| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesco Pistillo, Francesca Fasoli, Milena Moretti, Tristan McClure-Begley, Michele Zoli, Michael J Marks, Cecilia Gott. Chronic nicotine and withdrawal affect glutamatergic but not nicotinic receptor expression in the mesocorticolimbic pathway in a region-specific manner. Pharmacological research. vol 103. 2016-12-13. PMID:26631628. |
nicotine elicits its primary effects on neuronal nicotinic cholinergic receptors (nachrs), alters brain reward systems, and induces long-term changes during chronic nicotine use and withdrawal. |
2016-12-13 |
2023-08-13 |
mouse |
| Francesco Pistillo, Francesca Fasoli, Milena Moretti, Tristan McClure-Begley, Michele Zoli, Michael J Marks, Cecilia Gott. Chronic nicotine and withdrawal affect glutamatergic but not nicotinic receptor expression in the mesocorticolimbic pathway in a region-specific manner. Pharmacological research. vol 103. 2016-12-13. PMID:26631628. |
we analysed the effects of chronic nicotine treatment and withdrawal on the mesocorticolimbic pathway (a brain reward circuit in which addictive drugs induce widespread adaptations) by analysing the expression of nachrs in the midbrain, striatum and prefrontal cortex (pfc) of mice receiving intravenous infusions of nicotine (4mg/kg/h) or saline (control) for 14 days and mice sacrified two hours, and one, four and 14 days after treatment withdrawal. |
2016-12-13 |
2023-08-13 |
mouse |
| W Goutier, J P Lowry, A C McCreary, J J O'Conno. Frequency-Dependent Modulation of Dopamine Release by Nicotine and Dopamine D1 Receptor Ligands: An In Vitro Fast Cyclic Voltammetry Study in Rat Striatum. Neurochemical research. vol 41. issue 5. 2016-12-13. PMID:26975318. |
nicotine is a highly addictive drug and exerts this effect partially through the modulation of dopamine release and increasing extracellular dopamine in regions such as the brain reward systems. |
2016-12-13 |
2023-08-13 |
rat |
| W E Melroy-Greif, J A Stitzel, M A Ehringe. Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use. Genes, brain, and behavior. vol 15. issue 1. 2016-10-20. PMID:26351737. |
nicotine produces rewarding effects by interacting with these receptors in the brain's reward system. |
2016-10-20 |
2023-08-13 |
human |
| Kia J Jackson, Pretal P Muldoon, Carrie Walters, Mohamad Imad Dama. Neuronal calcium/calmodulin-dependent protein kinase II mediates nicotine reward in the conditioned place preference test in mice. Behavioural pharmacology. vol 27. issue 1. 2016-09-19. PMID:26292186. |
neuronal calcium/calmodulin-dependent protein kinase ii mediates nicotine reward in the conditioned place preference test in mice. |
2016-09-19 |
2023-08-13 |
mouse |
| Kia J Jackson, Pretal P Muldoon, Carrie Walters, Mohamad Imad Dama. Neuronal calcium/calmodulin-dependent protein kinase II mediates nicotine reward in the conditioned place preference test in mice. Behavioural pharmacology. vol 27. issue 1. 2016-09-19. PMID:26292186. |
behavioral and biochemical studies have shown that camkii is involved in acute and chronic nicotine behaviors and nicotine withdrawal; however, evidence of a role for camkii in nicotine reward is lacking. |
2016-09-19 |
2023-08-13 |
mouse |
| Kia J Jackson, Pretal P Muldoon, Carrie Walters, Mohamad Imad Dama. Neuronal calcium/calmodulin-dependent protein kinase II mediates nicotine reward in the conditioned place preference test in mice. Behavioural pharmacology. vol 27. issue 1. 2016-09-19. PMID:26292186. |
thus, the goal of the current study was to examine the role of camkii in nicotine reward. |
2016-09-19 |
2023-08-13 |
mouse |
| Kia J Jackson, Pretal P Muldoon, Carrie Walters, Mohamad Imad Dama. Neuronal calcium/calmodulin-dependent protein kinase II mediates nicotine reward in the conditioned place preference test in mice. Behavioural pharmacology. vol 27. issue 1. 2016-09-19. PMID:26292186. |
the findings from this study show that camkii mediates nicotine reward and suggest that increases in camkii activity in the vta and nac are relevant to nicotine reward behaviors. |
2016-09-19 |
2023-08-13 |
mouse |
| Xiaoli Qi, Lidia Guzhva, Yue Ji, Adriaan W Bruijnzee. Chronic treatment with the vasopressin 1b receptor antagonist SSR149415 prevents the dysphoria associated with nicotine withdrawal in rats. Behavioural brain research. vol 292. 2016-08-17. PMID:26112757. |
mecamylamine elevated the brain reward thresholds of the nicotine dependent rats, which reflects a negative mood state. |
2016-08-17 |
2023-08-13 |
rat |
| Xiaoli Qi, Lidia Guzhva, Yue Ji, Adriaan W Bruijnzee. Chronic treatment with the vasopressin 1b receptor antagonist SSR149415 prevents the dysphoria associated with nicotine withdrawal in rats. Behavioural brain research. vol 292. 2016-08-17. PMID:26112757. |
