| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fernando Gomez-Pinilla, Shoshanna Vaynman, Zhe Yin. Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition. The European journal of neuroscience. vol 28. issue 11. 2009-02-20. PMID:19046371. |
one week of voluntary exercise that enhanced learning and memory performance elevated the expression of molecular systems involved in the metabolism of energy [amp-activated protein kinase (ampk), ubiquitous mitochondrial creatine kinase (umtck) and uncoupling protein 2] and molecules that work at the interface of energy and synaptic plasticity [bdnf, insulin-like growth factor i (igf-i) and ghrelin]. |
2009-02-20 |
2023-08-12 |
rat |
| Yukako Nakajo, Susumu Miyamoto, Yoshikazu Nakano, Jing-Hui Xue, Takuya Hori, Hiroji Yanamot. Genetic increase in brain-derived neurotrophic factor levels enhances learning and memory. Brain research. vol 1241. 2009-01-26. PMID:18801341. |
brain-derived neurotrophic factor (bdnf), a neurotrophin, is known to promote neuronal differentiation stimulating neurite outgrowth in the developing cns, and is also known to modulate synaptic plasticity, thereby contributing to learning and memory in the mature brain. |
2009-01-26 |
2023-08-12 |
mouse |
| Yukako Nakajo, Susumu Miyamoto, Yoshikazu Nakano, Jing-Hui Xue, Takuya Hori, Hiroji Yanamot. Genetic increase in brain-derived neurotrophic factor levels enhances learning and memory. Brain research. vol 1241. 2009-01-26. PMID:18801341. |
here, we investigated the role of increased levels of intracerebral bdnf in learning and memory function. |
2009-01-26 |
2023-08-12 |
mouse |
| Yukako Nakajo, Susumu Miyamoto, Yoshikazu Nakano, Jing-Hui Xue, Takuya Hori, Hiroji Yanamot. Genetic increase in brain-derived neurotrophic factor levels enhances learning and memory. Brain research. vol 1241. 2009-01-26. PMID:18801341. |
because the maximum swimming velocity was not affected in the bdnf-transgenic mice, increased bdnf levels in the brain were found to enhance spatial learning and memory function. |
2009-01-26 |
2023-08-12 |
mouse |
| A Wu, Z Ying, F Gomez-Pinill. Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. Neuroscience. vol 155. issue 3. 2008-12-18. PMID:18620024. |
akt and camkii signaling are crucial step by which bdnf exerts its action on synaptic plasticity and learning and memory. |
2008-12-18 |
2023-08-12 |
rat |
| Ryota Hashimoto, Yoshiya Moriguchi, Fumio Yamashita, Takeyuki Mori, Kiyotaka Nemoto, Takeya Okada, Hiroaki Hori, Hiroko Noguchi, Hiroshi Kunugi, Takashi Ohnish. Dose-dependent effect of the Val66Met polymorphism of the brain-derived neurotrophic factor gene on memory-related hippocampal activity. Neuroscience research. vol 61. issue 4. 2008-11-26. PMID:18501457. |
brain-derived neurotrophic factor (bdnf) plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. |
2008-11-26 |
2023-08-12 |
human |
| Enrico Tongiorg. Activity-dependent expression of brain-derived neurotrophic factor in dendrites: facts and open questions. Neuroscience research. vol 61. issue 4. 2008-11-26. PMID:18550187. |
one of such mrnas encodes brain-derived neurotrophic factor (bdnf), a key molecule in neuronal development, learning and memory. |
2008-11-26 |
2023-08-12 |
Not clear |
| A G Xuan, D H Long, H G Gu, D D Yang, L P Hong, S L Len. BDNF improves the effects of neural stem cells on the rat model of Alzheimer's disease with unilateral lesion of fimbria-fornix. Neuroscience letters. vol 440. issue 3. 2008-11-05. PMID:18579298. |
learning and memory abilities were also measured by y-maze test and the results support that bdnf can enhance the treatment effects of nscs transplanted into brain lesion model. |
2008-11-05 |
2023-08-12 |
rat |
| Chin-Min Chuang, Ching-Liang Hsieh, Hui-Yi Lin, Jaung-Geng Li. Panax Notoginseng Burk attenuates impairment of learning and memory functions and increases ED1, BDNF and beta-secretase immunoreactive cells in chronic stage ischemia-reperfusion injured rats. The American journal of Chinese medicine. vol 36. issue 4. 2008-10-28. PMID:18711766. |
panax notoginseng burk attenuates impairment of learning and memory functions and increases ed1, bdnf and beta-secretase immunoreactive cells in chronic stage ischemia-reperfusion injured rats. |
2008-10-28 |
2023-08-12 |
rat |
| Chin-Min Chuang, Ching-Liang Hsieh, Hui-Yi Lin, Jaung-Geng Li. Panax Notoginseng Burk attenuates impairment of learning and memory functions and increases ED1, BDNF and beta-secretase immunoreactive cells in chronic stage ischemia-reperfusion injured rats. The American journal of Chinese medicine. vol 36. issue 4. 2008-10-28. PMID:18711766. |
pn attenuated the reduction in learning and memory functions induced by cerebral infarction in cerebral ischemia-reperfusion injured rats; it also increased the amount of activated microglia and bdnf. |
2008-10-28 |
2023-08-12 |
rat |
