| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroto Kuwabara, Stephen J Heishman, James R Brasic, Carlo Contoreggi, Nicola Cascella, Kristen M Mackowick, Richard Taylor, Olivier Rousset, William Willis, Marilyn A Huestis, Marta Concheiro, Gary Wand, Dean F Wong, Nora D Volko. Mu Opioid Receptor Binding Correlates with Nicotine Dependence and Reward in Smokers. PloS one. vol 9. issue 12. 2017-10-11. PMID:25493427. |
although we did not show differences between smokers and nonsmokers, the negative correlation with ftnd corroborates the role of mors in superior temporal cortices in nicotine addiction and provides preliminary evidence of a role of endogenous opioid signaling in frontal cortex in nicotine reward. |
2017-10-11 |
2023-08-13 |
human |
| Asti Jackson, Deniz Bagdas, Pretal P Muldoon, Aron H Lichtman, F Ivy Carroll, Mark Greenwald, Michael F Miles, M Imad Dama. In vivo interactions between α7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α: Implication for nicotine dependence. Neuropharmacology. vol 118. 2017-09-05. PMID:28279662. |
our results demonstrate the pparα antagonist gw6471 blocks actions of the α7 nachr agonist pnu282987 on nicotine reward in an unbiased cpp test in male icr adult mice. |
2017-09-05 |
2023-08-13 |
mouse |
| Asti Jackson, Deniz Bagdas, Pretal P Muldoon, Aron H Lichtman, F Ivy Carroll, Mark Greenwald, Michael F Miles, M Imad Dama. In vivo interactions between α7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α: Implication for nicotine dependence. Neuropharmacology. vol 118. 2017-09-05. PMID:28279662. |
this suggests that pparα plays a role in nicotine reward and withdrawal and that further studies are warranted to elucidate its function in mediating the effects of α7 nachrs in nicotine dependence. |
2017-09-05 |
2023-08-13 |
mouse |
| Maggie M Sweitzer, Charles F Geier, Merideth A Addicott, Rachel Denlinger, Bethany R Raiff, Jesse Dallery, F Joseph McClernon, Eric C Donn. Smoking Abstinence-Induced Changes in Resting State Functional Connectivity with Ventral Striatum Predict Lapse During a Quit Attempt. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 10. 2017-08-30. PMID:27091382. |
the ventral and dorsal striatum are critical substrates of reward processing and motivation and have been repeatedly linked to addictive disorders, including nicotine dependence. |
2017-08-30 |
2023-08-13 |
Not clear |
| Luis M Tuesta, Zuxin Chen, Alexander Duncan, Christie D Fowler, Masago Ishikawa, Brian R Lee, Xin-An Liu, Qun Lu, Michael Cameron, Matthew R Hayes, Theodore M Kamenecka, Matthew Pletcher, Paul J Kenn. GLP-1 acts on habenular avoidance circuits to control nicotine intake. Nature neuroscience. vol 20. issue 5. 2017-08-29. PMID:28368384. |
activation of glp-1 receptors in the mhb-ipn circuit abolished nicotine reward and decreased nicotine intake, whereas their knockdown or pharmacological blockade increased intake. |
2017-08-29 |
2023-08-13 |
mouse |
| Kenneth A Perkins, Joshua L Karelit. Potential sex differences in the pattern of sensory reinforcers enhanced by nicotine. Experimental and clinical psychopharmacology. vol 24. issue 3. 2017-07-17. PMID:27124265. |
this study compared reinforced responding for immediate auditory (music) or visual (video) sensory rewards, or no reward (nonspecific control), due to nicotine via ad lib smoking versus no nicotine (overnight abstinence), in a within-subjects design. |
2017-07-17 |
2023-08-13 |
human |
