| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huiwen Kang, Wei Zhang, Jiaru Jing, Danyang Huang, Lei Zhang, Jingyu Wang, Lin Han, Ziyan Liu, Ziyan Wang, Ai Ga. The gut-brain axis involved in polystyrene nanoplastics-induced neurotoxicity via reprogramming the circadian rhythm-related pathways. Journal of hazardous materials. vol 458. 2023-07-01. PMID:37392641. |
we found that 80 nm ps-nps could reach and cause neuronal damage in the hippocampus, and alter the expression of neuroplasticity-related molecules (5-ht, ache, gaba, bdnf and creb), and even affect the learning and memory ability of mice. |
2023-07-01 |
2023-08-14 |
mouse |
| Jingyuan Ma, Feng Xiong, Zhouru Li, Guokai Dong, Xiaoming Sun, Wenjiang Yin, Hongxing Ca. The effect of chronic alcohol exposure on spatial memory and BDNF-TrkB- PLCγ1 signaling in the hippocampus of male and female mice. Heliyon. vol 9. issue 6. 2023-06-12. PMID:37303582. |
given previously known effects of brain-derived neurotrophic factor (bdnf) in regulating synaptic plasticity and learning and memory, we investigated the effect of chronic alcohol consumption on spatial memory impairment in both sexes and changes in bdnf signaling in the hippocampus. |
2023-06-12 |
2023-08-14 |
mouse |
| Shiji Zhang, Weng Fu, Xiaoe Jia, Rengui Bade, Xiaolei Liu, Yabin Xie, Wei Xie, Shuyuan Jiang, Guo Sha. Hypoxic Preconditioning Modulates BDNF and Its Signaling through DNA Methylation to Promote Learning and Memory in Mice. ACS chemical neuroscience. 2023-06-08. PMID:37289948. |
hypoxic preconditioning modulates bdnf and its signaling through dna methylation to promote learning and memory in mice. |
2023-06-08 |
2023-08-14 |
mouse |
| Shiji Zhang, Weng Fu, Xiaoe Jia, Rengui Bade, Xiaolei Liu, Yabin Xie, Wei Xie, Shuyuan Jiang, Guo Sha. Hypoxic Preconditioning Modulates BDNF and Its Signaling through DNA Methylation to Promote Learning and Memory in Mice. ACS chemical neuroscience. 2023-06-08. PMID:37289948. |
therefore, this study focused on the mechanism by which hpc regulates bdnf and bdnf/trkb signaling through dna methylation to influence learning and memory. |
2023-06-08 |
2023-08-14 |
mouse |
| Shabnam Radbakhsh, Alexandra E Butler, Seyed Adel Moallem, Amirhossein Sahebka. The effects of curcumin on Brain-Derived Neurotrophic Factor expression in neurodegenerative disorders. Current medicinal chemistry. 2023-06-06. PMID:37278037. |
brain-derived neurotrophic factor (bdnf) is a crucial molecule implicated in plastic modifications related to learning and memory. |
2023-06-06 |
2023-08-14 |
human |
| Zijuan Zhang, Ziyang Yu, Ye Yuan, Jing Yang, Shijie Wang, He Ma, Li Hao, Jinlian Ma, Zhonghua Li, Zhenqiang Zhang, Christian Hölsche. Cholecystokinin Signaling can Rescue Cognition and Synaptic Plasticity in the APP/PS1 Mouse Model of Alzheimer's Disease. Molecular neurobiology. 2023-05-29. PMID:37247071. |
our study found that the cck analogue could effectively improve spatial learning and memory, enhance synaptic plasticity in the hippocampus, normalize synapse numbers and morphology and the levels of key synaptic proteins, up-regulate the pi3k/akt signaling pathway and normalize pka, creb, bdnf and trkb receptor levels in app/ps1 mice. |
2023-05-29 |
2023-08-14 |
mouse |
| Ya-Xin Sun, Yun-Ai Su, Qi Wang, Jia-Ya Zheng, Chen-Chen Zhang, Ting Wang, Xiao Liu, Yu-Nu Ma, Xue-Xin Li, Xian-Qiang Zhang, Xiao-Meng Xie, Xiao-Dong Wang, Ji-Tao Li, Tian-Mei S. The causal involvement of the BDNF-TrkB pathway in dentate gyrus in early-life stress-induced cognitive deficits in male mice. Translational psychiatry. vol 13. issue 1. 2023-05-24. PMID:37225683. |
early-life stress (els) leads to long-lasting deficits of hippocampus-dependent learning and memory in adult mice, which may be associated with the hypofunction of the brain-derived neurotrophic factor (bdnf) and its high-affinity receptor, tropomyosin receptor kinase b (trkb). |
2023-05-24 |
2023-08-14 |
mouse |
