| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susanne Meis, Thomas Endres, Thomas Munsch, Volkmar Lessman. Impact of Chronic BDNF Depletion on GABAergic Synaptic Transmission in the Lateral Amygdala. International journal of molecular sciences. vol 20. issue 17. 2020-01-27. PMID:31484392. |
brain-derived neurotrophic factor (bdnf) has previously been shown to play an important role in glutamatergic synaptic plasticity in the amygdala, correlating with cued fear learning. |
2020-01-27 |
2023-08-13 |
Not clear |
| Conor P Murphy, Nicolas Singewal. Role of MicroRNAs in Anxiety and Anxiety-Related Disorders. Current topics in behavioral neurosciences. vol 42. 2020-01-27. PMID:31485988. |
important functional target genes of these identified micrornas are associated with specific neurotransmitter/neuromodulator signaling, neurotrophin (e.g., bdnf) expression and other aspects of synaptic plasticity, as well as with stress-regulatory/hypothalamic-pituitary-axis function. |
2020-01-27 |
2023-08-13 |
Not clear |
| Taratorn Fainanta, Sukanya Jaroenporn, Patteera Wititsuwankul, Suchinda Malaivijitnon. Chronological Molecular Changes in Neuronal Communication in Androgen-Deficient Rats. Journal of molecular neuroscience : MN. vol 69. issue 1. 2020-01-21. PMID:31114953. |
transcript levels of the genes associated with loss of synaptic plasticity (bdnf, syn, glun1, α7-nachr, and m |
2020-01-21 |
2023-08-13 |
rat |
| Jason Y Tann, Lik-Wei Wong, Sreedharan Sajikumar, Carlos F Ibáñe. Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing. The EMBO journal. vol 38. issue 5. 2020-01-06. PMID:30692134. |
abnormal tdp-43 function impairs activity-dependent bdnf secretion, synaptic plasticity, and cognitive behavior through altered sortilin splicing. |
2020-01-06 |
2023-08-13 |
mouse |
| Jason Y Tann, Lik-Wei Wong, Sreedharan Sajikumar, Carlos F Ibáñe. Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing. The EMBO journal. vol 38. issue 5. 2020-01-06. PMID:30692134. |
adult mice lacking tdp-43 specifically in hippocampal ca1 show memory impairment and synaptic plasticity defects that can be rescued by restoring sortilin splicing or extracellular bdnf. |
2020-01-06 |
2023-08-13 |
mouse |
| Mei He, Jing-Xiang Wei, Min Mao, Guo-Yan Zhao, Jun-Jie Tang, Shuang Feng, Xiu-Min Lu, Yong-Tang Wan. Synaptic Plasticity in PTSD and associated Comorbidities: The Function and Mechanism for Diagnostics and Therapy. Current pharmaceutical design. vol 24. issue 34. 2019-12-18. PMID:30457048. |
in this review, we mainly focus on discussing the biological function and mechanism for diagnostics and therapy of synaptic plasticity in ptsd and associated comorbidities, such as schizophrenia, depression, sleep disturbances and alcohol dependence, and further studying the molecular mechanisms of ptsd with a particular focus on the ltp/ltd, glutamatergic ligand-receptor systems, voltage-gated calcium channels (vgccs) and brain-derived neurotrophic factor (bdnf)-tyrosine kinase b (trkb). |
2019-12-18 |
2023-08-13 |
Not clear |
| Chen-Jee Hong, Ying-Jay Liou, Shih-Jen Tsa. Reprint of: Effects of BDNF polymorphisms on brain function and behavior in health and disease. Brain research bulletin. vol 88. issue 5. 2019-11-20. PMID:22677226. |
brain-derived neurotrophic factor (bdnf), the most abundant neurotrophin in the brain, serves an important role during brain development and in synaptic plasticity. |
2019-11-20 |
2023-08-12 |
human |
| Manish Kumar Asthana, Bettina Brunhuber, Andreas Mühlberger, Andreas Reif, Simone Schneider, Martin J Herrman. Preventing the Return of Fear Using Reconsolidation Update Mechanisms Depends on the Met-Allele of the Brain Derived Neurotrophic Factor Val66Met Polymorphism. The international journal of neuropsychopharmacology. vol 19. issue 6. 2019-11-20. PMID:26721948. |
brain derived neurotrophic factor (bdnf) has been extensively investigated regarding its role in the formation of synaptic plasticity and in the alteration of fear memories. |
2019-11-20 |
2023-08-13 |
Not clear |
| Chris J Hunter, Judit Remenyi, Sonia A Correa, Lucia Privitera, Kathleen M S E Reyskens, Kirsty J Martin, Rachel Toth, Bruno G Frenguelli, J Simon C Arthu. MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins. FEBS open bio. vol 7. issue 6. 2019-11-20. PMID:28593137. |
the immediate early gene activity-regulated cytoskeletal protein (arc)/arg3.1 and the neurotrophin brain-derived neurotrophic factor (bdnf) play important roles in synaptic plasticity and learning and memory in the mammalian brain. |
2019-11-20 |
2023-08-13 |
Not clear |
| Zsuzsanna Tucsek, M Noa Valcarcel-Ares, Stefano Tarantini, Andriy Yabluchanskiy, Gábor Fülöp, Tripti Gautam, Albert Orock, Anna Csiszar, Ferenc Deak, Zoltan Ungvar. Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment. GeroScience. vol 39. issue 4. 2019-11-20. PMID:28664509. |