| Hiroji Yanamoto, Susumu Miyamoto, Yukako Nakajo, Yoshikazu Nakano, Takuya Hori, Hiroaki Naritomi, Haruhiko Kikuch. Repeated application of an electric field increases BDNF in the brain, enhances spatial learning, and induces infarct tolerance. Brain research. vol 1212. 2008-08-26. PMID:18439988. |
development of a safe method to increase brain-derived neurotrophic factor (bdnf) in the brain is expected to have utility in enhancing learning and memory, in protecting the brain, and in suppressing appetite. |
2008-08-26 |
2023-08-12 |
mouse |
| Kwok Ho Christopher Choy, Yvonne de Visser, Nancy R Nichols, Maarten van den Buus. Combined neonatal stress and young-adult glucocorticoid stimulation in rats reduce BDNF expression in hippocampus: effects on learning and memory. Hippocampus. vol 18. issue 7. 2008-08-20. PMID:18398848. |
combined neonatal stress and young-adult glucocorticoid stimulation in rats reduce bdnf expression in hippocampus: effects on learning and memory. |
2008-08-20 |
2023-08-12 |
rat |
| Kwok Ho Christopher Choy, Yvonne de Visser, Nancy R Nichols, Maarten van den Buus. Combined neonatal stress and young-adult glucocorticoid stimulation in rats reduce BDNF expression in hippocampus: effects on learning and memory. Hippocampus. vol 18. issue 7. 2008-08-20. PMID:18398848. |
to assess whether there were behavioral effects, which may correlate with the bdnf changes, learning and memory was tested in the y-maze test for short term spatial memory, the morris water maze for long-term spatial memory, and the t-maze test for working memory. |
2008-08-20 |
2023-08-12 |
rat |
| Kwok Ho Christopher Choy, Yvonne de Visser, Nancy R Nichols, Maarten van den Buus. Combined neonatal stress and young-adult glucocorticoid stimulation in rats reduce BDNF expression in hippocampus: effects on learning and memory. Hippocampus. vol 18. issue 7. 2008-08-20. PMID:18398848. |
this study demonstrates a persistent effect of two developmental disruptions on bdnf expression in the hippocampus, with parallel, but not completely correlative changes in learning and memory. |
2008-08-20 |
2023-08-12 |
rat |
| Enrico Tongiorgi, Gabriele Ba. Functions and mechanisms of BDNF mRNA trafficking. Novartis Foundation symposium. vol 289. 2008-08-07. PMID:18497100. |
one such mrna encodes brain derived neurotrophic factor (bdnf), a key molecule in neuronal development that plays a critical role in learning and memory, and which displays abnormal levels in several neuropsychiatric disorders. |
2008-08-07 |
2023-08-12 |
Not clear |
| Nobuyuki Mochizuki, Norio Takagi, Koji Kurokawa, Chika Onozato, Yoshiyuki Moriyama, Kouichi Tanonaka, Satoshi Take. Injection of neural progenitor cells improved learning and memory dysfunction after cerebral ischemia. Experimental neurology. vol 211. issue 1. 2008-07-30. PMID:18346733. |
these results suggest that the injection of exogenous npcs into the hippocampus can prevent cerebral ischemia-induced learning and memory dysfunction, possibly through maintenance of the bdnf level. |
2008-07-30 |
2023-08-12 |
rat |
| Pedro Bekinschtein, Martin Cammarota, Ivan Izquierdo, Jorge H Medin. BDNF and memory formation and storage. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 14. issue 2. 2008-06-12. PMID:17911219. |
in this review, we focus on the newer experiments that involve bdnf in different aspects of learning and memory processing-in particular, in memory persistence and storage. |
2008-06-12 |
2023-08-12 |
Not clear |
| Staci D Bilbo, Ruth M Barrientos, Andrea S Eads, Alexis Northcutt, Linda R Watkins, Jerry W Rudy, Steven F Maie. Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood. Brain, behavior, and immunity. vol 22. issue 4. 2008-06-04. PMID:17997277. |
bdnf is well characterized for its critical role in learning and memory. |
2008-06-04 |
2023-08-12 |
rat |
| S Krause, K Schindowski, S Zechel, O von Bohlen und Halbac. Expression of trkB and trkC receptors and their ligands brain-derived neurotrophic factor and neurotrophin-3 in the murine amygdala. Journal of neuroscience research. vol 86. issue 2. 2008-05-13. PMID:17828769. |
the neurotrophin brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3) and their cognate receptors, trkb and trkc, have a variety of physiological brain functions, ranging from cell survival to mechanisms involved in learning and memory and long-term potentiation (ltp). |
2008-05-13 |
2023-08-12 |
mouse |
| Lesley J White, Vanessa Castellan. Exercise and brain health--implications for multiple sclerosis: Part 1--neuronal growth factors. Sports medicine (Auckland, N.Z.). vol 38. issue 2. 2008-04-22. PMID:18201113. |
physical activity has also been shown to up-regulate hippocampal bdnf, which may play a role in mood states, learning and memory to lessen the decline in cognitive function associated with ms. |
2008-04-22 |
2023-08-12 |
Not clear |