| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jaclyn M Obermeyer, Anup Tuladhar, Samantha L Payne, Eric Ho, Cindi M Morshead, Molly S Shoiche. Local Delivery of Brain-Derived Neurotrophic Factor Enables Behavioral Recovery and Tissue Repair in Stroke-Injured Rats. Tissue engineering. Part A. vol 25. issue 15-16. 2020-05-22. PMID:30612516. |
we demonstrate that when delivered epicortically to a rat model of stroke, this composite allows bdnf to diffuse into the brain, resulting in enhanced behavioral recovery and synaptic plasticity in the contralesional hemisphere. |
2020-05-22 |
2023-08-13 |
rat |
| Eboni I Lance, Emily Barron-Casella, Allen D Everett, James F Casell. Brain-derived neurotrophic factor levels in pediatric sickle cell disease. Pediatric blood & cancer. vol 67. issue 2. 2020-04-22. PMID:31736231. |
brain-derived neurotrophic factor (bdnf) is a nerve growth factor associated with neuronal survival, synaptic plasticity, elevated transcranial doppler (tcd) velocities and increased risk of stroke in patients with scd. |
2020-04-22 |
2023-08-13 |
human |
| Siamak Shahidi, Omid Mehrpour, Reihaneh Sadeghian, Sara Soleimani Asl, Alireza Komak. Alteration level of hippocampus BDNF expression and long-term potentiation upon microinjection of BRL15572 hydrochloride in a rat model of methamphetamine relapse. Brain research bulletin. vol 148. 2020-04-17. PMID:30904722. |
methamphetamine (meth) relapse affects the function of the serotonergic system, which this system important for synaptic plasticity and brain-derived neurotrophic factor (bdnf) level. |
2020-04-17 |
2023-08-13 |
rat |
| Sujin Kim, Ji-Young Choi, Sohee Moon, Dong-Ho Park, Hyo-Bum Kwak, Ju-Hee Kan. Roles of myokines in exercise-induced improvement of neuropsychiatric function. Pflugers Archiv : European journal of physiology. vol 471. issue 3. 2020-04-09. PMID:30627775. |
among several myokines, brain-derived neurotrophic factor (bdnf) is the most studied myokine that regulates adult neurogenesis and synaptic plasticity. |
2020-04-09 |
2023-08-13 |
Not clear |
| Jie Xiang, Zhi-Hao Wang, Eun Hee Ahn, Xia Liu, Shan-Ping Yu, Fredric P Manfredsson, Ivette M Sandoval, Gong Ju, Shengxi Wu, Keqiang Y. Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 18. 2020-03-25. PMID:31004063. |
bdnf, an essential trophic factor implicated in synaptic plasticity and neuronal survival, is reduced in alzheimer's disease (ad). |
2020-03-25 |
2023-08-13 |
Not clear |
| Pasquale Di Carlo, Giovanna Punzi, Gianluca Ursin. Brain-derived neurotrophic factor and schizophrenia. Psychiatric genetics. vol 29. issue 5. 2020-02-26. PMID:31465000. |
the brain-derived neurotrophic factor (bdnf) is a secretory growth factor that promotes neuronal proliferation and survival, synaptic plasticity and long-term potentiation in the central nervous system. |
2020-02-26 |
2023-08-13 |
human |
| Francesca Caracci, Joyce Harary, Sherry Simkovic, Giulio Maria Pasinett. Grape-Derived Polyphenols Ameliorate Stress-Induced Depression by Regulating Synaptic Plasticity. Journal of agricultural and food chemistry. vol 68. issue 7. 2020-02-26. PMID:31532659. |
elevated levels of proinflammatory cytokines and reduced bdnf levels lead to impaired synaptic plasticity mechanisms that contribute to the pathophysiology of mdd. |
2020-02-26 |
2023-08-13 |
Not clear |