| Anthony Renda, Nora Penty, Pragya Komal, Raad Nashm. Vulnerability to nicotine self-administration in adolescent mice correlates with age-specific expression of α4* nicotinic receptors. Neuropharmacology. vol 108. 2017-07-07. PMID:27102349. |
the most prevalent is the widely expressed α4-containing (α4*) subtype which mediates reward and is strongly implicated in nicotine dependence. |
2017-07-07 |
2023-08-13 |
mouse |
| Mai Alajaji, Matthew F Lazenka, Dena Kota, Laura E Wise, Rabha M Younis, F Ivy Carroll, Amir Levine, Dana E Selley, Laura J Sim-Selley, M Imad Dama. Early adolescent nicotine exposure affects later-life cocaine reward in mice. Neuropharmacology. vol 105. 2017-06-22. PMID:26808314. |
early adolescent nicotine exposure affects later-life cocaine reward in mice. |
2017-06-22 |
2023-08-13 |
mouse |
| Mai Alajaji, Matthew F Lazenka, Dena Kota, Laura E Wise, Rabha M Younis, F Ivy Carroll, Amir Levine, Dana E Selley, Laura J Sim-Selley, M Imad Dama. Early adolescent nicotine exposure affects later-life cocaine reward in mice. Neuropharmacology. vol 105. 2017-06-22. PMID:26808314. |
we hypothesized that exposure to nicotine during early adolescence might increase the risk for drug reward in adulthood. |
2017-06-22 |
2023-08-13 |
mouse |
| Mai Alajaji, Matthew F Lazenka, Dena Kota, Laura E Wise, Rabha M Younis, F Ivy Carroll, Amir Levine, Dana E Selley, Laura J Sim-Selley, M Imad Dama. Early adolescent nicotine exposure affects later-life cocaine reward in mice. Neuropharmacology. vol 105. 2017-06-22. PMID:26808314. |
these results suggest that nicotine exposure during early adolescence increases drug-induced reward in adulthood through mechanisms that may involve the induction of Δfosb. |
2017-06-22 |
2023-08-13 |
mouse |
| James P Kesby, Athina Markou, Svetlana Semenov. The effects of HIV-1 regulatory TAT protein expression on brain reward function, response to psychostimulants and delay-dependent memory in mice. Neuropharmacology. vol 109. 2017-06-19. PMID:27316905. |
we evaluated brain reward function in response to tat expression, nicotine and methamphetamine administration in tat+ and tat- mice using the intracranial self-stimulation procedure. |
2017-06-19 |
2023-08-13 |
mouse |
| Yan-Xue Xue, Jia-Hui Deng, Ya-Yun Chen, Li-Bo Zhang, Ping Wu, Geng-Di Huang, Yi-Xiao Luo, Yan-Ping Bao, Yu-Mei Wang, Yavin Shaham, Jie Shi, Lin L. Effect of Selective Inhibition of Reactivated Nicotine-Associated Memories With Propranolol on Nicotine Craving. JAMA psychiatry. vol 74. issue 3. 2017-05-15. PMID:28146250. |
a relapse into nicotine addiction during abstinence often occurs after the reactivation of nicotine reward memories, either by acute exposure to nicotine (a smoking episode) or by smoking-associated conditioned stimuli (cs). |
2017-05-15 |
2023-08-13 |
Not clear |
| Jirawoot Srisontiyakul, Hanna E Kastman, Elena V Krstew, Piyarat Govitrapong, Andrew J Lawrenc. The Nicotinic α6-Subunit Selective Antagonist bPiDI Reduces Alcohol Self-Administration in Alcohol-Preferring Rats. Neurochemical research. vol 41. issue 12. 2017-03-15. PMID:27573375. |
the alpha6 subunit of nachr is expressed almost exclusively in the brain reward system and may modulate the rewarding properties of alcohol and nicotine. |
2017-03-15 |
2023-08-13 |
rat |
| Zhujing Shen, Peiyu Huang, Wei Qian, Chao Wang, Hualiang Yu, Yihong Yang, Minming Zhan. Severity of dependence modulates smokers' functional connectivity in the reward circuit: a preliminary study. Psychopharmacology. vol 233. issue 11. 2017-02-09. PMID:26955839. |
nicotine dependence is characterized as a neural circuit dysfunction, particularly with regard to the reward circuit. |
