| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manish Kumar Asthana, Bettina Brunhuber, Andreas Mühlberger, Andreas Reif, Simone Schneider, Martin J Herrman. Preventing the Return of Fear Using Reconsolidation Update Mechanisms Depends on the Met-Allele of the Brain Derived Neurotrophic Factor Val66Met Polymorphism. The international journal of neuropsychopharmacology. vol 19. issue 6. 2019-11-20. PMID:26721948. |
brain derived neurotrophic factor (bdnf) has been extensively investigated regarding its role in the formation of synaptic plasticity and in the alteration of fear memories. |
2019-11-20 |
2023-08-13 |
Not clear |
| Chris J Hunter, Judit Remenyi, Sonia A Correa, Lucia Privitera, Kathleen M S E Reyskens, Kirsty J Martin, Rachel Toth, Bruno G Frenguelli, J Simon C Arthu. MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins. FEBS open bio. vol 7. issue 6. 2019-11-20. PMID:28593137. |
the immediate early gene activity-regulated cytoskeletal protein (arc)/arg3.1 and the neurotrophin brain-derived neurotrophic factor (bdnf) play important roles in synaptic plasticity and learning and memory in the mammalian brain. |
2019-11-20 |
2023-08-13 |
Not clear |
| Zsuzsanna Tucsek, M Noa Valcarcel-Ares, Stefano Tarantini, Andriy Yabluchanskiy, Gábor Fülöp, Tripti Gautam, Albert Orock, Anna Csiszar, Ferenc Deak, Zoltan Ungvar. Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment. GeroScience. vol 39. issue 4. 2019-11-20. PMID:28664509. |
hypertension, similar to aging, was associated with changes in mrna expression of several genes involved in regulation of neuronal function, including down-regulation of bdnf, homer1, and dlg4, which may have a role in impaired synaptic plasticity. |
2019-11-20 |
2023-08-13 |
mouse |
| Sergio M G Solinas, Elke Edelmann, Volkmar Leßmann, Michele Miglior. A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP. PLoS computational biology. vol 15. issue 4. 2019-11-12. PMID:31017891. |
the neurotrophin brain-derived neurotrophic factor (bdnf) is known to promote structural and functional synaptic plasticity in the hippocampus, the cerebral cortex, and many other brain areas. |
2019-11-12 |
2023-08-13 |
mouse |
| Sergio M G Solinas, Elke Edelmann, Volkmar Leßmann, Michele Miglior. A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP. PLoS computational biology. vol 15. issue 4. 2019-11-12. PMID:31017891. |
thus, bdnf knock-out mice or mice that are deficient in bdnf receptor signaling via trkb and p75 receptors show deficits in neuronal development, synaptic plasticity, and memory formation. |
2019-11-12 |
2023-08-13 |
mouse |
| Deepti Sharma, Kalpana Kumari Barhwal, Surya Narayan Biswal, Anup Kumar Srivastava, Pushpendar Bhardwaj, Ashish Kumar, Om Prakash Chaurasia, Sunil Kumar Hot. Hypoxia-mediated alteration in cholesterol oxidation and raft dynamics regulates BDNF signalling and neurodegeneration in hippocampus. Journal of neurochemistry. vol 148. issue 2. 2019-10-28. PMID:30308090. |
brain-derived neurotrophic factor (bdnf) which is primarily associated with neuronal survivability, differentiation and synaptic plasticity has been reported to mediate neurodegeneration in hypoxia through its p75 neurotrophin receptors (p75ntr). |
2019-10-28 |
2023-08-13 |
rat |
| Ryoko Suzuki, Akihiro Fujikawa, Yukio Komatsu, Kazuya Kuboyama, Naomi Tanga, Masaharu Nod. Enhanced extinction of aversive memories in mice lacking SPARC-related protein containing immunoglobulin domains 1 (SPIG1/FSTL4). Neurobiology of learning and memory. vol 152. 2019-10-01. PMID:29783061. |