| Francesca Caracci, Joyce Harary, Sherry Simkovic, Giulio Maria Pasinett. Grape-Derived Polyphenols Ameliorate Stress-Induced Depression by Regulating Synaptic Plasticity. Journal of agricultural and food chemistry. vol 68. issue 7. 2020-02-26. PMID:31532659. |
there is accumulating evidence that the administration of polyphenols at doses ranging from 5 to 180 mg/kg of body weight can normalize elevated levels of proinflammatory cytokines and abnormal levels of bdnf and, thus, restore impaired synaptic plasticity mechanisms that mediate depressive behavior in animal models of stress. |
2020-02-26 |
2023-08-13 |
Not clear |
| Paul A Lapchak, Paul D Boitano, Rene Bombien, Douglas J Cook, Sarina Doyan, Jacqueline M Lara, David R Schuber. CNB-001, a pleiotropic drug is efficacious in embolized agyrencephalic New Zealand white rabbits and ischemic gyrencephalic cynomolgus monkeys. Experimental neurology. vol 313. 2020-02-24. PMID:30521790. |
mechanistically, cnb-001 inhibits human 5- and 15-lipoxygenase in vitro, and can attenuate ischemia-induced inflammatory markers, and oxidative stress markers, while potentially promoting synaptic plasticity mediated by enhanced brain-derived neurotrophic factor (bdnf). |
2020-02-24 |
2023-08-13 |
human |
| Fen Xue, Shan-Shan Xue, Ling Liu, Han-Fei Sang, Quan-Rui Ma, Qing-Rong Tan, Hua-Ning Wang, Cui-Hong Zhou, Zheng-Wu Pen. Early intervention with electroacupuncture prevents PTSD-like behaviors in rats through enhancing hippocampal endocannabinoid signaling. Progress in neuro-psychopharmacology & biological psychiatry. vol 93. 2020-02-14. PMID:30946940. |
the results showed that early ea intervention improved hippocampal synaptic plasticity and ameliorated ptsd-like behaviors and also increased expression of bdnf, daglα and cb1r. |
2020-02-14 |
2023-08-13 |
rat |
| Jo Wrigglesworth, Joanne Ryan, Nandita Vijayakumar, Sarah Whittl. Brain-derived neurotrophic factor DNA methylation mediates the association between neighborhood disadvantage and adolescent brain structure. Psychiatry research. Neuroimaging. vol 285. 2020-02-11. PMID:30771753. |
this study investigated whether dna methylation of the brain-derived neurotrophic factor (bdnf, which plays a key role in synaptic plasticity), mediated the association between neighborhood disadvantage and thickness of the pfc in adolescents. |
2020-02-11 |
2023-08-13 |
Not clear |
| Francesco Tomassoni-Ardori, Gianluca Fulgenzi, Jodi Becker, Colleen Barrick, Mary Ellen Palko, Skyler Kuhn, Vishal Koparde, Maggie Cam, Sudhirkumar Yanpallewar, Shalini Oberdoerffer, Lino Tessaroll. Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels. eLife. vol 8. 2020-01-31. PMID:31429825. |
brain-derived neurotrophic factor (bdnf) is a potent modulator of brain synaptic plasticity. |
2020-01-31 |
2023-08-13 |
Not clear |
| Julia Leschik, Robert Eckenstaler, Thomas Endres, Thomas Munsch, Elke Edelmann, Karin Richter, Oliver Kobler, Klaus-Dieter Fischer, Werner Zuschratter, Tanja Brigadski, Beat Lutz, Volkmar Lessman. Prominent Postsynaptic and Dendritic Exocytosis of Endogenous BDNF Vesicles in BDNF-GFP Knock-in Mice. Molecular neurobiology. vol 56. issue 10. 2020-01-30. PMID:30929164. |
brain-derived neurotrophic factor (bdnf) is a secreted messenger molecule that is crucial for neuronal function and induction of synaptic plasticity. |
2020-01-30 |
2023-08-13 |
mouse |
