| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruth M Barrientos, Matthew G Frank, Linda R Watkins, Steven F Maie. Memory impairments in healthy aging: Role of aging-induced microglial sensitization. Aging and disease. vol 1. issue 3. 2021-10-20. PMID:21132050. |
among the outcomes of this exaggerated neuroinflammatory response is an impairment in synaptic plasticity, and a reduction in key downstream mediators such as arc and bdnf. |
2021-10-20 |
2023-08-12 |
human |
| Romain Menet, Philippe Bourassa, Frédéric Calon, Ayman ElAl. Dickkopf-related protein-1 inhibition attenuates amyloid-beta pathology associated to Alzheimer's disease. Neurochemistry international. vol 141. 2021-10-18. PMID:33068684. |
moreover, dkk1 inhibition enhances vascular density, promotes blood-brain barrier (bbb) integrity by increasing claudin 5, glucose transporter-1 (glut1), and atp-binding cassette sub-family b member-1 (abcb1) protein expression, as well as ameliorates synaptic plasticity by increasing brain-derived neurotrophic factor (bdnf), and postsynaptic density protein-95 (psd-95) protein expression. |
2021-10-18 |
2023-08-13 |
mouse |
| Yao-Ching Fang, Jia-Yu Hsieh, Amelia Nur Vidyanti, Chih-Hao Yang, Jing-Shiun Jan, Kang-Wei Chang, Chaur-Jong Hu, Yong-Kwang T. HDACi protects against vascular cognitive impairment from CCH injury via induction of BDNF-related AMPA receptor activation. Journal of cellular and molecular medicine. vol 25. issue 15. 2021-10-15. PMID:34216182. |
bdnf is involved in cell proliferation and differentiation in development, synaptic plasticity and in learning and memory related with receptors or synaptic proteins. |
2021-10-15 |
2023-08-13 |
mouse |
| Machhindra Garad, Elke Edelmann, Volkmar Leßman. Long-term depression at hippocampal mossy fiber-CA3 synapses involves BDNF but is not mediated by p75NTR signaling. Scientific reports. vol 11. issue 1. 2021-10-13. PMID:33879805. |
bdnf plays a crucial role in the regulation of synaptic plasticity. |
2021-10-13 |
2023-08-13 |
Not clear |
| Machhindra Garad, Elke Edelmann, Volkmar Leßman. Long-term depression at hippocampal mossy fiber-CA3 synapses involves BDNF but is not mediated by p75NTR signaling. Scientific reports. vol 11. issue 1. 2021-10-13. PMID:33879805. |
while most experimental evidence for this bdnf dependence of synaptic plasticity in the hippocampus was derived from schaffer collateral (sc)-ca1 synapses, much less is known about the mechanisms of synaptic plasticity, in particular ltd, at hippocampal mossy fiber (mf) synapses onto ca3 neurons. |
2021-10-13 |
2023-08-13 |
Not clear |
| Hanan Polansky, Benjamin Gora. How an increase in the copy number of HSV-1 during latency can cause Alzheimer's disease: the viral and cellular dynamics according to the microcompetition model. Journal of neurovirology. 2021-10-12. PMID:34635992. |
third, we describe how an increase in this copy number can reduce the concentration of the nmda receptor subunits nr1 and nr2b (grin1 and grin2b genes), and brain derived neurotrophic factor (bdnf), which can cause an impaired synaptic plasticity, aβ accumulation and eventually alzheimer's disease. |
2021-10-12 |
2023-08-13 |
Not clear |
| A-Na Xu, Feng Ni. Brain-derived neurotrophic factor enhances the therapeutic effect of oleuropein in the lipopolysaccharide-induced models of depression. Folia neuropathologica. vol 59. issue 3. 2021-10-11. PMID:34628790. |
bdnf plays an important role in the development of the nervous system via the regulation of cellular differentiation, survival neurogenesis and synaptic plasticity; therefore, we hypothesized that overexpression of bdnf might contribute to the therapeutic effect of oleuropein. |
2021-10-11 |
2023-08-13 |
