| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ewelina Kurowska-Rucińska, Jan Ruciński, Dorota Myślińska, Beata Grembecka, Danuta Wrona, Irena Majkutewic. Dimethyl Fumarate Alleviates Adult Neurogenesis Disruption in Hippocampus and Olfactory Bulb and Spatial Cognitive Deficits Induced by Intracerebroventricular Streptozotocin Injection in Young and Aged Rats. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555093. |
our results showed that the stz-icv evoked spatial learning and memory impairment and disturbances in adult neurogenesis and bdnf expression in both examined brain structures. |
2022-12-23 |
2023-08-14 |
human |
| Jamileh Gholami, Sajad Sahab Negah, Arezoo Rajabian, Ehsan Saburi, Vahid Hajal. The effect of combination pretreatment of donepezil and environmental enrichment on memory deficits in amyloid-beta-induced Alzheimer-like rat model. Biochemistry and biophysics reports. vol 32. 2022-11-28. PMID:36438603. |
spatial learning and memory were assessed in the morris water maze (mwm) and real-time pcr was performed to assess the expression of brain-derived neurotrophic factor (bdnf) and m1 muscarinic acetylcholine receptor (achm1r) within the hippocampus. |
2022-11-28 |
2023-08-14 |
rat |
| Fu-Sheng Wei, Mu-Wen Rao, Yuan-Lu Huang, Shi-Biao Chen, Yu-Qian Wu, Lei Yan. miR-182-5p Delivered by Plasma Exosomes Promotes Sevoflurane-Induced Neuroinflammation and Cognitive Dysfunction in Aged Rats with Postoperative Cognitive Dysfunction by Targeting Brain-Derived Neurotrophic Factor and Activating NF-κB Pathway. Neurotoxicity research. 2022-10-29. PMID:36308704. |
besides, the morris water maze (mwm) and fear conditioning test were used to evaluate the learning and memory ability of rats; western blot to detect the expression levels of neurotrophic factors (brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf)) as well as nf-κb pathway-related proteins (p65 and p-p65) in rat hippocampal tissues or pc-12 cells; qrt-pcr to assess the expression levels of mir-182-5p and bdnf in rat plasma, plasma exosomes, hippocampal tissues, and pc-12 cells; elisa to evaluate the levels of tumor necrosis factor (tnf)-α, interleukin (il)-6, and il-1β in rat hippocampal tissues; and dual-luciferase reporter assay to verify the targeting relationship between mir-182-5p and bdnf. |
2022-10-29 |
2023-08-14 |
rat |
| Fu-Sheng Wei, Mu-Wen Rao, Yuan-Lu Huang, Shi-Biao Chen, Yu-Qian Wu, Lei Yan. miR-182-5p Delivered by Plasma Exosomes Promotes Sevoflurane-Induced Neuroinflammation and Cognitive Dysfunction in Aged Rats with Postoperative Cognitive Dysfunction by Targeting Brain-Derived Neurotrophic Factor and Activating NF-κB Pathway. Neurotoxicity research. 2022-10-29. PMID:36308704. |
inhibition of plasma exosomes or mir-182-5p could significantly ameliorate learning and memory disorders; decrease the levels of pro-inflammatory cytokines tnf-α, il-6, and il-1β; increase the expression of bdnf and ngf; and inhibit the activity of nf-κb signaling pathway in pocd rat hippocampus. |
2022-10-29 |
2023-08-14 |
rat |
| Wen Zhang, Meng-Meng Ge, Long-Qing Zhang, Xiao-Man Yuan, Si-Yi Han, Anne Manyande, Yu-Ke Tian, Xue-Bi Tia. nDysfunction of the BDNF-TrkB signaling pathway contributes to learning and memory impairments induced by neuroinflammation in mice. Neuroscience. 2022-10-20. PMID:36265757. |
accumulating evidence suggests that neuroinflammation is the main mechanism in cognitive dysfunction and that brain-derived neurotrophic factor (bdnf) is involved in learning and memory by binding to tyrosine kinase b (trkb) receptors. |
2022-10-20 |
2023-08-14 |
mouse |
| Elham Akbari, Dawood Hossaini, Ghulam Yahya Amiry, Mostafa Ansari, Murtaza Haidari, Farimah Beheshti, S Mohammad Ahmadi-Soleiman. Vitamin B12 administration prevents ethanol-induced learning and memory impairment through re-establishment of the brain oxidant/antioxidant balance, enhancement of BDNF and suppression of GFAP. Behavioural brain research. 2022-10-15. PMID:36243244. |
