| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fei Chen, Can-Can Zhou, Yin Yang, Jian-Wen Liu, Chong-Huai Ya. GM1 Ameliorates Lead-Induced Cognitive Deficits and Brain Damage Through Activating the SIRT1/CREB/BDNF Pathway in the Developing Male Rat Hippocampus. Biological trace element research. vol 190. issue 2. 2020-02-04. PMID:30414004. |
furthermore, we found that gm1 upregulated the expression of sirt1, creb phosphorylation, and bdnf, which underlie learning and memory in the lead-treated developing rat hippocampus. |
2020-02-04 |
2023-08-13 |
rat |
| Nasroallah Moradi-Kor, Ali Ghanbari, Hadi Rashidipour, Behpour Yousefi, Ahmad Reza Bandegi, Ali Rashidy-Pou. Beneficial effects of Spirulina platensis, voluntary exercise and environmental enrichment against adolescent stress induced deficits in cognitive functions, hippocampal BDNF and morphological remolding in adult female rats. Hormones and behavior. vol 112. 2020-01-30. PMID:30917909. |
following the interventions, spatial learning and memory, passive avoidance performance, hippocampal dendritic morphology and bdnf levels were assessed. |
2020-01-30 |
2023-08-13 |
rat |
| Nasroallah Moradi-Kor, Ali Ghanbari, Hadi Rashidipour, Behpour Yousefi, Ahmad Reza Bandegi, Ali Rashidy-Pou. Beneficial effects of Spirulina platensis, voluntary exercise and environmental enrichment against adolescent stress induced deficits in cognitive functions, hippocampal BDNF and morphological remolding in adult female rats. Hormones and behavior. vol 112. 2020-01-30. PMID:30917909. |
stressed rats showed deficits in spatial learning and memory and passive avoidance performance, decreased bdnf levels in the hippocampus, and reduced apical dendritic length and branch points of the ca3 pyramidal neurons. |
2020-01-30 |
2023-08-13 |
rat |
| Kathryn M Hixson, Meaghan Cogswell, Amy R Brooks-Kayal, Shelley J Russe. Evidence for a non-canonical JAK/STAT signaling pathway in the synthesis of the brain's major ion channels and neurotransmitter receptors. BMC genomics. vol 20. issue 1. 2020-01-08. PMID:31455240. |
brain-derived neurotrophic factor (bdnf) is a major signaling molecule that the brain uses to control a vast network of intracellular cascades fundamental to properties of learning and memory, and cognition. |
2020-01-08 |
2023-08-13 |
Not clear |
| Burcu Yön, Muaz Belviranlı, Nilsel Okuda. The effect of silymarin supplementation on cognitive impairment induced by diabetes in rats. Journal of basic and clinical physiology and pharmacology. vol 30. issue 4. 2020-01-06. PMID:31017870. |
conclusions the findings obtained from this study suggest that silymarin supplementation could improve anxiety-related behavior, and learning and memory in diabetic rats by increasing the bdnf levels. |
2020-01-06 |
2023-08-13 |
rat |
| Liuli Li, Hao Li, Peng Qu, Mingyang Xiao, Guopei Zhang, Qianye Zhang, Yuan Cai, Cuihong Jin, Jinghua Yang, Shengwen Wu, Xiaobo L. An Antagonism Joint Action of Lead and Di-2-Ethylhexyl Phthalate Explains an Improved Ability of Learning and Memory after Combined Exposure in Weaning Rats. Biological trace element research. vol 191. issue 1. 2019-12-24. PMID:30523571. |
the content of dehydroepiandrosterone (dhea) in serum and the mrna level of brain-derived neurotrophic factor (bdnf) in the hippocampus showed a similar trend to the ability of learning and memory. |
2019-12-24 |
2023-08-13 |
rat |
| Xin Zhao, Yanwu Jin, Haibo Li, Yuxiu Jia, Yuelan Wan. Sevoflurane impairs learning and memory of the developing brain through post-transcriptional inhibition of CCNA2 via microRNA-19-3p. Aging. vol 10. issue 12. 2019-12-19. PMID:30540563. |
we found that sevo exposure significantly decreased neuron cell proliferation, reduced bdnf levels in brain, and impaired learning and memory of neonatal rats in morris water maze test and plus-maze discriminative avoidance task (pm-dat), likely through downregulation of ccna2 protein. |
2019-12-19 |
2023-08-13 |
human |