brain-derived neurotrophic factor (bdnf) plays an important role in synaptic plasticity related to learning and memory. |
2019-10-01 |
2023-08-13 |
mouse |
| Wen Xu, Jian Cao, Yan Zhou, Lina Wang, Guoqi Zh. GPR30 activation improves memory and facilitates DHPG-induced LTD in the hippocampal CA3 of middle-aged mice. Neurobiology of learning and memory. vol 149. 2019-09-16. PMID:29421611. |
the regulation of hippocampal synaptic plasticity by g1 treatment might be related to brain-derived neurotrophic factor (bdnf)-tropomyosin receptor kinase b (trkb) signaling, as g15 also blocked g1-induced activation of the bdnf-trkb pathway. |
2019-09-16 |
2023-08-13 |
mouse |
| Bianca Cotto, Hongbo Li, Ronald F Tuma, Sara Jane Ward, Dianne Langfor. Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production. Neurobiology of disease. vol 117. 2019-09-06. PMID:29859319. |
methyl cpg binding protein 2 (mecp2) binds to the promoter region of bdnf to negatively regulate its expression and cocaine can recruit mecp2 to alter the expression of genes such as bdnf that are involved in synaptic plasticity. |
2019-09-06 |
2023-08-13 |
human |
| Bianca Cotto, Hongbo Li, Ronald F Tuma, Sara Jane Ward, Dianne Langfor. Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production. Neurobiology of disease. vol 117. 2019-09-06. PMID:29859319. |
for several decades, bdnf has been implicated in mediating synaptic plasticity associated with cocaine abuse, and most studies report that neurons are the primary source for bdnf production in the brain. |
2019-09-06 |
2023-08-13 |
human |
| Bianca Cotto, Hongbo Li, Ronald F Tuma, Sara Jane Ward, Dianne Langfor. Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production. Neurobiology of disease. vol 117. 2019-09-06. PMID:29859319. |
results from these studies show for the first time that cocaine self-administration increases microglial activation, and that microglial mecp2 is a sensitive target of cocaine resulting in increased release of bdnf from microglia, and possibly contributing to cocaine-induced synaptic plasticity. |
2019-09-06 |
2023-08-13 |
human |
| Martina Parrini, Diego Ghezzi, Gabriele Deidda, Lucian Medrihan, Enrico Castroflorio, Micol Alberti, Pietro Baldelli, Laura Cancedda, Andrea Contestabil. Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome. Scientific reports. vol 7. issue 1. 2019-07-05. PMID:29203796. |
pharmacological stimulation of bdnf signaling rescued synaptic plasticity and memory deficits in ts65dn mice. |
2019-07-05 |
2023-08-13 |
mouse |
| Xing-Ming Wang, Wei Pan, Ning Xu, Zhi-Qiang Zhou, Guang-Fen Zhang, Jin-Chun She. Environmental enrichment improves long-term memory impairment and aberrant synaptic plasticity by BDNF/TrkB signaling in nerve-injured mice. Neuroscience letters. vol 694. 2019-06-21. PMID:30496785. |
the pain threshold, long-term memory, expression of brain-derived neurotrophic factor (bdnf) and synaptic plasticity in hippocampus were determined. |
2019-06-21 |
2023-08-13 |
mouse |
| Xing-Ming Wang, Wei Pan, Ning Xu, Zhi-Qiang Zhou, Guang-Fen Zhang, Jin-Chun She. Environmental enrichment improves long-term memory impairment and aberrant synaptic plasticity by BDNF/TrkB signaling in nerve-injured mice. Neuroscience letters. vol 694. 2019-06-21. PMID:30496785. |
cci also induced the reduction of bdnf expression and synaptic plasticity impairments in the hippocampus, as represented by the dendritic spine density and postsynaptic density protein (psd)-95 reduction, and long-term potential (ltp) dysfunction. |