vitamin b12 administration prevents ethanol-induced learning and memory impairment through re-establishment of the brain oxidant/antioxidant balance, enhancement of bdnf and suppression of gfap. |
2022-10-15 |
2023-08-14 |
mouse |
| Tadahiro Numakawa, Haruki Odak. The Role of Neurotrophin Signaling in Age-Related Cognitive Decline and Cognitive Diseases. International journal of molecular sciences. vol 23. issue 14. 2022-07-27. PMID:35887075. |
brain-derived neurotrophic factor (bdnf) and its high affinity receptor trkb are highly expressed in the cortical and hippocampal areas and play an essential role in learning and memory. |
2022-07-27 |
2023-08-14 |
Not clear |
| Sanya Roysommuti, James Michael Wys. Brain-Derived Neurotrophic Factor Potentiates Entorhinal-Dentate but not Hippocampus CA1 Pathway in Adult Male Rats: A Mechanism of Taurine-Modulated BDNF on Learning and Memory. Advances in experimental medicine and biology. vol 1370. 2022-07-26. PMID:35882811. |
brain-derived neurotrophic factor potentiates entorhinal-dentate but not hippocampus ca1 pathway in adult male rats: a mechanism of taurine-modulated bdnf on learning and memory. |
2022-07-26 |
2023-08-14 |
rat |
| Sanya Roysommuti, James Michael Wys. Brain-Derived Neurotrophic Factor Potentiates Entorhinal-Dentate but not Hippocampus CA1 Pathway in Adult Male Rats: A Mechanism of Taurine-Modulated BDNF on Learning and Memory. Advances in experimental medicine and biology. vol 1370. 2022-07-26. PMID:35882811. |
taurine plays an important role in neural growth and function from early to adult life, particularly in learning and memory via bdnf action. |
2022-07-26 |
2023-08-14 |
rat |
| Jing-Yu Qi, Liu-Kun Yang, Xin-Shang Wang, Min Wang, Xu-Bo Li, Ban Feng, Yu-Mei Wu, Shui-Bing Liu, Kun Zhan. Mechanism of CNS regulation by irisin, a multifunctional protein. Brain research bulletin. 2022-07-19. PMID:35850187. |
it has been reported that irisin can cross the blood-brain barrier and increase the expression of a brain-derived neurotrophic factor (bdnf) in the hippocampus, which improves learning and memory. |
2022-07-19 |
2023-08-14 |
Not clear |
| Laura Boi, Sabrina Petralla, Barbara Monti, Giuseppe Talani, Enrico Sanna, Maria Giuseppina Pisu, Giulia Calderisi, Elisabetta Maciocco, Mariangela Serra, Alessandra Concas, Patrizia Porc. Chronic treatment with hormonal contraceptives alters hippocampal BDNF and histone H3 post-translational modifications but not learning and memory in female rats. Hormones and behavior. vol 144. 2022-07-05. PMID:35785712. |
chronic treatment with hormonal contraceptives alters hippocampal bdnf and histone h3 post-translational modifications but not learning and memory in female rats. |
2022-07-05 |
2023-08-14 |
rat |
| Khairunnuur Fairuz Azman, Rahimah Zakari. Recent Advances on the Role of Brain-Derived Neurotrophic Factor (BDNF) in Neurodegenerative Diseases. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35743271. |
the signaling cascades initiated by bdnf and its receptor are the key regulators of synaptic plasticity, which plays important role in learning and memory formation. |
2022-06-24 |
2023-08-14 |
Not clear |
| Tae-Woon Kim, Sang-Seo Park, Hye-Sang Par. Effects of Exercise Training during Advanced Maternal Age on the Cognitive Function of Offspring. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628329. |
we found that the offspring of mothers with ama without exercise training had decreased spatial learning and memory, brain-derived neurotrophic factor (bdnf) and postsynaptic density protein 95 (psd-95) protein levels, neurogenesis, and mitochondrial function, as well as hippocampal cell death. |
2022-05-28 |
2023-08-13 |
