| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Reza Sardar, Zahra Zandieh, Zeinab Namjoo, Mansoureh Soleimani, Reza Shirazi, Javad Ham. Laterality and sex differences in the expression of brain-derived neurotrophic factor in developing rat hippocampus. Metabolic brain disease. vol 36. issue 1. 2021-10-07. PMID:32975719. |
brain-derived neurotrophic factor (bdnf), as a member of neurotrophin family, plays an important role in neurogenesis, neuronal survival and synaptic plasticity. |
2021-10-07 |
2023-08-13 |
rat |
| Júnia L de Deus, Mateus R Amorim, Aline B Ribeiro, Procópio C G Barcellos-Filho, César C Ceballos, Luiz Guilherme S Branco, Alexandra O S Cunha, Ricardo M Leã. Loss of Brain-Derived Neurotrophic Factor Mediates Inhibition of Hippocampal Long-Term Potentiation by High-Intensity Sound. Cellular and molecular neurobiology. vol 41. issue 4. 2021-10-06. PMID:32445041. |
although sound stimulation did not affect glutamatergic or gabaergic neurotransmission in ca1, it did depress the level of brain-derived neurotrophic factor (bdnf), which is involved in promoting hippocampal synaptic plasticity. |
2021-10-06 |
2023-08-13 |
rat |
| Blanca Marin Bosch, Aurélien Bringard, Maria G Logrieco, Estelle Lauer, Nathalie Imobersteg, Aurélien Thomas, Guido Ferretti, Sophie Schwartz, Kinga Iglo. A single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men. Scientific reports. vol 11. issue 1. 2021-10-04. PMID:34257382. |
regular physical exercise enhances memory functions, synaptic plasticity in the hippocampus, and brain derived neurotrophic factor (bdnf) levels. |
2021-10-04 |
2023-08-13 |
human |
| Tobias E Karlsson, Katrin Wellfelt, Lars Olso. Spatiotemporal and Long Lasting Modulation of 11 Key Nogo Signaling Genes in Response to Strong Neuroexcitation. Frontiers in molecular neuroscience. vol 10. 2021-09-24. PMID:28442990. |
a temporo-spatial pattern of orderly transcriptional regulations emerges that strengthens the role of nogo-signaling mechanisms for synaptic plasticity in synchrony with transcriptional increases of bdnf mrna. |
2021-09-24 |
2023-08-13 |
Not clear |
| Patricia M Horvath, Natali L Chanaday, Baris Alten, Ege T Kavalali, Lisa M Monteggi. A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength. Cell reports. vol 36. issue 5. 2021-08-19. PMID:34348149. |
here, we study the effects of the balance between inhibitory and excitatory spontaneous neurotransmission on brain-derived neurotrophic factor (bdnf) regulation and synaptic plasticity. |
2021-08-19 |
2023-08-13 |
Not clear |
| Silvia Martinelli, Elmira A Anderzhanova, Thomas Bajaj, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Daniel E Heinz, Tim Ebert, Jakob Hartmann, Thomas M Geiger, Michael Döngi, Kathrin Hafner, Max L Pöhlmann, Lee Jollans, Alexandra Philipsen, Susanne V Schmidt, Ulrike Schmidt, Giuseppina Maccarrone, Valentin Stein, Felix Hausch, Christoph W Turck, Mathias V Schmidt, Anne-Kathrin Gellner, Bernhard Kuster, Nils C Gasse. Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion. Nature communications. vol 12. issue 1. 2021-08-17. PMID:34330919. |
bdnf is essential for adult synaptic plasticity and its pathway is associated with major depression and posttraumatic stress disorder. |
2021-08-17 |
2023-08-13 |
Not clear |
| Samuel Kohtala, Tomi Rantamäk. Rapid-acting antidepressants and the regulation of TrkB neurotrophic signalling-Insights from ketamine, nitrous oxide, seizures and anaesthesia. Basic & clinical pharmacology & toxicology. vol 129. issue 2. 2021-08-12. PMID:33973360. |
activation of bdnf (brain-derived neurotrophic factor) receptor trkb is considered a key molecular event for antidepressant-induced functional and structural synaptic plasticity. |
2021-08-12 |
2023-08-13 |
Not clear |