| Su-Su Wang, An-Xin Lu, Wan-He Li, Hong Zhang, Chun-Ping Hu, Jun-Xia Liu, Hui Pan, Mei-Qin Wu, Xi Xu, Chong-Huai Yan, Zhen-Yan Ga. Effects of food-borne cholesterol supplementation on lead-induced neurodevelopmental impairments of rats based on BDNF signaling pathway and cholesterol metabolism. Ecotoxicology and environmental safety. vol 259. 2023-05-21. PMID:37210997. |
however, cholesterol supplementation efficiently detoxified the negative effects of lead-induced neurotoxicity, reversing the inflammatory response, oxidative stress, inactivation of the bdnf signaling pathway, and imbalance of cholesterol metabolism, thus improving the learning and memory ability of rats. |
2023-05-21 |
2023-08-14 |
rat |
| Xiao-Ling Zhong, Bo-Ying Tong, Yi-Han Yang, Hui-Ling Zeng, Chi Lin, Yuan Jing, Ling-Ling He, Shi-Jing Yo. [Effect of transcutaneous electrical acupoint stimulation on learning and memory ability of chronic fatigue syndrome rats and its mechanisms]. Zhen ci yan jiu = Acupuncture research. vol 48. issue 4. 2023-05-15. PMID:37186194. |
to observe the effect of transcutaneous electrical acupoint stimulation (teas) on the histomorphological manifestations of hippocampal ca1 region and the expression of extracellular regulatory protein kinase (erk), cyclic adenosine response element binding protein (creb) and brain-derived neurotrophic factor (bdnf) in chronic fatigue syndrome (cfs) rats, so as to explore the mechanisms of teas in improving the learning and memory abilities of cfs rats. |
2023-05-15 |
2023-08-14 |
rat |
| Mahesh Rachamalla, Arash Salahinejad, Maria Khan, Ashok Kumar Datusalia, Som Niyog. Chronic dietary exposure to arsenic at environmentally relevant concentrations impairs cognitive performance in adult zebrafish (Danio rerio) via oxidative stress and dopaminergic dysfunction. The Science of the total environment. 2023-05-10. PMID:37164085. |
moreover, we also recorded significant downregulation of genes such as the brain-derived neurotrophic factor (bdnf) and ectonucleotidases (entpd2_mg, entpd2_mq, and 5'-nucleotidase), which are critical for learning and memory functions, in the zebrafish brain following chronic dietary exposure to arsenic. |
2023-05-10 |
2023-08-14 |
zebrafish |
| Mohammad Amin Rajizadeh, Mohammad Khaksari, Mohammad Abbas Bejeshk, Ladan Amirkhosravi, Elham Jafari, Zahra Jamalpoor, Akram Nezhad. The Role of Inhaled Estradiol and Myrtenol, Alone and in Combination, in Modulating Behavioral and Functional Outcomes Following Traumatic Experimental Brain Injury: Hemodynamic, Molecular, Histological and Behavioral Study. Neurocritical care. 2023-04-26. PMID:37100976. |
this study assessed the neuroprotective impacts of estradiol (e2), myrtenol (myr), and the combination of the two on the neurological outcome, hemodynamic parameters, learning and memory, brain-derived neurotrophic factor (bdnf) level, phosphoinositide 3-kinases (pi3k/akt) signaling, and inflammatory and oxidative factors in the hippocampus after tbi. |
2023-04-26 |
2023-08-14 |
Not clear |
| b' Rastislav Rovn\\xc3\\xbd, Martin Marko, Drahom\\xc3\\xadr Michalko, Milan Mitka, Barbora Cimrov\\xc3\\xa1, Zuzana Van\\xc4\\x8dov\\xc3\\xa1, Dominika Jar\\xc4\\x8du\\xc5\\xa1kov\\xc3\\xa1, Jozef Draga\\xc5\\xa1ek, Gabriel Min\\xc3\\xa1rik, Igor Rie\\xc4\\x8dansk\\xc3\\xb. BDNF Val66Met polymorphism is associated with consolidation of episodic memory during sleep. Biological psychology. 2023-04-19. PMID:37075935.' |
the brain-derived neurotrophic factor (bdnf) is an essential regulator of synaptic plasticity, a candidate neurobiological mechanism underlying learning and memory. |
2023-04-19 |
2023-08-14 |
Not clear |
| Moein Salari, Seyed Hassan Eftekhar-Vaghefi, Majid Asadi-Shekaari, Khadijeh Esmaeilpour, Somayeh Solhjou, Maryam Amiri, Meysam Ahmadi-Zeidabad. Impact of ketamine administration on chronic unpredictable stress-induced rat model of depression during extremely low-frequency electromagnetic field exposure: Behavioral, histological and molecular study. Brain and behavior. 2023-04-10. PMID:37032465. |
in the study, we examined the effects of ketamine and extremely low-frequency electromagnetic fields (elf-emf) on depression-like behavior, learning and memory, expression of gfap, caspase-3, p53, bdnf, and nmda receptor in animals subjected to chronic unpredictable stress (cus). |