2017-02-09 |
2023-08-13 |
Not clear |
| Claudia Chauvet, Celine Nicolas, Claire Lafay-Chebassier, Mohamed Jaber, Nathalie Thiriet, Marcello Solina. Statins Reduce the Risks of Relapse to Addiction in Rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 6. 2017-01-05. PMID:26466819. |
finally, the effects of simvastatin were found to generalize to another drug of abuse such as nicotine, but not to food reward, and to reinstatement of cocaine seeking induced by stress. |
2017-01-05 |
2023-08-13 |
rat |
| Mary Falcone, Bridgin Lee, Caryn Lerman, Julie A Blend. Translational Research on Nicotine Dependence. Current topics in behavioral neurosciences. vol 28. 2016-12-30. PMID:26873019. |
in this chapter, we review several lines of research highlighting the utility of cross-validation models in elucidating the biological underpinnings of nicotine reward and reinforcement, identifying factors which may influence individual response to treatment, and facilitating rapid translation of findings to practice. |
2016-12-30 |
2023-08-13 |
human |
| Ron C Hog. Contribution of Monoamine Oxidase Inhibition to Tobacco Dependence: A Review of the Evidence. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 18. issue 5. 2016-12-13. PMID:26508396. |
there is a hypothesis that substances present in, or derived from, tobacco smoke inhibit monoamine oxidase (mao) in the brains of smokers, reducing the degradation of catecholamine neurotransmitters involved in central reward pathways and acting synergistically with nicotine to increase its addictive effects. |
2016-12-13 |
2023-08-13 |
Not clear |
| Fawaz Alasmari, Salim S Al-Rejaie, Shakir D AlSharari, Youssef Sar. Targeting glutamate homeostasis for potential treatment of nicotine dependence. Brain research bulletin. vol 121. 2016-12-13. PMID:26589642. |
we and others have shown increased extracellular glutamate concentration, which was associated with down regulation of the major glutamate transporter, glutamate transporter 1 (glt-1), in brain reward regions of animals exposed to drug abuse, including nicotine and ethanol. |
2016-12-13 |
2023-08-13 |
Not clear |
| Francesco Pistillo, Francesca Fasoli, Milena Moretti, Tristan McClure-Begley, Michele Zoli, Michael J Marks, Cecilia Gott. Chronic nicotine and withdrawal affect glutamatergic but not nicotinic receptor expression in the mesocorticolimbic pathway in a region-specific manner. Pharmacological research. vol 103. 2016-12-13. PMID:26631628. |
nicotine elicits its primary effects on neuronal nicotinic cholinergic receptors (nachrs), alters brain reward systems, and induces long-term changes during chronic nicotine use and withdrawal. |
2016-12-13 |
2023-08-13 |
mouse |
| Francesco Pistillo, Francesca Fasoli, Milena Moretti, Tristan McClure-Begley, Michele Zoli, Michael J Marks, Cecilia Gott. Chronic nicotine and withdrawal affect glutamatergic but not nicotinic receptor expression in the mesocorticolimbic pathway in a region-specific manner. Pharmacological research. vol 103. 2016-12-13. PMID:26631628. |
we analysed the effects of chronic nicotine treatment and withdrawal on the mesocorticolimbic pathway (a brain reward circuit in which addictive drugs induce widespread adaptations) by analysing the expression of nachrs in the midbrain, striatum and prefrontal cortex (pfc) of mice receiving intravenous infusions of nicotine (4mg/kg/h) or saline (control) for 14 days and mice sacrified two hours, and one, four and 14 days after treatment withdrawal. |
2016-12-13 |
2023-08-13 |
mouse |