| Dany Khamsing, Solène Lebrun, Isabelle Fanget, Nathanaël Larochette, Christophe Tourain, Vincent de Sars, Maia Brunstein, Martin Oheim, Damien Carrel, François Darchen, Claire Desno. A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity. Molecular brain. vol 14. issue 1. 2021-08-12. PMID:34247625. |
the data demonstrate that two important triggers of synaptic plasticity, bdnf and nmda receptors, synergistically power the two arms of the mtorc1 activation mechanism, i.e., mtorc1 translocation to les and rheb activation. |
2021-08-12 |
2023-08-13 |
mouse |
| Sule Şule Deveci, Zeliha Matur, Yesim Yeşim Kesim, Gokce Gökçe Senturk Şentürk, Gulcan Gülcan Sargın-Kurt, Sibel Aylin Ugur Uğur, Ali Emre Oge Ög. Effect of the brain-derived neurotrophic factor gene Val66Met polymorphism on sensory-motor integration during a complex motor learning exercise. Brain research. vol 1732. 2021-07-27. PMID:31926908. |
the brain-derived neurotrophic factor (bdnf) gene val66met polymorphism may cause impairment in short-term motor learning by reducing activity-dependent bdnf expression, which causes alterations in synaptic plasticity by changing glutamatergic and gabaergic synaptic transmissions. |
2021-07-27 |
2023-08-13 |
human |
| Xiao-Chen Yu, Zhen Li, Xin-Ran Liu, Jia-Ni Hu, Rui Liu, Na Zhu, Yong L. The Antioxidant Effects of Whey Protein Peptide on Learning and Memory Improvement in Aging Mice Models. Nutrients. vol 13. issue 6. 2021-07-23. PMID:34205338. |
its specific mechanism may be related to reducing the degeneration of hippocampal nerve cells, reducing the apoptosis of nerve cells, improving the activity of ache, reducing the expression of inflammatory factors (tnf-α and il-1β) in brain tissue, reducing oxidative stress injury, and improving the expression of p-camkⅡ and bdnf synaptic plasticity protein. |
2021-07-23 |
2023-08-13 |
mouse |
| Yoonju Kim, Youn-Jung Ki. Effect of Obesity on Cognitive Impairment in Vascular Dementia Rat Model via BDNF-ERK-CREB Pathway. Biological research for nursing. vol 23. issue 2. 2021-07-21. PMID:32844660. |
in the present study, we evaluated whether obesity exacerbates cognitive impairment in vascular dementia rats and how it affects synaptic plasticity through the bdnf pathway. |
2021-07-21 |
2023-08-13 |
rat |
| Matthew G Pontifex, Anneloes Martinsen, Rasha Noureldin M Saleh, Glenn Harden, Noemi Tejera, Michael Müller, Chris Fox, David Vauzour, Anne-Marie Minihan. APOE4 genotype exacerbates the impact of menopause on cognition and synaptic plasticity in APOE-TR mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 5. 2021-07-19. PMID:33891334. |
molecular analysis indicated both vcd and genotype-related deficits in synaptic plasticity with bdnf, akt, mtor, and erk signaling compromised. |
2021-07-19 |
2023-08-13 |
mouse |
| Hideyuki Matsumoto, Yoshikazu Ugaw. Quadripulse stimulation (QPS). Experimental brain research. vol 238. issue 7-8. 2021-06-29. PMID:32211927. |
in this mini-review, we briefly introduce qps: (i) principle and cortical plasticity (stimulators and protocols, synaptic plasticity, underlying mechanisms, meta-plasticity, axonal plasticity, and drug effects), (ii) robust and strong neural plasticity induction (variability, influence of phasic muscle contraction, independency of bdnf polymorphism, sensory cortical plasticity, neural plasticity in the contralateral hemisphere, on-line effects on the brain networks, studies of normal brain physiology, and visuomotor sequence learning), (iii) therapeutic applications to neurological and psychiatric disorders (parkinson's disease, epilepsy, cerebrovascular disease, and major depression), (iv) safety, and (v) future issues. |
2021-06-29 |
2023-08-13 |
Not clear |
