| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Wang, Hong Liu, Ben-Shu Zhang, Jair C Soares, Xiang Yang Zhan. Low BDNF is associated with cognitive impairments in patients with Parkinson's disease. Parkinsonism & related disorders. vol 29. 2018-02-05. PMID:27245919. |
increasing evidence show that brain-derived neurotrophic factor (bdnf) plays a critical role in neuroplasticity in the hippocampus that is related to learning and memory. |
2018-02-05 |
2023-08-13 |
Not clear |
| Mitsugu Yoneda, Naotoshi Sugimoto, Masanori Katakura, Kentaro Matsuzaki, Hayate Tanigami, Akihiro Yachie, Takako Ohno-Shosaku, Osamu Shid. Theobromine up-regulates cerebral brain-derived neurotrophic factor and facilitates motor learning in mice. The Journal of nutritional biochemistry. vol 39. 2018-01-17. PMID:27833051. |
bdnf supports cell survival and neuronal functions, including learning and memory. |
2018-01-17 |
2023-08-13 |
mouse |
| Norimichi Itoh, Atsushi Enomoto, Taku Nagai, Masahide Takahashi, Kiyofumi Yamad. Molecular mechanism linking BDNF/TrkB signaling with the NMDA receptor in memory: the role of Girdin in the CNS. Reviews in the neurosciences. vol 27. issue 5. 2018-01-02. PMID:26927219. |
brain-derived neurotrophic factor (bdnf)/tropomyosin-related kinase b (trkb) signaling is involved in learning and memory formation by regulating synaptic plasticity. |
2018-01-02 |
2023-08-13 |
Not clear |
| Yu-Fei Ni, Wei Zhang, Xiao-Feng Bao, Wei Wang, Lu Song, Bo Jian. GM1 ganglioside reverses the cognitive deficits induced by MK801 in mice. Behavioural pharmacology. vol 27. issue 5. 2017-11-08. PMID:26960162. |
previous studies have reported that the brain-derived neurotrophic factor (bdnf) signaling is closely involved in learning and memory. |
2017-11-08 |
2023-08-13 |
mouse |
| G Leal, C R Bramham, C B Duart. BDNF and Hippocampal Synaptic Plasticity. Vitamins and hormones. vol 104. 2017-11-02. PMID:28215294. |
such observations prompted the suggestion that bdnf may regulate activity-dependent forms of synaptic plasticity such as long-term potentiation (ltp), a sustained enhancement of excitatory synaptic efficacy thought to underlie learning and memory. |
2017-11-02 |
2023-08-13 |
Not clear |
| Hui Han, Li-Min Wu, Ming-Xiang Han, Wen-Ming Yang, Yan-Xin Wang, Zhao-Hui Fan. Diabetes impairs spatial learning and memory and hippocampal neurogenesis via BDNF in rats with transient global ischemia. Brain research bulletin. vol 124. 2017-10-26. PMID:27233782. |
diabetes impairs spatial learning and memory and hippocampal neurogenesis via bdnf in rats with transient global ischemia. |
2017-10-26 |
2023-08-13 |
human |
| Hui Han, Li-Min Wu, Ming-Xiang Han, Wen-Ming Yang, Yan-Xin Wang, Zhao-Hui Fan. Diabetes impairs spatial learning and memory and hippocampal neurogenesis via BDNF in rats with transient global ischemia. Brain research bulletin. vol 124. 2017-10-26. PMID:27233782. |
on the other hand, treatment with bdnf effectively improves hippocampal neurogenesis and the spatial learning and memory in rat with diabetic ischemia. |
2017-10-26 |
2023-08-13 |
human |
| Hui Han, Li-Min Wu, Ming-Xiang Han, Wen-Ming Yang, Yan-Xin Wang, Zhao-Hui Fan. Diabetes impairs spatial learning and memory and hippocampal neurogenesis via BDNF in rats with transient global ischemia. Brain research bulletin. vol 124. 2017-10-26. PMID:27233782. |
