| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert S Gardner, Matthew T Ambalavanar, Paul E Gold, Donna L Koro. Enhancement of response learning in male rats with intrastriatal infusions of a BDNF - TrkB agonist, 7,8-dihydroxyflavone. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211174. |
enhancement of learning and memory by cognitive and physical exercise may be mediated by brain-derived neurotrophic factor (bdnf) acting at tropomyosin receptor kinase b (trkb). |
2024-08-30 |
2024-09-04 |
rat |
| Robert S Gardner, Matthew T Ambalavanar, Paul E Gold, Donna L Koro. Enhancement of response learning in male rats with intrastriatal infusions of a BDNF - TrkB agonist, 7,8-dihydroxyflavone. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211174. |
most prior studies of bdnf and 7,8-dhf effects on learning and memory have administered the drugs for days to months before assessing effects on cognition. |
2024-08-30 |
2024-09-04 |
rat |
| Robert S Gardner, Matthew T Ambalavanar, Paul E Gold, Donna L Koro. Enhancement of response learning in male rats with intrastriatal infusions of a BDNF - TrkB agonist, 7,8-dihydroxyflavone. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211174. |
the findings that a single, intra-striatal infusion of 7,8-dhf 20 min before training enhanced response learning in rats suggest that, in addition to its trophic effects, bdnf modulates learning and memory through receptor mediated cell signaling events. |
2024-08-30 |
2024-09-04 |
rat |
| Lorenzo Morè, Lucia Privitera, Marcia Lopes, J Simon C Arthur, Julie C Lauterborn, Sonia A L Corrêa, Bruno G Frenguell. MSK1 is required for the experience- and ampakine-dependent enhancement of spatial reference memory and reversal learning. Neuropharmacology. 2024-08-11. PMID:39128584. |
we have previously shown that msk1, by virtue of its ability to regulate gene transcription, converts the elevation of bdnf associated with environmental enrichment into molecular, synaptic, cognitive and genomic adaptations that underlie enrichment-induced enhanced synaptic plasticity and learning and memory, a property that msk1 retains across the lifespan. |
2024-08-11 |
2024-08-14 |
mouse |
| Farhad Sanaeifar, Sina Pourranjbar, Mohammad Pourranjbar, Sana Ramezani, Samira Rostami Mehr, Al-Hassan Soliman Wadan, Farnaz Khazeifar. Beneficial effects of physical exercise on cognitive-behavioral impairments and brain-derived neurotrophic factor alteration in the limbic system induced by neurodegeneration. Experimental gerontology. 2024-08-08. PMID:39116955. |
neurotrophins such as brain-derived neurotrophic factor (bdnf) are critical for neuron survival and synaptic plasticity, which is required for learning and memory. |
2024-08-08 |
2024-08-12 |
Not clear |
| Amir Basiri, Saeid Izadi, Samaneh Kakhki, Vida Alikahni, Saeedeh Askarian, Farimah Behesht. N‑acetylcysteine prevents hypothyroidism‑induced impairment of learning and memory in adolescent male rats via affecting oxidative status, inflammatory response and BDNF in hippocampal tissues. Acta neurobiologiae experimentalis. vol 84. issue 2. 2024-08-01. PMID:39087834. |
n‑acetylcysteine prevents hypothyroidism‑induced impairment of learning and memory in adolescent male rats via affecting oxidative status, inflammatory response and bdnf in hippocampal tissues. |
2024-08-01 |
2024-08-03 |
rat |
| Ali Niapour, Maryam Abdollahzadeh, Safa Ghaheri Fard, Hakimeh Saadat. The therapeutic potential of 1, 25-dihydroxy vitamin D3 on cisplatin-affected neurological functions is associated with the regulation of oxidative stress and inflammatory markers as well as levels of MMP2/9. Metabolic brain disease. 2024-07-17. PMID:39017968. |
the neuroprotective influence of calcitriol supplementation (100ng/kg/day for 5 weeks) was assessed through behavioral, electrophysiological, and molecular experiments. cisplatin administration impaired spatial learning and memory and decreased prefrontal brain-derived neurotrophic factor (bdnf). |