chronic treatment with ssr149415 completely prevented the elevations in brain reward thresholds associated with nicotine withdrawal while acute treatment only partly prevented nicotine withdrawal. |
2016-08-17 |
2023-08-13 |
rat |
| Paul T Harrell, Hui-Yi Lin, Jong Y Park, Melissa D Blank, David J Drobes, David E Evan. Dopaminergic genetic variation moderates the effect of nicotine on cigarette reward. Psychopharmacology. vol 233. issue 2. 2016-08-08. PMID:26497691. |
dopaminergic genetic variation moderates the effect of nicotine on cigarette reward. |
2016-08-08 |
2023-08-13 |
Not clear |
| Kenneth A Perkins, Joshua L Karelitz, Valerie C Michael, Margaret Fromuth, Cynthia A Conklin, K N Roy Chengappa, Chris Hope, Caryn Lerma. Initial Evaluation of Fenofibrate for Efficacy in Aiding Smoking Abstinence. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 18. issue 1. 2016-07-21. PMID:25895948. |
primate and rodent models show that peroxisome proliferator-activated receptor-alpha (ppar-α) ligands, including fibrate medications, reduce nicotine reinforcement, reward, and related effects. |
2016-07-21 |
2023-08-13 |
Not clear |
| Brandon J Henderson, Teagan R Wall, Beverley M Henley, Charlene H Kim, Weston A Nichols, Ruin Moaddel, Cheng Xiao, Henry A Leste. Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 10. 2016-07-19. PMID:26961950. |
menthol alone upregulates midbrain nachrs, alters nachr subtype stoichiometry, alters dopamine neuron firing frequency, and prevents nicotine reward. |
2016-07-19 |
2023-08-13 |
mouse |
| David Díaz, Azucena Rodrigo Murias, Carmelo Antonio Ávila-Zarza, Rodrigo Muñoz-Castañeda, José Aijón, José Ramón Alonso, Eduardo Weruag. Striatal NOS1 has dimorphic expression and activity under stress and nicotine sensitization. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 10. 2016-07-12. PMID:26235957. |
nicotine exerts its addictive influence through the meso-cortico-limbic reward system, where the striatum is essential. |
2016-07-12 |
2023-08-13 |
mouse |
| Rebecca L Pomfrey, Tamaara A Bostwick, B Bradley Wetzell, Anthony L Rile. Adolescent nicotine exposure fails to impact cocaine reward, aversion and self-administration in adult male rats. Pharmacology, biochemistry, and behavior. vol 137. 2016-06-24. PMID:26255152. |
adolescent nicotine exposure fails to impact cocaine reward, aversion and self-administration in adult male rats. |
2016-06-24 |
2023-08-13 |
human |
| C R Pinheiro, E Oliveira, A C Manhães, M C Fraga, S Claudio-Neto, V Younes-Rapozo, B M Lotufo, E G Moura, P C Lisbo. Exposure to nicotine increases dopamine receptor content in the mesocorticolimbic pathway of rat dams and offspring during lactation. Pharmacology, biochemistry, and behavior. vol 136. 2016-05-17. PMID:26219213. |
we evidenced that postnatal nicotine exposure induces relevant changes in the brain reward system of dams and pups, possibly associated with changes in leptinemia and increased offspring anxiety-like behavior. |
2016-05-17 |
2023-08-13 |
rat |
| Alyssa L Peechatka, Alexis E Whitton, Stacey L Farmer, Diego A Pizzagalli, Amy C Jane. Cigarette craving is associated with blunted reward processing in nicotine-dependent smokers. Drug and alcohol dependence. vol 155. 2016-05-06. PMID:26233484. |
dysfunctional reward processing leading to the undervaluation of non-drug rewards is hypothesized to play a crucial role in nicotine dependence. |
2016-05-06 |
2023-08-13 |
Not clear |
| Alyssa L Peechatka, Alexis E Whitton, Stacey L Farmer, Diego A Pizzagalli, Amy C Jane. Cigarette craving is associated with blunted reward processing in nicotine-dependent smokers. Drug and alcohol dependence. vol 155. 2016-05-06. PMID:26233484. |
however, it is unclear if blunted reward responsivity and the desire to use nicotine are directly linked after a brief period of abstinence. |
2016-05-06 |
2023-08-13 |
Not clear |
| Alyssa L Peechatka, Alexis E Whitton, Stacey L Farmer, Diego A Pizzagalli, Amy C Jane. Cigarette craving is associated with blunted reward processing in nicotine-dependent smokers. Drug and alcohol dependence. vol 155. 2016-05-06. PMID:26233484. |
such an association would suggest that individuals with reduced reward responsivity may be at increased risk to experience nicotine craving. |
2016-05-06 |
2023-08-13 |
Not clear |
| Michael Amlung, James MacKillo. Clarifying the relationship between impulsive delay discounting and nicotine dependence. Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors. vol 28. issue 3. 2016-05-05. PMID:24841186. |
impulsive delayed reward discounting (drd) has been linked to nicotine dependence, but with some inconsistency. |
2016-05-05 |
2023-08-13 |
Not clear |