mouse |
| Reza Sardar, Zahra Zandieh, Zeinab Namjoo, Mansoureh Soleimani, Reza Shirazi, Javad Ham. Laterality and sex differences in the expression of brain-derived neurotrophic factor in developing rat hippocampus. Metabolic brain disease. vol 36. issue 1. 2021-10-07. PMID:32975719. |
brain-derived neurotrophic factor (bdnf), as a member of neurotrophin family, plays an important role in neurogenesis, neuronal survival and synaptic plasticity. |
2021-10-07 |
2023-08-13 |
rat |
| Júnia L de Deus, Mateus R Amorim, Aline B Ribeiro, Procópio C G Barcellos-Filho, César C Ceballos, Luiz Guilherme S Branco, Alexandra O S Cunha, Ricardo M Leã. Loss of Brain-Derived Neurotrophic Factor Mediates Inhibition of Hippocampal Long-Term Potentiation by High-Intensity Sound. Cellular and molecular neurobiology. vol 41. issue 4. 2021-10-06. PMID:32445041. |
although sound stimulation did not affect glutamatergic or gabaergic neurotransmission in ca1, it did depress the level of brain-derived neurotrophic factor (bdnf), which is involved in promoting hippocampal synaptic plasticity. |
2021-10-06 |
2023-08-13 |
rat |
| Blanca Marin Bosch, Aurélien Bringard, Maria G Logrieco, Estelle Lauer, Nathalie Imobersteg, Aurélien Thomas, Guido Ferretti, Sophie Schwartz, Kinga Iglo. A single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men. Scientific reports. vol 11. issue 1. 2021-10-04. PMID:34257382. |
regular physical exercise enhances memory functions, synaptic plasticity in the hippocampus, and brain derived neurotrophic factor (bdnf) levels. |
2021-10-04 |
2023-08-13 |
human |
| Tobias E Karlsson, Katrin Wellfelt, Lars Olso. Spatiotemporal and Long Lasting Modulation of 11 Key Nogo Signaling Genes in Response to Strong Neuroexcitation. Frontiers in molecular neuroscience. vol 10. 2021-09-24. PMID:28442990. |
a temporo-spatial pattern of orderly transcriptional regulations emerges that strengthens the role of nogo-signaling mechanisms for synaptic plasticity in synchrony with transcriptional increases of bdnf mrna. |
2021-09-24 |
2023-08-13 |
Not clear |
| Patricia M Horvath, Natali L Chanaday, Baris Alten, Ege T Kavalali, Lisa M Monteggi. A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength. Cell reports. vol 36. issue 5. 2021-08-19. PMID:34348149. |
here, we study the effects of the balance between inhibitory and excitatory spontaneous neurotransmission on brain-derived neurotrophic factor (bdnf) regulation and synaptic plasticity. |
2021-08-19 |
2023-08-13 |
Not clear |
| Silvia Martinelli, Elmira A Anderzhanova, Thomas Bajaj, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Daniel E Heinz, Tim Ebert, Jakob Hartmann, Thomas M Geiger, Michael Döngi, Kathrin Hafner, Max L Pöhlmann, Lee Jollans, Alexandra Philipsen, Susanne V Schmidt, Ulrike Schmidt, Giuseppina Maccarrone, Valentin Stein, Felix Hausch, Christoph W Turck, Mathias V Schmidt, Anne-Kathrin Gellner, Bernhard Kuster, Nils C Gasse. Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion. Nature communications. vol 12. issue 1. 2021-08-17. PMID:34330919. |
bdnf is essential for adult synaptic plasticity and its pathway is associated with major depression and posttraumatic stress disorder. |
2021-08-17 |
2023-08-13 |
Not clear |
| Samuel Kohtala, Tomi Rantamäk. Rapid-acting antidepressants and the regulation of TrkB neurotrophic signalling-Insights from ketamine, nitrous oxide, seizures and anaesthesia. Basic & clinical pharmacology & toxicology. vol 129. issue 2. 2021-08-12. PMID:33973360. |
activation of bdnf (brain-derived neurotrophic factor) receptor trkb is considered a key molecular event for antidepressant-induced functional and structural synaptic plasticity. |
2021-08-12 |
2023-08-13 |
Not clear |