all together, our data suggest that diabetes impaired spatial learning and memory and hippocampal neurogenesis in rats with ischemia by inhibition of the bdnf expression in the hippocampus. |
2017-10-26 |
2023-08-13 |
human |
| Dagmar Bruenig, Janine Lurie, Charles P Morris, Wendy Harvey, Bruce Lawford, Ross McD Young, Joanne Voise. A Case-Control Study and Meta-Analysis Reveal BDNF Val66Met Is a Possible Risk Factor for PTSD. Neural plasticity. vol 2016. 2017-10-26. PMID:27413557. |
brain-derived neurotrophic factor (bdnf) is highly expressed in the mammalian brain and is thought to be involved in learning and memory processes. |
2017-10-26 |
2023-08-13 |
Not clear |
| Elyse Rosa, Sujeivan Mahendram, Yazi D Ke, Lars M Ittner, Stephen D Ginsberg, Margaret Fahnestoc. Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease. Neurobiology of aging. vol 48. 2017-10-12. PMID:27676333. |
we hypothesized that overexpression of wild-type tau downregulates brain-derived neurotrophic factor (bdnf), a neurotrophic peptide essential for learning and memory. |
2017-10-12 |
2023-08-13 |
mouse |
| A R Graves, S J Moore, N Spruston, A K Tryba, C C Kaczorowsk. Brain-derived neurotrophic factor differentially modulates excitability of two classes of hippocampal output neurons. Journal of neurophysiology. vol 116. issue 2. 2017-09-07. PMID:27146982. |
brain-derived neurotrophic factor (bdnf) plays an important role in hippocampus-dependent learning and memory. |
2017-09-07 |
2023-08-13 |
Not clear |
| Lengqiu Guo, Zhuangli Guo, Xiaoqing Luo, Rui Liang, Shui Yang, Haigang Ren, Guanghui Wang, Xuechu Zhe. Phosphodiesterase 10A inhibition attenuates sleep deprivation-induced deficits in long-term fear memory. Neuroscience letters. vol 635. 2017-08-15. PMID:27743798. |
brain-derived neurotropic factor (bdnf) and phosphorylated camp response element-binding protein (pcreb) were altered in specific brain regions associated with learning and memory in rem-sd rats. |
2017-08-15 |
2023-08-13 |
rat |
| Tomoe Y Nakamura, Shu Nakao, Yukako Nakajo, Jun C Takahashi, Shigeo Wakabayashi, Hiroji Yanamot. Possible Signaling Pathways Mediating Neuronal Calcium Sensor-1-Dependent Spatial Learning and Memory in Mice. PloS one. vol 12. issue 1. 2017-08-09. PMID:28122057. |
our findings indicate that ncs-1 may regulate spatial learning and memory function at least in part through activation of camkii-α signaling, which may directly or indirectly increase bdnf production. |
2017-08-09 |
2023-08-13 |
mouse |
| Seyed Morteza Shafiee, Abbas Ali Vafaei, Ali Rashidy-Pou. Effects of maternal hypothyroidism during pregnancy on learning, memory and hippocampal BDNF in rat pups: Beneficial effects of exercise. Neuroscience. vol 329. 2017-07-26. PMID:27181637. |
the findings of the present study indicate that hypothyroidism during the fetal period and the early postnatal period is associated with the impairment of spatial learning and memory and reduced hippocampal bdnf levels in both male and female rat offspring. |
2017-07-26 |
2023-08-13 |
rat |
| Yinjie Li, Jikai Xu, Pu Xu, Shijie Song, Peng Liu, Tianyan Chi, Xuefei Ji, Ge Jin, Shimeng Qiu, Yapeng Hou, Chen Zheng, Lili Wang, Dali Meng, Libo Zo. Xanthoceras sorbifolia extracts ameliorate dendritic spine deficiency and cognitive decline via upregulation of BDNF expression in a rat model of Alzheimer's disease. Neuroscience letters. vol 629. 2017-07-26. PMID:27412235. |