2023-04-10 |
2023-08-14 |
rat |
| Jinmei Zhang, Qiaojing Gao, Jun Gao, Liting Lv, Renfan Liu, Yi Wu, Xue Li, Yu Jin, Lu Wan. Moderate-Intensity Intermittent Training Alters the DNA Methylation Pattern of PDE4D Gene in Hippocampus to Improve the Ability of Spatial Learning and Memory in Aging Rats Reduced by D-Galactose. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979232. |
the morris water maze test was performed before and after miit to evaluate the spatial learning and memory ability, then to observe the synaptic ultrastructure of the hippocampus ca1 region, to detect the expression of synaptic-related protein synaptophysin (syp) and postsynaptic density protein 95 (psd95), and to detect the expression of pde4 subtypes, camp, and its signal pathway protein kinase a (pka)/camp response element binding protein (creb)/brain-derived neurotrophic factor (bdnf), and the pde4 methylation level. |
2023-03-29 |
2023-08-14 |
rat |
| Tadahiro Numakawa, Ryutaro Kajihar. Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer's Disease. Life (Basel, Switzerland). vol 13. issue 3. 2023-03-29. PMID:36983803. |
on the other hand, it is well known that neurotrophic factors, especially brain-derived neurotrophic factor (bdnf) and its high-affinity receptor trkb, have multiple roles in the central nervous system (cns), including neuronal maintenance, synaptic plasticity, and neurogenesis, which are closely linked to learning and memory function. |
2023-03-29 |
2023-08-14 |
Not clear |
| Aoshuang Zhou, Marie-Laure Ancelin, Karen Ritchie, Joanne Rya. Childhood adverse events and Frontiers in psychiatry. vol 14. 2023-03-13. PMID:36911114. |
brain-derived neurotropic factor (bdnf) is a neurotransmitter involved in learning and memory, and altered |
2023-03-13 |
2023-08-14 |
Not clear |
| Nurdarina Ausi Zulkifli, Zurina Hassan, Mohd Zulkifli Mustafa, Wan Norlina Wan Azman, Siti Nurma Hanim Hadie, Nurhafizah Ghani, Anani Aila Mat Zi. The potential neuroprotective effects of stingless bee honey. Frontiers in aging neuroscience. vol 14. 2023-02-27. PMID:36846103. |
through bdnf, sbh can stimulate synaptic plasticity and synaptogenesis, promoting learning and memory. |
2023-02-27 |
2023-08-14 |
bee |
| Barbara Miranda Sartori, Renato Elias Moreira Júnior, Isadora Marques Paiva, Izabela Barbosa Moraes, Luis David Solis Murgas, Ana Lúcia Brunialti-Godar. Acute ethanol exposure leads to long-term effects on memory, behavior, and transcriptional regulation in the zebrafish brain. Behavioural brain research. vol 444. 2023-02-26. PMID:36842314. |
accordingly, we used the zebrafish as a model to evaluate the effects of ethanol on the learning and memory process, as well as its relationship with behavior and transcriptional regulation of lrfn2, lrrk2, grin1a, and bdnf genes in the brain. |
2023-02-26 |
2023-08-14 |
zebrafish |
| Travis D Gibbons, James D Cotter, Philip N Ainslie, Wickliffe C Abraham, Bruce G Mockett, Holly A Campbell, Emma M W Jones, Elliott J Jenkins, Kate N Thoma. Fasting for 20 h does not affect exercise-induced increases in circulating BDNF in humans. The Journal of physiology. 2023-01-11. PMID:36631068. |
this cerebral substrate switch has been implicated in upregulating brain-derived neurotrophic factor (bdnf), a protein involved in neuroplasticity, learning and memory, and may underlie some of these neuroprotective effects. |
2023-01-11 |
2023-08-14 |
human |
| Atilla Topcu, Sinan Saral, Aykut Ozturk, Ozlem Saral, Ali Koray Kay. The effect of the calcium channel blocker nimodipine on hippocampal BDNF/Ach levels in rats with experimental cognitive impairment. Neurological research. 2023-01-04. PMID:36598971. |
nimodipine appears to possess the potential to reverse cognitive impairment-induced dysfunction in learning and memory through its regulatory effect on the brain-derived neurotrophic factor (bdnf), acetylcholine (ach), and acetylcholinesterase (ache) pathway in the hippocampus and prefrontal cortex. |
2023-01-04 |
2023-08-14 |
rat |