| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John J Alam, Michael Krakovsky, Ursula Germann, Aharon Lev. Continuous administration of a p38α inhibitor during the subacute phase after transient ischemia-induced stroke in the rat promotes dose-dependent functional recovery accompanied by increase in brain BDNF protein level. PloS one. vol 15. issue 12. 2021-01-13. PMID:33275615. |
it also resulted in a dose-related increase in brain-derived neurotrophic factor (bdnf) protein levels, a previously reported potential marker of synaptic plasticity that was measured in brain homogenates at sacrifice. |
2021-01-13 |
2023-08-13 |
rat |
| John J Alam, Michael Krakovsky, Ursula Germann, Aharon Lev. Continuous administration of a p38α inhibitor during the subacute phase after transient ischemia-induced stroke in the rat promotes dose-dependent functional recovery accompanied by increase in brain BDNF protein level. PloS one. vol 15. issue 12. 2021-01-13. PMID:33275615. |
taken together with literature evidence on the role of p38α-dependent suppression by interleukin-1β of bdnf-mediated synaptic plasticity and bdnf production, our findings support a mechanistic model in which inhibition of p38α promotes functional recovery after ischemic stroke by blocking the deleterious effects of interleukin-1β on synaptic plasticity. |
2021-01-13 |
2023-08-13 |
rat |
| Joshua T Reycraft, Hashim Islam, Logan K Townsend, Grant C Hayward, Tom J Hazell, Rebecca E K Macpherso. Exercise Intensity and Recovery on Circulating Brain-derived Neurotrophic Factor. Medicine and science in sports and exercise. vol 52. issue 5. 2020-12-28. PMID:31815833. |
brain-derived neurotrophic factor (bdnf) is an exercise-induced neurotropin mediating neuroprotection and synaptic plasticity. |
2020-12-28 |
2023-08-13 |
Not clear |
| Qingfei Chen, Feifei Wang, Yunchao Zhang, Yan Liu, Li An, Zhongliang Ma, Jingzhong Zhang, Shuang Y. Neonatal DEX exposure leads to hyperanxious and depressive-like behaviors as well as a persistent reduction of BDNF expression in developmental stages. Biochemical and biophysical research communications. vol 527. issue 1. 2020-12-21. PMID:32446386. |
brain-derived neurotrophic factor (bdnf), which regulates the neuronal survival, differentiation and synaptic plasticity, has been proved to play a critical role in the pathology and treatment of several psychiatric disorders including depression. |
2020-12-21 |
2023-08-13 |
Not clear |
| Zofia Piotrowicz, Małgorzata Chalimoniuk, Miłosz Czuba, Józef Langfor. Role of brain-derived neurotrophic factor in appetite control Postepy biochemii. vol 66. issue 3. 2020-12-18. PMID:33315318. |
in addition to involvement in neurogenesis, neuroprotection and synaptic plasticity, bdnf has anorexigenic activity. |
2020-12-18 |
2023-08-13 |
Not clear |
| Ivani Credidio Trombetta, José Roberto DeMoura, Cleber Rene Alves, Renato Carbonari-Brito, Felipe Xerez Cepeda, José Ribeiro Lemo. Serum Levels of BDNF in Cardiovascular Protection and in Response to Exercise. Arquivos brasileiros de cardiologia. vol 115. issue 2. 2020-12-04. PMID:32876194. |
bdnf is a neurotrophin found at high concentrations in the hippocampus and cerebral cortex and is considered a key molecule for the maintenance of synaptic plasticity and survival of neuronal cells. |
2020-12-04 |
2023-08-13 |
Not clear |
| Genevieve Saw, Kumar Krishna, Neelima Gupta, Tuck Wah Soong, Karthik Mallilankaraman, Sreedharan Sajikumar, S Thameem Dhee. Epigenetic regulation of microglial phosphatidylinositol 3-kinase pathway involved in long-term potentiation and synaptic plasticity in rats. Glia. vol 68. issue 3. 2020-11-19. PMID:31702864. |
