| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Monica Reis, Emily Mavin, Lindsay Nicholson, Kile Green, Anne M Dickinson, Xiao-Nong Wan. Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Dendritic Cell Maturation and Function. Frontiers in immunology. vol 9. 2019-10-03. PMID:30473695. |
msc-evs were isolated from msc conditioned media using differential ultracentrifugation. |
2019-10-03 |
2023-08-13 |
human |
| Alessandra Pelagalli, Anna Nardelli, Enrico Lucarelli, Antonella Zannetti, Arturo Brunett. Autocrine signals increase ovine mesenchymal stem cells migration through Aquaporin-1 and CXCR4 overexpression. Journal of cellular physiology. vol 233. issue 8. 2019-09-23. PMID:29345324. |
recently, several studies have shown that msc function is largely dependent on factors that mscs release in the environment, as well as, in conditioned medium (cm). |
2019-09-23 |
2023-08-13 |
Not clear |
| R R Klimova, Е D Momotyuk, N A Demidova, E I Yarigina, A A Kushc. [Mesenchymal stem cells enhance immune response and protect mice against lethal herpes viral infection.] Voprosy virusologii. vol 63. issue 6. 2019-09-13. PMID:30641021. |
conditioned media from msc collected after 4-5 passages inhibited hsv1 infection in vitro by 64-70% and contained il-6 and tnf-α, whose concentrations were 5- and 20-fold higher, respectively, than in the control. |
2019-09-13 |
2023-08-13 |
mouse |
| Jonathan G Thomas, Brittany C Parker Kerrigan, Anwar Hossain, Joy Gumin, Naoki Shinojima, Felix Nwajei, Ravesanker Ezhilarasan, Patrice Love, Erik P Sulman, Frederick F Lan. Ionizing radiation augments glioma tropism of mesenchymal stem cells. Journal of neurosurgery. vol 128. issue 1. 2019-09-12. PMID:28362237. |
methods to assess the effect of ir on msc migration in vitro, transwell assays using conditioned medium (cm) from an irradiated commercially available glioma cell line (u87) and from irradiated patient-derived glioma stem-like cells (gscs; gsc7-2 and gsc11) were employed. |
2019-09-12 |
2023-08-13 |
mouse |
| Georgy Sagaradze, Olga Grigorieva, Peter Nimiritsky, Nataliya Basalova, Natalia Kalinina, Zhanna Akopyan, Anastasia Efimenk. Conditioned Medium from Human Mesenchymal Stromal Cells: Towards the Clinical Translation. International journal of molecular sciences. vol 20. issue 7. 2019-07-30. PMID:30987106. |
due to comparable effects along with superior safety msc conditioned medium (msc-cm) containing a complex of msc-secreted products is considered a reasonable alternative to cell therapy. |
2019-07-30 |
2023-08-13 |
human |
| Fábio G Teixeira, Miguel M Carvalho, Krishna M Panchalingam, Ana J Rodrigues, Bárbara Mendes-Pinheiro, Sandra Anjo, Bruno Manadas, Leo A Behie, Nuno Sousa, António J Salgad. Impact of the Secretome of Human Mesenchymal Stem Cells on Brain Structure and Animal Behavior in a Rat Model of Parkinson's Disease. Stem cells translational medicine. vol 6. issue 2. 2019-07-08. PMID:28191785. |
additionally, using dynamic culturing conditions (through computer-controlled bioreactors) can further modulate the msc secretome, thereby generating a more potent neurotrophic factor cocktail (i.e., conditioned medium). |
2019-07-08 |
2023-08-13 |
human |
| Claudia Lo Sicco, Daniele Reverberi, Carolina Balbi, Valentina Ulivi, Elisa Principi, Luisa Pascucci, Pamela Becherini, Maria Carla Bosco, Luigi Varesio, Chiara Franzin, Michela Pozzobon, Ranieri Cancedda, Roberta Tass. Mesenchymal Stem Cell-Derived Extracellular Vesicles as Mediators of Anti-Inflammatory Effects: Endorsement of Macrophage Polarization. Stem cells translational medicine. vol 6. issue 3. 2019-06-28. PMID:28186708. |
the ev-isolation method was based on repeated ultracentrifugations of the medium conditioned by msc exposed to normoxic or hypoxic conditions (ev |
