| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Shen, Yaqing Li, Chujie Qu, Linling Xu, Huimin Sun, Junjian Zhan. The enriched environment ameliorates chronic unpredictable mild stress-induced depressive-like behaviors and cognitive impairment by activating the SIRT1/miR-134 signaling pathway in hippocampus. Journal of affective disorders. vol 248. 2019-05-14. PMID:30716615. |
however, it is still not clearly understood whether an epigenetic mechanism is involved in the bdnf modulation and synaptic plasticity that occurs after ee treatment for the depressive-like behaviors and cognitive deficits elicited by cums. |
2019-05-14 |
2023-08-13 |
Not clear |
| Meng Zhang, Yating Zhai, Yaping Sun, Wenli Zhang, Qian Li, Darrell Brann, Ruimin Wan. Swimming improves cognitive reserve in ovariectomized rats and enhances neuroprotection after global cerebral ischemia. Brain research. vol 1692. 2019-05-08. PMID:29778778. |
we also examined the neuroprotective effect of swimming after global cerebral ischemia (gci) and explored the effect of swimming preconditioning on activation of the mapk cascade signaling pathway, synaptic proteins and brain-derived growth factor (bdnf) - all factors implicated in regulating synaptic plasticity and neuroprotection in the brain. |
2019-05-08 |
2023-08-13 |
rat |
| Pai-Kai Chiang, Feng-Yi Yan. A potential treatment of low intensity pulsed ultrasound on cavernous nerve injury for erectile dysfunction. Medical hypotheses. vol 122. 2019-05-06. PMID:30593410. |
brain-derived neurotrophic factor (bdnf) is a member of the neurotrophin family, which plays an important role in the survival of existing neurons, the differentiation of new neurons, and synaptic plasticity. |
2019-05-06 |
2023-08-13 |
Not clear |
| Zhenzhen Chen, Quan Hu, Qingfeng Xie, Shamin Wu, Qiongyi Pang, Meixia Liu, Yun Zhao, Fengxia Tu, Chan Liu, Xiang Che. Effects of Treadmill Exercise on Motor and Cognitive Function Recovery of MCAO Mice Through the Caveolin-1/VEGF Signaling Pathway in Ischemic Penumbra. Neurochemical research. vol 44. issue 4. 2019-04-26. PMID:30661230. |
these findings indicate that exercise improves angiogenesis, neurogenesis and synaptic plasticity to ameliorate motor and cognitive impairment after stroke partially through the caveolin-1/vegf pathway, which is associated with the coregulator factor, bdnf. |
2019-04-26 |
2023-08-13 |
mouse |
| Joe C Brague, Christine N Lenchur, Julia M Hayden, Rachel H Davidson, Kelly Corrigan, Garrett T Santini, Jennifer M Swan. BDNF infusion into the MPN mag is sufficient to restore copulatory behavior in the castrated Syrian hamster. Hormones and behavior. vol 102. 2019-04-25. PMID:29750970. |
as brain derived neurotrophic factor (bdnf) plays an integral role in regulating synaptic plasticity and gonadal steroids regulate the levels of bdnf, we hypothesize that bdnf may mediate the effects of gonadal hormones on copulatory behavior. |
2019-04-25 |
2023-08-13 |
Not clear |
| Anastacia Y Kudinova, Terrence Deak, Molly M Deak, Brandon E Gib. Circulating Levels of Brain-Derived Neurotrophic Factor and History of Suicide Attempts in Women. Suicide & life-threatening behavior. vol 49. issue 1. 2019-04-15. PMID:28960421. |
a growing body of research examining biological factors associated with suicidal behaviors highlights the role of brain-derived neurotropic factor (bdnf), involved in neurogenesis and synaptic plasticity. |
2019-04-15 |
2023-08-13 |
Not clear |