2019-06-21 |
2023-08-13 |
mouse |
| Xing-Ming Wang, Wei Pan, Ning Xu, Zhi-Qiang Zhou, Guang-Fen Zhang, Jin-Chun She. Environmental enrichment improves long-term memory impairment and aberrant synaptic plasticity by BDNF/TrkB signaling in nerve-injured mice. Neuroscience letters. vol 694. 2019-06-21. PMID:30496785. |
notably, ee can ameliorate the pain threshold and bdnf reduction, long-term memory deficits, and synaptic plasticity impairments in nerve-injured mice. |
2019-06-21 |
2023-08-13 |
mouse |
| Xing-Ming Wang, Wei Pan, Ning Xu, Zhi-Qiang Zhou, Guang-Fen Zhang, Jin-Chun She. Environmental enrichment improves long-term memory impairment and aberrant synaptic plasticity by BDNF/TrkB signaling in nerve-injured mice. Neuroscience letters. vol 694. 2019-06-21. PMID:30496785. |
in conclusion, ee improved the pain threshold reduction, long-term memory and synaptic plasticity deficits in nerve-injured mice; bdnf / trk b signaling may contribute to the relief of long-term memory and synaptic plasticity deficits induced by ee in nerve-injured mice. |
2019-06-21 |
2023-08-13 |
mouse |
| Camilla Lazzaretti, Grasielle Clotildes Kincheski, Pablo Pandolfo, Rachel Krolow, Ana Paula Toniazzo, Danusa Mar Arcego, Natividade de Sá Couto-Pereira, Fares Zeidán-Chuliá, Ben-Hur Neves de Oliveira, Diego Bertolini, Raquel Luísa Breunig, Andréa Kurek Ferreira, Janaína Kolling, Cassiana Siebert, Angela Teresinha Wyse, Tadeu Mello E Souza, Carla Dalma. Neonatal handling impairs intradimensional shift and alters plasticity markers in the medial prefrontal cortex of adult rats. Physiology & behavior. vol 197. 2019-06-11. PMID:30266584. |
we evaluated proteins related to synaptic plasticity (brain-derived neurotrophic factor [bdnf] and synaptophysin [syp]) as well as na |
2019-06-11 |
2023-08-13 |
rat |
| Bárbara Bruna, Pedro Lobos, Rodrigo Herrera-Molina, Cecilia Hidalgo, Andrea Paula-Lima, Tatiana Adasm. The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca Biochemical and biophysical research communications. vol 505. issue 1. 2019-05-28. PMID:30243728. |
the signaling pathways underlying bdnf-induced nrf2 hippocampal nuclear translocation involve ros, ryr-mediated ca the neurotrophin brain-derived neurotrophic factor (bdnf) induces complex neuronal signaling cascades that are critical for the cellular changes underlying synaptic plasticity. |
2019-05-28 |
2023-08-13 |
Not clear |
| Siamak Shahidi, Alireza Komaki, Reihaneh Sadeghian, Sara Soleimani As. Different doses of methamphetamine alter long-term potentiation, level of BDNF and neuronal apoptosis in the hippocampus of reinstated rats. The journal of physiological sciences : JPS. vol 69. issue 2. 2019-05-28. PMID:30680641. |
these results suggest that alterations in synaptic plasticity, expression of bdnf and neuronal apoptosis in the hippocampus has a vital role in the context-induced reinstatement of meth seeking. |
2019-05-28 |
2023-08-13 |
rat |
| Jun Shen, Yaqing Li, Chujie Qu, Linling Xu, Huimin Sun, Junjian Zhan. The enriched environment ameliorates chronic unpredictable mild stress-induced depressive-like behaviors and cognitive impairment by activating the SIRT1/miR-134 signaling pathway in hippocampus. Journal of affective disorders. vol 248. 2019-05-14. PMID:30716615. |
enriched environment (ee) showed a beneficial effect on depression and cognition by enhancing brain derived neurotrophic factor (bdnf) expression and synaptic plasticity. |
2019-05-14 |
2023-08-13 |
Not clear |