| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan-Dan Hu, Wei Pang, Cong-Cong He, Hao Lu, Wei Liu, Zi-Yu Wang, Yan-Qiang Liu, Cheng-Yu Huang, Yu-Gang Jian. The cognitive impairment induced by zinc deficiency in rats aged 0∼2 months related to BDNF DNA methylation changes in the hippocampus. Nutritional neuroscience. vol 20. issue 9. 2018-06-01. PMID:27329329. |
this study was carried out to understand the effects of zinc deficiency in rats aged 0∼2 months on learning and memory, and the brain-derived neurotrophic factor (bdnf) gene methylation status in the hippocampus. |
2018-06-01 |
2023-08-13 |
rat |
| Xu Wang, Le Zhang, Yufeng Zhan, Dengping Li, Yuangui Zhang, Gongming Wang, Mengyuan Zhan. Contribution of BDNF/TrkB signalling in the rACC to the development of pain-related aversion via activation of ERK in rats with spared nerve injury. Brain research. vol 1671. 2018-05-17. PMID:28732667. |
brain-derived neurotrophic factor (bdnf) is known to play a critical role in activity-dependent synaptic plasticity, learning and memory. |
2018-05-17 |
2023-08-13 |
rat |
| Wandert Schaafsma, Laura Bozal Basterra, Sabrina Jacobs, Nieske Brouwer, Peter Meerlo, Anne Schaafsma, Erik W G M Boddeke, Bart J L Egge. Maternal inflammation induces immune activation of fetal microglia and leads to disrupted microglia immune responses, behavior, and learning performance in adulthood. Neurobiology of disease. vol 106. 2018-05-15. PMID:28751257. |
microglia-derived bdnf has been shown to be important for learning and memory processes. |
2018-05-15 |
2023-08-13 |
mouse |
| Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. |
in this study, six different kaixin san formulas were compared to investigate their effects on learning and memory decline, brain-derived neurotrophic factor (bdnf) in the hippocampus, tau protein, acetylcholinesterase (ache) and n-terminal pro-brain natriuretic peptide (nt-probnp). |
2018-05-15 |
2023-08-13 |
mouse |
| Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. |
kunming mice were selected and established a mouse model of alzheimer's by intraperitoneal injection of d-galactose and sodium nitrite, continued intragastric 4 weeks, using the ability of learning and memory in morris water maze test to evaluate the animals in each group; the content of bdnf in the hippocampus of mice with western blotting detected; elisa method for the detection of each group of mice hippocampal tau protein,p-tau protein, aβ,ach,ache and serum nt-probnp levels. |
2018-05-15 |
2023-08-13 |
mouse |
| Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. |
the results showed that, kaixin san of qianjin yaofang three dose recorded significantly improved learning and memory ability of mice; increased the content of bdnf and ach in the hippocampus; decreased the content of aβ, tau protein, p-tau protein in the hippocampus; high, middle dose significantly decreased the serum nt-probnp and ache in hippocampus, the effect is most significant. |
2018-05-15 |
2023-08-13 |
mouse |
| Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. |
part dose of kaixin san of yixin fang, kaixin wan of yimen fang, dingzhi xiaowan of beji qianjin yaofang and dingzhi wan of guji luyan could improve the learning and memory ability evaluation indicators, significantly increased bdnf and ach in the hippocampus of ad model mice, reduced the aβ, tau protein, p-tau protein in hippocampus of ad model mice, decreased the nt-probnp and ache in serum of ad mice, the effect is more significant. |
2018-05-15 |
2023-08-13 |
mouse |
| Chuan-Fang Wang, Cheng-Cheng Zhao, Gan Jiang, Xiao Gu, Jun-Feng Feng, Ji-Yao Jian. The Role of Posttraumatic Hypothermia in Preventing Dendrite Degeneration and Spine Loss after Severe Traumatic Brain Injury. Scientific reports. vol 6. 2018-05-08. PMID:27833158. |
increasing cortical and hippocampal bdnf levels might be the mechanism through which hypothermia prevents dendrite degeneration and spine loss and preserves learning and memory function. |
2018-05-08 |
2023-08-13 |
mouse |
| Asokan Prema, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasagam, Musthafa Mohamed Essa, Gilles J Guillemi. Fenugreek Seed Powder Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress, and Inflammation in a Rat Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 60. issue s1. 2018-04-06. PMID:28269780. |
the result of the present study indicated that the chronic administration of alcl3 induced significant learning and memory impairments, oxidative stress, and alterations in the protein immunocontent patterns of ide and cdk5 (enzymes involved in the metabolism of tau and amyloid proteins), ptau, gfap and iba-1, il-1β, il-6, tnf-α, inos, nf-κb, cox-2, cdk5, bdnf, and stat3. |
2018-04-06 |
2023-08-13 |
rat |
| B M Shilpa, V Bhagya, G Harish, M M Srinivas Bharath, B S Shankaranarayana Ra. Environmental enrichment ameliorates chronic immobilisation stress-induced spatial learning deficits and restores the expression of BDNF, VEGF, GFAP and glucocorticoid receptors. Progress in neuro-psychopharmacology & biological psychiatry. vol 76. 2018-04-02. PMID:28288856. |
