| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura E O'Dell, Oscar V Torre. A mechanistic hypothesis of the factors that enhance vulnerability to nicotine use in females. Neuropharmacology. vol 76 Pt B. 2014-07-29. PMID:23684991. |
this review highlights key factors that promote nicotine use in females, and future studies on sex-dependent interactions of stress and reward systems are needed to test our mechanistic hypotheses. |
2014-07-29 |
2023-08-12 |
rat |
| Pauline Charbogne, Brigitte L Kieffer, Katia Befor. 15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse. Neuropharmacology. vol 76 Pt B. 2014-07-29. PMID:24035914. |
the kappa receptor mainly interacts with pdyn peptides to limit drug reward, and mediate dysphoric effects of cannabinoids and nicotine. |
2014-07-29 |
2023-08-12 |
mouse |
| Christie D Fowler, Paul J Kenn. Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability. Neuropharmacology. vol 76 Pt B. 2014-07-29. PMID:24055497. |
nicotine stimulates brain reward circuitries, most prominently the mesocorticolimbic dopamine system, and this action plays a critical in establishing and maintaining the tobacco smoking habit. |
2014-07-29 |
2023-08-12 |
Not clear |
| Christie D Fowler, Paul J Kenn. Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability. Neuropharmacology. vol 76 Pt B. 2014-07-29. PMID:24055497. |
compounds that attenuate nicotine reward are considered promising therapeutic candidates for tobacco dependence, but many of these agents have other actions that limit their potential utility. |
2014-07-29 |
2023-08-12 |
Not clear |
| Christie D Fowler, Paul J Kenn. Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability. Neuropharmacology. vol 76 Pt B. 2014-07-29. PMID:24055497. |
first, the role of the mesocorticolimbic system, so often associated with nicotine reward, in regulating nicotine aversion is highlighted. |
2014-07-29 |
2023-08-12 |
Not clear |
| Christie D Fowler, Paul J Kenn. Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability. Neuropharmacology. vol 76 Pt B. 2014-07-29. PMID:24055497. |
finally, the feasibility of developing novel therapeutic agents for tobacco dependence that act not by blocking nicotine reward but by enhancing nicotine avoidance will be considered. |
2014-07-29 |
2023-08-12 |
Not clear |
| Scott T Barret, Rick A Bevin. Nicotine enhances operant responding for qualitatively distinct reinforcers under maintenance and extinction conditions. Pharmacology, biochemistry, and behavior. vol 114-115. 2014-07-22. PMID:24422211. |
nicotine enhancement of reward has been implicated as an important contributor to tobacco addiction. |
2014-07-22 |
2023-08-12 |
Not clear |
| Scott T Barret, Rick A Bevin. Nicotine enhances operant responding for qualitatively distinct reinforcers under maintenance and extinction conditions. Pharmacology, biochemistry, and behavior. vol 114-115. 2014-07-22. PMID:24422211. |
despite the attention that reward enhancement has received, the behavioral mechanisms whereby nicotine enhances operant responding remain largely unknown. |
2014-07-22 |
2023-08-12 |
Not clear |
| Luis A Natividad, Oscar V Torres, Theodore C Friedman, Laura E O'Del. Adolescence is a period of development characterized by short- and long-term vulnerability to the rewarding effects of nicotine and reduced sensitivity to the anorectic effects of this drug. Behavioural brain research. vol 257. 2014-06-25. PMID:24120402. |
importantly, our findings suggest that adolescent nicotine exposure produces long-lasting consequences that enhance nicotine reward and promote tolerance to the anorectic effects of this drug. |
2014-06-25 |
2023-08-12 |
rat |
| F Nees, S H Witt, A Lourdusamy, S Vollstädt-Klein, S Steiner, L Poustka, T Banaschewski, G J Barker, C Büchel, P J Conrod, J Frank, J Gallinat, H Garavan, A Heinz, B Ittermann, E Loth, K Mann, E Artiges, T Paus, Z Pausova, M N Smolka, M Struve, G Schumann, M Rietschel, H Flo. Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 11. 2014-05-05. PMID:23689675. |
genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents. |
2014-05-05 |
2023-08-12 |
Not clear |
| David C Pryde, Lyn H Jones, David P Gervais, David R Stead, David C Blakemore, Matthew D Selby, Alan D Brown, Jotham W Coe, Matthew Badland, David M Beal, Rebecca Glen, Yvonne Wharton, Gavin J Miller, Phil White, Ningli Zhang, Michelle Benoit, Karen Robertson, James R Merson, Heather L Davis, Michael J McCluski. Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice. PloS one. vol 8. issue 10. 2014-04-29. PMID:24098532. |
