| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Georgios Misailidis, Georgia Ragia, Desislava D Ivanova, Anna Tavridou, Vangelis G Manolopoulo. Gene-gene interaction of μ-opioid receptor and GluR5 kainate receptor subunit is associated with smoking behavior in a Greek population: presence of a dose allele effect. Drug metabolism and personalized therapy. vol 30. issue 2. 2016-02-22. PMID:25941919. |
the μ-opioid receptor (oprm1) binds the endogenous opioid peptide β-endorphin and mediates the reinforcing effects of nicotine, while the glur5 kainate receptor subunit (encoded by grik1 gene), a binding site for known mediators of glutamate neurotransmission, potentially affects the glutaminergic system that is also indirectly implicated in the reward system. |
2016-02-22 |
2023-08-13 |
Not clear |
| Michael J McCluskie, Jennifer Thorn, Paul R Mehelic, Parag Kolhe, Keshab Bhattacharya, Jari I Finneman, David R Stead, Michele Bailey Piatchek, Ningli Zhang, Ghania Chikh, Janna Cartier, Dana M Evans, James R Merson, Heather L Davi. Molecular attributes of conjugate antigen influence function of antibodies induced by anti-nicotine vaccine in mice and non-human primates. International immunopharmacology. vol 25. issue 2. 2016-01-04. PMID:25737198. |
anti-nicotine vaccines aim to prevent nicotine entering the brain, and thus reduce or eliminate the reward that drives nicotine addiction. |
2016-01-04 |
2023-08-13 |
mouse |
| Sarah S Sanjakdar, Pretal P Maldoon, Michael J Marks, Darlene H Brunzell, Uwe Maskos, J Michael McIntosh, M Scott Bowers, M Imad Dama. Differential roles of α6β2* and α4β2* neuronal nicotinic receptors in nicotine- and cocaine-conditioned reward in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 2. 2015-12-18. PMID:25035086. |
furthermore, α6β2* nachrs in nucleus accumbens were found to have an important role in nicotine-conditioned reward as the intra-accumbal injection of the selective α6β2* α-conotoxin mii [h9a; l15a], blocked nicotine cpp. |
2015-12-18 |
2023-08-13 |
mouse |
| Matthew I Palmatier, Marissa R Kellicut, A Brianna Sheppard, Russell W Brown, Donita L Robinso. The incentive amplifying effects of nicotine are reduced by selective and non-selective dopamine antagonists in rats. Pharmacology, biochemistry, and behavior. vol 126. 2015-11-09. PMID:25230311. |
to test this hypothesis, separate groups of rats were injected with nicotine (0.4mg/kg base) or saline prior to pavlovian conditioning sessions in which a cs (30s illumination of a light or presentation of a lever) was immediately followed by a sweet reward delivered in an adjacent location. |
2015-11-09 |
2023-08-13 |
rat |
| Matthew I Palmatier, Marissa R Kellicut, A Brianna Sheppard, Russell W Brown, Donita L Robinso. The incentive amplifying effects of nicotine are reduced by selective and non-selective dopamine antagonists in rats. Pharmacology, biochemistry, and behavior. vol 126. 2015-11-09. PMID:25230311. |
both saline and nicotine pretreated rats exhibited similar levels of conditioned approach to the reward location (goal tracking), but nicotine pretreatment significantly increased approach to the cs (sign tracking), regardless of type (lever or light). |
2015-11-09 |
2023-08-13 |
rat |
| Nicola Lindson-Hawley, Tim Coleman, Graeme Docherty, Peter Hajek, Sarah Lewis, Deborah Lycett, Andy McEwen, Hayden McRobbie, Marcus R Munafò, Steve Parrott, Paul Aveyar. Nicotine patch preloading for smoking cessation (the preloading trial): study protocol for a randomized controlled trial. Trials. vol 15. 2015-10-28. PMID:25052334. |
nicotine preloading could improve quit rates by reducing satisfaction from smoking prior to quitting and breaking the association between smoking and reward. |
2015-10-28 |
2023-08-13 |
Not clear |
| Mustafa al'Absi, Andrine Lemieux, Motohiro Nakajima, Dorothy K Hatsukami, Sharon Alle. Circulating leptin and pain perception among tobacco-dependent individuals. Biological psychology. vol 107. 2015-10-23. PMID:25720946. |
in light of leptin's influence on reward pathways, further investigation of leptin's involvement in nicotine dependence is warranted. |
2015-10-23 |
2023-08-13 |
Not clear |
| Shingo Kawazoe, Takahiro Shinka. [Nicotine dependence]. Nihon rinsho. Japanese journal of clinical medicine. vol 73. issue 9. 2015-10-16. PMID:26394514. |
as for physical nicotine dependence, nicotine produces rewarding effects by interacting with nicotinic acetylcholine receptors on neurons in the brain's reward system. |
2015-10-16 |
2023-08-13 |
Not clear |
| Adrie W Bruijnzeel, Jon C Alexander, Pablo D Perez, Rayna Bauzo-Rodriguez, Gabrielle Hall, Rachel Klausner, Valerie Guerra, Huadong Zeng, Moe Igari, Marcelo Feb. Acute nicotine administration increases BOLD fMRI signal in brain regions involved in reward signaling and compulsive drug intake in rats. The international journal of neuropsychopharmacology. vol 18. issue 2. 2015-10-06. PMID:25552431. |
acute nicotine administration increases bold fmri signal in brain regions involved in reward signaling and compulsive drug intake in rats. |
2015-10-06 |
2023-08-13 |
rat |