| Damian G Maur, Cecilia G Pascuan, Ana M Genaro, Maria A Zorrilla-Zubilet. Involvement of Nitric Oxide, Neurotrophins and HPA Axis in Neurobehavioural Alterations Induced by Prenatal Stress. Advances in neurobiology. vol 10. 2019-11-20. PMID:25287536. |
it has been demonstrated that the no-citrulline cycle acts together with bdnf in maintaining the progress of neural differentiation.in the present chapter, we explore the interrelation between nitric oxide, glucocorticoids and neurotrophins in brain areas that are key structures in learning and memory processes. |
2019-11-20 |
2023-08-13 |
Not clear |
| Chris J Hunter, Judit Remenyi, Sonia A Correa, Lucia Privitera, Kathleen M S E Reyskens, Kirsty J Martin, Rachel Toth, Bruno G Frenguelli, J Simon C Arthu. MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins. FEBS open bio. vol 7. issue 6. 2019-11-20. PMID:28593137. |
the immediate early gene activity-regulated cytoskeletal protein (arc)/arg3.1 and the neurotrophin brain-derived neurotrophic factor (bdnf) play important roles in synaptic plasticity and learning and memory in the mammalian brain. |
2019-11-20 |
2023-08-13 |
Not clear |
| Teng Zhao, Ying Ding, Min Li, Chunkui Zhou, Weihong Li. Silencing lncRNA PVT1 inhibits activation of astrocytes and increases BDNF expression in hippocampus tissues of rats with epilepsy by downregulating the Wnt signaling pathway. Journal of cellular physiology. 2019-11-20. PMID:30805931. |
successfully modeled rats were grouped, and their spatial learning and memory, neuronal loss, number of tdt-mediated dutp nick labeling (tunel)-positive cells, and the expression of cleaved-caspase-3, pro-caspase-3, bax, bcl-2, gfap, bdnf, tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β), il-6, axin, and cyclin d1 in hippocampus tissues were evaluated. |
2019-11-20 |
2023-08-13 |
rat |
| Teng Zhao, Ying Ding, Min Li, Chunkui Zhou, Weihong Li. Silencing lncRNA PVT1 inhibits activation of astrocytes and increases BDNF expression in hippocampus tissues of rats with epilepsy by downregulating the Wnt signaling pathway. Journal of cellular physiology. 2019-11-20. PMID:30805931. |
silencing of pvt1 improved spatial learning and memory, decreased neuronal loss, decreased the number of tunel-positive cell, decreased the expression of cleaved-caspase-3 and bax while increased pro-caspase-3 and bcl-2 expression, decreased the expression of gfap, increased the expression of bdnf, decreased the expression of tnf-α, il-1β, and il-6, and decreased the expression of axin and cyclin d1 in hippocampus tissues in epileptic rats. |
2019-11-20 |
2023-08-13 |
rat |
| Ali-Akbar Salari, Hanieh Samadi, Judith R Homberg, Morteza Kosari-Nasa. Small litter size impairs spatial memory and increases anxiety- like behavior in a strain-dependent manner in male mice. Scientific reports. vol 8. issue 1. 2019-10-22. PMID:30050150. |
we measured body weight, learning and memory, anxiety-related behaviors, interleukin-(il)-1β and brain-derived-neurotrophic-factor (bdnf) levels in the hippocampus, and both basal and stress corticosterone levels in adult mice which have been nursed in small litters compared with those from control litters. |
2019-10-22 |
2023-08-13 |
mouse |
| Ryoko Suzuki, Akihiro Fujikawa, Yukio Komatsu, Kazuya Kuboyama, Naomi Tanga, Masaharu Nod. Enhanced extinction of aversive memories in mice lacking SPARC-related protein containing immunoglobulin domains 1 (SPIG1/FSTL4). Neurobiology of learning and memory. vol 152. 2019-10-01. PMID:29783061. |
brain-derived neurotrophic factor (bdnf) plays an important role in synaptic plasticity related to learning and memory. |
2019-10-01 |
2023-08-13 |
mouse |
| Ryoko Suzuki, Akihiro Fujikawa, Yukio Komatsu, Kazuya Kuboyama, Naomi Tanga, Masaharu Nod. Enhanced extinction of aversive memories in mice lacking SPARC-related protein containing immunoglobulin domains 1 (SPIG1/FSTL4). Neurobiology of learning and memory. vol 152. 2019-10-01. PMID:29783061. |
