| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Islam Hany Gamaleddin, Jose M Trigo, Aliou B Gueye, Alexander Zvonok, Alexandros Makriyannis, Steven R Goldberg, Bernard Le Fol. Role of the endogenous cannabinoid system in nicotine addiction: novel insights. Frontiers in psychiatry. vol 6. 2015-04-10. PMID:25859226. |
the cb1 receptor inverse agonist/antagonist rimonabant (also known as sr141716) was effective to decrease nicotine-taking and nicotine-seeking in rodents, as well as the elevation of dopamine induced by nicotine in brain reward area. |
2015-04-10 |
2023-08-13 |
human |
| Shuilian Chu, Dan Xiao, Shuangkun Wang, Peng Peng, Teng Xie, Yong He, Chen Wan. Spontaneous brain activity in chronic smokers revealed by fractional amplitude of low frequency fluctuation analysis: a resting state functional magnetic resonance imaging study. Chinese medical journal. vol 127. issue 8. 2015-04-06. PMID:24762597. |
similar to other substances, nicotine dependence is related to many important brain regions, particular in mesolimbic reward circuit. |
2015-04-06 |
2023-08-13 |
Not clear |
| Louise Adermark, Bo Söderpalm, John M Burkhard. Brain region specific modulation of ethanol-induced depression of GABAergic neurons in the brain reward system by the nicotine receptor antagonist mecamylamine. Alcohol (Fayetteville, N.Y.). vol 48. issue 5. 2015-02-23. PMID:24961541. |
brain region specific modulation of ethanol-induced depression of gabaergic neurons in the brain reward system by the nicotine receptor antagonist mecamylamine. |
2015-02-23 |
2023-08-13 |
mouse |
| S Vlachou, G Panagi. Regulation of brain reward by the endocannabinoid system: a critical review of behavioral studies in animals. Current pharmaceutical design. vol 20. issue 13. 2015-02-20. PMID:23829366. |
behavioral studies have shown that cannabinoid reward may involve the same brain circuits and similar brain mechanisms with other drugs of abuse, such as nicotine, cocaine, alcohol and heroin, as well as natural rewards, such as food, water and sucrose, although the conditions under which cannabinoids exert their rewarding effects may be more limited. |
2015-02-20 |
2023-08-12 |
mouse |
| K Suriyaprom, R Tungtrongchitr, K Thawnashom, Y Pimaino. BDNF Val66Met polymorphism and serum concentrations of BDNF with smoking in Thai males. Genetics and molecular research : GMR. vol 12. issue 4. 2015-02-20. PMID:24301752. |
many studies have suggested that brain-derived neurotrophic factor (bdnf) is involved in the reward system of addiction, and that nicotine may induce alterations in bdnf gene expression and its protein level within the mesocorticolimbic system. |
2015-02-20 |
2023-08-12 |
human |
| Michele L Pergadia, Andre Der-Avakian, Manoranjan S D'Souza, Pamela A F Madden, Andrew C Heath, Saul Shiffman, Athina Markou, Diego A Pizzagall. Association between nicotine withdrawal and reward responsiveness in humans and rats. JAMA psychiatry. vol 71. issue 11. 2015-02-20. PMID:25208057. |
association between nicotine withdrawal and reward responsiveness in humans and rats. |
2015-02-20 |
2023-08-13 |
rat |
| Joseph R Trois. Acquisition, extinction, recovery, and reversal of different response sequences under conditional control by nicotine in rats. The Journal of general psychology. vol 140. issue 3. 2015-02-12. PMID:24837654. |
eight rats were trained in an operant procedure that used nicotine and non-drug (saline) states as interoceptive cues that signaled which of two behavioral sequences led to food reward. |
2015-02-12 |
2023-08-13 |
rat |
| Taryn E Grieder, Melissa A Herman, Candice Contet, Laura A Tan, Hector Vargas-Perez, Ami Cohen, Michal Chwalek, Geith Maal-Bared, John Freiling, Joel E Schlosburg, Laura Clarke, Elena Crawford, Pascale Koebel, Vez Repunte-Canonigo, Pietro P Sanna, Andrew R Tapper, Marisa Roberto, Brigitte L Kieffer, Paul E Sawchenko, George F Koob, Derek van der Kooy, Olivier Georg. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nature neuroscience. vol 17. issue 12. 2015-02-06. PMID:25402857. |
these results link the brain reward and stress systems in the same brain region to signaling of the negative motivational effects of nicotine withdrawal. |
2015-02-06 |
2023-08-13 |
Not clear |
| Jason M Uslaner, Christopher J Winrow, Anthony L Gotter, Anthony J Roecker, Paul J Coleman, Pete H Hutson, Anh D Le, John J Renge. Selective orexin 2 receptor antagonism blocks cue-induced reinstatement, but not nicotine self-administration or nicotine-induced reinstatement. Behavioural brain research. vol 269. 2015-01-15. PMID:24746488. |
here we evaluated the impact of the novel and selective orexin 2 receptor antagonist, 2-sora 18, on motivation for nicotine as measured by responding on a progressive ratio schedule, as well as cue-induced reinstatement of a response previously associated with nicotine reward, and nicotine-induced reinstatement. |
2015-01-15 |
2023-08-13 |
Not clear |
| Munir G Kutlu, Dennis Burke, Susan Slade, Brandon J Hall, Jed E Rose, Edward D Levi. Role of insular cortex D₁ and D₂ dopamine receptors in nicotine self-administration in rats. Behavioural brain research. vol 256. 2014-12-18. PMID:23948214. |
