| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah Ateaque, Spyros Merkouris, Sean Wyatt, Nicholas D Allen, Jia Xie, Peter S DiStefano, Ronald M Lindsay, Yves-Alain Bard. Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC. Journal of neurochemistry. 2022-05-10. PMID:35536742. |
downstream of trk activation, the changes in gene expression caused by trkc activation were found to be similar to those resulting from trkb activation by bdnf, including a number of genes involved in synaptic plasticity. |
2022-05-10 |
2023-08-13 |
human |
| Fatemeh Khani-Habibabadi, Leila Zare, Mohammad Ali Sahraian, Mohammad Javan, Mehrdad Behmanes. Hotair and Malat1 Long Noncoding RNAs Regulate Bdnf Expression and Oligodendrocyte Precursor Cell Differentiation. Molecular neurobiology. 2022-05-02. PMID:35499794. |
brain-derived neurotrophic factor (bdnf) is a member of the neurotrophins family with well-known roles in neural development, differentiation, survival, and synaptic plasticity; however, it has not been explained thoroughly how the expression of this critical gene is regulated. |
2022-05-02 |
2023-08-13 |
rat |
| Charles N S Allen, Sterling P Arjona, Maryline Santerre, Claudio De Lucia, Walter J Koch, Bassel E Saway. Metabolic Reprogramming in HIV-Associated Neurocognitive Disorders. Frontiers in cellular neuroscience. vol 16. 2022-04-14. PMID:35418836. |
the accumulation of probdnf results in signaling that increases the expression of the inducible camp early repressor (icer) protein which then occupies the camp response element (cre)-binding sites within the bdnf promoters ii and iv, thus altering normal synaptic plasticity. |
2022-04-14 |
2023-08-13 |
Not clear |
| Jing Wen, Yaowei Xu, Zhixiang Yu, Yifan Zhou, Wenting Wang, Jingjie Yang, Yiming Wang, Qian Bai, Zhisong L. The cAMP Response Element- Binding Protein/Brain-Derived Neurotrophic Factor Pathway in Anterior Cingulate Cortex Regulates Neuropathic Pain and Anxiodepression Like Behaviors in Rats. Frontiers in molecular neuroscience. vol 15. 2022-04-11. PMID:35401106. |
at the same time, brain-derived neurotrophic factor (bdnf), as important targets of creb, is intricate in neuronal growth, differentiation, as well as the establishment of synaptic plasticity. |
2022-04-11 |
2023-08-13 |
rat |
| Risto Halonen, Liisa Kuula, Jari Lahti, Katri Räikkönen, Anu-Katriina Pesone. The association between overnight recognition accuracy and slow oscillation-spindle coupling is moderated by BDNF Val66Met. Behavioural brain research. 2022-04-11. PMID:35405173. |
brain-derived neurotrophic factor (bdnf) val66met and catechol-o-methyltransferase (comt) val158met are repeatedly reported to implicate the structure and function of prefrontal and hippocampal areas as well as molecular events promoting synaptic plasticity. |
2022-04-11 |
2023-08-13 |
Not clear |
| Sanjay Arora, Takahisa Kanekiyo, Jagdish Sing. Functionalized nanoparticles for brain targeted BDNF gene therapy to rescue Alzheimer's disease pathology in transgenic mouse model. International journal of biological macromolecules. 2022-04-04. PMID:35378156. |
brain-derived neurotrophic factor (bdnf) is actively produced and utilized in cortical circuits throughout life to sustain neuronal function and synaptic plasticity. |
2022-04-04 |
2023-08-13 |
mouse |
| Rundong Liu, Lin Bai, Mengchen Liu, Ruike Wang, Yingying Wu, Qiong Li, Yue Ba, Huizhen Zhang, Guoyu Zhou, Fangfang Yu, Hui Huan. Combined exposure of lead and high-fat diet enhanced cognitive decline via interacting with CREB-BDNF signaling in male rats. Environmental pollution (Barking, Essex : 1987). 2022-04-01. PMID:35364187. |
pb and hfd decreased the levels of synapsin-1, gap-43 and psd-95 protein related to synaptic properties and sirt1, nmdars, phosphorylated creb and bdnf related to synaptic plasticity regulatory, and these decreases was greater when combined exposure. |