| Susanne Meis, Thomas Endres, Thomas Munsch, Volkmar Lessman. Impact of Chronic BDNF Depletion on GABAergic Synaptic Transmission in the Lateral Amygdala. International journal of molecular sciences. vol 20. issue 17. 2020-01-27. PMID:31484392. |
brain-derived neurotrophic factor (bdnf) has previously been shown to play an important role in glutamatergic synaptic plasticity in the amygdala, correlating with cued fear learning. |
2020-01-27 |
2023-08-13 |
Not clear |
| Conor P Murphy, Nicolas Singewal. Role of MicroRNAs in Anxiety and Anxiety-Related Disorders. Current topics in behavioral neurosciences. vol 42. 2020-01-27. PMID:31485988. |
important functional target genes of these identified micrornas are associated with specific neurotransmitter/neuromodulator signaling, neurotrophin (e.g., bdnf) expression and other aspects of synaptic plasticity, as well as with stress-regulatory/hypothalamic-pituitary-axis function. |
2020-01-27 |
2023-08-13 |
Not clear |
| Taratorn Fainanta, Sukanya Jaroenporn, Patteera Wititsuwankul, Suchinda Malaivijitnon. Chronological Molecular Changes in Neuronal Communication in Androgen-Deficient Rats. Journal of molecular neuroscience : MN. vol 69. issue 1. 2020-01-21. PMID:31114953. |
transcript levels of the genes associated with loss of synaptic plasticity (bdnf, syn, glun1, α7-nachr, and m |
2020-01-21 |
2023-08-13 |
rat |
| Jason Y Tann, Lik-Wei Wong, Sreedharan Sajikumar, Carlos F Ibáñe. Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing. The EMBO journal. vol 38. issue 5. 2020-01-06. PMID:30692134. |
abnormal tdp-43 function impairs activity-dependent bdnf secretion, synaptic plasticity, and cognitive behavior through altered sortilin splicing. |
2020-01-06 |
2023-08-13 |
mouse |
| Jason Y Tann, Lik-Wei Wong, Sreedharan Sajikumar, Carlos F Ibáñe. Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing. The EMBO journal. vol 38. issue 5. 2020-01-06. PMID:30692134. |
adult mice lacking tdp-43 specifically in hippocampal ca1 show memory impairment and synaptic plasticity defects that can be rescued by restoring sortilin splicing or extracellular bdnf. |
2020-01-06 |
2023-08-13 |
mouse |
| Mei He, Jing-Xiang Wei, Min Mao, Guo-Yan Zhao, Jun-Jie Tang, Shuang Feng, Xiu-Min Lu, Yong-Tang Wan. Synaptic Plasticity in PTSD and associated Comorbidities: The Function and Mechanism for Diagnostics and Therapy. Current pharmaceutical design. vol 24. issue 34. 2019-12-18. PMID:30457048. |
in this review, we mainly focus on discussing the biological function and mechanism for diagnostics and therapy of synaptic plasticity in ptsd and associated comorbidities, such as schizophrenia, depression, sleep disturbances and alcohol dependence, and further studying the molecular mechanisms of ptsd with a particular focus on the ltp/ltd, glutamatergic ligand-receptor systems, voltage-gated calcium channels (vgccs) and brain-derived neurotrophic factor (bdnf)-tyrosine kinase b (trkb). |
2019-12-18 |
2023-08-13 |
Not clear |
| Chen-Jee Hong, Ying-Jay Liou, Shih-Jen Tsa. Reprint of: Effects of BDNF polymorphisms on brain function and behavior in health and disease. Brain research bulletin. vol 88. issue 5. 2019-11-20. PMID:22677226. |
brain-derived neurotrophic factor (bdnf), the most abundant neurotrophin in the brain, serves an important role during brain development and in synaptic plasticity. |
2019-11-20 |
2023-08-12 |
human |