this study shows that microglial pi3k is regulated epigenetically through histone modifications and posttranslationally through sumoylation and is involved in long-term potentiation (ltp) by modulating the expression of brain-derived neurotrophic factor (bdnf), which has been shown to be involved in neuronal synaptic plasticity. |
2020-11-19 |
2023-08-13 |
rat |
| Genevieve Saw, Kumar Krishna, Neelima Gupta, Tuck Wah Soong, Karthik Mallilankaraman, Sreedharan Sajikumar, S Thameem Dhee. Epigenetic regulation of microglial phosphatidylinositol 3-kinase pathway involved in long-term potentiation and synaptic plasticity in rats. Glia. vol 68. issue 3. 2020-11-19. PMID:31702864. |
however, ltp was rescued when the same hippocampal slices were treated with active pi3k or bdnf, indicating that microglial pi3k/akt signaling contributes to ltp and synaptic plasticity. |
2020-11-19 |
2023-08-13 |
rat |
| Anastasia Levchenko, Natalia M Vyalova, Timur Nurgaliev, Ivan V Pozhidaev, German G Simutkin, Nikolay A Bokhan, Svetlana A Ivanov. Frontiers in genetics. vol 11. 2020-11-17. PMID:33193575. |
bdnf regulates a number of key aspects in neurodevelopment and synaptic plasticity. |
2020-11-17 |
2023-08-13 |
Not clear |
| Sigfus Kristinsson, Grigori Yourganov, Feifei Xiao, Leonardo Bonilha, Brielle C Stark, Chris Rorden, Alexandra Basilakos, Julius Fridriksso. Brain-Derived Neurotrophic Factor Genotype-Specific Differences in Cortical Activation in Chronic Aphasia. Journal of speech, language, and hearing research : JSLHR. vol 62. issue 11. 2020-10-29. PMID:31756156. |
purpose the brain-derived neurotrophic factor (bdnf) gene has been shown to be important for synaptic plasticity in animal models. |
2020-10-29 |
2023-08-13 |
human |
| Ren-Shi Li, Ryo Fukumori, Tomoki Takeda, Yingxia Song, Satoshi Morimoto, Ruri Kikura-Hanajiri, Taku Yamaguchi, Kazuhito Watanabe, Kousuke Aritake, Yoshitaka Tanaka, Hideyuki Yamada, Tsuneyuki Yamamoto, Yuji Ishi. Elevation of endocannabinoids in the brain by synthetic cannabinoid JWH-018: mechanism and effect on learning and memory. Scientific reports. vol 9. issue 1. 2020-10-26. PMID:31270353. |
additionally, we showed that jwh-018 causes a reduction in the levels of brain-derived neurotrophic factor (bdnf), which is known to modulate synaptic plasticity and adaptive processes underlying learning and memory. |
2020-10-26 |
2023-08-13 |
Not clear |
| Mamoru Fukuch. Identifying inducers of BDNF gene expression from pharmacologically validated compounds; antipyretic drug dipyrone increases BDNF mRNA in neurons. Biochemical and biophysical research communications. vol 524. issue 4. 2020-10-26. PMID:32059848. |
low levels of brain-derived neurotrophic factor (bdnf), a key regulator of synaptic plasticity, are associated with neurological diseases, including depression and alzheimer's disease. |
2020-10-26 |
2023-08-13 |
Not clear |
| Mamoru Fukuchi, Yui Okuno, Hironori Nakayama, Aoi Nakano, Hisashi Mori, Satoru Mitazaki, Yuka Nakano, Kazufumi Toume, Michiko Jo, Ichiro Takasaki, Kazuki Watanabe, Naotoshi Shibahara, Katsuko Komatsu, Akiko Tabuchi, Masaaki Tsud. Screening inducers of neuronal BDNF gene transcription using primary cortical cell cultures from BDNF-luciferase transgenic mice. Scientific reports. vol 9. issue 1. 2020-10-22. PMID:31413298. |
brain-derived neurotrophic factor (bdnf) is a key player in synaptic plasticity, and consequently, learning and memory. |
2020-10-22 |
2023-08-13 |