2022-04-01 |
2023-08-13 |
rat |
| Antonino Giordano, Ferdinando Clarelli, Miryam Cannizzaro, Elisabetta Mascia, Silvia Santoro, Melissa Sorosina, Laura Ferrè, Letizia Leocani, Federica Esposit. Frontiers in neurology. vol 13. 2022-03-10. PMID:35265024. |
motor recovery depends on synaptic plasticity, in which the brain-derived neurotrophic factor (bdnf) is a key player, through its binding to the neurotrophic-tyrosine kinase-2 (ntrk2) receptor. |
2022-03-10 |
2023-08-13 |
Not clear |
| Mahshid Ebrahimnejad, Paniz Azizi, Vahide Alipour, Mohammad-Reza Zarrindast, Salar Vasegh. Complicated Role of Exercise in Modulating Memory: A Discussion of the Mechanisms Involved. Neurochemical research. 2022-02-23. PMID:35195832. |
in this article, the role of brain-derived neurotrophic factor (bdnf) and tropomyosin receptor kinase b (involved in synaptic plasticity and neurogenesis), and vascular endothelial growth factor, nerve growth factor, insulin-like growth factor 1, inflammatory markers, apoptotic factors, and antioxidant system was discussed in the modulation of exercise effects on memory. |
2022-02-23 |
2023-08-13 |
Not clear |
| Kazunori Suda, Kazunori Matsud. How Microbes Affect Depression: Underlying Mechanisms via the Gut-Brain Axis and the Modulating Role of Probiotics. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163104. |
short-chain fatty acids such as butyrate are known to contribute to the up-regulation of brain-derived neurotrophic factor (bdnf), and gut dysbiosis causes decreased levels of bdnf, which could affect neuronal development and synaptic plasticity. |
2022-02-15 |
2023-08-13 |
Not clear |
| Joyce Keife. Regulation of AMPAR trafficking in synaptic plasticity by BDNF and the impact of neurodegenerative disease. Journal of neuroscience research. 2022-02-07. PMID:35128708. |
regulation of ampar trafficking in synaptic plasticity by bdnf and the impact of neurodegenerative disease. |
2022-02-07 |
2023-08-13 |
Not clear |
| Joyce Keife. Regulation of AMPAR trafficking in synaptic plasticity by BDNF and the impact of neurodegenerative disease. Journal of neuroscience research. 2022-02-07. PMID:35128708. |
here, research showing that bdnf drives ampars to synapses, ampar trafficking is essential for synaptic plasticity and learning, and that neurodegenerative disease results in a significant decline in bdnf will be reviewed. |
2022-02-07 |
2023-08-13 |
Not clear |
| Jing Gao, Ming-Yin Lai, Thi Tanh-Tam Mai, Wen Fu, Meng-Yu Wang, Bai-le Ning, Wen-Bin F. [Effects of electroacupuncture on BNDF/mTORC1 signaling pathway and synaptic plasticity in prefrontal cortex of rats exposed to chronic unpredictable mild stress]. Zhen ci yan jiu = Acupuncture research. vol 47. issue 1. 2022-02-07. PMID:35128865. |
to investigate the effects of electroacupuncture (ea) on the expression of related proteins in the brain-derived neurotrophic factor (bdnf)/mammalian target of rapamycin complex 1 (mtorc1) signaling pathway and synapse-associated proteins and the density of dendrite spines in the prefrontal cortex (pfc) of depression model rats, and to reveal the underlying mechanism by which ea regulates the synaptic plasticity to improve depressive symptoms. |
2022-02-07 |
2023-08-13 |
rat |
| Serena Camuso, Piergiorgio La Rosa, Maria Teresa Fiorenza, Sonia Canterin. Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders. Neurobiology of disease. 2022-01-02. PMID:34974125. |
brain-derived neurotrophic factor (bdnf) is one of the most studied neurotrophins in the mammalian brain, essential not only to the development of the central nervous system but also to synaptic plasticity. |
2022-01-02 |
2023-08-13 |
Not clear |