| Adrie W Bruijnzeel, Jon C Alexander, Pablo D Perez, Rayna Bauzo-Rodriguez, Gabrielle Hall, Rachel Klausner, Valerie Guerra, Huadong Zeng, Moe Igari, Marcelo Feb. Acute nicotine administration increases BOLD fMRI signal in brain regions involved in reward signaling and compulsive drug intake in rats. The international journal of neuropsychopharmacology. vol 18. issue 2. 2015-10-06. PMID:25552431. |
acute nicotine administration potentiates brain reward function and enhances motor and cognitive function. |
2015-10-06 |
2023-08-13 |
rat |
| Munir G Kutlu, Leonardo A Ortega, Thomas J Goul. Strain-dependent performance in nicotine-induced conditioned place preference. Behavioral neuroscience. vol 129. issue 1. 2015-09-23. PMID:25546366. |
this initial investigation lays the foundation for future studies examining the genetic substrates of nicotine reward. |
2015-09-23 |
2023-08-13 |
mouse |
| Sheketha R Hauser, Gerald A Deehan, Jamie E Toalston, Richard L Bell, William J McBride, Zachary A Rod. Enhanced alcohol-seeking behavior by nicotine in the posterior ventral tegmental area of female alcohol-preferring (P) rats: modulation by serotonin-3 and nicotinic cholinergic receptors. Psychopharmacology. vol 231. issue 18. 2015-09-10. PMID:24599396. |
alcohol, nicotine, and serotonin-3 (5-ht3) receptors interact within the posterior ventral tegmental area (pvta) to regulate drug reward. |
2015-09-10 |
2023-08-12 |
rat |
| Lee Hogarth, Joseph R Trois. A hierarchical instrumental decision theory of nicotine dependence. Current topics in behavioral neurosciences. vol 23. 2015-09-08. PMID:25655891. |
we favor instead a hierarchical instrumental decision account, wherein expectations about the instrumental contingency between voluntary tobacco-seeking and the receipt of nicotine reward determines the probability of executing this behavior. |
2015-09-08 |
2023-08-13 |
Not clear |
| Hyunchan Lee, Mi-Seon Kang, Jun-Mo Chung, Jihyun No. Repeated nicotine exposure in adolescent rats: Reduction of medial habenular activity and augmentation of nicotine preference. Physiology & behavior. vol 138. 2015-08-26. PMID:25449387. |
nicotine not only stimulates brain reward circuits to establish and maintain the tobacco smoking habit, but also produces aversive reactions to nicotine after initial exposure, due to its noxious properties. |
2015-08-26 |
2023-08-13 |
rat |
| Jennifer Ngolab, Liwang Liu, Rubing Zhao-Shea, Guangping Gao, Paul D Gardner, Andrew R Tappe. Functional Upregulation of α4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 22. 2015-08-19. PMID:26041923. |
functional upregulation of α4* nicotinic acetylcholine receptors in vta gabaergic neurons increases sensitivity to nicotine reward. |
2015-08-19 |
2023-08-13 |
mouse |
| Jennifer Ngolab, Liwang Liu, Rubing Zhao-Shea, Guangping Gao, Paul D Gardner, Andrew R Tappe. Functional Upregulation of α4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 22. 2015-08-19. PMID:26041923. |
chronic nicotine exposure increases sensitivity to nicotine reward during a withdrawal period, which may facilitate relapse in abstinent smokers, yet the molecular neuroadaptation(s) that contribute to this phenomenon are unknown. |
2015-08-19 |
2023-08-13 |
mouse |
| Jennifer Ngolab, Liwang Liu, Rubing Zhao-Shea, Guangping Gao, Paul D Gardner, Andrew R Tappe. Functional Upregulation of α4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 22. 2015-08-19. PMID:26041923. |
interestingly, chronic nicotine use induces functional upregulation of nicotinic acetylcholine receptors (nachrs) in the mesocorticolimbic reward pathway potentially linking upregulation to increased drug sensitivity. |
2015-08-19 |
2023-08-13 |
mouse |
| Jennifer Ngolab, Liwang Liu, Rubing Zhao-Shea, Guangping Gao, Paul D Gardner, Andrew R Tappe. Functional Upregulation of α4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 22. 2015-08-19. PMID:26041923. |
to test the hypothesis that increased functional expression of α4* nachrs in these neurons modulates nicotine reward behaviors, we engineered a cre recombinase-dependent gene expression system to selectively express α4 nachr subunits harboring a "gain-of-function" mutation [a leucine mutated to a serine residue at the 9' position (leu9'ser)] in vta gabaergic neurons of adult mice. |
2015-08-19 |
2023-08-13 |
mouse |
| Jennifer Ngolab, Liwang Liu, Rubing Zhao-Shea, Guangping Gao, Paul D Gardner, Andrew R Tappe. Functional Upregulation of α4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 22. 2015-08-19. PMID:26041923. |
together, these data indicate that functional upregulation of α4* nachrs in vta gabaergic neurons confers increased sensitivity to nicotine reward and points to nachr subtypes specifically expressed in gabaergic vta neurons as molecular targets for smoking cessation therapeutics. |
2015-08-19 |
2023-08-13 |
mouse |
| Kenneth A Perkins, Joshua L Karelit. Sensory reinforcement-enhancing effects of nicotine via smoking. Experimental and clinical psychopharmacology. vol 22. issue 6. 2015-08-03. PMID:25180451. |
we assessed acute effects of nicotine via smoking on responding for music or video rewards (sensory), for monetary reward (nonsensory), or for no reward (control), to gauge the generalizability of nicotine's reinforcement-enhancing effects. |
2015-08-03 |
2023-08-13 |
Not clear |