we previously reported that sparc-related protein containing immunoglobulin domains 1 (spig1, also known as follistatin-like protein 4, fstl4) binds to pro-bdnf and negatively regulates bdnf maturation; however, its neurological functions, particularly in learning and memory, have not yet been elucidated. |
2019-10-01 |
2023-08-13 |
mouse |
| Marta Pardo, Yuyan Cheng, Dmitry Velmeshev, Marco Magistri, Hagit Eldar-Finkelman, Ana Martinez, Mohammad A Faghihi, Richard S Jope, Eleonore Beure. Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice. JCI insight. vol 2. issue 6. 2019-08-19. PMID:28352664. |
in wt mice, intranasally administered brain-derived neurotrophic factor (bdnf) sirna or hdac4 sirna impaired learning and memory, which was partially due to reduced insulin-like growth factor-2 (igf2) levels because the bdnf sirna- or hdac4 sirna-induced cognitive impairments were ameliorated by intranasal igf2 administration. |
2019-08-19 |
2023-08-13 |
mouse |
| Haiyan Li, Chihiro Ishikawa, Takashi Shig. Effects of postnatal handling on adult behavior and brain mRNA expression of serotonin receptor, brain-derived neurotrophic factor and GABA-A receptor subunit. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 68. 2019-08-06. PMID:29678562. |
taken together, the present study suggests that postnatal handling reduced anxiety-like behavior and improved learning and memory, which were accompanied by changes in mrna expression of 5-ht1a receptor, bdnf and gaba-a receptor α2 subunit in the amygdala, 5-ht1a receptor in the dorsal raphe nucleus and bdnf in the dorsal hippocampus. |
2019-08-06 |
2023-08-13 |
mouse |
| b' Caroline Peres Klein, Juliana Bender Hoppe, Andr\\xc3\\xa9 Brum Saccomori, Bernardo Gindri Dos Santos, Jo\\xc3\\xa3o Pedro Sagini, Mariana Scortegagna Crestani, Pauline Maciel August, R\\xc3\\xa9gis Mateus H\\xc3\\xb6zer, Mateus Grings, Belisa Parmeggiani, Guilhian Leipnitz, Pl\\xc3\\xa1cido Navas, Christianne Gazzana Salbego, Cristiane Matt\\xc3\\xa. Physical Exercise During Pregnancy Prevents Cognitive Impairment Induced by Amyloid-\\xce\\xb2 in Adult Offspring Rats. Molecular neurobiology. vol 56. issue 3. 2019-07-01. PMID:29982984.' |
aβos-injected rats of the sedentary maternal group exhibited learning and memory deficits, along with reduced synaptophysin, brain-derived neurotrophic factor (bdnf) levels, and alterations of mitochondrial function. |
2019-07-01 |
2023-08-13 |
rat |
| Amir Bagheri, Parham Habibzadeh, Seyedeh Fatemeh Razavipour, Claude-Henry Volmar, Nancy T Chee, Shaun P Brothers, Claes Wahlestedt, Seyed Javad Mowla, Mohammad Ali Faghih. HDAC Inhibitors Induce International journal of molecular sciences. vol 20. issue 5. 2019-06-10. PMID:30841499. |
hdac inhibitors induce besides its key role in neural development, brain-derived neurotrophic factor (bdnf) is important for long-term potentiation and neurogenesis, which makes it a critical factor in learning and memory. |
2019-06-10 |
2023-08-13 |
human |
| Paul D Loprinzi, Emily Frit. A brief primer on the mediational role of BDNF in the exercise-memory link. Clinical physiology and functional imaging. vol 39. issue 1. 2019-04-09. PMID:29719116. |
this review briefly discusses the mechanistic role that bdnf may play in facilitating learning and memory. |
2019-04-09 |
2023-08-13 |
human |
| Jie Gao, Bingrui Xiong, Bo Zhang, Shan Li, Niannian Huang, Gaofeng Zhan, Riyue Jiang, Ling Yang, Yeshun Wu, Liying Miao, Bin Zhu, Chun Yang, Ailin Lu. Sulforaphane Alleviates Lipopolysaccharide-induced Spatial Learning and Memory Dysfunction in Mice: The Role of BDNF-mTOR Signaling Pathway. Neuroscience. vol 388. 2019-03-29. PMID:30086367. |
the present study aimed to investigate the therapeutic effects of sulforaphane (sfn) on lipopolysaccharide (lps)-induced spatial learning and memory dysfunction, and tried to elucidate its relationship with the role of hippocampal brain-derived neurotrophic factor (bdnf)-mammalian target of rapamycin (mtor) signaling pathway. |
2019-03-29 |
2023-08-13 |
mouse |