| Karin Seidler, Michelle Barro. Intermittent Fasting and Cognitive Performance - Targeting BDNF as Potential Strategy to Optimise Brain Health. Frontiers in neuroendocrinology. 2021-12-20. PMID:34929259. |
aging-related loss of bdnf has been associated with reduced synaptic plasticity, memory and learning as well as increased risk of cognitive impairment and alzheimer's disease. |
2021-12-20 |
2023-08-13 |
human |
| Waleska Maria Almeida Barros, Matheus Santos de Sousa Fernandes, Roberta Karlize Pereira Silva, Karollainy Gomes da Silva, Ana Patricia da Silva Souza, Mariluce Rodrigues Marques Silva, Ana Beatriz Januario da Silva, Gabriela Carvalho Jurema Santos, Maria Eduarda Rodrigues Alves Dos Santos, Taciane Silva do Carmo, Sandra Lopes de Souza, Viviane de Oliveira Nogueira Souz. Does the enriched environment alter memory capacity in malnourished rats by modulating BDNF expression? Journal of applied biomedicine. vol 19. issue 3. 2021-12-15. PMID:34907761. |
the bdnf may interfere in synaptic plasticity processes, such as memory. |
2021-12-15 |
2023-08-13 |
rat |
| Waleska Maria Almeida Barros, Matheus Santos de Sousa Fernandes, Roberta Karlize Pereira Silva, Karollainy Gomes da Silva, Ana Patricia da Silva Souza, Mariluce Rodrigues Marques Silva, Ana Beatriz Januario da Silva, Gabriela Carvalho Jurema Santos, Maria Eduarda Rodrigues Alves Dos Santos, Taciane Silva do Carmo, Sandra Lopes de Souza, Viviane de Oliveira Nogueira Souz. Does the enriched environment alter memory capacity in malnourished rats by modulating BDNF expression? Journal of applied biomedicine. vol 19. issue 3. 2021-12-15. PMID:34907761. |
thereby, evidence from the scientific literature suggests that the mechanisms of synaptic plasticity in the hippocampus of adult animals are influenced by malnutrition and ee, and these alterations may involve the participation of bdnf as a key regulator in memory processes in the adult animal hippocampus. |
2021-12-15 |
2023-08-13 |
rat |
| Debora Cutuli, Eugenia Landolfo, Laura Petrosini, Francesca Gelf. Environmental Enrichment Effects on the Brain-Derived Neurotrophic Factor Expression in Healthy Condition, Alzheimer's Disease, and Other Neurodegenerative Disorders. Journal of Alzheimer's disease : JAD. 2021-12-13. PMID:34897089. |
brain-derived neurotrophic factor (bdnf), a protein belonging to the neurotrophin family, is known to be heavily involved in synaptic plasticity processes that support brain development, post-lesion regeneration, and cognitive performances, such as learning and memory. |
2021-12-13 |
2023-08-13 |
Not clear |
| Ying Yu, Zhaokun Shi, Dan Xu, Ying Li, Jun Qin, Zhaohui Zhang, Hui Wan. Prenatal ethanol exposure increases susceptibility to depression- and anxiety-like behavior in adult female offspring and its underlying mechanism. Reproductive toxicology (Elmsford, N.Y.). vol 96. 2021-12-06. PMID:32497709. |
the latter inhibits the hippocampal bdnf pathway, leading to the disruption of hippocampal neurogenesis, apoptosis and decreased synaptic plasticity. |
2021-12-06 |
2023-08-13 |
rat |
| Wenya Pei, Fanqi Meng, Qingwen Deng, Baobao Zhang, Yuan Gu, Boyu Jiao, Haoyu Xu, Jiuqing Tan, Xin Zhou, Zhiling Li, Guanheng He, Jingwen Ruan, Ying Din. Electroacupuncture promotes the survival and synaptic plasticity of hippocampal neurons and improvement of sleep deprivation-induced spatial memory impairment. CNS neuroscience & therapeutics. vol 27. issue 12. 2021-12-01. PMID:34623740. |
this study aimed to investigate whether electroacupuncture (ea) promotes the survival and synaptic plasticity of hippocampal neurons by activating brain-derived neurotrophic factor (bdnf)/tyrosine receptor kinase (trkb)/extracellular signal-regulated kinase (erk) signaling, thereby improving spatial memory deficits in rats under sd. |
2021-12-01 |
2023-08-13 |
rat |