li Sin, Pui Wai Eu, Juan Zhou, Judy Chia Ghee Sng, Kang Sim, Alice Medali. Plasticity of DNA methylation, functional brain connectivity and efficiency in cognitive remediation for schizophrenia. Journal of psychiatric research. vol 126. 2021-05-14. PMID:32317108. |
outcome measures included dna methylation of genes central to synaptic plasticity (cpg sites of reelin promoter and bdnf promoter) from buccal swabs, resting-state functional brain connectivity and topological network efficiency, and global scores of a cognitive battery from 35 inpatients in a rehabilitative ward (18 cr, 17 non-cr) with similar premorbid iq to 15 healthy controls. |
2021-05-14 |
2023-08-13 |
Not clear |
| Alessandro Minutillo, Gabriele Panza, Massimo Carlo Maur. Musical practice and BDNF plasma levels as a potential marker of synaptic plasticity: an instrument of rehabilitative processes. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 42. issue 5. 2021-05-14. PMID:32940801. |
musical practice and bdnf plasma levels as a potential marker of synaptic plasticity: an instrument of rehabilitative processes. |
2021-05-14 |
2023-08-13 |
Not clear |
| Qi He, Zhenyu Li, Tiegang Li, Zhiqian Zhang, Jing Zha. ATP Stimulation Promotes Functional Recovery after Intracerebral Haemorrhage by Increasing the mBDNF/proBDNF Ratio. Neuroscience. vol 459. 2021-05-14. PMID:33421569. |
brain-derived neurotrophic factor (bdnf), including mature bdnf (mbdnf) and precursor bdnf (probdnf), plays a pivotal role in neuronal survival, synaptic plasticity and neurogenesis. |
2021-05-14 |
2023-08-13 |
rat |
| Sajjad Rezaei, Karim Asgari Mobarake, Alia Saber. BDNF (rs6265) Val < Met polymorphism can buffer cognitive functions against post stroke CT/MRI pathological findings. Applied neuropsychology. Adult. 2021-05-10. PMID:33073590. |
although previous studies have emphasized that bdnf val66met polymorphism had a substantial role in neurogenesis and synaptic plasticity, it remains unclear to what extent an interaction may be appeared between neuroimaging findings and val66met variants on different cognitive functions following stroke. |
2021-05-10 |
2023-08-13 |
Not clear |
| Punita Kumari, Meetu Wadhwa, Garima Chauhan, Shahnawaz Alam, Koustav Roy, Prabhash Kumar Jha, Krishna Kishore, Koushik Ray, Sanjeev Kumar, Tapas Chandra Nag, Usha Panjwan. Hypobaric hypoxia induced fear and extinction memory impairment and effect of Ginkgo biloba in its amelioration: Behavioral, neurochemical and molecular correlates. Behavioural brain research. vol 387. 2021-05-05. PMID:32194184. |
decline in mrna expression level of synaptic plasticity genes and immunoreactivity of bdnf, synaptophysin, psd95, spinophilin was observed following hh exposure. |
2021-05-05 |
2023-08-13 |
rat |
| Marie Woelfer, Meng Li, Lejla Colic, Thomas Liebe, Xin Di, Bharat Biswal, James Murrough, Volkmar Lessmann, Tanja Brigadski, Martin Walte. Ketamine-induced changes in plasma brain-derived neurotrophic factor (BDNF) levels are associated with the resting-state functional connectivity of the prefrontal cortex. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 21. issue 9. 2021-04-27. PMID:31680600. |
synaptic plasticity and brain-derived neurotrophic factor (bdnf) signalling are proposed to play key roles in antidepressant drug action. |
2021-04-27 |
2023-08-13 |
Not clear |