2024-07-17 |
2024-07-19 |
rat |
| Ali Niapour, Maryam Abdollahzadeh, Safa Ghaheri Fard, Hakimeh Saadat. The therapeutic potential of 1, 25-dihydroxy vitamin D3 on cisplatin-affected neurological functions is associated with the regulation of oxidative stress and inflammatory markers as well as levels of MMP2/9. Metabolic brain disease. 2024-07-17. PMID:39017968. |
learning and memory impairments along with bdnf changes caused by cisplatin were amended with calcitriol supplementation. |
2024-07-17 |
2024-07-19 |
rat |
| Forough Radfar, Mehdi Shahbazi, Shahzad Tahmasebi Boroujeni, Elahe Arab Ameri, Maryam Farahmandfa. Moderate aerobic training enhances the effectiveness of insulin therapy through hypothalamic IGF1 signaling in rat model of Alzheimer's disease. Scientific reports. vol 14. issue 1. 2024-07-10. PMID:38987609. |
we investigated the effects of treadmill exercise and intranasal insulin on learning and memory impairment and the expression of igf1, bdnf, and glut4 in hypothalamus. |
2024-07-10 |
2024-07-13 |
rat |
| Kuang-Min Cheng, Wei-Lun Hsu, Yun-Li Ma, Yen-Chen Liu, Eminy H Y Le. Novel role of NCoR1 in impairing spatial memory through the mediation of a novel interacting protein DEC2. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-06-20. PMID:38900294. |
whereas knockdown of bdnf, integrin α3 or sgk1 expression impairs spatial learning and memory, it does not affect y-maze performance, suggesting that bdnf, integrin α3 and sgk1 are involved in long-term memory formation, but not short-term memory formation. |
2024-06-20 |
2024-06-22 |
mouse |
| Xiaoyu Wang, Qian Pang, Jiangqi Hu, Bin Luo, Yunping Lu, Xu Sun, Shixiang Meng, Qingsong Jian. Cognitive decline in Sprague-Dawley rats induced by neuroplasticity changes after occlusal support loss. CNS neuroscience & therapeutics. vol 30. issue 6. 2024-06-20. PMID:38898731. |
the most well-known function of the hippocampus is learning and memory, and the mechanism behind is neuroplasticity, which strongly depends on the level of brain-derived neurotrophic factor (bdnf). |
2024-06-20 |
2024-06-22 |
rat |
| Ayman Alzu'bi, Ejlal Abu-El-Rub, Fatimah Almahasneh, Lena Tahat, Rabaa Y Athamneh, Ramada Khasawneh, Hiba Alzoubi, Doaa S Ghorab, Rawan Almazari, Mazhar Salim Al Zoubi, Raed M Al-Zoub. Delineating the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice. Neurotoxicology. vol 103. 2024-06-08. PMID:38823587. |
these findings were found to be correlated with increased level of oxidative stress, neuroinflammation, and apoptosis markers, and reduced expression of brain-derived neurotrophic factor (bdnf), which plays an essential role in modulating synaptic plasticity integral for promoting learning and memory in the hippocampus. |
2024-06-08 |
2024-06-11 |
mouse |
| Hyo-Sun Choi, Joonki Kim, Sang-Bin Lee, Lijun Zhang, Dowan Kwon, Huynh Nguyen Khanh Tran, Siqi Zhang, Tianqi Huang, Jae Sik Yu, Gakyung Lee, Hyun Ok Yan. Euonymus hamiltonianus Extract Improves Amnesia in APPswe/Tau Transgenic and Scopolamine-Induced Dementia Models. Molecular neurobiology. 2024-05-27. PMID:38801629. |
kgc07eh also improved scopolamine-induced learning and memory impairment in scopolamine-injected mice, and in their cerebral cortex and hippocampus, the expression levels of p-erk, p-creb, p-akt, and bdnf were attenuated. |
2024-05-27 |
2024-05-31 |
mouse |
| Zahra Tajabadi Farahani, Salar Vaseghi, Elham Rajabbeigi, Batool Ghorbani Yekt. The effect of olanzapine on spatial memory impairment, depressive-like behavior, pain perception, and BDNF and synaptophysin expression following childhood chronic unpredictable mild stress in adult male and female rats. Behavioural brain research. vol 468. 2024-05-09. PMID:38718877. |