cis resulted in weight loss, anhedonia, increased immobility, spatial learning and memory impairment, enhanced anxiety, and reduced expression of bdnf, vegf, gfap and glucocorticoid receptors (gr) in discrete brain regions. |
2018-04-02 |
2023-08-13 |
rat |
| Gurdeep Marwarha, Kate Claycombe-Larson, Jared Schommer, Othman Ghrib. Maternal low-protein diet decreases brain-derived neurotrophic factor expression in the brains of the neonatal rat offspring. The Journal of nutritional biochemistry. vol 45. 2018-03-26. PMID:28432877. |
herein, we demonstrate that a maternal lp diet causes, in the brains of the neonatal rat offspring, an attenuation in the basal expression of the brain-derived neurotrophic factor (bdnf), a neurotrophin indispensable for learning and memory. |
2018-03-26 |
2023-08-13 |
rat |
| Yeli Gong, Youhua Yang, Xiaoqing Chen, Min Yang, Dan Huang, Rong Yang, Lianying Zhou, Changlei Li, Qiuju Xiong, Zhe Xion. Hyperoside protects against chronic mild stress-induced learning and memory deficits. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 91. 2018-03-19. PMID:28501772. |
furthermore, k252a, an inhibitor of the bdnf receptor trkb, prevented the protective effects of hyperoside on learning and memory in cms rats. |
2018-03-19 |
2023-08-13 |
rat |
| Manju Sasi, Beatrice Vignoli, Marco Canossa, Robert Blu. Neurobiology of local and intercellular BDNF signaling. Pflugers Archiv : European journal of physiology. vol 469. issue 5-6. 2018-03-05. PMID:28280960. |
in many brain circuits, synaptically released bdnf is essential for structural and functional long-term potentiation, two prototypical cellular models of learning and memory formation. |
2018-03-05 |
2023-08-13 |
Not clear |
| Raluca Armeanu, Mikael Mokkonen, Bernard Cresp. Meta-Analysis of BDNF Levels in Autism. Cellular and molecular neurobiology. vol 37. issue 5. 2018-02-23. PMID:27501933. |
brain-derived neurotrophic factor (bdnf) centrally mediates growth, differentiation and survival of neurons, and the synaptic plasticity that underlies learning and memory. |
2018-02-23 |
2023-08-13 |
human |
| Long Tan, Hongpeng Yang, Wei Pang, Haiqiang Li, Wei Liu, Shoudan Sun, Nan Song, Wanqi Zhang, Yugang Jian. Investigation on the Role of BDNF in the Benefits of Blueberry Extracts for the Improvement of Learning and Memory in Alzheimer's Disease Mouse Model. Journal of Alzheimer's disease : JAD. vol 56. issue 2. 2018-02-23. PMID:28035919. |
investigation on the role of bdnf in the benefits of blueberry extracts for the improvement of learning and memory in alzheimer's disease mouse model. |
2018-02-23 |
2023-08-13 |
mouse |
| Man Wang, Dongxue Li, Di Yun, Yinghan Zhuang, Vez Repunte-Canonigo, Pietro Paolo Sanna, Thomas Behnisc. Translation of BDNF-gene transcripts with short 3' UTR in hippocampal CA1 neurons improves memory formation and enhances synaptic plasticity-relevant signaling pathways. Neurobiology of learning and memory. vol 138. 2018-02-22. PMID:27394686. |
while the brain-derived neurotrophic factor (bdnf) gene and its multiple transcripts have been recognized as a key factor for learning, but the specific involvement of bdnf translated from bdnf transcripts with short-3' untranslated region (short 3' utr) in learning and memory requires further analysis. |
2018-02-22 |
2023-08-13 |
mouse |
| Qian Xu, Xue-Fei Ji, Tian-Yan Chi, Peng Liu, Ge Jin, Ling Chen, Li-Bo Zo. Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor. Journal of the neurological sciences. vol 376. 2018-02-21. PMID:28431607. |
after ischemic operation, contrast with the σ1r knockout mice, pre084 significantly ameliorated learning and memory impairments in the behavioral evaluation, and prevented the protein decline of bdnf, nr2a, camkiv and torc1 expression in wild-type mice. |
2018-02-21 |
2023-08-13 |
mouse |
| Qian Xu, Xue-Fei Ji, Tian-Yan Chi, Peng Liu, Ge Jin, Ling Chen, Li-Bo Zo. Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor. Journal of the neurological sciences. vol 376. 2018-02-21. PMID:28431607. |
however, the effects of pre084 on camkiv-torc1-creb and bdnf, even for learning and memory impairment, were antagonized by the co-administration of peaqx, an antagonist of nr2a. |
2018-02-21 |
2023-08-13 |
mouse |
| Qian Xu, Xue-Fei Ji, Tian-Yan Chi, Peng Liu, Ge Jin, Ling Chen, Li-Bo Zo. Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor. Journal of the neurological sciences. vol 376. 2018-02-21. PMID:28431607. |
the activation of σ1r improves the impairment of learning and memory in the ischemia/reperfusion model, and the expression of bdnf, which may have been achieved through the nr2a-camkiv-torc1 pathway. |
2018-02-21 |
2023-08-13 |
mouse |
| Elizabeth G Pitts, Jane R Taylor, Shannon L Gourle. Prefrontal cortical BDNF: A regulatory key in cocaine- and food-reinforced behaviors. Neurobiology of disease. vol 91. 2018-02-20. PMID:26923993. |
brain-derived neurotrophic factor (bdnf) affects synaptic plasticity and neural structure and plays key roles in learning and memory processes. |
2018-02-20 |
2023-08-13 |
Not clear |