| Ronald S Duman, Satoshi Deyama, Manoela Viar Fogaç. Role of BDNF in the pathophysiology and treatment of depression: Activity-dependent effects distinguish rapid-acting antidepressants. The European journal of neuroscience. vol 53. issue 1. 2021-06-28. PMID:31811669. |
the role of neurotrophic factors, particularly brain-derived neurotrophic factor (bdnf), has been of particular interest as these factors play a key role in activity-dependent regulation of synaptic plasticity. |
2021-06-28 |
2023-08-13 |
Not clear |
| Chiara Lanzillotta, Antonella Tramutola, Graziella Di Giacomo, Federico Marini, D Allan Butterfield, Fabio Di Domenico, Marzia Perluigi, Eugenio Baron. Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: A harmful synergistic path in down syndrome. Free radical biology & medicine. vol 165. 2021-06-28. PMID:33516914. |
furthermore, we analyzed whether changes of brain insulin signaling were associated with alterations of: (i) proteins regulating brain energy metabolism (mitochondrial complexes, hexokinase-ii, sirt1); (ii) oxidative stress (os) markers (iii) app cleavage; and (iv) proteins mediating synaptic plasticity mechanisms (psd95, syntaxin-1 and bdnf). |
2021-06-28 |
2023-08-13 |
mouse |
| Thomas Andreska, Patrick Lüningschrör, Michael Sendtne. Regulation of TrkB cell surface expression-a mechanism for modulation of neuronal responsiveness to brain-derived neurotrophic factor. Cell and tissue research. vol 382. issue 1. 2021-06-23. PMID:32556728. |
this process can occur in very short time periods and the resulting rapid modulation of target cell sensitivity to bdnf could represent a mechanism for fine-tuning of synaptic plasticity and communication in complex neuronal networks. |
2021-06-23 |
2023-08-13 |
Not clear |
| Susanne Meis, Thomas Endres, Volkmar Lessman. Neurotrophin signalling in amygdala-dependent cued fear learning. Cell and tissue research. vol 382. issue 1. 2021-06-23. PMID:32845430. |
the neurotrophin brain-derived neurotrophic factor (bdnf) is known to regulate synaptic plasticity and memory formation in many areas of the mammalian brain including the amygdala, where bdnf signalling via tropomyosin-related kinase b (trkb) receptors is prominently involved in fear learning. |
2021-06-23 |
2023-08-13 |
Not clear |
| Wu Zhou, Zhiping Xie, Chengcai Li, Zelong Xing, Shenke Xie, Meihua Li, Jianguo Ya. Driving effect of BDNF in the spinal dorsal horn on neuropathic pain. Neuroscience letters. vol 756. 2021-06-22. PMID:34022262. |
bdnf is an important regulator of neuronal development, synaptic transmission, and cellular and synaptic plasticity, which are essential for nerve maintenance and repair. |
2021-06-22 |
2023-08-13 |
Not clear |
| Tadahiro Numakawa, Haruki Odak. Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer's Disease: Beneficial Effects of Flavonoids for Neuroprotection. International journal of molecular sciences. vol 22. issue 11. 2021-06-22. PMID:34071978. |
the function of the brain-derived neurotrophic factor (bdnf) via activation through its high-affinity receptor tropomyosin receptor kinase b (trkb) has a pivotal role in cell differentiation, cell survival, synaptic plasticity, and both embryonic and adult neurogenesis in central nervous system neurons. |
2021-06-22 |
2023-08-13 |
Not clear |
| Erin Wosnitzka, Xinsheng Nan, Jeff Nan, Pedro Chacón-Fernández, Lothar Kussmaul, Michael Schuler, Bastian Hengerer, Yves-Alain Bard. A New Mouse Line Reporting the Translation of Brain-Derived Neurotrophic Factor Using Green Fluorescent Protein. eNeuro. vol 7. issue 1. 2021-06-18. PMID:31882533. |
while bdnf is receiving considerable attention for its role in synaptic plasticity and in nervous system dysfunction, identifying brain circuits involving bdnf-expressing neurons has been challenging. |
2021-06-18 |
2023-08-13 |
mouse |