hypertension, similar to aging, was associated with changes in mrna expression of several genes involved in regulation of neuronal function, including down-regulation of bdnf, homer1, and dlg4, which may have a role in impaired synaptic plasticity. |
2019-11-20 |
2023-08-13 |
mouse |
| Sergio M G Solinas, Elke Edelmann, Volkmar Leßmann, Michele Miglior. A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP. PLoS computational biology. vol 15. issue 4. 2019-11-12. PMID:31017891. |
the neurotrophin brain-derived neurotrophic factor (bdnf) is known to promote structural and functional synaptic plasticity in the hippocampus, the cerebral cortex, and many other brain areas. |
2019-11-12 |
2023-08-13 |
mouse |
| Sergio M G Solinas, Elke Edelmann, Volkmar Leßmann, Michele Miglior. A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP. PLoS computational biology. vol 15. issue 4. 2019-11-12. PMID:31017891. |
thus, bdnf knock-out mice or mice that are deficient in bdnf receptor signaling via trkb and p75 receptors show deficits in neuronal development, synaptic plasticity, and memory formation. |
2019-11-12 |
2023-08-13 |
mouse |
| Deepti Sharma, Kalpana Kumari Barhwal, Surya Narayan Biswal, Anup Kumar Srivastava, Pushpendar Bhardwaj, Ashish Kumar, Om Prakash Chaurasia, Sunil Kumar Hot. Hypoxia-mediated alteration in cholesterol oxidation and raft dynamics regulates BDNF signalling and neurodegeneration in hippocampus. Journal of neurochemistry. vol 148. issue 2. 2019-10-28. PMID:30308090. |
brain-derived neurotrophic factor (bdnf) which is primarily associated with neuronal survivability, differentiation and synaptic plasticity has been reported to mediate neurodegeneration in hypoxia through its p75 neurotrophin receptors (p75ntr). |
2019-10-28 |
2023-08-13 |
rat |
| Ryoko Suzuki, Akihiro Fujikawa, Yukio Komatsu, Kazuya Kuboyama, Naomi Tanga, Masaharu Nod. Enhanced extinction of aversive memories in mice lacking SPARC-related protein containing immunoglobulin domains 1 (SPIG1/FSTL4). Neurobiology of learning and memory. vol 152. 2019-10-01. PMID:29783061. |
brain-derived neurotrophic factor (bdnf) plays an important role in synaptic plasticity related to learning and memory. |
2019-10-01 |
2023-08-13 |
mouse |
| Wen Xu, Jian Cao, Yan Zhou, Lina Wang, Guoqi Zh. GPR30 activation improves memory and facilitates DHPG-induced LTD in the hippocampal CA3 of middle-aged mice. Neurobiology of learning and memory. vol 149. 2019-09-16. PMID:29421611. |
the regulation of hippocampal synaptic plasticity by g1 treatment might be related to brain-derived neurotrophic factor (bdnf)-tropomyosin receptor kinase b (trkb) signaling, as g15 also blocked g1-induced activation of the bdnf-trkb pathway. |
2019-09-16 |
2023-08-13 |
mouse |
| Bianca Cotto, Hongbo Li, Ronald F Tuma, Sara Jane Ward, Dianne Langfor. Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production. Neurobiology of disease. vol 117. 2019-09-06. PMID:29859319. |
methyl cpg binding protein 2 (mecp2) binds to the promoter region of bdnf to negatively regulate its expression and cocaine can recruit mecp2 to alter the expression of genes such as bdnf that are involved in synaptic plasticity. |
2019-09-06 |
2023-08-13 |
human |
| Bianca Cotto, Hongbo Li, Ronald F Tuma, Sara Jane Ward, Dianne Langfor. Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production. Neurobiology of disease. vol 117. 2019-09-06. PMID:29859319. |
for several decades, bdnf has been implicated in mediating synaptic plasticity associated with cocaine abuse, and most studies report that neurons are the primary source for bdnf production in the brain. |
2019-09-06 |
2023-08-13 |
human |
| Bianca Cotto, Hongbo Li, Ronald F Tuma, Sara Jane Ward, Dianne Langfor. Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production. Neurobiology of disease. vol 117. 2019-09-06. PMID:29859319. |
results from these studies show for the first time that cocaine self-administration increases microglial activation, and that microglial mecp2 is a sensitive target of cocaine resulting in increased release of bdnf from microglia, and possibly contributing to cocaine-induced synaptic plasticity. |
2019-09-06 |
2023-08-13 |
human |
| Martina Parrini, Diego Ghezzi, Gabriele Deidda, Lucian Medrihan, Enrico Castroflorio, Micol Alberti, Pietro Baldelli, Laura Cancedda, Andrea Contestabil. Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome. Scientific reports. vol 7. issue 1. 2019-07-05. PMID:29203796. |
pharmacological stimulation of bdnf signaling rescued synaptic plasticity and memory deficits in ts65dn mice. |
2019-07-05 |
2023-08-13 |
mouse |
| Xing-Ming Wang, Wei Pan, Ning Xu, Zhi-Qiang Zhou, Guang-Fen Zhang, Jin-Chun She. Environmental enrichment improves long-term memory impairment and aberrant synaptic plasticity by BDNF/TrkB signaling in nerve-injured mice. Neuroscience letters. vol 694. 2019-06-21. PMID:30496785. |
the pain threshold, long-term memory, expression of brain-derived neurotrophic factor (bdnf) and synaptic plasticity in hippocampus were determined. |
2019-06-21 |
2023-08-13 |
mouse |