anti-nicotine vaccines may aid smoking cessation via the induction of anti-nicotine antibodies (ab) which reduce nicotine entering the brain, and hence the associated reward. |
2014-04-29 |
2023-08-12 |
mouse |
| Amanda J Morgan, Steven B Harrod, Ryan T Lacy, Emily M Stanley, Jim R Fade. Intravenous prenatal nicotine exposure increases orexin expression in the lateral hypothalamus and orexin innervation of the ventral tegmental area in adult male rats. Drug and alcohol dependence. vol 132. issue 3. 2014-04-22. PMID:23664126. |
animal models indicate that prenatal nicotine (pn) exposure alone alters the development of the mesocorticolimbic dopamine (da) system, which, in part, organizes motivated behavior and reward. |
2014-04-22 |
2023-08-12 |
rat |
| K J Jackson, J B Wang, E Barbier, M I Damaj, X Che. The histidine triad nucleotide binding 1 protein is involved in nicotine reward and physical nicotine withdrawal in mice. Neuroscience letters. vol 550. 2014-04-11. PMID:23810802. |
the histidine triad nucleotide binding 1 protein is involved in nicotine reward and physical nicotine withdrawal in mice. |
2014-04-11 |
2023-08-12 |
mouse |
| K J Jackson, J B Wang, E Barbier, M I Damaj, X Che. The histidine triad nucleotide binding 1 protein is involved in nicotine reward and physical nicotine withdrawal in mice. Neuroscience letters. vol 550. 2014-04-11. PMID:23810802. |
we tested male hint1 wild-type (+/+) and knockout (-/-) mice in the nicotine conditioned place preference (cpp) test of reward, a nicotine withdrawal model assessing both physical and affective signs, and the nicotine withdrawal conditioned place aversion (cpa) test. |
2014-04-11 |
2023-08-12 |
mouse |
| K J Jackson, J B Wang, E Barbier, M I Damaj, X Che. The histidine triad nucleotide binding 1 protein is involved in nicotine reward and physical nicotine withdrawal in mice. Neuroscience letters. vol 550. 2014-04-11. PMID:23810802. |
overall, our data support a role for the hint1 gene in mediating behaviors associated with nicotine reward and physical nicotine withdrawal, and provide insight into the role of hint1 in nicotine dependence-like behaviors. |
2014-04-11 |
2023-08-12 |
mouse |
| b' Mikl\\xc3\\xb3s Palotai, Zsolt Bagosi, Mikl\\xc3\\xb3s J\\xc3\\xa1szber\\xc3\\xa9nyi, Krisztina Csabafi, Roberta Dochnal, M\\xc3\\xa1t\\xc3\\xa9 Manczinger, Gyula Telegdy, Gyula Szab\\xc3\\xb. Ghrelin amplifies the nicotine-induced dopamine release in the rat striatum. Neurochemistry international. vol 63. issue 4. 2014-04-02. PMID:23831084.' |
the orexigenic peptide ghrelin plays a prominent role in the regulation of energy balance and in the mediation of reward mechanisms and reinforcement for addictive drugs, such as nicotine. |
2014-04-02 |
2023-08-12 |
rat |
| b' Mikl\\xc3\\xb3s Palotai, Zsolt Bagosi, Mikl\\xc3\\xb3s J\\xc3\\xa1szber\\xc3\\xa9nyi, Krisztina Csabafi, Roberta Dochnal, M\\xc3\\xa1t\\xc3\\xa9 Manczinger, Gyula Telegdy, Gyula Szab\\xc3\\xb. Ghrelin and nicotine stimulate equally the dopamine release in the rat amygdala. Neurochemical research. vol 38. issue 10. 2014-03-28. PMID:23836294.' |
the orexigenic peptide ghrelin plays a prominent role in the regulation of energy balance and in the mediation of reward processes and reinforcement for addictive drugs, such as nicotine. |
2014-03-28 |
2023-08-12 |
rat |
| Xiomara A Perez, J Michael McIntosh, Maryka Qui. Long-term nicotine treatment down-regulates α6β2* nicotinic receptor expression and function in nucleus accumbens. Journal of neurochemistry. vol 127. issue 6. 2014-02-18. PMID:23992036. |
these changes may play a key role in nicotine reward and dependence. |
2014-02-18 |
2023-08-12 |
rat |
| Oguz Gozen, Burcu Balkan, Emre Yildirim, Ersin O Koylu, Sakire Pogu. The epigenetic effect of nicotine on dopamine D1 receptor expression in rat prefrontal cortex. Synapse (New York, N.Y.). vol 67. issue 9. 2014-02-13. PMID:23447334. |
nicotine is a highly addictive drug and exerts its effect partially through causing dopamine release, thereby increasing intrasynaptic dopamine levels in the brain reward systems. |
2014-02-13 |
2023-08-12 |
rat |
| Leigh V Panlilio, Claudio Zanettini, Chanel Barnes, Marcelo Solinas, Steven R Goldber. Prior exposure to THC increases the addictive effects of nicotine in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 7. 2014-01-24. PMID:23314220. |
when the price of nicotine was manipulated by increasing the response requirement, thc-exposed rats maintained higher levels of intake than vehicle-exposed rats, indicating that thc exposure increased the value of nicotine reward. |
2014-01-24 |
2023-08-12 |
rat |