to investigate whether xanthoceras sorbifolia extracts (xse) improve cognition and protect dendritic spines, we performed behavioral tests to investigate learning and memory in an aβ25-35-induced dementia animal model of ad as well as golgi staining to observe dendritic spine formation in ca1 pyramidal neurons and western blots to test the expression levels of psd95, bdnf and downstream signaling pathways. |
2017-07-26 |
2023-08-13 |
rat |
| Lianliang Liu, Jinxuan Cao, Jiong Chen, Xin Zhang, Zufang Wu, Huan Xian. Effects of peptides from Phascolosoma esculenta on spatial learning and memory via anti-oxidative character in mice. Neuroscience letters. vol 631. 2017-07-26. PMID:27519930. |
qrt-pcr results showed that 50 and 100mg/kg administration peptide and 100mg/kg ferrous-chelating peptide can significantly improve mrna expression of nr2a, nr2b and bdnf with oxidative stress status (gsh-px, sod, tac and mda), which explained mechanism for improving learning and memory ability in mice via anti-oxidative character. |
2017-07-26 |
2023-08-13 |
mouse |
| Pietro Cacialli, Marie-Madeleine Gueguen, Pascal Coumailleau, Livia D'Angelo, Olivier Kah, Carla Lucini, Elisabeth Pellegrin. BDNF Expression in Larval and Adult Zebrafish Brain: Distribution and Cell Identification. PloS one. vol 11. issue 6. 2017-07-24. PMID:27336917. |
bdnf plays significant roles in neurogenesis, neuronal maturation and/or synaptic plasticity and is involved in cognitive functions such as learning and memory. |
2017-07-24 |
2023-08-13 |
zebrafish |
| Michelle D Failla, Shannon B Juengst, Patricia M Arenth, Amy K Wagne. Preliminary Associations Between Brain-Derived Neurotrophic Factor, Memory Impairment, Functional Cognition, and Depressive Symptoms Following Severe TBI. Neurorehabilitation and neural repair. vol 30. issue 5. 2017-07-14. PMID:26276123. |
brain-derived neurotrophic factor (bdnf) is a likely target based on evidence of reduced bdnf signaling in experimental tbi and depression models and its role in learning and memory. |
2017-07-14 |
2023-08-13 |
human |
| Liang Zhong, Foquan Luo, Weilu Zhao, Yunlin Feng, Liuqin Wu, Jiamei Lin, Tianyin Liu, Shengqiang Wang, Xuexue You, Wei Zhan. Propofol exposure during late stages of pregnancy impairs learning and memory in rat offspring via the BDNF-TrkB signalling pathway. Journal of cellular and molecular medicine. vol 20. issue 10. 2017-07-11. PMID:27297627. |
the brain-derived neurotrophic factor (bdnf)-tyrosine kinase b (trkb) (bdnf-trkb) signalling pathway plays a crucial role in regulating learning and memory. |
2017-07-11 |
2023-08-13 |
rat |
| Liang Zhong, Foquan Luo, Weilu Zhao, Yunlin Feng, Liuqin Wu, Jiamei Lin, Tianyin Liu, Shengqiang Wang, Xuexue You, Wei Zhan. Propofol exposure during late stages of pregnancy impairs learning and memory in rat offspring via the BDNF-TrkB signalling pathway. Journal of cellular and molecular medicine. vol 20. issue 10. 2017-07-11. PMID:27297627. |
it was discovered that maternal exposure to propofol on day e18 impaired spatial learning and memory of rat offspring, decreased mrna and protein levels of bdnf and trkb, and decreased the levels of both phospho-trkb and synaptophysin in the hippocampus. |
2017-07-11 |
2023-08-13 |
rat |