| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kiyofumi Yamada, Toshitaka Nabeshim. Brain-derived neurotrophic factor/TrkB signaling in memory processes. Journal of pharmacological sciences. vol 91. issue 4. 2004-03-01. PMID:12719654. |
genetic as well as pharmacologic deprivation of bdnf or trkb impairs learning and memory. |
2004-03-01 |
2023-08-12 |
Not clear |
| J Patrick Kesslak, Kenneth R Chuang, Nicole C Berchtol. Spatial learning is delayed and brain-derived neurotrophic factor mRNA expression inhibited by administration of MK-801 in rats. Neuroscience letters. vol 353. issue 2. 2004-01-16. PMID:14664909. |
these data suggest that bdnf expression is important for nmda-dependent learning and memory. |
2004-01-16 |
2023-08-12 |
rat |
| J Patrick Kesslak, Kenneth R Chuang, Nicole C Berchtol. Spatial learning is delayed and brain-derived neurotrophic factor mRNA expression inhibited by administration of MK-801 in rats. Neuroscience letters. vol 353. issue 2. 2004-01-16. PMID:14664909. |
increases in bdnf and nmda activity may be significant components in learning and memory, and modulation of these systems may be beneficial for developing strategies to improve cognitive function. |
2004-01-16 |
2023-08-12 |
rat |
| Rachel D Groth, Paul G Mermelstei. Brain-derived neurotrophic factor activation of NFAT (nuclear factor of activated T-cells)-dependent transcription: a role for the transcription factor NFATc4 in neurotrophin-mediated gene expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 22. 2003-10-02. PMID:12954875. |
within the adult brain, bdnf is also important in neuronal adaptive processes, such as the activity-dependent plasticity that underlies learning and memory. |
2003-10-02 |
2023-08-12 |
rat |
| M Mizuno, K Yamada, N Takei, M H Tran, J He, A Nakajima, H Nawa, T Nabeshim. Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formation. Molecular psychiatry. vol 8. issue 2. 2003-09-23. PMID:12610654. |
brain-derived neurotrophic factor (bdnf) plays a critical role in synaptic plasticity such as long-term potentiation (ltp), a form of synaptic correlate of learning and memory. |
2003-09-23 |
2023-08-12 |
rat |
| M Mizuno, K Yamada, N Takei, M H Tran, J He, A Nakajima, H Nawa, T Nabeshim. Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formation. Molecular psychiatry. vol 8. issue 2. 2003-09-23. PMID:12610654. |
bdnf is also implicated in learning and memory. |
2003-09-23 |
2023-08-12 |
rat |
| M Mizuno, K Yamada, N Takei, M H Tran, J He, A Nakajima, H Nawa, T Nabeshim. Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formation. Molecular psychiatry. vol 8. issue 2. 2003-09-23. PMID:12610654. |
we have demonstrated that radial arm maze training in rats for spatial learning and memory results in a significant increase in the bdnf mrna expression in the hippocampus. |
2003-09-23 |
2023-08-12 |
rat |
| Ahmad R Hariri, Terry E Goldberg, Venkata S Mattay, Bhaskar S Kolachana, Joseph H Callicott, Michael F Egan, Daniel R Weinberge. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 17. 2003-09-03. PMID:12890761. |
bdnf plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. |
2003-09-03 |
2023-08-12 |
human |
| Marzia Malcangio, Volkmar Lessman. A common thread for pain and memory synapses? Brain-derived neurotrophic factor and trkB receptors. Trends in pharmacological sciences. vol 24. issue 3. 2003-04-08. PMID:12628355. |
here, we focus on brain-derived neurotrophic factor (bdnf), which exerts a modulatory action at hippocampal synapses that are involved in learning and memory, and at the first pain synapse between primary sensory neurones and dorsal horn neurones. |
2003-04-08 |
2023-08-12 |
Not clear |
| Mary Eve McCutchen, Clive R Bramham, Lucas D Pozzo-Mille. Modulation of neuronal calcium signaling by neurotrophic factors. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 20. issue 3-5. 2002-12-17. PMID:12175855. |
these results suggest that, despite bdnf's profound effects on hippocampal synaptic plasticity, and of l-type ca(2+) channels on neuronal gene transcription, the role of bdnf in cellular models of hippocampus-dependent learning and memory does not involve modulation of voltage-gated dendritic ca(2+) signaling mediated by l-type channels in apical dendrites of ca1 pyramidal neurons. |
2002-12-17 |
2023-08-12 |
Not clear |
| R Molteni, R J Barnard, Z Ying, C K Roberts, F Gómez-Pinill. A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience. vol 112. issue 4. 2002-09-03. PMID:12088740. |
in particular, animals maintained on the hfs diet showed a decrease in levels of: (i) synapsin i mrna and protein (total and phosphorylated), important for neurotransmitter release; (ii) cyclic amp-response element-binding protein (creb) mrna and protein (total and phosphorylated); creb is required for various forms of memory and is under regulatory control of bdnf; (iii) growth-associated protein 43 mrna, important for neurite outgrowth, neurotransmitter release, and learning and memory. |