| Dany Khamsing, Solène Lebrun, Isabelle Fanget, Nathanaël Larochette, Christophe Tourain, Vincent de Sars, Maia Brunstein, Martin Oheim, Damien Carrel, François Darchen, Claire Desno. A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity. Molecular brain. vol 14. issue 1. 2021-08-12. PMID:34247625. |
the data demonstrate that two important triggers of synaptic plasticity, bdnf and nmda receptors, synergistically power the two arms of the mtorc1 activation mechanism, i.e., mtorc1 translocation to les and rheb activation. |
2021-08-12 |
2023-08-13 |
mouse |
| Sule Şule Deveci, Zeliha Matur, Yesim Yeşim Kesim, Gokce Gökçe Senturk Şentürk, Gulcan Gülcan Sargın-Kurt, Sibel Aylin Ugur Uğur, Ali Emre Oge Ög. Effect of the brain-derived neurotrophic factor gene Val66Met polymorphism on sensory-motor integration during a complex motor learning exercise. Brain research. vol 1732. 2021-07-27. PMID:31926908. |
the brain-derived neurotrophic factor (bdnf) gene val66met polymorphism may cause impairment in short-term motor learning by reducing activity-dependent bdnf expression, which causes alterations in synaptic plasticity by changing glutamatergic and gabaergic synaptic transmissions. |
2021-07-27 |
2023-08-13 |
human |
| Xiao-Chen Yu, Zhen Li, Xin-Ran Liu, Jia-Ni Hu, Rui Liu, Na Zhu, Yong L. The Antioxidant Effects of Whey Protein Peptide on Learning and Memory Improvement in Aging Mice Models. Nutrients. vol 13. issue 6. 2021-07-23. PMID:34205338. |
its specific mechanism may be related to reducing the degeneration of hippocampal nerve cells, reducing the apoptosis of nerve cells, improving the activity of ache, reducing the expression of inflammatory factors (tnf-α and il-1β) in brain tissue, reducing oxidative stress injury, and improving the expression of p-camkⅡ and bdnf synaptic plasticity protein. |
2021-07-23 |
2023-08-13 |
mouse |
| Yoonju Kim, Youn-Jung Ki. Effect of Obesity on Cognitive Impairment in Vascular Dementia Rat Model via BDNF-ERK-CREB Pathway. Biological research for nursing. vol 23. issue 2. 2021-07-21. PMID:32844660. |
in the present study, we evaluated whether obesity exacerbates cognitive impairment in vascular dementia rats and how it affects synaptic plasticity through the bdnf pathway. |
2021-07-21 |
2023-08-13 |
rat |
| Matthew G Pontifex, Anneloes Martinsen, Rasha Noureldin M Saleh, Glenn Harden, Noemi Tejera, Michael Müller, Chris Fox, David Vauzour, Anne-Marie Minihan. APOE4 genotype exacerbates the impact of menopause on cognition and synaptic plasticity in APOE-TR mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 5. 2021-07-19. PMID:33891334. |
molecular analysis indicated both vcd and genotype-related deficits in synaptic plasticity with bdnf, akt, mtor, and erk signaling compromised. |
2021-07-19 |
2023-08-13 |
mouse |
| Hideyuki Matsumoto, Yoshikazu Ugaw. Quadripulse stimulation (QPS). Experimental brain research. vol 238. issue 7-8. 2021-06-29. PMID:32211927. |
in this mini-review, we briefly introduce qps: (i) principle and cortical plasticity (stimulators and protocols, synaptic plasticity, underlying mechanisms, meta-plasticity, axonal plasticity, and drug effects), (ii) robust and strong neural plasticity induction (variability, influence of phasic muscle contraction, independency of bdnf polymorphism, sensory cortical plasticity, neural plasticity in the contralateral hemisphere, on-line effects on the brain networks, studies of normal brain physiology, and visuomotor sequence learning), (iii) therapeutic applications to neurological and psychiatric disorders (parkinson's disease, epilepsy, cerebrovascular disease, and major depression), (iv) safety, and (v) future issues. |
2021-06-29 |
2023-08-13 |
Not clear |