Not clear |
| Eun-Jung Yoon, Yunseo Choi, Dongsun Par. Improvement of Cognitive Function in Ovariectomized Rats by Human Neural Stem Cells Overexpressing Choline Acetyltransferase via Secretion of NGF and BDNF. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628371. |
we evaluated whether an increase in brain-derived neurotrophic factor (bdnf) and nerve-growth factor (ngf) levels, through transplantation of choline acetyltransferase (chat)-overexpressing neural stem cells (f3.chat), improved learning and memory in ovariectomized rats. |
2022-05-28 |
2023-08-13 |
mouse |
| Darren Ty, Barbara Kania, Alexis Sotelo, Jonathan Wisc. Gut Dysbiosis: A Review of the Effects of a High-Fat Diet on Iron Regulation and Brain-Derived Neurotrophic Factor (BDNF) Expression in the Brain-Gut Axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556900. |
one particular protein of interest is called brain-derived neurotrophic factor (bdnf), which is a protein found in the brain that is important for learning and memory through stabilization of long-term potentiation (ltp). |
2022-05-13 |
2023-08-13 |
human |
| Johanna L Keeler, Olivia Patsalos, Raymond Chung, Ulrike Schmidt, Gerome Breen, Janet Treasure, Himmerich Hubertus, Bethan Dalto. Short communication: Serum levels of brain-derived neurotrophic factor and association with pro-inflammatory cytokines in acute and recovered anorexia nervosa. Journal of psychiatric research. vol 150. 2022-03-29. PMID:35349796. |
brain-derived neurotrophic factor (bdnf) is a neuroprotective molecule known to be involved in neuroplasticity, learning and memory. |
2022-03-29 |
2023-08-13 |
Not clear |
| Dai-Ting Lin, Ning-Juo Kao, Tzu-Wen Liu Cross, Wei-Ju Lee, Shyh-Hsiang Li. Effects of ketogenic diet on cognitive functions of mice fed high-fat-high-cholesterol diet. The Journal of nutritional biochemistry. vol 104. 2022-03-28. PMID:35196576. |
after consuming the hfhc diet for 16 weeks and subsequently receiving the mct diet for 8 weeks, results showed that the mice fed a mct diet had significantly better spatial learning and memory performance, lower expression of nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb), tumor necrosis factor-α (tnf-α), glial fibrillary acidic protein (gfap), amyloid protein precursor (app) and phosphate tau, and higher expression of brain-derived neurotrophic factor (bdnf) than the mice fed the hfhc diet. |
2022-03-28 |
2023-08-16 |
mouse |
| Divya Yadav, Pravir Kuma. Restoration and targeting of aberrant neurotransmitters in Parkinson's disease therapeutics. Neurochemistry international. 2022-03-25. PMID:35331828. |
while the non-dopaminergic system can efficiently target non-motor symptoms, for instance, the noradrenergic system regulates the synthesis of bdnf via the mapk pathway, which is important in learning and memory. |
2022-03-25 |
2023-08-13 |
Not clear |
| Joyce Keife. Regulation of AMPAR trafficking in synaptic plasticity by BDNF and the impact of neurodegenerative disease. Journal of neuroscience research. 2022-02-07. PMID:35128708. |
bdnf is a neurotrophic factor that supports neuronal growth and is required for learning and memory. |
2022-02-07 |
2023-08-13 |
Not clear |
| Medha Kaushik, Pooja Kaushik, Suhel Parve. Memory Related Molecular Signatures: The Pivots for Memory Consolidation and Alzheimer's Related Memory Decline. Ageing research reviews. 2022-02-01. PMID:35104629. |
research on learning and memory has identified several molecular signatures such as protein kinase m zeta (pkmζ), calcium/calmodulin-dependent protein kinase ii (camkii), brain-derived neurotrophic factor (bdnf), camp-response element binding protein (creb), activity-regulated cytoskeleton-associated protein (arc) crucial for the maintenance and stabilization of long-term memory in the brain. |
2022-02-01 |
2023-08-13 |
Not clear |