2019-06-28 |
2023-08-13 |
human |
| Feng Dong, Shyam Patnaik, Zhong-Hui Duan, Matthew Kiedrowski, Marc S Penn, Maritza E Mayorg. A Novel Role for CAMKK1 in the Regulation of the Mesenchymal Stem Cell Secretome. Stem cells translational medicine. vol 6. issue 9. 2019-06-27. PMID:28688176. |
studies suggest that the effects of mesenchymal stem cells (msc) are due to paracrine factors released by msc, as the benefits of msc can be achieved through delivery of conditioned media (cm) alone. |
2019-06-27 |
2023-08-13 |
Not clear |
| Jae Hoon Lee, Jeonghyun Park, Jae-Woo Le. Therapeutic use of mesenchymal stem cell-derived extracellular vesicles in acute lung injury. Transfusion. vol 59. issue S1. 2019-06-03. PMID:30383895. |
while certain logistic obstacles limit the clinical applications of msc-conditioned medium such as the volume required for treatment and lack of standardization of what constitutes the components of conditioned medium, the therapeutic application of msc evs remains promising, primarily due to ability of evs to maintain the functional phenotype of the parent cell. |
2019-06-03 |
2023-08-13 |
Not clear |
| Xu-Xin Chen, Lu Tang, Zhi-Hai Han, Wen-Jing Wang, Ji-Guang Men. Coculture with bone marrow‑derived mesenchymal stem cells attenuates inflammation and apoptosis in lipopolysaccharide‑stimulated alveolar epithelial cells via enhanced secretion of keratinocyte growth factor and angiopoietin‑1 modulating the Toll‑like receptor‑4 signal pathway. Molecular medicine reports. vol 19. issue 3. 2019-05-31. PMID:30628710. |
kgf and/or angpt1 neutralizing antibodies diminished the beneficial effect of msc conditioned medium. |
2019-05-31 |
2023-08-13 |
Not clear |
| Wai Hoe Ng, Mimi Zulaikha Umar Fuaad, Siti Maisura Azmi, Yin Yee Leong, Yoke Keong Yong, Angela Min Hwei Ng, Jun Jie Ta. Guided evaluation and standardisation of mesenchymal stem cell culture conditions to generate conditioned medium favourable to cardiac c-kit cell growth. Cell and tissue research. vol 375. issue 2. 2019-05-10. PMID:30232595. |
this study aims to optimise msc growth conditions and medium formulation for generating the conditioned medium (cdm) to facilitate cc growth and expansion in vitro. |
2019-05-10 |
2023-08-13 |
Not clear |
| Berly Cahuascanco, Javiera Bahamonde, Olger Huaman, Miguel Jervis, Jahaira Cortez, Jaime Palomino, Alejandro Escobar, Patricio Retamal, Cristian G Torres, Oscar Alejandro Peralt. Bovine fetal mesenchymal stem cells exert antiproliferative effect against mastitis causing pathogen Staphylococcus aureus. Veterinary research. vol 50. issue 1. 2019-04-23. PMID:30975214. |
the aim of the present study was to evaluate the in vitro antibacterial potential against s. aureus of conditioned medium (cm) from msc derived from fetal bovine bone marrow (bm-msc) and adipose tissue (at-msc). |
2019-04-23 |
2023-08-13 |
cattle |
| G D Sagaradze, N A Basalova, V I Kirpatovsky, D A Ohobotov, O A Grigorieva, V Yu Balabanyan, A A Kamalov, A Yu Efimenk. Application of rat cryptorchidism model for the evaluation of mesenchymal stromal cell secretome regenerative potential. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-03-26. PMID:30551394. |
using the rat model of bilateral abdominal cryptorchidism, we studied the contribution of msc conditioned medium contained bioactive cell secreted products to the spermatogenesis recovery. |
2019-03-26 |
2023-08-13 |
rat |
| Satoru Otsuru, Laura Desbourdes, Adam J Guess, Ted J Hofmann, Theresa Relation, Takashi Kaito, Massimo Dominici, Masahiro Iwamoto, Edwin M Horwit. Extracellular vesicles released from mesenchymal stromal cells stimulate bone growth in osteogenesis imperfecta. Cytotherapy. vol 20. issue 1. 2019-03-18. PMID:29107738. |