both cums and olanzapine can also affect the expression level of brain-derived neurotrophic factor (bdnf) and synaptophysin, the molecular factors involved in synaptic function, and learning and memory. |
2024-05-09 |
2024-05-27 |
rat |
| Zahra Tajabadi Farahani, Salar Vaseghi, Elham Rajabbeigi, Batool Ghorbani Yekt. The effect of olanzapine on spatial memory impairment, depressive-like behavior, pain perception, and BDNF and synaptophysin expression following childhood chronic unpredictable mild stress in adult male and female rats. Behavioural brain research. vol 468. 2024-05-09. PMID:38718877. |
in this study, we investigated the effect of olanzapine on locomotor activity (using open field test), pain threshold (using hot plate), depressive-like behavior (using forced swim test), spatial learning and memory (using morris water maze), and bdnf and synaptophysin hippocampal expression (using real-time pcr) in both male and female cums rats. |
2024-05-09 |
2024-05-27 |
rat |
| Tareq I Jibril, Karem H Alzoubi, Nizar M Mhaidat, Omar F Khabour, Mohammad A Y Alqudah, Abeer M Rababa'h, Nasr Alrabadi, Doaa Al-Udat. Sildenafil prevents chronic psychosocial stress-induced working memory impairment: Role of brain-derived neurotrophic factor. Current research in pharmacology and drug discovery. vol 6. 2024-05-06. PMID:38706525. |
reduced brain-derived neurotrophic factor (bdnf) levels, increased oxidative stress, and alteration of synaptic plasticity biomarkers are also possible contributors to the negative impact of stress on learning and memory. |
2024-05-06 |
2024-05-08 |
rat |
| Jafar Shahraki, Kaveh Tabrizian, Ramin Rezaee, Behnam Tashakori, Zahra Dadrezaei, Vahideh Ghorani, Gholamreza Bagheri, Hosseinali Jahantigh, Mahmoud Hashemzae. Hesperidin neuroprotective effects against carbon monoxide-induced toxicity in male rats. Naunyn-Schmiedeberg's archives of pharmacology. 2024-05-03. PMID:38700797. |
after evaluation of spatial learning and memory using a morris water maze (mwm), animals were sacrificed and oxidative stress status in blood samples, and akt, bax, bcl2, and brain-derived neurotrophic factor (bdnf) expression in brain samples were assessed. |
2024-05-03 |
2024-05-05 |
rat |
| Lancheng Wei, Hongjian He, Shuting Yang, Qianqian Shi, Xinhang Wang, Liyuan Huang, Jianyong Lu, Yinghui Shen, Kaikai Zhi, Junni Xiang, Chengying Chen, Jiao Mo, Zhijian Zheng, Yunfeng Zou, Xiaobo Yang, Shen Tang, Xiyi Li, Cailing L. Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure. Ecotoxicology and environmental safety. vol 277. 2024-04-24. PMID:38657452. |
synergistic suppression of bdnf via epigenetic mechanism deteriorating learning and memory impairment caused by mn and pb co-exposure. |
2024-04-24 |
2024-04-28 |
mouse |
| Lancheng Wei, Hongjian He, Shuting Yang, Qianqian Shi, Xinhang Wang, Liyuan Huang, Jianyong Lu, Yinghui Shen, Kaikai Zhi, Junni Xiang, Chengying Chen, Jiao Mo, Zhijian Zheng, Yunfeng Zou, Xiaobo Yang, Shen Tang, Xiyi Li, Cailing L. Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure. Ecotoxicology and environmental safety. vol 277. 2024-04-24. PMID:38657452. |
suppression of bdnf is implicated in learning and memory impairment induced by exposure to manganese (mn) or lead (pb) individually. |
2024-04-24 |
2024-04-28 |
mouse |
| Lancheng Wei, Hongjian He, Shuting Yang, Qianqian Shi, Xinhang Wang, Liyuan Huang, Jianyong Lu, Yinghui Shen, Kaikai Zhi, Junni Xiang, Chengying Chen, Jiao Mo, Zhijian Zheng, Yunfeng Zou, Xiaobo Yang, Shen Tang, Xiyi Li, Cailing L. Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure. Ecotoxicology and environmental safety. vol 277. 2024-04-24. PMID:38657452. |
our findings reveal that co-exposure to mn and pb leads to severe learning and memory impairment in mice, which correlates with the accumulation of metals in the hippocampus and synergistic suppression of bdnf. |
2024-04-24 |
2024-04-28 |
mouse |