2002-09-03 |
2023-08-12 |
rat |
| Kiyofumi Yamada, Makoto Mizuno, Toshitaka Nabeshim. Role for brain-derived neurotrophic factor in learning and memory. Life sciences. vol 70. issue 7. 2002-02-22. PMID:11833737. |
these results suggest a role for bdnf in learning and memory processes, since memory acquisition is considered to involve both short-term changes in electrical properties and long-term structural alterations in synapses. |
2002-02-22 |
2023-08-12 |
mouse |
| Kiyofumi Yamada, Makoto Mizuno, Toshitaka Nabeshim. Role for brain-derived neurotrophic factor in learning and memory. Life sciences. vol 70. issue 7. 2002-02-22. PMID:11833737. |
moreover, the pharmacologic and genetic deprivation of bdnf or its receptor trkb results in severe impairment of learning and memory in mice, rats and chicks. |
2002-02-22 |
2023-08-12 |
mouse |
| Kiyofumi Yamada, Makoto Mizuno, Toshitaka Nabeshim. Role for brain-derived neurotrophic factor in learning and memory. Life sciences. vol 70. issue 7. 2002-02-22. PMID:11833737. |
the effect of bdnf on learning and memory may be linked to the modulation of nmda and non-nmda receptor functions as well as the expression of synaptic proteins required for exocytosis. |
2002-02-22 |
2023-08-12 |
mouse |
| L Tong, P L Thornton, R Balazs, C W Cotma. Beta -amyloid-(1-42) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival Is not compromised. The Journal of biological chemistry. vol 276. issue 20. 2001-07-05. PMID:11278679. |
in view of the critical role of creb and bdnf in neuronal plasticity, including learning and memory, the observations indicate a novel pathway through which abeta may interfere with neuronal functions and contribute to cognitive deficit in alzheimer's disease before the stage of massive neuronal degeneration. |
2001-07-05 |
2023-08-12 |
Not clear |
| C R Almli, T J Levy, B H Han, A R Shah, J M Gidday, D M Holtzma. BDNF protects against spatial memory deficits following neonatal hypoxia-ischemia. Experimental neurology. vol 166. issue 1. 2000-12-07. PMID:11031087. |
the present study explored potential relationships between neural protective and behavioral protective strategies in this neonatal h-i model by determining if neonatal h-i was associated with behavioral spatial learning and memory deficits and whether the neurotrophin bdnf was protective against both brain injury and spatial learning/memory dysfunction. |
2000-12-07 |
2023-08-12 |
human |
| C R Almli, T J Levy, B H Han, A R Shah, J M Gidday, D M Holtzma. BDNF protects against spatial memory deficits following neonatal hypoxia-ischemia. Experimental neurology. vol 166. issue 1. 2000-12-07. PMID:11031087. |
postnatal day seven rats received vehicle or bdnf pretreatments (intracerebroventricular injections) followed by h-i or sham treatments and then tested for spatial learning and memory on the simple place task in the morris water maze from postnatal days 20 to 30, and their brains were histologically analyzed at 4 weeks following treatments. |
2000-12-07 |
2023-08-12 |
human |
| M Mizuno, K Yamada, A Olariu, H Nawa, T Nabeshim. Involvement of brain-derived neurotrophic factor in spatial memory formation and maintenance in a radial arm maze test in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 18. 2000-10-18. PMID:10995859. |
to clarify the causal relation between bdnf mrna expression and spatial memory formation, we examined the effects of antisense bdnf treatment on spatial learning and memory. |
2000-10-18 |
2023-08-12 |
rat |
| M J Schaaf, R M Sibug, R Duurland, M F Fluttert, M S Oitzl, E R De Kloet, E Vreugdenhi. Corticosterone effects on BDNF mRNA expression in the rat hippocampus during morris water maze training. Stress (Amsterdam, Netherlands). vol 3. issue 2. 2000-09-14. PMID:10938578. |
hence, our results suggest that in this situation bdnf is resistant to regulation by endogenous corticosterone, which may be important for learning and memory processes. |
2000-09-14 |
2023-08-12 |
rat |
| D Liu, J Diorio, J C Day, D D Francis, M J Meane. Maternal care, hippocampal synaptogenesis and cognitive development in rats. Nature neuroscience. vol 3. issue 8. 2000-08-15. PMID:10903573. |
thus, the offspring of mothers that show high levels of pup licking and grooming and arched-back nursing showed increased expression of nmda receptor subunit and brain-derived neurotrophic factor (bdnf) mrna, increased cholinergic innervation of the hippocampus and enhanced spatial learning and memory. |
2000-08-15 |
2023-08-12 |
rat |