using an animal model of oi we have previously shown that msc infusion stimulates chondrocyte proliferation in the growth plate and that this enhanced proliferation is also observed with infusion of msc conditioned medium in lieu of mscs, suggesting that bone growth is due to trophic effects of mscs. |
2019-03-18 |
2023-08-13 |
Not clear |
| Juan Andrés Parga, María García-Garrote, Salvador Martínez, Ángel Raya, José Luis Labandeira-García, Jannette Rodríguez-Pallare. Prostaglandin EP2 Receptors Mediate Mesenchymal Stromal Cell-Neuroprotective Effects on Dopaminergic Neurons. Molecular neurobiology. vol 55. issue 6. 2019-02-26. PMID:28717970. |
we analyzed the viability of dopaminergic cells from different sources in response to conditioned medium derived from bone marrow msc (msc-cm). |
2019-02-26 |
2023-08-13 |
human |
| Fei Luo, Zhao Sun, Qin Han, Chunling Xue, Chunmei Ba. Effect of Human Hepatocellular Carcinoma HepG2 Cell-derived Exosome on the Differentiation of Mesenchymal Stem Cells and Their Interaction. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 39. issue 3. 2019-02-08. PMID:28695799. |
hepg2 cells were co-cultured with the conditioned media(cm),in which hepg2 exosome induced the differentiation of msc into caf. |
2019-02-08 |
2023-08-13 |
human |
| Fei Luo, Zhao Sun, Qin Han, Chunling Xue, Chunmei Ba. Effect of Human Hepatocellular Carcinoma HepG2 Cell-derived Exosome on the Differentiation of Mesenchymal Stem Cells and Their Interaction. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 39. issue 3. 2019-02-08. PMID:28695799. |
the conditioned media which hepg2 exosome induced msc differentiation caf(caf-cm)could significantly promote hepg2 cells proliferation(1.075±0.104),compared to bsa control(0.874±0.066,p=0.023)and msc-cm(0.649±0.034,p=0.0005). |
2019-02-08 |
2023-08-13 |
human |
| Fei Luo, Zhao Sun, Qin Han, Chunling Xue, Chunmei Ba. Effect of Human Hepatocellular Carcinoma HepG2 Cell-derived Exosome on the Differentiation of Mesenchymal Stem Cells and Their Interaction. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 39. issue 3. 2019-02-08. PMID:28695799. |
moreover the conditioned medium which hepg2 exosome induced msc to differentiate into caf could also promote the expressions of mesenchyme-related genes smad interacting protein 1(p=0.040),β-catenin(p=0.038),fibronectin(p=0.029),and vimentin(p=0.013)and inhibit the expression of epithelial related genes zonula ocdudens-1(p=0.010).conclusions exosome extracted from hepg2 cells can induce human adipose-derived msc to differentiate into cancer-associated myofibroblasts. |
2019-02-08 |
2023-08-13 |
human |
| Chelsea R Wood, Ibtesam R T Al Delfi, John F Innes, Peter Myint, William E B Johnso. Exposing mesenchymal stem cells to chondroitin sulphated proteoglycans reduces their angiogenic and neuro-adhesive paracrine activity. Biochimie. vol 155. 2018-12-11. PMID:29680669. |
culture conditioned medium harvested from these cultures (primed msc cm) was used as both culture substrata and soluble medium for ea.hy926 endothelial cells and sh-sy5y neuronal cells. |
2018-12-11 |
2023-08-13 |
Not clear |
| Patrick C Baer, Jürgen M Overath, Anja Urbschat, Ralf Schubert, Benjamin Koch, Asanke A Bohn, Helmut Geige. Effect of Different Preconditioning Regimens on the Expression Profile of Murine Adipose-Derived Stromal/Stem Cells. International journal of molecular sciences. vol 19. issue 6. 2018-10-08. PMID:29890767. |
optimization of this regenerative potential of mesenchymal stromal/stem cells (msc) or their conditioned medium by in vitro preconditioning regimens are considered to be a promising strategy to improve the release of regenerative factors. |
2018-10-08 |
2023-08-13 |
mouse |