| Paul D Loprinzi, Emily Frit. A brief primer on the mediational role of BDNF in the exercise-memory link. Clinical physiology and functional imaging. vol 39. issue 1. 2019-04-09. PMID:29719116. |
as discussed herein, bdnf may influence memory via bdnf-induced alterations in membrane receptor expression and translocation, as well as activating several pathways (plc-y, pi3k, erk) that act together to facilitate cellular effects that influence synaptic plasticity. |
2019-04-09 |
2023-08-13 |
human |
| P Zanos, T D Goul. Mechanisms of ketamine action as an antidepressant. Molecular psychiatry. vol 23. issue 4. 2019-04-04. PMID:29532791. |
we also discuss links between ketamine's antidepressant actions and downstream mechanisms regulating synaptic plasticity, including brain-derived neurotrophic factor (bdnf), eukaryotic elongation factor 2 (eef2), mechanistic target of rapamycin (mtor) and glycogen synthase kinase-3 (gsk-3). |
2019-04-04 |
2023-08-13 |
Not clear |
| Francis S Lee, Barbara L Hempstea. New Roles for an Ancient Factor. Trends in neurosciences. vol 41. issue 11. 2019-04-04. PMID:30219601. |
in 1996, hyejin kang and erin schuman, in search of new functions for the secreted growth factor brain-derived neurotrophic factor (bdnf), identified the protein synthesis requirement of bdnf in regulating synaptic plasticity. |
2019-04-04 |
2023-08-13 |
Not clear |
| Hui Chen, Larbi Amazit, Marc Lombès, Damien Le Menue. Crosstalk Between Glucocorticoid Receptor and Early-growth Response Protein 1 Accounts for Repression of Brain-derived Neurotrophic Factor Transcript 4 Expression. Neuroscience. vol 399. 2019-03-11. PMID:30578973. |
the brain-derived neurotrophic factor (bdnf) is a key player in brain functions such as synaptic plasticity, stress, and behavior. |
2019-03-11 |
2023-08-13 |
Not clear |
| Yuan Zhong, Yitong Zhu, Ting He, Wei Li, Qinjie Li, Ya Mia. Brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the PI3K/Akt pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30365051. |
it is not known whether brain‑derived neurotrophic factor (bdnf) protects hippocampal neurons from high glucose‑induced apoptosis and/or synaptic plasticity dysfunction. |
2019-03-05 |
2023-08-13 |
rat |
| Wenping Zhang, Yuqiang Shi, Yanxi Peng, Ling Zhong, Shuang Zhu, Wenbo Zhang, Shao-Jun Tan. Neuron activity-induced Wnt signaling up-regulates expression of brain-derived neurotrophic factor in the pain neural circuit. The Journal of biological chemistry. vol 293. issue 40. 2019-03-04. PMID:30139740. |
brain-derived neurotrophic factor (bdnf) is a master regulator of synaptic plasticity in various neural circuits of the mammalian central nervous system. |
2019-03-04 |
2023-08-13 |
Not clear |
| Stine Normann Hansen, David Højland Ipsen, Anne Marie Schou-Pedersen, Jens Lykkesfeldt, Pernille Tveden-Nybor. Long term Westernized diet leads to region-specific changes in brain signaling mechanisms. Neuroscience letters. vol 676. 2019-02-22. PMID:29655945. |
here we investigate the effects of dyslipidemia induced by two high fat diets with or without high sucrose on hippocampal and frontal cortical oxidative stress, brain-derived neurotrophic factor (bdnf) and down-stream markers of synaptic plasticity, as well as alterations in monoaminergic neurotransmitter levels. |
2019-02-22 |
2023-08-13 |
Not clear |
| Xu Ding, Ya-Jing Liang, Li Su, Fei-Fei Liao, Dong Fang, Jun Tai, Guo-Gang Xin. BDNF contributes to the neonatal incision-induced facilitation of spinal long-term potentiation and the exacerbation of incisional pain in adult rats. Neuropharmacology. vol 137. 2019-02-20. PMID:29729892. |