these studies show the importance of da d₁ systems in the insula for nicotine reward. |
2014-12-18 |
2023-08-12 |
rat |
| F Ivy Carroll, Bruce E Blough, S Wayne Mascarella, Hernán A Navarro, Ronald J Lukas, M Imad Dama. Bupropion and bupropion analogs as treatments for CNS disorders. Advances in pharmacology (San Diego, Calif.). vol 69. 2014-11-06. PMID:24484978. |
these combined effects of bupropion and its active metabolite may be responsible for its ability to decrease nicotine reward and withdrawal. |
2014-11-06 |
2023-08-12 |
Not clear |
| M A Quintana, D V Cont. Integrative variable selection via Bayesian model uncertainty. Statistics in medicine. vol 32. issue 28. 2014-10-27. PMID:23824835. |
finally, we demonstrate the power and flexibility of ibmu for integrating both gene structure and functional biomarker information into a candidate gene study investigating over 50 genes in the brain reward system and their role with smoking cessation from the pharmacogenetics of nicotine addiction and treatment consortium. |
2014-10-27 |
2023-08-12 |
Not clear |
| George A Buzzell, John R Fedota, Daniel M Roberts, Craig G McDonal. The N2 ERP component as an index of impaired cognitive control in smokers. Neuroscience letters. vol 563. 2014-10-24. PMID:24486891. |
impaired cognitive control has been proposed as a hallmark of nicotine dependence and is thought to arise, in part, from synaptic alterations in anterior cingulate cortex (acc), a primary component of the dopamine reward pathway. |
2014-10-24 |
2023-08-12 |
Not clear |
| Hisatsugu Miyat. [Reconsideration of nicotine and other substance dependence: a clue from dependence-related mentation including reward, motivation, learning, delusion and hallucination toward understanding the concept of non-substance-related addiction]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 33. issue 5-6. 2014-09-25. PMID:25069257. |
[reconsideration of nicotine and other substance dependence: a clue from dependence-related mentation including reward, motivation, learning, delusion and hallucination toward understanding the concept of non-substance-related addiction]. |
2014-09-25 |
2023-08-13 |
Not clear |
| Liwang Liu, Linzy M Hendrickson, Melissa J Guildford, Rubing Zhao-Shea, Paul D Gardner, Andrew R Tappe. Nicotinic acetylcholine receptors containing the α4 subunit modulate alcohol reward. Biological psychiatry. vol 73. issue 8. 2014-09-01. PMID:23141806. |
although nicotine elicits reward by activating ventral tegmental area dopaminergic (daergic) neurons via high-affinity neuronal nicotinic acetylcholine receptors (nachrs), the mechanism by which alcohol activates these neurons is unclear. |
2014-09-01 |
2023-08-12 |
Not clear |
| Irene Morganstern, Olga Lukatskaya, Sang-Ho Moon, Wei-Ran Guo, Jane Shaji, Olga Karatayev, Sarah F Leibowit. Stimulation of nicotine reward and central cholinergic activity in Sprague-Dawley rats exposed perinatally to a fat-rich diet. Psychopharmacology. vol 230. issue 4. 2014-09-01. PMID:23836027. |
stimulation of nicotine reward and central cholinergic activity in sprague-dawley rats exposed perinatally to a fat-rich diet. |
2014-09-01 |
2023-08-12 |
rat |
| George Panagis, Brian Mackey, Styliani Vlacho. Cannabinoid Regulation of Brain Reward Processing with an Emphasis on the Role of CB1 Receptors: A Step Back into the Future. Frontiers in psychiatry. vol 5. 2014-08-18. PMID:25132823. |
importantly, behavioral studies have shown that cannabinoid compounds activate brain reward mechanisms and circuits in a similar manner to other drugs of abuse, such as nicotine, alcohol, cocaine, and heroin, although the conditions under which cannabinoids exert their rewarding effects may be more limited. |
2014-08-18 |
2023-08-13 |
mouse |
| Hakan Kayir, Svetlana Semenova, Athina Marko. Baseline impulsive choice predicts the effects of nicotine and nicotine withdrawal on impulsivity in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 48. 2014-08-01. PMID:24060391. |
in li rats, chronic nicotine exposure decreased preference for the large reward with larger effects at longer delays, indicating increased impulsive choice. |
2014-08-01 |
2023-08-12 |
human |
| Hakan Kayir, Svetlana Semenova, Athina Marko. Baseline impulsive choice predicts the effects of nicotine and nicotine withdrawal on impulsivity in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 48. 2014-08-01. PMID:24060391. |
in hi rats, nicotine exposure and nicotine withdrawal had no effect on impulsive choice, although there was a tendency for decreased preference for the large reward at short delays. |
2014-08-01 |
2023-08-12 |
human |
| Laura E O'Dell, Oscar V Torre. A mechanistic hypothesis of the factors that enhance vulnerability to nicotine use in females. Neuropharmacology. vol 76 Pt B. 2014-07-29. PMID:23684991. |
taken together, females display enhanced nicotine reward via estrogen and amplified effects of withdrawal via stress systems. |
2014-07-29 |
2023-08-12 |
rat |