mouse |
| Manuela Bomba, Alberto Granzotto, Vanessa Castelli, Marco Onofrj, Rossano Lattanzio, Annamaria Cimini, Stefano L Sens. Exenatide Reverts the High-Fat-Diet-Induced Impairment of BDNF Signaling and Inflammatory Response in an Animal Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 70. issue 3. 2020-10-09. PMID:31256135. |
however, exenatide has also been shown to affect the signaling of the brain-derived neurotrophic factor (bdnf), synaptic plasticity, and cognitive performances in animal models. |
2020-10-09 |
2023-08-13 |
mouse |
| Ja Wook Koo, Dipesh Chaudhury, Ming-Hu Han, Eric J Nestle. Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression. Biological psychiatry. vol 86. issue 10. 2020-10-06. PMID:31327473. |
brain-derived neurotrophic factor (bdnf) is widely accepted as being critical for neural and synaptic plasticity throughout the nervous system. |
2020-10-06 |
2023-08-13 |
mouse |
| Yin-Xiu Han, Chen Tao, Xin-Ran Gao, Le-le Wang, Fu-Hao Jiang, Chong Wang, Ke Fang, Xing-Xing Chen, Zheng Chen, Jin-Fang G. BDNF-Related Imbalance of Copine 6 and Synaptic Plasticity Markers Couples With Depression-Like Behavior and Immune Activation in CUMS Rats. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30429764. |
the plasma concentrations of c-reactive protein (crp) and interleukin-6 (il-6) were measured, and the protein expressions of brain-derived neurotrophic factor (bdnf), copine 6, and synaptic plasticity markers in the hippocampus and the pfc were also detected. |
2020-10-01 |
2023-08-13 |
rat |
| Ana Paula De Vincenti, Antonella S Ríos, Gustavo Paratcha, Fernanda Ledd. Mechanisms That Modulate and Diversify BDNF Functions: Implications for Hippocampal Synaptic Plasticity. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31024262. |
mechanisms that modulate and diversify bdnf functions: implications for hippocampal synaptic plasticity. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ana Paula De Vincenti, Antonella S Ríos, Gustavo Paratcha, Fernanda Ledd. Mechanisms That Modulate and Diversify BDNF Functions: Implications for Hippocampal Synaptic Plasticity. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31024262. |
brain-derived neurotrophic factor (bdnf) is a neurotrophin that has pleiotropic effects on neuronal morphology and synaptic plasticity that underlie hippocampal circuit development and cognition. |
2020-10-01 |
2023-08-13 |
Not clear |
| Zülal Kaptan, Kadriye Akgün Dar, Ayşegül Kapucu, Huri Bulut, Gülay Üzü. Effect of enriched environment and predictable chronic stress on spatial memory in adolescent rats: Predominant expression of BDNF, nNOS, and interestingly malondialdehyde in the right hippocampus. Brain research. vol 1721. 2020-10-01. PMID:31299186. |
the levels of brain-derived neurotrophic factor (bdnf) and neuronal nitric oxide synthase (nnos), which are critical for synaptic plasticity; malondialdehyde (mda; lipid-peroxidation indicator); protein carbonyl (protein-oxidation indicator); and superoxide dismutase (antioxidant enzyme) were evaluated in the left and right hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Maria Carolina Gonzalez, Andressa Radiske, Martín Cammarot. On the Involvement of BDNF Signaling in Memory Reconsolidation. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31507380. |
extensive literature implicates brain-derived neurotrophic factor (bdnf), a key regulator of synaptogenesis and synaptic plasticity, in the acquisition, consolidation and extinction of several memory types. |
2020-10-01 |
2023-08-13 |
Not clear |