thus, spinal bdnf may combine the changes of microglial reactivity and synaptic plasticity in nin-in rats. |
2019-02-20 |
2023-08-13 |
rat |
| Gabriel Keine Kuga, Vitor Rosetto Muñoz, Rafael Calais Gaspar, Susana Castelo Branco Ramos Nakandakari, Adelino Sanchez Ramos da Silva, José Diego Botezelli, José Alexandre Curiacos de Almeida Leme, Ricardo José Gomes, Leandro Pereira de Moura, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo Paul. Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B. Experimental gerontology. vol 104. 2019-02-19. PMID:29421605. |
the insulin and brain-derived neurotrophic factor (bdnf) signaling in the hippocampus promotes synaptic plasticity and memory formation. |
2019-02-19 |
2023-08-13 |
rat |
| Joao Tomé-Carneiro, M Carmen Crespo, Emma Burgos-Ramos, Cristina Tomas-Zapico, Alba García-Serrano, Pilar Castro-Gómez, Cesar Venero, Inmaculada Pereda-Pérez, Shishir Baliyan, Azucena Valencia, Javier Fontecha, Alberto Dávalos, Francesco Visiol. Buttermilk and Krill Oil Phospholipids Improve Hippocampal Insulin Resistance and Synaptic Signaling in Aged Rats. Molecular neurobiology. vol 55. issue 9. 2019-02-04. PMID:29397560. |
moreover, n-3 fatty acids (fas) ingested as phospholipids increase bdnf levels favoring an improvement in energy state within neurons and facilitating both mitochondrial and protein synthesis, which are necessary for synaptic plasticity. |
2019-02-04 |
2023-08-13 |
rat |
| Marta Zagrebelsky, N Gödecke, A Remus, Martin Kort. Cell type-specific effects of BDNF in modulating dendritic architecture of hippocampal neurons. Brain structure & function. vol 223. issue 8. 2019-01-25. PMID:30022251. |
brain-derived neurotrophin factor (bdnf) has been implicated in neuronal survival, differentiation and activity-dependent synaptic plasticity in the central nervous system. |
2019-01-25 |
2023-08-13 |
mouse |
| Yun Pei, Zhexiao Jiao, Wanting Dong, Linguo Pei, Xia He, Hui Wang, Dan X. Excitotoxicity and compensatory upregulation of GAD67 in fetal rat hippocampus caused by prenatal nicotine exposure are associated with inhibition of the BDNF pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 123. 2019-01-15. PMID:30389584. |
compared with the control group, fetal rats by pne showed increased hippocampal apoptosis, reduced synaptic plasticity and downregulation of the brain-derived neurotrophic factor (bdnf) pathway, whereas glutamic acid decarboxylase 67 (gad67) expression was upregulated. |
2019-01-15 |
2023-08-13 |
rat |
| Yvonne Naegelin, Hayley Dingsdale, Katharina Säuberli, Sabine Schädelin, Ludwig Kappos, Yves-Alain Bard. Measuring and Validating the Levels of Brain-Derived Neurotrophic Factor in Human Serum. eNeuro. vol 5. issue 2. 2019-01-11. PMID:29662942. |
brain-derived neurotrophic factor (bdnf) secreted by neurons is a significant component of synaptic plasticity. |
2019-01-11 |
2023-08-13 |
human |
| Yu-Jia Wang, Kai-Yun Chen, Li-Na Kuo, Wen-Chang Wang, Yu-Wen Hsu, Henry Sung-Ching Wong, Chien-Min Lin, Kuo-Hsing Liao, Yan-Feng Zhang, Yung-Hsiao Chiang, Wei-Chiao Chan. The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury. BMC medical genetics. vol 19. issue 1. 2018-12-17. PMID:29357818. |
brain-derived neurotrophic factor (bdnf) is one of the most abundant neurotrophins in the adult brain, and it plays important roles in modulating synaptic plasticity and synaptogenesis. |
2018-12-17 |
2023-08-13 |
Not clear |